Non-Abelian Chern-Simons-Higgs vortices with a quartic potential

We have constructed numerically non-Abelian vortices in an SU(2) Chern-Simons-Higgs theory with a quartic Higgs potential. We have analyzed these solutions in detail by means of improved numerical codes and found some unexpected features we did not find when a sixth-order Higgs potential was used. The generic non-Abelian solutions have been generated by using their corresponding Abelian counterparts as initial guess. Typically, the energy of the non-Abelian solutions is lower than that of the corresponding Abelian one (except in certain regions of the parameter space). Regarding the angular momentum, the Abelian solutions possess the maximal value, although there exist non-Abelian solutions which reach that maximal value too. In order to classify the solutions it is useful to consider the non-Abelian solutions with asymptotically vanishing $A_t$ component of the gauge potential, which may be labelled by an integer number $m$. For vortex number $n=3$ and above, we have found uniqueness violation: two different non-Abelian solutions with all the global charges equal. Finally, we have investigated the limit of infinity Higgs self-coupling parameter and found a piecewise Regge-like relation between the energy and the angular momentum.Comment: 9 pages, 13 figure

Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization

We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into nanonetworks which provide availability of critical binding domains. Importantly, the growth factor binding (FNIII12-14) and integrin binding (FNIII9-10) regions are simultaneously available on FN fibrils assembled on PEA. This material platform promotes synergistic integrin/VEGF signalling which is highly effective for vascularization events in vitro with low concentrations of VEGF. VEGF specifically binds to FN fibrils on PEA compared to control polymers (poly(methyl acrylate), PMA) where FN remains in a globular conformation and integrin/GF binding domains are not simultaneously available. The vasculogenic response of human endothelial cells seeded on these synergistic interfaces (VEGF bound to FN assembled on PEA) was significantly improved compared to soluble administration of VEGF at higher doses. Early onset of VEGF signalling (PLCγ1 phosphorylation) and both integrin and VEGF signalling (ERK1/2 phosphorylation) were increased only when VEGF was bound to FN nanonetworks on PEA, while soluble VEGF did not influence early signalling. Experiments with mutant FN molecules with impaired integrin binding site (FN-RGE) confirmed the role of the integrin binding site of FN on the vasculogenic response via combined integrin/VEGF signalling. In vivo experiments using 3D scaffolds coated with FN and VEGF implanted in the murine fat pad demonstrated pro-vascularization signalling by enhanced formation of new tissue inside scaffold pores. PEA-driven organization of FN promotes efficient presentation of VEGF to promote vascularization in regenerative medicine applications

Schwann cells and mesenchymal stem cells in laminin- or fibronectin-aligned matrices and regeneration across a critical size defect of 15 mm in the rat sciatic nerve

OBJECTIVE Artificial nerve guides are being developed to substitute for autograft repair after peripheral nerve injuries. However, the use of conduits is limited by the length of the gap that needs to be bridged, with the success of regeneration highly compromised in long gaps. Addition of aligned proregenerative cells and extracellular matrix (ECM) components inside the conduit can be a good strategy to achieve artificial grafts that recreate the natural environment offered by a nerve graft. The purpose of this study was to functionalize chitosan devices with different cell types to support regeneration in limiting gaps in the rat peripheral nerve. METHODS The authors used chitosan devices combined with proteins of the ECM and cells in a rat model of sciatic nerve injury. Combinations of fibronectin and laminin with mesenchymal stem cells (MSCs) or Schwann cells (SCs) were aligned within tethered collagen-based gels, which were placed inside chitosan tubes that were then used to repair a critical-size gap of 15 mm in the rat sciatic nerve. Electrophysiology and algesimetry tests were performed to analyze functional recovery during the 4 months after injury and repair. Histological analysis was performed at the midlevel and distal level of the tubes to assess the number of regenerated myelinated fibers. RESULTS Functional analysis demonstrated that SC-aligned scaffolds resulted in 100% regeneration success in a 15-mm nerve defect in this rat model. In contrast, animals that underwent repair with MSC-aligned constructs had only 90% regeneration success, and those implanted with acellular bridges had only 75% regeneration success. CONCLUSIONS These results indicate that the combination of chitosan conduits with ECM-enriched cellular gels represents a good alternative to the use of autografts for repairing long nerve gaps

Negative ions formed in N₂/CH₄/Ar discharge – a simulation of Titan's atmosphere chemistry

The formation of negative ions produced in a negative point-to-plane corona discharge fed by a Ar/N2//CH4/ gas mixture has been studied using mass spectrometry. The measurements were carried out in flowing regime at ambient temperature and a reduced pressure of 460 mbar. The CN ? anion has been found to be the most dominant negative ion in the discharge and is believed to be the precursor of heavier negative ions such as C3/N ? and C5/N ? . The most likely pathway for the formation of such molecular anions is H-loss dissociative electron attachment to HCN, H3/CN and H5/CN formed in the discharge. These same anions have been detected in Titan's atmosphere and the present experiments may provide some novel insights into the chemical and physical mechanisms prevalent in Titan's atmosphere and hence assist in the interpretation of results from the Cassini Huygens space mission

