O diagnóstico do autismo e a construção da linguagem no ensino da arte inclusivo

O estudo teve o propósito de revisar e discutir alguns conceitos do autismo, as novas possibilidades de auxílios no diagnóstico bem como apresentar reflexões sobre as formas alternativas de linguagem com as pessoas que apresentam o autismo. Existem muitas dificuldades para estabelecer programas pedagógicos que atendam especificamente alunos autistas devido a diagnósticos errôneos ou imprecisos. A metodologia realizada foi uma revisão de literatura, estabelecendo critérios de artigos que abordassem apenas os temas focalizados. Como considerações sugerem-se o estabelecimento de instrumentos de pesquisa que ajudem aos professores a compreender melhor a funcionalidade dos alunos com autismo

Technological factors associated with oil palm yield gaps in the Central Region in Colombia

This study builds on the results from a previous study (Ruiz, 2017), aimed to identify and quantify yield gaps in a sample of lots from small and medium scale producers, all suppliers of the same mill. The technical staff from the mill provides technical assistance to the aforementioned growers. This study was aimed at identifying what technological factors are associated with such gaps. Regarding the methodological approach, first, it was used the technology balance index (TBI) in order to quantify technology adoption. The TBI allows for rating technology adoption at oil palm crops by considering five processes (which comprehend 25 cropping practices). The processes evaluated are establishment, weeding and pruning, fertilizing, pests control and harvesting. The TBI assigns a category for each practice: high if it is fully adopted, intermediate if it is partially adopted and low if it is not adopted at all. Secondly, in order to determine those practices affecting yield gaps; we used a multiple correspondence analysis (MCA). MCA allowed to synthesize data into two dimensions with 51% of the variability given by the data gathered (qualification of the adoption of 25 crop management practices). Thirdly, we used cluster analysis in order to group lots according to adoption of technology. Then we related the obtained groups with the yield records. MCA results indicated that proper establishment, harvest and nutrition practices are the ones causing most of the variability in terms of technology adoption. The groups resulting from CA, provided evidence that a greater adoption of technology, leads greater yields (i.e. smaller yield gaps).Este estudio se basa en los resultados de un estudio previo (Ruiz, 2017), dirigido a identificar y cuantificar las brechas de rendimiento en una muestra de lotes de productores de palma de aceite de pequeña y mediana escala que son proveedores de la misma planta extractora El personal técnico de la planta proporciona asistencia técnica a los productores antes mencionados. Este estudio tuvo por objetivo identificar cuáles son los factores tecnológicos que están asociados a las brechas en el rendimiento. Con respecto a la metodología, en primer lugar, se utilizó el Índice de Balance Tecnológico (IBT) para cuantificar la adopción de tecnología. El IBT permite valorar la adopción de tecnología en cultivos de palma de aceite considerando cinco procesos (que comprenden 25 prácticas de manejo del cultivo). Los procesos evaluados fueron el establecimiento, desmalezado y poda, fertilización, control de plagas y cosecha. El IBT asigna una categoría para cada práctica: alta si es plenamente adoptada,intermedio si se adopta parcialmente y baja si no se adopta. En segundo lugar, con el fin de determinar las prácticas que se asocian a las brechas de rendimiento, se utilizó un análisis de correspondencias múltiples (ACM). Este análisis permite  sintetizar en dos dimensiones el 51% de la variabilidad de los datos recogidos (calificación de la adopción de 25 prácticas de manejo del cultivo). En tercer lugar, se utilizó el análisis de conglomerados (AC) para conformar grupos de lotes, según la adopción de la tecnología. Posteriormente, identificamos los rendimientos de cada uno de los grupos conformados. Los resultados del ACM indicaron que las prácticas de establecimiento, cosecha y nutrición adecuadas, son las que causan la mayor parte de la variabilidad en términos de adopción de tecnología. Los grupos resultantes de AC, proporcionaron evidencia en el sentido de que a mayor adopción de tecnología, se encuentran mayores rendimientos (es decir, menores brechas en el rendimiento)

Development and implementation of a virtual laboratory for training process improvement in the mechanics of continuous media

The project arises from the need to develop improved teaching methodologies in field of the mechanics of continuous media. The objective is to offer the student a learning process to acquire the necessary theoretical knowledge, cognitive skills and the responsibility and autonomy to professional development in this area. Traditionally the teaching of the concepts of these subjects was performed through lectures and laboratory practice. During these lessons the students attitude was usually passive, and therefore their effectiveness was poor. The proposed methodology has already been successfully employed in universities like University Bochum, Germany, University the South Australia and aims to improve the effectiveness of knowledge acquisition through use by the student of a virtual laboratory. This laboratory allows to adapt the curricula and learning techniques to the European Higher Education and improve current learning processes in the University School of Public Works Engineers -EUITOP- of the Technical University of Madrid -UPM-, due there are not laboratories in this specialization. The virtual space is created using a software platform built on OpenSim, manages 3D virtual worlds, and, language LSL -Linden Scripting Language-, which imprints specific powers to objects. The student or user can access this virtual world through their avatar -your character in the virtual world- and can perform practices within the space created for the purpose, at any time, just with computer with internet access and viewfinder. The virtual laboratory has three partitions. The virtual meeting rooms, where the avatar can interact with peers, solve problems and exchange existing documentation in the virtual library. The interactive game room, where the avatar is has to resolve a number of issues in time. And the video room where students can watch instructional videos and receive group lessons. Each audiovisual interactive element is accompanied by explanations framing it within the area of knowledge and enables students to begin to acquire a vocabulary and practice of the profession for which they are being formed. Plane elasticity concepts are introduced from the tension and compression testing of test pieces of steel and concrete. The behavior of reticulated and articulated structures is reinforced by some interactive games and concepts of tension, compression, local and global buckling will by tests to break articulated structures. Pure bending concepts, simple and composite torsion will be studied by observing a flexible specimen. Earthquake resistant design of buildings will be checked by a laboratory test video

