183 research outputs found
Completion of Advance Directives: Do Social Work Preadmission Interviews Make a Difference?
Objectives: This study tests the efficacy of a preadmission, educational interview on advance directives, in this case, health care proxies (HCPs) offered to elective, orthopedic patients. Method: Using a quasi-experimental design, participants (n = 54) are assigned to either treatment group (who received the educational interview, conducted by a social worker, over and above the federally mandated written information on HCPs) or comparison group (who received the written information only). Results: Logistic regression analysis indicates there is a statistically significantly higher probability that a patient would sign an HCP if assigned to the treatment group than if assigned to the comparison condition. Conclusion: Benefits of educating patients about HCPs as part of routine social work practice are outlined
Post-Newtonian SPH calculations of binary neutron star coalescence. II. Binary mass ratio, equation of state, and spin dependence
Using our new Post-Newtonian SPH (smoothed particle hydrodynamics) code, we
study the final coalescence and merging of neutron star (NS) binaries. We vary
the stiffness of the equation of state (EOS) as well as the initial binary mass
ratio and stellar spins. Results are compared to those of Newtonian
calculations, with and without the inclusion of the gravitational radiation
reaction. We find a much steeper decrease in the gravity wave peak strain and
luminosity with decreasing mass ratio than would be predicted by simple
point-mass formulae. For NS with softer EOS (which we model as simple
polytropes) we find a stronger gravity wave emission, with a
different morphology than for stiffer EOS (modeled as polytropes as
in our previous work). We also calculate the coalescence of NS binaries with an
irrotational initial condition, and find that the gravity wave signal is
relatively suppressed compared to the synchronized case, but shows a very
significant second peak of emission. Mass shedding is also greatly reduced, and
occurs via a different mechanism than in the synchronized case. We discuss the
implications of our results for gravity wave astronomy with laser
interferometers such as LIGO, and for theoretical models of gamma-ray bursts
(GRBs) based on NS mergers.Comment: RevTeX, 38 pages, 24 figures, Minor Corrections, to appear in Phys.
Rev.
Post-Newtonian SPH calculations of binary neutron star coalescence. I. Method and first results
We present the first results from our Post-Newtonian (PN) Smoothed Particle
Hydrodynamics (SPH) code, which has been used to study the coalescence of
binary neutron star (NS) systems. The Lagrangian particle-based code
incorporates consistently all lowest-order (1PN) relativistic effects, as well
as gravitational radiation reaction, the lowest-order dissipative term in
general relativity. We test our code on sequences of single NS models of
varying compactness, and we discuss ways to make PN simulations more relevant
to realistic NS models. We also present a PN SPH relaxation procedure for
constructing equilibrium models of synchronized binaries, and we use these
equilibrium models as initial conditions for our dynamical calculations of
binary coalescence. Though unphysical, since tidal synchronization is not
expected in NS binaries, these initial conditions allow us to compare our PN
work with previous Newtonian results.
We compare calculations with and without 1PN effects, for NS with stiff
equations of state, modeled as polytropes with . We find that 1PN
effects can play a major role in the coalescence, accelerating the final
inspiral and causing a significant misalignment in the binary just prior to
final merging. In addition, the character of the gravitational wave signal is
altered dramatically, showing strong modulation of the exponentially decaying
waveform near the end of the merger. We also discuss briefly the implications
of our results for models of gamma-ray bursts at cosmological distances.Comment: RevTeX, 37 pages, 17 figures, to appear in Phys. Rev. D, minor
corrections onl
Platelet-activating factor (PAF) mediates NLRP3-NEK7 inflammasome induction independently of PAFR
The role of lipids in inflammasome activation remains underappreciated. The phospholipid, platelet-activating factor (PAF), exerts multiple physiological functions by binding to a G protein-coupled seven-transmembrane receptor (PAFR). PAF is associated with a number of inflammatory disorders, yet the molecular mechanism underlying its proinflammatory function remains to be fully elucidated. We show that multiple PAF isoforms and PAF-like lipids can activate the inflammasome, resulting in IL-1ÎČ and IL-18 maturation. This is dependent on NLRP3, ASC, caspase-1, and NEK7, but not on NLRC4, NLRP1, NLRP6, AIM2, caspase-11, or GSDMD. Inflammasome activation by PAF also requires potassium efflux and calcium influx but not lysosomal cathepsin or mitochondrial reactive oxygen species. PAF exacerbates peritonitis partly through inflammasome activation, but PAFR is dispensable for PAF-induced inflammasome activation in vivo or in vitro. These findings reveal that PAF represents a damage-associated signal that activates the canonical inflammasome independently of PAFR and provides an explanation for the ineffectiveness of PAFR antagonist in blocking PAF-mediated inflammation in the clinic
Gendering the careers of young professionals: some early findings from a longitudinal study. in Organizing/theorizing: developments in organization theory and practice
Wonders whether companies actually have employees best interests at heart across physical, mental and spiritual spheres. Posits that most organizations ignore their workforce â not even, in many cases, describing workers as assets! Describes many studies to back up this claim in theis work based on the 2002 Employment Research Unit Annual Conference, in Cardiff, Wales
Evaluating optimal solutions to environmental breakdown
The severity of environmental threats, especially climate change, biodiversity loss and pollution, are well established, as is the urgent need for them to be addressed. These threats act both in isolation as well as synergistically to contribute to overall âenvironmental breakdownâ. Debate exists around the most optimal governance and policy approaches to address these threats and, to date, little quantitative evidence exists to compare the different approaches. Using a modified Bayesian belief network model to assess the probability of environmental threats, we compare and contrast a range of proposed policy solutions to a selection of contemporary environmental problems that have been identified as having the potential to contribute to, or indeed may lead to environmental breakdown. Through interrogation of the models, we conclude that policies that prioritise economic growth at the expense of nature would be largely ineffective, whereas a more integrated approach, adopting comprehensive âGreen New Dealâ policies combined with nature-based solutions would be the most effective approaches to preventing environmental breakdown, as they address societal and environmental issues simultaneously. We therefore recommend that decision makers take an integrated approach to decision making and policy development, accounting for social, economic and environmental drivers that ensure delivery of multiple benefits and real change
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed
Genetic studies on telomere length are important for understanding age-related diseases. Prior GWASs for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally diverse individuals (European, African, Asian, and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole-genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n = 109,122 individuals. We identified 59 sentinel variants (p < 5 Ă 10â9) in 36 loci associated with telomere length, including 20 newly associated loci (13 were replicated in external datasets). There was little evidence of effect size heterogeneity across populations. Fine-mapping at OBFC1 indicated that the independent signals colocalized with cell-type-specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated that our TL polygenic trait scores (PTSs) were associated with an increased risk of cancer-related phenotypes
The MeerKAT Galaxy Cluster Legacy Survey: I. Survey overview and highlights
Please abstract in the article.The South African Radio Astronomy Observatory (SARAO), the National Research Foundation (NRF), the National Radio Astronomy Observatory, US National Science Foundation, the South African Research Chairs Initiative of the DSI/NRF, the SARAO HCD programme, the South African Research Chairs Initiative of the Department of Science and Innovation.http://www.aanda.orghj2022Physic
- âŠ