35 research outputs found
A multimodal interaction system for big displays
Big displays and ultrawalls are increasingly present in nowadays environments (e.g. in city spaces, buildings, transportation means, teaching rooms, operation rooms, convention centers, etc.), at the same time that they are widely used as tools for collaborative work, monitoring and control in many other contexts. How to enhance interaction with big displays to make it more natural and fluent is still an open challenge. This paper presents a system for multimodal interaction based on pointing and speech recognition. The system makes possible for the user to control the big display through a combination of pointing gestures and a set of control commands built on a predefined vocabulary. The system is already prototyped and being used for service demonstrations for different applications
Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies
Pompe disease (PD) is a rare disorder caused by mutations in the acid alpha-glucosidase
(GAA) gene. Most gene therapies (GT) partially rely on the cross-correction of unmodified cells
through the uptake of the GAA enzyme secreted by corrected cells. In the present study, we generated
isogenic murine GAA-KO cell lines resembling severe mutations from Pompe patients. All of the
generated GAA-KO cells lacked GAA activity and presented an increased autophagy and increased
glycogen content by means of myotube differentiation as well as the downregulation of mannose
6-phosphate receptors (CI-MPRs), validating them as models for PD. Additionally, different chimeric
murine GAA proteins (IFG, IFLG and 2G) were designed with the aim to improve their therapeutic
activity. Phenotypic rescue analyses using lentiviral vectors point to IFG chimera as the best candidate
in restoring GAA activity, normalising the autophagic marker p62 and surface levels of CI-MPRs.
Interestingly, in vivo administration of liver-directed AAVs expressing the chimeras further confirmed
the good behaviour of IFG, achieving cross-correction in heart tissue. In summary, we generated
different isogenic murine muscle cell lines mimicking the severe PD phenotype, as well as validating
their applicability as preclinical models in order to reduce animal experimentation.Fundacion Poco Frecuente (Almeria)Asociacion Espanola de Enfermos de Glucogenosis (AEEG)Asociacion Espanola de Enfermos de Pompe (AEEP
ENE-COVID nationwide serosurvey served to characterize asymptomatic infections and to develop a symptom-based risk score to predict COVID-19
Objectives: To characterize asymptomatic SARS-CoV-2 infections and develop a symptom-based risk score useful in primary healthcare. Study design and setting: Sixty-one thousand ninty-two community-dwelling participants in a nationwide population-based serosurvey completed a questionnaire on COVID-19 symptoms and received an immunoassay for SARS-CoV-2 IgG antibodies between April 27 and June 22, 2020. Standardized prevalence ratios for asymptomatic infection were estimated across participant characteristics. We constructed a symptom-based risk score and evaluated its ability to predict SARS-CoV-2 infection. Results: Of all, 28.7% of infections were asymptomatic (95% CI 26.1-31.4%). Standardized asymptomatic prevalence ratios were 1.19 (1.02-1.40) for men vs. women, 1.82 (1.33-2.50) and 1.45 (0.96-2.18) for individuals <20 and ≥80 years vs. those aged 40-59, 1.27 (1.03-1.55) for smokers vs. nonsmokers, and 1.91 (1.59-2.29) for individuals without vs. with case contact. In symptomatic population, a symptom-based score (weights: severe tiredness = 1; absence of sore throat = 1; fever = 2; anosmia/ageusia = 5) reached standardized seroprevalence ratio of 8.71 (7.37-10.3), discrimination index of 0.79 (0.77-0.81), and sensitivity and specificity of 71.4% (68.1-74.4%) and 74.2% (73.1-75.2%) for a score ≥3. Conclusion: The presence of anosmia/ageusia, fever with severe tiredness, or fever without sore throat should serve to suspect COVID-19 in areas with active viral circulation. The proportion of asymptomatics in children and adolescents challenges infection control.The ENE-COVID study was supported by the Spanish Ministry of Health, the Institute of Health Carlos III, and the Spanish National Health System. The funders were in- volved in the study logistics, but they had no role in study design or in the collection, analysis, interpretation of data, or the decision to submit the article for publicationS
Development and Validation of an Early Mortality Risk Score for Older Patients Treated with Chemotherapy for Cancer
Background: Estimation of life expectancy in older patients is relevant to select the best treatment strategy. We aimed to develop and validate a score to predict early mortality in older patients with cancer. Patients and Methods: A total of 749 patients over 70 years starting new chemotherapy regimens were prospectively included. A prechemotherapy assessment that included sociodemographic variables, tumor/treatment variables, and geriatric assessment variables was performed. Association between these factors and early death was examined using multivariable logistic regression. Score points were assigned to each risk factor. External validation was performed on an independent cohort. Results: In the training cohort, the independent predictors of 6-month mortality were metastatic stage (OR 4.8, 95% CI [2.4-9.6]), ECOG-PS 2 (OR 2.3, 95% CI [1.1-5.2]), ADL ≤ 5 (OR 1.7, 95% CI [1.1-3.5]), serum albumin levels ≤ 3.5 g/dL (OR 3.4, 95% CI [1.7-6.6]), BMI < 23 kg/m2 (OR 2.5, 95% CI [1.3-4.9]), and hemoglobin levels < 11 g/dL (OR 2.4, 95% CI (1.2-4.7)). With these results, we built a prognostic score. The area under the ROC curve was 0.78 (95% CI, 0.73 to 0.84), and in the validation set, it was 0.73 (95% CI: 0.67-0.79). Conclusions: This simple and highly accurate tool can help physicians making decisions in elderly patients with cancer who are planned to initiate chemotherapy treatment
