Towards Grid Interoperability

The Grid paradigm promises to provide global access to computing resources, data storage and experimental instruments. It also provides an elegant solution to many resource administration and provisioning problems while offering a platform for collaboration and resource sharing. Although substantial progress has been made towards these goals, nevertheless there is still a lot of work to be done until the Grid can deliver its promises. One of the central issues is the development of standards and Grid interoperability. Job execution is one of the key capabilities in all Grid environments. This is a well understood, mature area with standards and implementations. This paper describes some proof of concept experiments demonstrating the interoperability between various Grid environments

The OMII Software Distribution

This paper describes the work carried out at the Open Middleware Infrastructure Institute (OMII) and the key elements of the OMII software distribution that have been developed in collaboration with members of the Managed Programme Initiative. The main objective of the OMII is to preserve and consolidate the achievements of the UK e-Science Programme by collecting, maintaining and improving the software modules that form the key components of a generic Grid middleware. Recently, the activity at Southampton has been extended beyond 2009 through a new project, OMII-UK, that forms a partnership that now includes the OGSA-DAI activities at Edinburgh and the myGrid project at Manchester

Solitary Confinement and Criminogenic Attitudes: Is Isolation Reinforcing Pro-Criminal Thoughts, Feelings, and Beliefs?

Documented increases of problematic symptomatology following exposure to social exclusion contexts may be suggestive of increases in antisocial cognition and pro-criminal attitudes among prisoners. An exacerbation in behavioral indicators of criminality in correctional populations including aggressive behavior, reduced cooperation, and deficits in impulse control may suggest that restrictive and exclusionary correctional practices can aggravate criminogenic thoughts, feelings, or beliefs. Existing literature indicates that an endorsement of pro-criminal attitudes is one of the greatest predictors of future criminal behavior. The study will recruit 400 randomly selected female adult inmates from Florence McClure Women’s Correctional Facility of Las Vegas, Nevada. A hard copy of self-report survey will be given to the participants and is expected to take 1 hour to complete. After informed consent, participants will be asked to complete a survey regarding their demographics, confinement, and pro-criminal attitudes. Participants will be surveyed at the beginning of the study, and approximately 1 week after they are released from segregation. At least one participant from the initial sample who approximately matches the demographics of the participant who is exiting segregation will also be surveyed at the same time as part of a control group. The primary goal of this study is to demonstrate the negative effects of solitary confinement. The secondary goal is to impact policy in correctional institutions. This study aims to understand whether being placed in solitary confinement can affect pro-criminal attitudes. This research will become a strong premise to the argument of abolishing solitary confinement.https://digitalscholarship.unlv.edu/durep_posters/1032/thumbnail.jp

Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study.

OBJECTIVE: Despite epidemiologic data showing an increased stroke incidence in African ancestry populations, genetic studies in this group have so far been limited, and there has been little characterization of the genetic contribution to stroke liability in this population, particularly for stroke subtypes. METHODS: We evaluated the evidence that genetic factors contribute to stroke and stroke subtypes in a population of 917 African and African Caribbean stroke cases and 868 matched controls from London, United Kingdom. We (1) estimated the heritability of stroke in this population using genomic-relatedness matrix-restricted maximum likelihood approaches, (2) assessed loci associated with stroke in Europeans in our population, and (3) evaluated the influence of genetic factors underlying cardiovascular risk factors on stroke using polygenic risk scoring. RESULTS: Our results indicate a substantial genetic contribution to stroke risk in African ancestry populations (h2 = 0.35 [SE = 0.19], p = 0.043). Polygenic risk scores indicate that cardiovascular risk scores contribute to the genetic liability (odds ratio [OR] 1.09 [95% confidence interval (CI) 1.01-1.17], p = 0.029) and point to a strong influence of type 2 diabetes in large vessel stroke (OR 1.62 [95% CI 1.19-2.22], p = 0.0024). Single nucleotide polymorphisms associated with ischemic stroke in Europeans shared direction of effect in SLESS (p = 0.031), suggesting that disease mechanisms are shared across ancestries. CONCLUSIONS: Stroke in African ancestry populations is highly heritable and influenced by genetic determinants underlying cardiovascular risk factors. In addition, stroke loci identified in Europeans share direction of effect in African populations. Future genome-wide association studies must focus on incorporating African ancestry individuals

Linking Genetics of Brain Changes to Alzheimer's Disease:Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts

