Low Dose Perioperative Lidocaine Infusion for Post-Operative Pain in Open Cholecystectomy

compare low dose peri-operative lidocaine infusion and placebo for post-operative mean pain score and mean analgesic requirement in open cholecystectomy.Methods: In this prospective randomized comparative study 120 patients, undergoing open cholecystectomy in general anaesthesia, were included. Patients were randomly allocated to either lidocaine infusion (L) or saline group (S) using systematic randomized sampling with 60 patients in each group. Patients in the lidocaine infusion group were given bolus injection of lidocaine 30 minutes before the skin incision followed by a continuous intraveonous via infusion pump whereas the patients in the saline group received 0.9% normal saline in equal volume and in the same manner. The infusion was continued throughout the surgery and was terminated 60 min after the skin closure.Results: Out of the 120 patients 34 (28.3%) were male while 86 (71.7%) were female. Mean age was 41.32±11.512 years. Both mean VAS pain score and mean analgesic requirement were found to be significantly lower in the lidocaine Group (p-values 0.04 and 0.29 respectively), as compared to controls.Conclusion: Peri-operative low dose systemic lidocaine appears to reduce pain in the immediate post-operative period

Gastroprotective potential and mechanisms of action of Hedera nepalensis

Hedera nepalensis (H. nepalensis) , belonging to the family Araliaceae, is a medicinal plant traditionally used to treat stomach problems. The current study investigated the gastroprotective potential and the mechanism of action of H. nepalensis in diclofenac-and ethanol-induced ulcer models. Anti-oxidant and lipid peroxidation inhibitory prospects of H. nepalensis were checked out by free radical scavenging assay and UV spectrophotometer respectively. Effect of H. nepalensis on the pH, gastric total acidity of gastric juice and protective effects of H. nepalensis against ulcer models have been examined. Histopathological studies have been carried out. The aqueous methanol extract of H. nepalensis (100 µg/mL) showed anti-oxidant (83.55%) and lipid peroxidation inhibitory (70.88%) potential at 1000 µg/mL; the extract had no buffer potential. The extract (400 mg/kg) significantly (81.12% and 63.46%) showed gastroprotective effect in diclofenac and ethanol-induced rat ulcer models respectively. Histopathological studies confirmed the biochemical findings. FTIR analysis showed the presence of carboxylic acid, alkanes, conjugated alkanes, aldehydes and alkyl-aryl ethers. Gallic acid, M-coumaric acid and quercetin were found by HPLC analysis. H. nepalensis exhibited significant protection against diclofenac and ethanol induced gastric damage by anti-oxidant and lipid peroxidation suppression effects suggesting potential broad utility in treatment of diseases characterized with gastric damage

Fracture Pattern Analysis of the Upper Cretaceous-Eocene Carbonates along with the Ghumawan Dome, Hazara Basin

Deformational history of the Hazara basin indicates a primitive collision of the two landmasses that undergoes an episodic deformation with NE-SW structural trend. Panjal Thrust (PT) and Main Boundary Thrust (MBT) demarcate the northern and southern extremities of the basin, respectively. The area bounded between these two thrusts is the core consideration of the present research. Different stratigraphic units juxtapose along the Hazara Kashmir Syntaxes (HKS), while the strike-slip component is indicated by imbrication due to thrusts. The study is amied to analyze the paleo-stresses along with developed fracture patterns. Field data were collected via Circle Inventory Method from various localities of the Ghumawan dome, Hazara basin. The zones of upper Cretaceous to Eocene carbonates were mainly targeted during the data collection. Win-Tensor was the key software that helps to analyze the paleo-stresses and fracture pattern of the study area. NW-trending fracture pattern was observed with a highly non-symmetric to dense fracture pattern. The local thrust system lead to severely de-shape the study area. N-S oriented σ1 indicated the compressional tectonic condition that prevailed during deformation of this area. Some segments also show extensional features i.e. normal faulting

Effect of animal manure, crop type, climate zone, and soil attributes on greenhouse gas emissions from agricultural soils A global meta-analysis

