Scrabble and Retrograde Analysis

Reading Mike Keith\u27s article Scrabble-Tile Double Word Squares and Rectangles (WW Feb 2011) led me to ask the following question: which of the word grids he gave are actually legal positions in a game of Scrabble? Chess problemists use the term retrograde analysis for the study of how chess positions might have arisen in a legal game; this concept is of course equally applicable to other games, including Scrabble

Properties of Sequences

Anil (WW 41 (2) p223) asks whether there is a theory which explains how the periodic behaviour of Fibconacci letter-sequences works. The answer is yes, there is indeed such a theory, and it has many other applications, both mathematical and practical. Though this theory has nothing to do with words, I hope that readers will he interested in its results. However, most of the proofs will be beyond the scope of this article

Suspicion of money laundering reporting obligations: auditor compliance, or sceptical failure to engage?

Money laundering has become of increasing concern to law makers in recent years, principally because of its associations with terrorism. Recent legislative changes in the United Kingdom mean that auditors risk becoming state law enforcement agents in the private sector. We examine this legislation from the perspective of the changing nature of the relationship between auditors and the state, and the surveillant assemblage within which this is located. Auditors are statutorily obliged to file Suspicious Activity Reports (SARs) into an online database, ELMER, but without much guidance regarding how suspicion is determined. Criminal rather than civil or regulatory sanctions apply to auditors’ instances of non-compliance. This paper evaluates the surveillance implications of the legislation for auditors through lenses developed in the accounting and sociological literature by Brivot and Gendron, Neu and Heincke, Deleuze and Guattari, and Haggerty and Ericson. It finds that auditors are generating information flows which are subsequently reassembled into discrete and virtual ‘data doubles’ to be captured and utilised by authorised third parties for unknown purposes. The paper proposes that the surveillant assemblage has extended into the space of the auditor-client relationship, but this extension remains inhibited as a result of auditors’ relatively weak level of engagement in providing SARs, thereby pointing to a degree of resistance in professional service firms regarding the deployment of regulation that compromises the foundations of this relationship

Methods For Robust Quantification Of Rna Alternative Splicing In Heterogeneous Rna-Seq Datasets

RNA alternative splicing is primarily responsible for transcriptome diversity and is relevant to human development and disease. However, current approaches to splicing quantication make simplifying assumptions which are violated when RNA sequencing data are heterogeneous. Influences from genetic and environmental background contribute to variability within a group of samples purported to represent the same biological condition. This work describes three methods which account for data heterogeneity when detecting differential RNA splicing between sample groups. First, a robust model is implemented for outlier detection within a group of purported replicates. Next, large RNA-seq datasets with high within-group variability are addressed with a statistical approach which retains power to detect changing splice junctions without sacricing specicity. Finally, applying these tools to call sQTLs in GTEx tissues has identified splicing variations associated with risk loci for cardiovascular disease and anomalous skeletal development. Each of these methods correctly handles the properties of heterogeneous RNA-seq data to improve precision and reduce false discovery rate

Vegetation database of Great Britain: Countryside Survey

This paper describes the vegetation database created as part of the Countryside Survey (CS) of Great Britain (GIVD ID EU-GB-003) which was established to monitor ecological and land use change in 1978 (http://www.countrysidesurvey.org.uk). The sample design is based on a series of stratified, randomly selected 1 km squares, which numbered 256 in the 1978 survey, 500 in the 1990 survey, 569 in the 1998 survey and 591 in the 2007 survey. Stratification of sample squares was based on predefined strata (called land classes) which have been derived from a classification of all 1 km squares in Britain based on their topographic, climatic and geological attributes obtained from published maps. A series of vegetation plots were located within each 1 km square using a restricted randomisation procedure designed to reduce aggregation. Linear features (road verges, watercourse banks, hedges, arable margins and field boundaries) and areal features (fields, unenclosed land and small semi-natural biotope patches) were sampled. Linear plots were 1 x 10 m laid out along a feature whilst unenclosed land and small biotopes were sampled using 2 m x 2 m plots. Larger randomly-placed plots were nested 14 m² plots with an inner nest of 2 m x 2 m. Within each 1 km Countryside Survey sample square the land cover and all landscape features were mapped and each parcel of land (and vegetation plot) has been assigned to a Broad Habitat/EUNIS habitat type. This database of vegetation plots is a very useful resource. The data is freely available from the website, however, there are restrictions on the release of the spatial location of the plots. There is now a considerable time-series of plots within the database going back to 1978 representing different habitat types and landscape features that can be analysed to determine changes in vegetation metrics (e.g. Ellenberg scores) and individual species. Vegetation changes can be linked to environmental drivers and the spatial scale (across GB) is sufficiently large to analyse gradients in most driving variables