Background: Alzheimer's disease (AD) is a highly heritable disease, but until recently few replicated genetic markers have been identified. Markers identified so far are likely to account for only a tiny fraction of the heritability of AD and many more genetic risk alleles are thought to be undiscovered.  Objective: Identifying genetic markers for AD using combined analysis of genetics and brain imaging data.  Methods: Imaging quantitative trait loci (iQTLs) has recently emerged as an interesting research area for linking genetics of brain changes to AD. We consider a genome-wide association scan of 109 brain-wide regional imaging phenotypes to identify genetic susceptibility loci for AD from a combined set of 1,045 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the AddNeuroMed studies. We use one-SNP-at-a-time as well as multi-SNP Hyperlasso based iQTL methods for the analysis.  Results: We identified several novel markers associated with AD, namely HOMER2 (rs1256429; intronic, p = 8.7x10(-10)), EOMES (rs2724509; flanking), JAM2 (rs2829841; intronic), and WEE1 (rs10770042; coding). The SNP rs1256429 (HOMER2) was one of the top hits in Hyperlasso as well as in the single-SNP analysis showing an association with the volume of the right thalamus and AD, a brain region reported to be linked with AD in several studies.  Conclusion: We believe that the markers identified in this study are novel additions to the existing list of genetic variants associated with AD which can be validated in future replicated studies

Lagrangian Descriptors: A Method for Revealing Phase Space Structures of General Time Dependent Dynamical Systems

In this paper we develop new techniques for revealing geometrical structures in phase space that are valid for aperiodically time dependent dynamical systems, which we refer to as Lagrangian descriptors. These quantities are based on the integration, for a finite time, along trajectories of an intrinsic bounded, positive geometrical and/or physical property of the trajectory itself. We discuss a general methodology for constructing Lagrangian descriptors, and we discuss a "heuristic argument" that explains why this method is successful for revealing geometrical structures in the phase space of a dynamical system. We support this argument by explicit calculations on a benchmark problem having a hyperbolic fixed point with stable and unstable manifolds that are known analytically. Several other benchmark examples are considered that allow us the assess the performance of Lagrangian descriptors in revealing invariant tori and regions of shear. Throughout the paper "side-by-side" comparisons of the performance of Lagrangian descriptors with both finite time Lyapunov exponents (FTLEs) and finite time averages of certain components of the vector field ("time averages") are carried out and discussed. In all cases Lagrangian descriptors are shown to be both more accurate and computationally efficient than these methods. We also perform computations for an explicitly three dimensional, aperiodically time-dependent vector field and an aperiodically time dependent vector field defined as a data set. Comparisons with FTLEs and time averages for these examples are also carried out, with similar conclusions as for the benchmark examples.Comment: 52 pages, 25 figure

Genetic Risk as a Marker of Amyloid-β and Tau Burden in Cerebrospinal Fluid.

BACKGROUND: The search for a biomarker of Alzheimer's disease (AD) pathology (amyloid-β (Aβ) and tau) is ongoing, with the best markers currently being measurements of Aβ and tau in cerebrospinal fluid (CSF) and via positron emission tomography (PET) scanning. These methods are relatively invasive, costly, and often have high screening failure rates. Consequently, research is aiming to elucidate blood biomarkers of Aβ and tau. OBJECTIVE: This study aims to investigate a case/control polygenic risk score (PGRS) as a marker of tau and investigate blood markers of a combined Aβ and tau outcome for the first time. A sub-study also considers plasma tau as markers of Aβ and tau pathology in CSF. METHODS: We used data from the EDAR*, DESCRIPA**, and Alzheimer's Disease Neuroimaging Initiative (ADNI) cohorts in a logistic regression analysis to investigate blood markers of Aβ and tau in CSF. In particular, we investigated the extent to which a case/control PGRS is predictive of CSF tau, CSF amyloid, and a combined amyloid and tau outcome. The predictive ability of models was compared to that of age, gender, and APOE genotype ('basic model'). RESULTS: In EDAR and DESCRIPA test data, inclusion of a case/control PGRS was no more predictive of Aβ, and a combined Aβ and tau endpoint than the basic models (accuracies of 66.0%, and 73.3% respectively). The tau model saw a small increase in accuracy compared to basic models (59.6%). ADNI 2 test data also showed a slight increase in accuracy for the Aβ model when compared to the basic models (61.4%). CONCLUSION: We see some evidence that a case/control PGRS is marginally more predictive of Aβ and tau pathology than the basic models. The search for predictive factors of Aβ and tau pathologies, above and beyond demographic information, is still ongoing. Better understanding of AD risk alleles, development of more sensitive assays, and studies of larger sample size are three avenues that may provide such factors. However, the clinical utility of possible predictors of brain Aβ and tau pathologies must also be investigated.*'Beta amyloid oligomers in the early diagnosis of AD and as marker for treatment response'**'Development of screening guidelines and criteria for pre-dementia Alzheimer's disease'.Multiple funders listed on paper