Agricultural lands, because of their large area and exhaustive management practices, have a substantial impact on the earth's carbon and nitrogen cycles, and agricultural activities consequence in discharges of greenhouse gases (GHGs). Globally, greenhouse gases (GHGs) emissions especially carbon dioxide (CO2), methane (CH4) and nitrous oxide (N2O) from the agricultural sector are increasing due to anthropogenic activities. Although, the application of animal manure to the agricultural soil as an organic fertilizer not only improves soil health and agricultural production but also has a significant impact on GHGs emissions. But the extent of GHGs emissions in response to manure application under diverse environmental conditions is still uncertain. Here, a meta-analysis study was conducted using field data (48 peer-reviewed publications) published from 1989 to 2019. Meta-analysis results showed that poultry manure considerably increased CO2, CH4, and N2O emissions than pig and cattle manure. Furthermore, application of poultry manure also increased (¯(〖lnRR〗^ ) =0.141, 95% CI =0.526-0.356) GWP (global warming potential) of total soil GHGs emissions. While, the significant effects on CO2, CH4, and N2O emissions also occurred at manure rate > 320 kg N ha-1 and > 60% water filled pore space. The maximum concentrations of CO2, CH4, and N2O emissions were observed in neutral soils (¯(〖lnRR〗^ ) =3.375, 95% CI =3.323-3.428), alkaline soils (¯(〖lnRR〗^ ) =1.468, 95% CI =1.403-1.532), and acidic soils (¯(〖lnRR〗^ ) =2.355, 95% CI =2.390-2.400), respectively. Soil texture, climate zone and crop type were also found significant factors to increase GHGs emissions. Thus, this meta-analysis revealed a knowledge gap concerning the consequences of animal manure application and rate, climate zone, and physicochemical properties of soil on GHGs emissions from agricultural soils.Awais Shakoor would like to express his gratitude for the grant provided by the University of Lleida, Spain. The authors would like to appreciate the valuable comments from the editors and anonymous reviewers to improve the quality of this study

Role of MicroRNA in Endometrial Carcinoma

Endometrial carcinoma (EC) is a hall mark of gynecological malignancies that usually affects women above the age 50. It is one of the major causes of mortality in females with ever increasing prevalence and the mortality rate is 1.7 to 2.4 per 100000 and each year 10000 death occur due to ECs. MiRNAs regulate the expression of different proto-oncogenes and signaling pathways that are directly or indirectly involved in the development of cancer. Different miRNAs i.e. (miRNA-449, miRNA 370, miRNA-424, and miRNA-152) which gets up or down regulated during endometrial cancer are the potential biomarkers for early diagnosis of EC. Targeting this relationship between the miRNA and signaling pathways may help in the development of new treatment in endometrial cancer. In current study, we reviewed literature from PubMed using miRNA and endometrial cancer as keywords and outlined the synthesis of potent miRNA and role of different miRNAs involved in ECs. The study revealed different sub types of miRNA played crucial role in the development of cancer by up and down regulation of different metabolic pathways. Many evidences have supported that miRNAs play role in control and regulation of different pathways leading to cancer and targeting these pathways may bring changes in the diagnosis as well as in treatment of EC

Relationship of BMI and age with gallstone disease

Objective: To find out the relationship of BMI and age in patients with gallstone disease.  Methodology: This is a cross-sectional study done from March 2019 to February 2020 at the Department of General Surgery PIMS, Islamabad. All patients admitted with a diagnosis of Cholelithiasis were included and patients with previous abdominal surgery were excluded from the study. Patients’ data was collected about their age, sex, dietary habits, occupation and medical history. Their weight in kilograms and heights in centimeters were measured and BMI was calculated in kg/cm2. All data was collected, recorded and analyzed using SPSS 22. Results: A total of 158 patients were included in the study with mean age was 46.2±6.7 years (18 - 83 years). Majority (63%) of the patients were between 41 and 60 age group. There were 120 females and 38 males with ratio of 3:1. The mean BMI of the study population was 25.8 ± 7.61 (Range 19.37 - 33.12). Most of the patients were healthy (n=86, 54.4%) having their BMIs between 18 and 24.9 whereas 72 (46.6%) patients were overweight and obese. Conclusion: Increased frequency of cholelithiasis is found with increasing age even with normal BMI

