Magneto–Coriolis waves in a spherical Couette flow experiment

International audienceThe dynamics of fluctuations in a fast rotating spherical Couette flow experiment in the presence of a strong dipolar magnetic field is investigated in detail, through a thorough analysis of the experimental data as well as a numerical study. Fluctuations within the conducting fluid (liquid sodium) are characterized by the presence of several oscillation modes, identified as magneto-Coriolis (MC) modes, with definite symmetry and azimuthal number. A numerical simulation provides eigensolutions which exhibit oscillation frequencies and magnetic signature comparable to the observation. The main characteristics of these hydromagnetic modes is that the magnetic contribution has a fundamental influence on the dynamical properties through the Lorentz forces, although its importance remains weak in an energetical point of view. Another specificity is that the Lorentz forces are confined near the inner sphere where the dipolar magnetic field is the strongest, while the Coriolis forces are concentrated in the outer fluid volume close to the outer sphere

Architecture for an efficient integration of wireless sensor networks to the Internet through Internet of Things gateways

International audienceIn recent years, Internet of Things has changed the way people work and live, thereby opening new opportunities. This article describes a framework architecture for interconnecting several wireless sensor networks to the Internet to achieve the vision of Internet of Things. Connecting things together is done through gateways that act as single points of failure to bridge the connection between wireless sensor network and the traditional wired Internet. To cope with the unreliable nature of wireless links and scale to a large number of sensors and wireless sensor networks, several gateways should be installed. Given a number of previously deployed gateways, the contribution of this article is twofold. First, it focuses on choosing the most suitable ones for connecting wireless sensor networks to the Internet in a efficient and cost-effective manner, using integer linear programming to develop the mathematical model. Second, a network topology that puts the integration of wireless sensor networks to the Internet in place is built. A three-layer architecture is used in such a way that the intermediate layer adapts dynamically to network changes and evolution. Gateway selection procedure at this layer was implemented using CPLEX linear solver, and the gateway was integrated on Raspberry Pi cheaper hardware which serves as the routing protocol for low-power and lossy network root for the wireless sensor network configuration. Experiments and real deployments have been conducted to demonstrate the effectiveness of the proposed scheme

Survey on RPL enhancements: a focus on topology, security and mobility

International audienceA few years ago, the IPv6 Routing Protocol for Low-power and Lossy Networks (RPL) was proposed by IETF as the routing standard designed for classes of networks in which both nodes and their interconnects are constrained. Since then, great attention has been paid by the scientific and industrial communities for the protocol evaluation and improvement. Indeed, depending on applications scenarios, constraints related to the target environments or other requirements, many adaptations and improvements can be made. So, since the initial release of the standard, several implementations were proposed, some targeting specific optimization goals whereas others would optimize several criteria while building the routing topology. They include, but are not limited to, extending the network lifetime, maximizing throughput at the sink node, avoiding the less secured nodes, considering nodes or sink mobility. Sometimes, to consider the Quality of Service (QoS), it is necessary to consider several of those criteria at the same time. This paper reviews recent works on RPL and highlights major contributions to its improvement, especially those related to topology optimization, security and mobility. We aim to provide an insight into relevant efforts around the protocol, draw some lessons and give useful guidelines for future developments

Percutaneous mitral annuloplasty through the coronary sinus: An anatomic point of view

ObjectiveWe assessed the anatomic relationships among the mitral annulus, coronary sinus, and circumflex artery in human cadaver hearts.MethodsPercutaneous posterior mitral annuloplasty has been proposed to treat functional mitral regurgitation on the basis of the proximity of the coronary sinus to the mitral annulus. However, concern remains about the ability to perform a trigone-to-trigone posterior annuloplasty and the potential for compromise of the circumflex coronary artery. Ten hearts were studied after injection of expansible foam into the coronary sinus and circumflex artery. The mitral annulus perimeter, posterior intertrigonal (T1–T2) and intercommissural (C1–C2) distance, and coronary sinus projection on the native annulus (S1–S2) were measured. The spatial geometry of the coronary sinus was correlated with the circumflex artery route and the distance with the native mitral annulus.ResultsThe projection of coronary sinus annuloplasty achieves at best a commissure-to-commissure annuloplasty 14.5 (6–24) mm behind each trigone: T1–T2: 74 (56–114) mm, C1–C2: 62.2 (48–80) mm, S1–S2: 59.5 (40–80) mm. The coronary sinus was distant from the native annulus (8–14 mm at the coronary sinus ostium, 13.7–20.4 mm at the middle of the coronary sinus, 6.9–14 mm at the level of the great coronary vein). The circumflex artery was located between the coronary sinus and the mitral annulus in 45.5% of cases.ConclusionsThis anatomic study highlights the 3-dimensional structure of the coronary sinus and its distance from the native mitral annulus and fibrous trigones. Human anatomic studies are mandatory for the further development of percutaneous mitral repair technology

Transcatheter valve implantation for patients with aortic stenosis: a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions (EAPCI)