Evaluation of a new, rapid, simple test for the detection of influenza virus

BACKGROUND: Influenza virus infections are responsible for significant morbidity and mortality in both pediatric and adult populations worldwide. Rapid and accurate diagnosis of influenza is necessary for appropriate patient management during the influenza season and for optimal utilization of anti-influenza therapy. We prospectively tested the accuracy of a simple and rapid diagnostic method. METHODS: Ninety-eight samples (nasal and pharyngeal swabs) from patients with upper respiratory tract infection symptoms who presented to primary healthcare centres in Barcelona (Spain) were prospectively analyzed. The samples were collected as part of influenza surveillance program. Samples that had enough volume to make the new test after aliquoting the amount needed to perform routine tests were included. None of the samples were pre-selected as a result of their status in relation to influenza virus. Samples were analyzed by in-house real-time PCR and Alere™ i Influenza A & B (Alere™ i), which uses isothermal amplification of nucleic acids for the qualitative detection of influenza A and B in nasal swabs transported in viral transport media. The two techniques were compared by positive percent agreement (PPA) and negative percent agreement (NPA). Statistical analysis was performed with Stata. RESULTS: Of the 98 samples analysed 90 were concordant; 46 (46.9%) were positive and 44 (44.9%) were negative. Five samples showed invalid results with the Alere™ i test and could be not re-tested due to insufficient sample volume and were not included in the final statistical analysis. In the 93 remaining samples, the Alere™ i test showed 97% of accuracy having correctly classified 90 samples. We obtained discordant results in 3 samples (3%). The PPA was 93.8% for influenza A and 94.1% for influenza B, and NPA was 100% for influenza A and influenza B virus. In addition, the Alere™ i was very rapid (15 minutes or less) and extremely easy to use. CONCLUSIONS: The Alere™ i test provided a good correlation compared to the real-time PCR test for the diagnosis of influenza. Since this method can be performed in minutes, it allows immediate, accurate clinical decisions to prescribe appropriate antiviral treatment or isolation of patients

The first hominin of Europe

The earliest hominin occupation of Europe is one of the most debated topics in palaeoanthropology. However, the purportedly oldest of the Early Pleistocene sites in Eurasia lack precise age control and contain stone tools rather than human fossil remains(1-5). Here we report the discovery of a human mandible associated with an assemblage of Mode 1 lithic tools and faunal remains bearing traces of hominin processing, in stratigraphic level TE9 at the site of the Sima del Elefante, Atapuerca, Spain(6-8). Level TE9 has been dated to the Early Pleistocene ( approximately 1.2 - 1.1 Myr), based on a combination of palaeomagnetism, cosmogenic nuclides and biostratigraphy. The Sima del Elefante site thus emerges as the oldest, most accurately dated record of human occupation in Europe, to our knowledge. The study of the human mandible suggests that the first settlement of Western Europe could be related to an early demographic expansion out of Africa. The new evidence, with previous findings in other Atapuerca sites ( level TD6 from Gran Dolina(9-13)), also suggests that a speciation event occurred in this extreme area of the Eurasian continent during the Early Pleistocene, initiating the hominin lineage represented by the TE9 and TD6 hominins.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62855/1/nature06815.pd

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Clustering COVID-19 ARDS patients through the first days of ICU admission. An analysis of the CIBERESUCICOVID Cohort

Background Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.Methods Multicenter, observational prospective, and retrospective study of patients admitted due to ARDS related to COVID-19 infection in Spain. Patients were grouped according to a clustering mixed-type data algorithm (k-prototypes) using continuous and categorical readily available variables at baseline and day 3.Results Of 6205 patients, 3743 (60%) were included in the study. According to silhouette analysis, patients were grouped in two clusters. At baseline, 1402 (37%) patients were included in cluster 1 and 2341(63%) in cluster 2. On day 3, 1557(42%) patients were included in cluster 1 and 2086 (57%) in cluster 2. The patients included in cluster 2 were older and more frequently hypertensive and had a higher prevalence of shock, organ dysfunction, inflammatory biomarkers, and worst respiratory indexes at both time points. The 90-day mortality was higher in cluster 2 at both clustering processes (43.8% [n = 1025] versus 27.3% [n = 383] at baseline, and 49% [n = 1023] versus 20.6% [n = 321] on day 3). Four hundred and fifty-eight (33%) patients clustered in the first group were clustered in the second group on day 3. In contrast, 638 (27%) patients clustered in the second group were clustered in the first group on day 3.Conclusions During the first days, patients can be clustered into two groups and the process of clustering patients may change as they continue to evolve. This means that despite a vast majority of patients remaining in the same cluster, a minority reaching 33% of patients analyzed may be re-categorized into different clusters based on their progress. Such changes can significantly impact their prognosis