8 research outputs found
Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals.
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18-94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBPMAP/DBPcal), or bSBP/diastolic blood pressure (cSBPSBP/DBPcal), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBPMAP/DBPcal were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBPSBP/DBPcal, respectively. We pragmatically propose as upper normal limit for 24-hour cSBPMAP/DBPcal 135 mm Hg and for 24-hour cSBPSBP/DBPcal 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young participants and decreased with increasing age. Central SBPSBP/DBPcal dipping was less pronounced (-8.7% in young participants). In contrast, cSBPMAP/DBPcal dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation
2022 World Hypertension League, Resolve To Save Lives and International Society of Hypertension dietary sodium (salt) global call to action
Aging and Vascular Disease:A Multidisciplinary Overview
Vascular aging, i.e., the deterioration of the structure and function of the arteries over the life course, predicts cardiovascular events and mortality. Vascular degeneration can be recognized before becoming clinically symptomatic; therefore, its assessment allows the early identification of individuals at risk. This opens the possibility of minimizing disease progression. To review these issues, a search was completed using PubMed, MEDLINE, and Google Scholar from 2000 to date. As a network of clinicians and scientists involved in vascular medicine, we here describe the structural and functional age-dependent alterations of the arteries, the clinical tools for an early diagnosis of vascular aging, and the cellular and molecular events implicated. It emerges that more studies are necessary to identify the best strategy to quantify vascular aging, and to design proper physical activity programs, nutritional and pharmacological strategies, as well as social interventions to prevent, delay, and eventually revert the disease
Pathophysiology of Circulating Biomarkers and Relationship With Vascular Aging: A Review of the Literature From VascAgeNet Group on Circulating Biomarkers, European Cooperation in Science and Technology Action 18216
Impairment of the arteries is a product of sustained exposure to various
deleterious factors and progresses with time; a phenomenon inherent to
vascular aging. Oxidative stress, inflammation, the accumulation of
harmful agents in high cardiovascular risk conditions, changes to the
extracellular matrix, and/or alterations of the epigenetic modification
of molecules, are all vital pathophysiological processes proven to
contribute to vascular aging, and also lead to changes in levels of
associated circulating molecules. Many of these molecules are
consequently recognized as markers of vascular impairment and
accelerated vascular aging in clinical and research settings, however,
for these molecules to be classified as biomarkers of vascular aging,
further criteria must be met. In this paper, we conducted a scoping
literature review identifying thirty of the most important, and eight
less important, biomarkers of vascular aging. Herein, we overview a
selection of the most important molecules connected with the
above-mentioned pathological conditions and study their usefulness as
circulating biomarkers of vascular aging
Twenty-fourhour central (aortic) systolic blood pressure : reference values and dipping patterns in untreated individuals
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by the heart, the brain, and the kidneys. If properly measured, cSBP is closer associated with hypertension-mediated organ damage and prognosis, as compared with brachial SBP (bSBP). We investigated 24-hour profiles of bSBP and cSBP, measured simultaneously using Mobilograph devices, in 2423 untreated adults (1275 women; age, 18–94 years), free from overt cardiovascular disease, aiming to develop reference values and to analyze daytime-nighttime variability. Central SBP was assessed, using brachial waveforms, calibrated with mean arterial pressure (MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure (cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144 509 valid brachial and 130 804 valid central measurements. Averaged 24-hour, daytime, and nighttime brachial BP across all individuals was 124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour, daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and 125 mm Hg and 115, 117, and 107 mm Hg for cSBP(SBP/DBPcal), respectively. We pragmatically propose as upper normal limit for 24-hour cSBP(MAP/DBPcal) 135 mm Hg and for 24-hour cSBP(SBP/DBPcal) 120 mm Hg. bSBP dipping (nighttime-daytime/daytime SBP) was −10.6 % in young participants and decreased with increasing age. Central SBP(SBP/DBPcal) dipping was less pronounced (−8.7% in young participants). In contrast, cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group and less pronounced in all other participants. These data may serve for comparison in various diseases and have potential implications for refining hypertension diagnosis and management. The different dipping behavior of bSBP versus cSBP requires further investigation
Twenty-Four-Hour Central (Aortic) Systolic Blood Pressure: Reference Values and Dipping Patterns in Untreated Individuals
Central (aortic) systolic blood pressure (cSBP) is the pressure seen by
the heart, the brain, and the kidneys. If properly measured, cSBP is
closer associated with hypertension-mediated organ damage and prognosis,
as compared with brachial SBP (bSBP). We investigated 24-hour profiles
of bSBP and cSBP, measured simultaneously using Mobilograph devices, in
2423 untreated adults (1275 women; age, 18-94 years), free from overt
cardiovascular disease, aiming to develop reference values and to
analyze daytime-nighttime variability. Central SBP was assessed, using
brachial waveforms, calibrated with mean arterial pressure
(MAP)/diastolic BP (cSBP(MAP/DBPcal)), or bSBP/diastolic blood pressure
(cSBP(SBP/DBPcal)), and a validated transfer function, resulting in 144
509 valid brachial and 130 804 valid central measurements. Averaged
24-hour, daytime, and nighttime brachial BP across all individuals was
124/79, 126/81, and 116/72 mm Hg, respectively. Averaged 24-hour,
daytime, and nighttime values for cSBP(MAP/DBPcal) were 128, 128, and
125 mm Hg and 115, 117, and 107 mm Hg for cSBP(SBP/DBPcal),
respectively. We pragmatically propose as upper normal limit for 24-hour
cSBP(MAP/DBPcal) 135 mm Hg and for 24-hour cSBP(SBP/DBPcal) 120 mm Hg.
bSBP dipping (nighttime-daytime/daytime SBP) was -10.6 % in young
participants and decreased with increasing age. Central SBPSBP/DBPcal
dipping was less pronounced (-8.7% in young participants). In contrast,
cSBP(MAP/DBPcal) dipping was completely absent in the youngest age group
and less pronounced in all other participants. These data may serve for
comparison in various diseases and have potential implications for
refining hypertension diagnosis and management. The different dipping
behavior of bSBP versus cSBP requires further investigation
Developing technologies to assess vascular ageing:a roadmap from VascAgeNet
Vascular ageing is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges
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Developing technologies to assess vascular ageing: a roadmap from VascAgeNet.
Vascular ageing is the deterioration of arterial structure and function which occurs naturally with age, and which can be accelerated with disease. Measurements of vascular ageing are emerging as markers of cardiovascular risk, with potential applications in disease diagnosis and prognosis, and for guiding treatments. However, vascular ageing is not yet routinely assessed in clinical practice. A key step towards this is the development of technologies to assess vascular ageing. In this Roadmap, experts discuss several aspects of this process, including: measurement technologies; the development pipeline; clinical applications; and future research directions. The Roadmap summarises the state of the art, outlines the major challenges to overcome, and identifies potential future research directions to address these challenges