374 research outputs found
Crossmodal attention effects on brain responses to different stimulus classes
BACKGROUND: Attending to a point in space in one modality may facilitate processing to information from the same region in another modality. The involvement of sensory-specific cortical areas in intramodal and crossmodal selective spatial attention can be assessed with event-related brain potentials (ERPs). ERPs were recorded in two groups of young participants (each n = 11). Stimulus sequences comprised visual standard stimuli (p = 0.4, a white square), visual deviant stimuli (p = 0.05, a white square with small black rectangle) and visual novel stimuli (p = 0.05, different multicolored checkerboards) as well as auditory standard (p = 0.4, 800 Hz tone), deviant (p = 0.05, 900 Hz tone), and novel (p = 0.05, random combination of three sine-wave tones) stimuli, occurring in random order at locations 30 degrees left and right of a fixation point. The "auditory group" of participants attended either to the left or to the right speaker in order to respond to the infrequent auditory deviants at that location by a speeded button press. Visual stimuli were irrelevant for this group. The "visual group" had the analogue task for the visual modality. For these participants auditory stimuli were irrelevant throughout the experiment. RESULTS: ERPs showed a typical enhancement of early sensory specific components by intramodal spatial attention (visual group: visual P1 and N1; auditory group: auditory Nd). Crossmodal spatial attention effects included a modulation of the Nd to auditory standards in the visual group and a modulation of the P1 to visual novels and N1 for visual standards for the auditory group. Similar to previous studies crossmodal spatial attention effects on visual standard and novel stimuli also included a frontocentral positivity in the 200â400 ms range that was not seen for intramodal spatial visual attention suggesting involvement of later supramodal areas. CONCLUSION: These findings are consistent with an action of crossmodal spatial attention on early, sensory specific processing stages
Landscapeâmediated variation in diet is associated with egg size and maculation in a generalist forager
Human impacts alter landscapes with consequences for the distribution and availability of highâquality food resources to populations inhabiting those landscapes, which may impact on the reproductive output of individuals in those populations. Sensitivity of wild populations to changes in food resources may vary among stages of the annual cycle. For example, in birds, effects are likely to be greater during costly stages such as egg production. Here we compare assimilated diet (from stable isotope analysis of chick feathers) and egg traits (egg size, shape, eggshell colour and maculation, using patternâanalysis software) in Herring Gulls Larus argentatus, across seven colonies in southwest Scotland and Northern Ireland
Egg investment in response to helper presence in cooperatively breeding Tibetan ground tits
Life-history theory predicts a trade-off between current and future reproduction to maximize lifetime fitness. In cooperatively breeding species, where offspring care is shared between breeders and helpers, helper presence may influence the female breeders' egg investment, and consequently, survival and future reproductive success. For example, female breeders may reduce egg investment in response to helper presence if this reduction is compensated by helpers during provisioning. Alternatively, female breeders may increase egg investment in response to helper presence if helpers allow the breeders to raise more or higher quality offspring successfully. In the facultatively cooperative-breeding Tibetan ground tit Pseudopodoces humilis, previous studies found that helpers improve total nestling provisioning rates and fledgling recruitment, but have no apparent effects on the number and body mass of fledglings produced, while breeders with helpers show reduced provisioning rates and higher survival. Here, we investigated whether some of these effects may be explained by female breeders reducing their investment in eggs in response to helper presence. In addition, we investigated whether egg investment is associated with the female breeder's future fitness. Our results showed that helper presence had no effect on the female breeders' egg investment, and that egg investment was not associated with breeder survival and reproductive success. Our findings suggest that the responses of breeders to helping should be investigated throughout the breeding cycle, because the conclusions regarding the breeders' adjustment of reproductive investment in response to being helped may depend on which stage of the breeding cycle is considered