Salivary oxidative stress and antioxidant capacity in smokeless tobacco (Naswar) users

Naswar, a smokeless tobacco product, commonly consumed in Pakistan, is associated with a 10-fold increase in the risk of oral cancer. However, little is known about Naswar's underlying toxicity mechanisms. The current study aimed to investigate the effects of Naswar use on oral health and salivary parameters. A case-control study was conducted among Naswar users ( =42) and age-matched healthy controls ( =42) in Pakistan in 2019. Participant data were collected using questionnaires. Decayed, missing, and filled teeth (DMFT) scores were computed during clinical examinations. Unstimulated whole saliva was collected to assess salivary flow rate, pH, and salivary total oxidative stress (TOS)/total antioxidant capacity (TAC) using commercially available kits. Participants' oral health parameters were compared between cases and controls using ANOVA. No significant differences were observed between the two groups in terms of age, oral health, and hygiene practices and mean DMFT score. Mean salivary pH and the salivary flow rate was significantly ( <0.001) higher in Naswar users (7.7 and 0.71 mL/minute, respectively) than in non-users (6.95 and 0.52 mL/minute, respectively). Although TOS and TAC were not significantly different between the groups, Naswar users generally had a higher TOS (51.6±42 µmol/L) and lower TAC (0.55±0.18 mmol/L) than non-users (TOS 45.5±38.2 µmol/L and TAC 0.57±0.17 mmol/L). Correlational analysis also revealed a significant positive correlation between DMFT score and Naswar use duration ( =0.796, <0.001) and the number of dips/units consumed each day ( =0.515; <0.001). Habitual Naswar use is associated with increased salivary flow rate, pH, and TOS, and reduced TAC levels in Pakistani adults compared to non-users. The pro-oxidant changes may contribute toward deleterious effects of Naswar use including oral cancer

FEDRP Based Model Implementation of Intelligent Energy Management Scheme for a Residential Community in Smart Grids Network

ABSTRACT In the framework of liberalized deregulated electricity market, dynamic competitive environment exists between wholesale and retail dealers for energy supplying and management. Smart Grids topology in form of energy management has forced power supplying agencies to become globally competitive. Demand Response (DR) Programs in context with smart energy network have influenced prosumers and consumers towards it. In this paper Fair Emergency Demand Response Program (FEDRP) is integrated for managing the loads intelligently by using the platform of Smart Grids for Residential Setup. The paper also provides detailed modeling and analysis of respective demands of residential consumers in relation with economic load model for FEDRP. Due to increased customer&apos;s partaking in this program the load on the utility is reduced and managed intelligently during emergency hours by providing fair and attractive incentives to residential clients, thus shifting peak load to off peak hours. The numerical and graphical results are matched for intelligent energy management scenario

Birthmark based identification of software piracy using Haar wavelet

Piracy of software is an increasing problem of modern day software industry. Piracy of software is the unlawful use of software or part of it without proper permission as described in license agreement. Software piracy is a serious crime but not taken seriously by most people. Preventing software piracy is very important for the growing software industry. Efforts are being made to prevent and detect software piracy. Several techniques have been developed most important of which is software birthmark. The birthmark of a software is the intrinsic properties of software. A recent research shows that a features based software birthmark can be used as a strong mechanism to detect piracy of a software and how much piracy performed has been performed on it. An objective measure is needed to overcome this problem and to compare features based birthmark of a software which efficiently and precisely detect piracy in reproduction of software. The proposed study presents Haar wavelet collocation method for software features (birthmark) to detect piracy. The proposed method gives an exclusive solution for the features based birthmark of software and is then further used for comparisons of birthmark. The results of the proposed study show the effectiveness in terms of accuracy and efficiency to compare the features based software