Spanish National Hip Fracture Registry (RNFC) : First-year results and comparison with other registries and prospective multi-centric studies from Spain
Fundamentos: El Registro Nacional de Fracturas de Cadera (RNFC) es un registro español multicéntrico, prospectivo y continuo, que comenzó en 2017. El objetivo de este artículo fue presentar los datos del primer informe anual y compararlos con los registros autonómicos y los estudios multicéntricos realizados recientemente en España. Métodos: Se incluyeron las personas de 75 años o más atendidas con el diagnóstico de fractura de cadera por fragilidad en alguno de los hospitales participantes en el RNFC, entre enero y octubre de 2017. En el análisis estadístico se utilizó la media y desviación estándar o mediana y rangos intercuartílicos para las variables numéricas y los porcentajes para las variables categóricas. Se realizó un análisis descriptivo global de la casuística y se comparó con los datos disponibles de los estudios previos mencionados. Resultados: Se registraron 7.208 personas de 54 hospitales, con una edad media de 86,7 años (DE 5,6). El 75,4% fueron mujeres y el 36,4% presentaron deterioro cognitivo previo. La demora quirúrgica media fue de 75,7 horas (DE 63,6) y la estancia media fue de 10,9 días (DE 6,7). De las personas que vivían en un domicilio antes de la fractura (75,4%), menos de la mitad (37,0%) volvieron a él tras el alta hospitalaria. Al mes, había fallecido el 7,1%. La comparación con los otros estudios mostró algunas diferencias importantes, sobre todo en la ubicación previa, en el porcentaje de pacientes institucionalizados de novo (7,7-29,4%) y en el porcentaje con tratamiento antiosteoporótico al alta (14,5-36,7%). Conclusiones: El RNFC es la mayor base de datos prospectiva que aporta datos sobre el perfil de los pacientes hospitalizados por fractura de cadera en España. La comparación con otros estudios recientes muestra algunas diferencias importantes.OBJECTIVE: The Spanish National Hip Fracture Registry (Registro Nacional de Fracturas de Cadera or RNFC) is a Spanish, prospective, multi- centric registry, commenced in 2017. The goal of this paper is to present the data from the first annual report and to compare them with autonomic registries and recent prospective multi-centric studies performed in Spain. METHODS: We included persons 75 years or older treated for fragility hip fractures in any of the centers participating in the RNFC between January and October 2017. The descriptive statistics of each variable used the mean (and standard deviation) or the median (and interquartile ranges) for the ordinal variables and the percentage for the categoric variables. A descriptive analysis of the casemix was performed and compared with available data from the aforementioned studies. RESULTS: The RNFC included 7.208 patients from 54 hospitals, with a mean age of 86.7 (SD 5.6) years; 75.4% were women, and 36.4% showed cognitive decline. Mean surgical delay was 75.7 (SD 63.6) hours, and length of stay averaged 10.9 (SD 6.7) days. Of the patients who lived at home (75.4%), less than half (37.0%) returned home at discharge. One-month mortality was 7.1%. Comparison with other studies showed important differences, especially regarding patients newly sent to nursing homes (7.7-29.4%) and with antiosteoporotic treatment at discharge (14.5-36.7%). CONCLUSIONS: The RNFC is the largest prospective database to date that offers data regarding the characteristics of patients hospitalized for hip fractures in Spain. Comparison with recent studies showed some important differences
Registro Nacional de Fracturas de Cadera (RNFC): Resultados del primer año y comparación con otros registros y estudios multicéntricos españoles
Background: The Spanish National Hip
Fracture Registry (Registro Nacional de Fracturas
de Cadera or RNFC) is a Spanish, prospective, multi-
centric registry, commenced in 2017. The goal of
this paper is to present the data from the first annual
report and to compare them with autonomic registries
and recent prospective multi-centric studies
performed in Spain.
Methods: We included persons 75 years of age
or older treated for fragility hip fractures in any
of the centers participating in the RNFC between
January and October 2017. The descriptive statistics
of each variable used the mean (and standard
deviation) or the median (and interquartile ranges)
for the ordinal variables and the percentage for the
categoric variables. A descriptive analysis of the casemix
was performed and compared with available
data from the aforementioned studies.