Wacky Words and Steiner Systems

I suspect that many readers will have noticed that all the vowels (including Y) occur at odd positions in the alphabet (let\u27s call them odd letters). This led me to think of the set of words using only odd letters

Modelling chemotherapy resistance in palliation and failed cure

The goal of palliative cancer chemotherapy treatment is to prolong survival and improve quality of life when tumour eradication is not feasible. Chemotherapy protocol design is considered in this context using a simple, robust, model of advanced tumour growth with Gompertzian dynamics, taking into account the effects of drug resistance. It is predicted that reduced chemotherapy protocols can readily lead to improved survival times due to the effects of competition between resistant and sensitive tumour cells. Very early palliation is also predicted to quickly yield near total tumour resistance and thus decrease survival duration. Finally, our simulations indicate that failed curative attempts using dose densification, a common protocol escalation strategy, can reduce survival times

COLLABORATIVE RESEARCH: Interactive Effects of Chronic N Deposition, Acidification, and Phosphorus Limitation on Coupled Element Cycling in Streams

Human activity has doubled the amount of nitrogen on the landscape, creating a pollution problem and changing the balance among multiple nutrients that limit biological activity in ecosystems. At the same time, other disturbances, such as acidification, interact with nitrogen enrichment in ways that strongly influence the productivity and health of terrestrial and aquatic ecosystems. This project examines the interactions among multiple elements and disturbances (nitrogen, phosphorus, metals, and acidification) along a continuum from the atmosphere through soils to streams. This project takes advantage of two unique experiments in which entire watersheds have been experimentally enriched with nitrogen and acid for nearly two decades. A series of new studies in those watersheds examine how chemical and biological changes in soils alter the ability of streams to take up, use, and retain nitrogen and phosphorus. These nutrient interactions are then related to important biological processes that affect the productivity and health of streams.This research addresses an important pollution problem that requires an approach that integrates biology and geochemistry along flow paths that link the terrestrial and aquatic ecosystems. This type of integration is a challenge, but needed for effective environmental management, environmental research, and science teaching. Results from this project and interactions between university and US Forest Service researchers will inform effective management of watersheds faced with multiple pollution problems. A series of collaborative workshops in which high school, undergraduate, and graduate students work with researchers and teachers will promote multidisciplinary learning. The collaboration will seek to develop a computer simulation model for use in teaching integrated biology and chemistry in high school and college science curricula

A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies

Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by diverse neuropsychiatric, cognitive, and motor impairments. Autosomal dominant mutations in the MAPT gene cause heterogeneous forms of frontotemporal lobar degeneration with tauopathy (FTLD-Tau). Common and rare variants in the MAPT gene increase the risk for sporadic FTLD-Tau, including progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). We generated a collection of fibroblasts from 140 MAPT mutation/risk variant carriers, PSP, CBD, and cognitively normal controls; 31 induced pluripotent stem cell (iPSC) lines from MAPT mutation carriers, non-carrier family members, and autopsy-confirmed PSP patients; 33 genome engineered iPSCs that were corrected or mutagenized; and forebrain neural progenitor cells (NPCs). Here, we present a resource of fibroblasts, iPSCs, and NPCs with comprehensive clinical histories that can be accessed by the scientific community for disease modeling and development of novel therapeutics for tauopathies

Suspicious activity reporting in the United Kingdom and the United States: statutory obligations of auditors and optimal harvesting of information

Purpose: This study aims to evaluate the advantages and disadvantages of auditor mandatory suspicious activity reporting versus the exercise of professional judgement in the anti-money laundering regimes of the UK and the USA. Design/methodology/approach: The research draws upon the following sources. Firstly, statistics provided by the UK National Crime Agency, 2019 (NCA) regarding suspicious activity report (SAR) filing rates. Secondly, anti-money laundering legislation in the USA and UK. Thirdly, statements made in the political domain in the USA, particularly those which raised constitutional concerns during the progress of the Patriot Act 2001. Finally, statements and recommendations by a UK Parliamentary Commission enquiring into the effectiveness of the suspicious activity reporting regime. Findings: The UK reporting regime does not accommodate professional judgement, resulting in the filing of SARs with limited intelligence value. This contrasts with discretionary reporting in the USA: voluntary reporting guides and influences auditor behaviour rather than mandating it. Defensive filing by UK auditors (defence to anti-money launderings [DAMLs]) has increased in recent years but the number of SARs filed has declined. Originality/value: The study evaluates auditor behavioural responses to legislative regimes which mandate or alternatively accommodate discretion in the reporting suspicion of money laundering. Consideration of constitutional and judicial activism in this context is a novel contribution to the literature. For its theoretical framework the study uses Foucault’s concept of discipline of the self to evaluate auditor behaviour under both regimes