Kleinian groups and the complex of curves

We examine the internal geometry of a Kleinian surface group and its relations to the asymptotic geometry of its ends, using the combinatorial structure of the complex of curves on the surface. Our main results give necessary conditions for the Kleinian group to have `bounded geometry' (lower bounds on injectivity radius) in terms of a sequence of coefficients (subsurface projections) computed using the ending invariants of the group and the complex of curves. These results are directly analogous to those obtained in the case of punctured-torus surface groups. In that setting the ending invariants are points in the closed unit disk and the coefficients are closely related to classical continued-fraction coefficients. The estimates obtained play an essential role in the solution of Thurston's ending lamination conjecture in that case.Comment: 32 pages. Published copy, also available at http://www.maths.warwick.ac.uk/gt/GTVol4/paper3.abs.htm

Human activity recognition from inertial sensor time-series using batch normalized deep LSTM recurrent networks

In recent years machine learning methods for human activity recognition have been found very effective. These classify discriminative features generated from raw input sequences acquired from body-worn inertial sensors. However, it involves an explicit feature extraction stage from the raw data, and although human movements are encoded in a sequence of successive samples in time most state-of-the-art machine learning methods do not exploit the temporal correlations between input data samples. In this paper we present a Long-Short Term Memory (LSTM) deep recurrent neural network for the classification of six daily life activities from accelerometer and gyroscope data. Results show that our LSTM can processes featureless raw input signals, and achieves 92 % average accuracy in a multi-class-scenario. Further, we show that this accuracy can be achieved with almost four times fewer training epochs by using a batch normalization approach

Severe pneumonia due to Parachlamydia acanthamoebae following intranasal inoculation: a mice model.

Parachlamydia acanthamoebae is an obligate intracellular bacterium naturally infecting free-living amoebae. The role of this bacterium as an agent of pneumonia is suggested by sero-epidemiological studies and molecular surveys. Furthermore, P. acanthamoebae may escape macrophages microbicidal effectors. Recently, we demonstrated that intratracheal inoculation of P. acanthamoebae induced pneumonia in 100% of infected mice. However, the intratracheal route of infection is not the natural way of infection and we therefore developed an intranasal murine model. Mice inoculated with P. acanthamoebae by intranasal inoculation lost 18% of their weight up to 8 days post-inoculation. All mice presented histological signs of pneumonia at day 2, 4, 7, and 10 post-inoculation, whereas no control mice harboured signs of pneumonia. A 5-fold increase in bacterial load was observed from day 0 to day 4 post-inoculation. Lungs of inoculated mice were positive by Parachlamydia-specific immunohistochemistry 4 days post-inoculation, and P. acanthamoebae were localized within macrophages. Thus, we demonstrated that P. acanthamoebae induce a severe pneumonia in mice. This animal model (i) further supports the role of P. acanthamoebae as an agent of pneumonia, confirming the third Koch postulate, and (ii) identified alveolar macrophages as one of the initial cells where P. acanthamoebae is localized following infection

Investigating Inflammasome Activation in Response to Legionella Pneumophila and its Application to Other Bacterial Pathogens