Aims: To critically review the available transcatheter aortic valve implantation techniques and their results, as well as propose recommendations for their use and development. Methods and results: A committee of experts including European Association of Cardio-Thoracic Surgery and European Society of Cardiology representatives met to reach a consensus based on the analysis of the available data obtained with transcatheter aortic valve implantation and their own experience. The evidence suggests that this technique is feasible and provides haemodynamic and clinical improvement for up to 2 years in patients with severe symptomatic aortic stenosis at high risk or with contraindications for surgery. Questions remain mainly concerning safety and long-term durability, which have to be assessed. Surgeons and cardiologists working as a team should select candidates, perform the procedure, and assess the results. Today, the use of this technique should be restricted to high-risk patients or those with contraindications for surgery. However, this may be extended to lower risk patients if the initial promise holds to be true after careful evaluation. Conclusion: Transcatheter aortic valve implantation is a promising technique, which may offer an alternative to conventional surgery for high-risk patients with aortic stenosis. Today, careful evaluation is needed to avoid the risk of uncontrolled diffusio

Interferon and Biologic Signatures in Dermatomyositis Skin: Specificity and Heterogeneity across Diseases

BACKGROUND: Dermatomyositis (DM) is an autoimmune disease that mainly affects the skin, muscle, and lung. The pathogenesis of skin inflammation in DM is not well understood. METHODOLOGY AND FINDINGS: We analyzed genome-wide expression data in DM skin and compared them to those from healthy controls. We observed a robust upregulation of interferon (IFN)-inducible genes in DM skin, as well as several other gene modules pertaining to inflammation, complement activation, and epidermal activation and differentiation. The interferon (IFN)-inducible genes within the DM signature were present not only in DM and lupus, but also cutaneous herpes simplex-2 infection and to a lesser degree, psoriasis. This IFN signature was absent or weakly present in atopic dermatitis, allergic contact dermatitis, acne vulgaris, systemic sclerosis, and localized scleroderma/morphea. We observed that the IFN signature in DM skin appears to be more closely related to type I than type II IFN based on in vitro IFN stimulation expression signatures. However, quantitation of IFN mRNAs in DM skin shows that the majority of known type I IFNs, as well as IFN g, are overexpressed in DM skin. In addition, both IFN-beta and IFN-gamma (but not other type I IFN) transcript levels were highly correlated with the degree of the in vivo IFN transcriptional response in DM skin. CONCLUSIONS AND SIGNIFICANCE: As in the blood and muscle, DM skin is characterized by an overwhelming presence of an IFN signature, although it is difficult to conclusively define this response as type I or type II. Understanding the significance of the IFN signature in this wide array of inflammatory diseases will be furthered by identification of the nature of the cells that both produce and respond to IFN, as well as which IFN subtype is biologically active in each diseased tissue

Oxia Planum: The Landing Site for the ExoMars “Rosalind Franklin” Rover Mission: Geological Context and Prelanding Interpretation

The European Space Agency (ESA) and Roscosmos ExoMars mission will launch the “Rosalind Franklin” rover in 2022 for a landing on Mars in 2023.The goals of the mission are to search for signs of past and present life on Mars, investigate the water/geochemical environment as a function of depth in the shallow subsurface, and characterize the surface environment. To meet these scientific objectives while minimizing the risk for landing, a 5-year-long landing site selection process was conducted by ESA, during which eight candidate sites were down selected to one: Oxia Planum. Oxia Planum is a 200 km-wide low-relief terrain characterized by hydrous clay-bearing bedrock units located at the southwest margin of Arabia Terra. This region exhibits Noachian-aged terrains. We show in this study that the selected landing site has recorded at least two distinct aqueous environments, both of which occurred during the Noachian: (1) a first phase that led to the deposition and alteration of ∼100 m of layered clay-rich deposits and (2) a second phase of a fluviodeltaic system that postdates the widespread clay-rich layered unit. Rounded isolated buttes that overlie the clay-bearing unit may also be related to aqueous processes. Our study also details the formation of an unaltered mafic-rich dark resistant unit likely of Amazonian age that caps the other units and possibly originated from volcanism. Oxia Planum shows evidence for intense erosion from morphology (inverted features) and crater statistics. Due to these erosional processes, two types of Noachian sedimentary rocks are currently exposed. We also expect rocks at the surface to have been exposed to cosmic bombardment only recently, minimizing organic matter damage

The SuperCam Instrument Suite on the Mars 2020 Rover: Science Objectives and Mast-Unit Description

On the NASA 2020 rover mission to Jezero crater, the remote determination of the texture, mineralogy and chemistry of rocks is essential to quickly and thoroughly characterize an area and to optimize the selection of samples for return to Earth. As part of the Perseverance payload, SuperCam is a suite of five techniques that provide critical and complementary observations via Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), visible and near-infrared spectroscopy (VISIR), high-resolution color imaging (RMI), and acoustic recording (MIC). SuperCam operates at remote distances, primarily 2-7 m, while providing data at sub-mm to mm scales. We report on SuperCam's science objectives in the context of the Mars 2020 mission goals and ways the different techniques can address these questions. The instrument is made up of three separate subsystems: the Mast Unit is designed and built in France; the Body Unit is provided by the United States; the calibration target holder is contributed by Spain, and the targets themselves by the entire science team. This publication focuses on the design, development, and tests of the Mast Unit; companion papers describe the other units. The goal of this work is to provide an understanding of the technical choices made, the constraints that were imposed, and ultimately the validated performance of the flight model as it leaves Earth, and it will serve as the foundation for Mars operations and future processing of the data.In France was provided by the Centre National d'Etudes Spatiales (CNES). Human resources were provided in part by the Centre National de la Recherche Scientifique (CNRS) and universities. Funding was provided in the US by NASA's Mars Exploration Program. Some funding of data analyses at Los Alamos National Laboratory (LANL) was provided by laboratory-directed research and development funds