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The Intraflagellar Transport Protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3
Mechanochemical basis of protein degradation by a double-ring AAA+ machine
Molecular machines containing double or single AAA+ rings power energy-dependent protein degradation and other critical cellular processes, including disaggregation and remodeling of macromolecular complexes. How the mechanical activities of double-ring and single-ring AAA+ enzymes differ is unknown. Using single-molecule optical trapping, we determine how the double-ring âClpA enzyme from Escherichia coli, in complex with the âClpP peptidase, mechanically degrades proteins. We demonstrate that âClpA unfolds some protein substrates substantially faster than does the single-ring âClpX enzyme, which also degrades substrates in collaboration with âClpP. We find that âClpA is a slower polypeptide translocase and that it moves in physical steps that are smaller and more regular than steps taken by âClpX. These direct measurements of protein unfolding and translocation define the core mechanochemical behavior of a double-ring AAA+ machine and provide insight into the degradation of proteins that unfold via metastable intermediates.Howard Hughes Medical InstituteNational Institutes of Health (U.S.) (Grant AI-16892
Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models
Mutations in the Retinitis Pigmentosa GTPase Regulator (RPGR) cause X-linked RP (XLRP), an untreatable, inherited retinal dystrophy that leads to premature blindness. RPGR localises to the photoreceptor connecting cilium where its function remains unknown. Here we show, using murine and human induced pluripotent stem cell models, that RPGR interacts with and activates the actin-severing protein gelsolin, and that gelsolin regulates actin disassembly in the connecting cilium, thus facilitating rhodopsin transport to photoreceptor outer segments. Disease-causing RPGR mutations perturb this RPGR-gelsolin interaction, compromising gelsolin activation. Both RPGR and Gelsolin knockout mice show abnormalities of actin polymerisation and mislocalisation of rhodopsin in photoreceptors. These findings reveal a clinically-significant role for RPGR in the activation of gelsolin, without which abnormalities in actin polymerisation in the photoreceptor connecting cilia cause rhodopsin mislocalisation and eventual retinal degeneration in XLRP.Mutations in the Retinitis Pigmentosa GTPase Regulator (RPGR) cause retinal dystrophy, but how this arises at a molecular level is unclear. Here, the authors show in induced pluripotent stem cells and mouse knockouts that RPGR mediates actin dynamics in photoreceptors via the actin-severing protein, gelsolin
Maternal condition but not corticosterone is linked to brood sex ratio adjustment in a passerine bird
There is evidence of offspring sex ratio adjustment in a range of species, but the potential mechanisms remain largely unknown. Elevated maternal corticosterone (CORT) is associated with factors that can favour brood sex ratio adjustment, such as reduced maternal condition, food availability and partner attractiveness. Therefore, the steroid hormone has been suggested to play a key role in sex ratio manipulation. However, despite correlative and causal evidence CORT is linked to sex ratio manipulation in some avian species, the timing of adjustment varies between studies. Consequently, whether CORT is consistently involved in sex-ratio adjustment, and how the hormone acts as a mechanism for this adjustment remains unclear. Here we measured maternal baseline CORT and body condition in free-living blue tits (Cyanistes caeruleus) over three years and related these factors to brood sex ratio and nestling quality. In addition, a non-invasive technique was employed to experimentally elevate maternal CORT during egg laying, and its effects upon sex ratio and nestling quality were measured. We found that maternal CORT was not correlated with brood sex ratio, but mothers with elevated CORT fledged lighter offspring. Also, experimental elevation of maternal CORT did not influence brood sex ratio or nestling quality. In one year, mothers in superior body condition produced male biased broods, and maternal condition was positively correlated with both nestling mass and growth rate in all years. Unlike previous studies maternal condition was not correlated with maternal CORT. This study provides evidence that maternal condition is linked to brood sex ratio manipulation in blue tits. However, maternal baseline CORT may not be the mechanistic link between the maternal condition and sex ratio adjustment. Overall, this study serves to highlight the complexity of sex ratio adjustment in birds and the difficulties associated with identifying sex biasing mechanisms
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