The mucosal surfaces of metazoan organisms provide niches for colonization by commensal microbes. However, these barrier surfaces also encounter pathogens. Therefore, sentinel immune cells must be capable of distinguishing between pathogenic and non-pathogenic organisms to tailor appropriate immune responses. Virulent microorganisms often uniquely possess mechanisms for accessing the host cell cytosol. Therefore, to detect pathogens, innate immune cells encode cytosolic receptors, which recognize conserved, pathogen-associated molecular patterns. Many mammalian cytosolic receptors activate the inflammasome, a multi-protein complex that activates the host enzyme caspase-1. Caspase-1 mediates IL-1 family cytokine release and a pro-inflammatory form of cell death, which are important for host defense. The canonical inflammasome activates caspase-1, but recent studies have shown that a related enzyme, caspase-11, contributes to inflammasome activation. However, it remains unclear if caspase-11 mediates inflammasome responses against bacteria that use virulence-associated secretion systems to deliver bacterial products into the host cytosol. Additionally, humans encode two orthologs of caspase-11, caspase-4 and caspase-5, and it is unclear if either enzyme contributes to inflammasome activation in primary macrophages. Furthermore, the bacterial ligands that trigger inflammasome activation in human cells are poorly defined. Legionella pneumophila, which causes pneumonia, uses a specialized secretion system to access the host cytosol to establish a replicative niche in both murine and human cells. Therefore, we investigated the host and bacterial requirements for inflammasome activation in response to L. pneumophila, and we interrogated if these requirements are conserved for the response against other Gram-negative bacterial pathogens. Our studies demonstrate that caspase-11 contributes to IL-1 release and cell death in response to bacterial pathogens in murine macrophages, and we find that inflammasome activation requires the presence of virulence-associated secretion systems. Using neutralizing antibodies, we show that IL-1α and IL-1β have distinct roles in pulmonary defense against L. pneumophila in vivo. Through siRNA knockdown studies, we demonstrate that human caspase-4 has a conserved role in inflammasome activation in response to multiple Gram-negative bacterial pathogens. Finally, using bacterial mutants, we show that flagellin is a trigger for inflammasome activation in human macrophages. Overall, our studies help define the mechanism by which host cells initiate defense against bacterial pathogens

Sociological and Communication-Theoretical Perspectives on the Commercialization of the Sciences

Both self-organization and organization are important for the further development of the sciences: the two dynamics condition and enable each other. Commercial and public considerations can interact and "interpenetrate" in historical organization; different codes of communication are then "recombined." However, self-organization in the symbolically generalized codes of communication can be expected to operate at the global level. The Triple Helix model allows for both a neo-institutional appreciation in terms of historical networks of university-industry-government relations and a neo-evolutionary interpretation in terms of three functions: (i) novelty production, (i) wealth generation, and (iii) political control. Using this model, one can appreciate both subdynamics. The mutual information in three dimensions enables us to measure the trade-off between organization and self-organization as a possible synergy. The question of optimization between commercial and public interests in the different sciences can thus be made empirical.Comment: Science & Education (forthcoming

Inter-sectoral and multilevel coordination alone do not reduce deforestation and advance environmental justice:Why bold contestation works when collaboration fails

Policy makers, academics, and conservationists often posit that poor coordination between different land use sectors, and between levels of governance, as an underlying challenge for reducing deforestation and forest degradation. This paper analyzes this argument using data from interviews with over 500 respondents from government, nongovernmental organizations, private companies, local and indigenous communities, activists, and individuals involved in 35 diverse land use initiatives in three countries: Peru, Indonesia, and Mexico. We find that while there is strong evidence of widespread coordination failures between sectors and levels, more fundamental political issues preclude effective coordination. We argue that political coalitions act to oppose environmental objectives and to impede their opponents from participating in land use governance. Moreover, we find that where coordination between actors does occur, it does not necessarily produce environmentally sustainable and socially just land use outcomes. Where we do find successful initiatives to reduce deforestation and benefit local people, effective coordination between well-informed actors is often present, but it does not occur spontaneously, and is instead driven by political organizing over time by activists, local people, nongovernmental organizations, and international donors. We suggest that the global environmental community must recognize explicitly these political dimensions of land use governance in order to successfully collaborate with local people to reduce deforestation

Entrepreneurial sons, patriarchy and the Colonels' experiment in Thessaly, rural Greece