Results: The RNFC included 7.208 patients
from 54 hospitals, with a mean age of 86.7 (SD
5.6) years; 75.4% were women, and 36.4% showed
cognitive decline. Mean surgical delay was 75.7
(SD 63.6) hours, and length of stay averaged 10.9
(SD 6.7) days. Of the patients who lived at home
(75.4%), less than half (37.0%) returned home
at discharge. One-month mortality was 7.1%.
Comparison with other studies showed important
differences, especially regarding patients newly
sent to nursing homes (7.7-29.4%) and with antiosteoporotic
treatment at discharge (14.5-36.7%).
Conclusions: The RNFC is the largest prospective
database to date that offers data regarding
the characteristics of patients hospitalized for hip
fractures in Spain. Comparison with recent studies
showed some important differencesFundamentos: El Registro Nacional de
Fracturas de Cadera (RNFC) es un registro español
multicéntrico, prospectivo y continuo, que comenzó
en 2017. El objetivo de este artículo fue presentar
los datos del primer informe anual y compararlos
con los registros autonómicos y los estudios
multicéntricos realizados recientemente en España.
Métodos: Se incluyeron las personas de 75
años o más atendidas con el diagnóstico de fractura
de cadera por fragilidad en alguno de los hospitales
participantes en el RNFC, entre enero y octubre de
2017. En el análisis estadístico se utilizó la media y
desviación estándar o mediana y rangos intercuartílicos
para las variables numéricas y los porcentajes
para las variables categóricas. Se realizó un análisis
descriptivo global de la casuística y se comparó
con los datos disponibles de los estudios previos
mencionados.
Resultados: Se registraron 7.208 personas de
54 hospitales, con una edad media de 86,7 años
(DE 5,6). El 75,4% fueron mujeres y el 36,4%
presentaron deterioro cognitivo previo. La demora
quirúrgica media fue de 75,7 horas (DE 63,6)
y la estancia media fue de 10,9 días (DE 6,7). De
las personas que vivían en un domicilio antes de la
fractura (75,4%), menos de la mitad (37,0%) volvieron
a él tras el alta hospitalaria. Al mes, había
fallecido el 7,1%. La comparación con los otros estudios
mostró algunas diferencias importantes, sobre
todo en la ubicación previa, en el porcentaje de
pacientes institucionalizados de novo (7,7-29,4%)
y en el porcentaje con tratamiento antiosteoporótico
al alta (14,5-36,7%).
Conclusiones: El RNFC es la mayor base de
datos prospectiva que aporta datos sobre el perfil
de los pacientes hospitalizados por fractura de cadera
en España. La comparación con otros estudios
recientes muestra algunas diferencias importantesThe RNFC has been financed through donations by AMGEN SA, UCB Pharma, Abbott Laboratories and FAES Farma, as well as a Research Grant from the Fundación Mutua Madrileña (AP169672018)
Design Trinking y aula invertida. Emprender hacia una educación inclusiva en mujeres con discapacidad auditiva y su inclusión laboral
Se ha seguido investigando sobre el emprendimiento social como competencia transversal “iniciativa y espíritu emprendedor” en las asignaturas de: 1. Bases Teóricas del Trabajo Social, Trabajo Social y Mediación, Trabajo Social Sociosanitarios, Practicum (donde debe realizarse un Proyecto Social); y en la asignatura del Trabajo Fin de Grado (TFG), ayudando a configurar el perfil profesional del alumnado, visualizando nuevas formas de dar respuesta a las necesidades de la población.Desde metodologías innovadoras en la docencia con la utilización de la metodología Design Thinking y el aula invertida
Adquisición de competencias profesionales en los estudiantes del Grado de Trabajo Social. La argumentación y elaboración en el diagnóstico social a través de diferentes instrumentos
Se presentan los resultados obtenidos en el Proyecto Nº 21 Adquisición de competencias profesionales en los estudiantes del Grado de Trabajo Social. La argumentación y elaboración en el diagnóstico social a través de diferentes instrumentos, acerca de reforzar la argumentación en el alumnado del Grado de Trabajo Social a través de instrumentos, que refuercen su aprendizaje en la elaboración del diagnóstico social, donde se visualiza la calidad y eficacia de la intervención profesional
Aula Maker en emprendimiento social. Inclusión sociolaboral de las personas con discapacidad desde el trabajo social
Se presenta la memoria del proyecto número 12, denominado Aula Maker en emprendimiento social. Inclusión sociolaboral de las personas con discapacidad desde el trabajo social, realizado durante el curso 2020/2021, de la Convocatoria de Proyectos de Innovación y Mejora de la Calidad Docente de la UCM