Statistical analysis of soy cultivation in Argentina

Argentina are analyzed. The main objective is to obtain information that will be useful for the analysis of the environmental consequences of the progress of this crop in the country. This has been made by a descriptive statistical analysis and a factor analysis was used to identify factors which characterize the soybean crop and also a classification or clustering between provinces with similar characteristics. The information parameters studied were: the tendency and dispersion measures for soybean yield of 15 provinces in which it was grown between the 2001/02 and 2010/11 or from 2001/02 to 2010/11; the correlations between area harvested acreage, seeded area, production and performance, and the factors that bind some variables that characterize the soybean crop that allows a grouping between provinces with similar characteristics. Analyses were performed by using data obtained from: 1) MinAgri (last 10 seasons) b) 2001 National Census c) CNA 2002. From a group of variables: region extension (ha); population density 2001; population of the region in 2001; NBI 2001, literate people older than 10 years 2001; illiterate people older than 10 years 2001; permanent workers in the farming sector 2002; seeded area (ha) 2002; cultivated area of oily plants (ha) 2002; tractors 2002; harvesters 2002; seeded area (ha) 2001/02; harvested area (ha) 2001/02; production (Tn) 2001/02.Fil: Miranda del Fresno, Ma. Carolina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones y Estudios Ambientales; ArgentinaFil: Villacampa, Y.. Universidad de Alicante. Departamento de Qui­mica Orgánica; EspañaFil: Navarro Gonzalez, F. J.. Universidad de Alicante. Departamento de Qui­mica Orgánica; EspañaFil: Sastre Vazquez, P.. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Agronomia; Argentin

Implications of Halo Inside-out Growth on the X-Ray Properties of Nearby Galaxy Systems within the Preheating Scenario

We present an entirely analytic model for a preheated, polytropic intergalactic medium in hydrostatic equilibrium within a NFW dark halo potential in which the evolution of the halo structure between major merger events proceeds inside-out by accretion. This model is used to explain, within a standard $\Lambda$CDM cosmogony, the observed X-ray properties of nearby relaxed, non-cooling flow groups and clusters of galaxies. We find that our preferred solution to the equilibrium equations produces scaling relations in excellent agreement with observations, while simultaneously accounting for the typical structural characteristics of the distribution of the diffuse baryons. In the class of preheating models, ours stands out because it offers a unified description of the intrahalo medium for galaxy systems with total masses above \sm 2\times 10^{13}\msun, does not produce baryonic configurations with large isentropic cores, and reproduces faithfully the observed behavior of the gas entropy at large radii. All this is achieved with a moderate level of energy injection of about half a keV, which can be easily accommodated within the limits of the total energy released by the most commonly invoked feedback mechanisms, as well as with a polytropic index of 1.2, consistent with both many observational determinations and predictions from high-resolution gas-dynamical simulations of non-cooling flow clusters. More interestingly, our scheme offers a physical motivation for the adoption of this specific value of the polytropic index, as it is the one that best ensures the conservation after halo virialization of the balance between the total specific energies of the gas and dark matter components for the full range of masses investigated.Comment: 18 pages, 11 figures, accepted for publication in the Astrophysical Journa

Accelerating Sequence Alignments Based on FM-Index Using the Intel KNL Processor

FM-index is a compact data structure suitable for fast matches of short reads to large reference genomes. The matching algorithm using this index exhibits irregular memory access patterns that cause frequent cache misses, resulting in a memory bound problem. This paper analyzes different FM-index versions presented in the literature, focusing on those computing aspects related to the data access. As a result of the analysis, we propose a new organization of FM-index that minimizes the demand for memory bandwidth, allowing a great improvement of performance on processors with high-bandwidth memory, such as the second-generation Intel Xeon Phi (Knights Landing, or KNL), integrating ultra high-bandwidth stacked memory technology. As the roofline model shows, our implementation reaches 95% of the peak random access bandwidth limit when executed on the KNL and almost all the available bandwidth when executed on other Intel Xeon architectures with conventional DDR memory. In addition, the obtained throughput in KNL is much higher than the results reported for GPUs in the literature. IEE

Detection of vortex tubes in solar granulation from observations with Sunrise

We have investigated a time series of continuum intensity maps and corresponding Dopplergrams of granulation in a very quiet solar region at the disk center, recorded with the Imaging Magnetograph eXperiment (IMaX) on board the balloon-borne solar observatory Sunrise. We find that granules frequently show substructure in the form of lanes composed of a leading bright rim and a trailing dark edge, which move together from the boundary of a granule into the granule itself. We find strikingly similar events in synthesized intensity maps from an ab initio numerical simulation of solar surface convection. From cross sections through the computational domain of the simulation, we conclude that these `granular lanes' are the visible signature of (horizontally oriented) vortex tubes. The characteristic optical appearance of vortex tubes at the solar surface is explained. We propose that the observed vortex tubes may represent only the large-scale end of a hierarchy of vortex tubes existing near the solar surface.Comment: Astrophysical Journal Letters: Sunrise Special Issue, reveived 2010 June 16; accepted 2010 August

Mars Climate Database version 5

The Mars Climate Database (MCD) is a database of meteorological fields derived from General Circulation Model (GCM) numerical simulations [2,4] of the Martian atmosphere and validated using available observational data. The MCD includes complementary post-processing schemes such as high spatial resolution interpolation of environmental data and means of reconstructing the variability thereof. The GCM is developed at LMD (Laboratoire de Météorologie Dynamique, Paris, France) in collaboration with several teams in Europe: LATMOS (Laboratoire Atmosphères, Milieux, Observations Spatiales, Paris, France), the Open University (UK), the Oxford University (UK) and the Instituto de Astrofisica de Andalucia (Spain) with support from the European Space Agency (ESA) and the Centre National d'Etudes Spatiales (CNES). The MCD is freely distributed and intended to be useful and used in the framework of engineering applications as well as in the context of scientific studies which require accurate knowledge of the state of the Martian atmosphere. The Mars Climate Database (MCD) has over the years been distributed to more than 150 teams around the world. With the many improvements implemented in the GCM over the last few years, a new series of reference simulations have been run and compiled in a new version (version 5) of the Mars Climate Database, released in the first half of 2012