Existing studies within the field of institutional entrepreneurship explore how entrepreneurs influence change in economic institutions. This paper turns the attention of scholarly inquiry on the antecedents of deinstitutionalization and more specifically, the influence of entrepreneurship in shaping social institutions such as patriarchy. The paper draws from the findings of ethnographic work in two Greek lowland village communities during the military Dictatorship (1967–1974). Paradoxically this era associated with the spread of mechanization, cheap credit, revaluation of labour and clear means-ends relations, signalled entrepreneurial sons’ individuated dissent and activism who were now able to question the Patriarch’s authority, recognize opportunities and act as unintentional agents of deinstitutionalization. A ‘different’ model of institutional change is presented here, where politics intersects with entrepreneurs, in changing social institutions. This model discusses the external drivers of institutional atrophy and how handling dissensus (and its varieties over historical time) is instrumental in enabling institutional entrepreneurship

Cigarette smoking and adenocarcinomas of the esophagus and esophagogastric junction: a pooled analysis from the International BEACON Consortium

BackgroundPrevious studies that showed an association between smoking and adenocarcinomas of the esophagus and esophagogastric junction were limited in their ability to assess differences by tumor site, sex, dose–response, and duration of cigarette smoking cessation.MethodsWe used primary data from 10 population-based case–control studies and two cohort studies from the Barrett’s Esophagus and Esophageal Adenocarcinoma Consortium. Analyses were restricted to white non-Hispanic men and women. Patients were classified as having esophageal adenocarcinoma (n = 1540), esophagogastric junctional adenocarcinoma (n = 1450), or a combination of both (all adenocarcinoma; n = 2990). Control subjects (n = 9453) were population based. Associations between pack-years of cigarette smoking and risks of adenocarcinomas were assessed, as well as their potential modification by sex and duration of smoking cessation. Study-specific odds ratios (ORs) estimated using multivariable logistic regression models, adjusted for age, sex, body mass index, education, and gastroesophageal reflux, were pooled using a meta-analytic methodology to generate summary odds ratios. All statistical tests were two-sided.ResultsThe summary odds ratios demonstrated strong associations between cigarette smoking and esophageal adenocarcinoma (OR = 1.96, 95% confidence interval [CI] = 1.64 to 2.34), esophagogastric junctional adenocarcinoma (OR = 2.18, 95% CI = 1.84 to 2.58), and all adenocarcinoma (OR = 2.08, 95% CI = 1.83 to 2.37). In addition, there was a strong dose–response association between pack-years of cigarette smoking and each outcome ( P &lt; .001). Compared with current smokers, longer smoking cessation was associated with a decreased risk of all adenocarcinoma after adjusting for pack-years (&lt;10 years of smoking cessation: OR = 0.82, 95% CI = 0.60 to 1.13; and ≥10 years of smoking cessation: OR = 0.71, 95% CI = 0.56 to 0.89). Sex-specific summary odds ratios were similar.ConclusionsCigarette smoking is associated with increased risks of adenocarcinomas of the esophagus and esophagogastric junction in white men and women; compared with current smoking, smoking cessation was associated with reduced risks.<br/

Exploring Pompeii: discovering hospitality through research synergy

Hospitality research continues to broaden through an ever-increasing dialogue and alignment with a greater number of academic disciplines. This paper demonstrates how an enhanced understanding of hospitality can be achieved through synergy between archaeology, the classics and sociology. It focuses on classical Roman life, in particular Pompeii, to illustrate the potential for research synergy and collaboration, to advance the debate on hospitality research and to encourage divergence in research approaches. It demonstrates evidence of commercial hospitality activities through the excavation hotels, bars and taverns, restaurants and fast food sites. The paper also provides an example of the benefits to be gained from multidisciplinary analysis of hospitality and tourism

Organizational innovation in the multinational enterprise: internalization theory and business history

This article engages in a methodological experiment by using historical evidence to challenge a common misperception about internalization theory. The theory has often been criticized for maintaining that it assumes a hierarchically organized MNE based on knowledge flowing from the home country. This is not an accurate description of how global firms operate in recent decades, but this article shows it has never been true historically. Using longitudinal data on individual firms from the nineteenth century onwards, it reveals evidence of how entrepreneurs and firms with multinational activity faced with market imperfections changed the design of their headquarters and their organizational structures