1,237 research outputs found
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Kleshchev's decomposition numbers and branching coefficients in the Fock space
10.1090/S0002-9947-07-04202-XTransactions of the American Mathematical Society36031179-119
Regulatory T cells in melanoma revisited by a computational clustering of FOXP3+ T cell subpopulations
CD4+ T cells that express the transcription factor FOXP3 (FOXP3+ T cells) are commonly regarded as immunosuppressive regulatory T cells (Treg). FOXP3+ T cells are reported to be increased in tumour-bearing patients or animals, and considered to suppress anti-tumour immunity, but the evidence is often contradictory. In addition, accumulating evidence indicates that FOXP3 is induced by antigenic stimulation, and that some non-Treg FOXP3+ T cells, especially memory-phenotype FOXP3low cells, produce proinflammatory cytokines. Accordingly, the subclassification of FOXP3+ T cells is fundamental for revealing the significance of FOXP3+ T cells in tumour immunity, but the arbitrariness and complexity of manual gating have complicated the issue. Here we report a computational method to automatically identify and classify FOXP3+ T cells into subsets using clustering algorithms. By analysing flow cytometric data of melanoma patients, the proposed method showed that the FOXP3+ subpopulation that had relatively high FOXP3, CD45RO, and CD25 expressions was increased in melanoma patients, whereas manual gating did not produce significant results on the FOXP3+ subpopulations. Interestingly, the computationally-identified FOXP3+ subpopulation included not only classical FOXP3high Treg but also memory-phenotype FOXP3low cells by manual gating. Furthermore, the proposed method successfully analysed an independent dataset, showing that the same FOXP3+ subpopulation was increased in melanoma patients, validating the method. Collectively, the proposed method successfully captured an important feature of melanoma without relying on the existing criteria of FOXP3+ T cells, revealing a hidden association between the T cell profile and melanoma, and providing new insights into FOXP3+ T cells and Treg
Parallelotope tilings and q-decomposition numbers
We provide closed formulas for a large subset of the canonical basis vectors of the Fock space representation of Uq(slₑ). These formulas arise from parallelotopes which assemble to form polytopal complexes. The subgraphs of the Ext¹ -quivers of v-Schur algebras at complex e-th roots of unity generated by simple modules corresponding to these canonical basis vectors are given by the 1-skeletons of the polytopal complexes
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A v-analogue of Peel's theorem
We compute the v-decomposition numbers dλμ(v) for λ being a hook partition, and μ e-regular
Persistent Homology Over Directed Acyclic Graphs
We define persistent homology groups over any set of spaces which have
inclusions defined so that the corresponding directed graph between the spaces
is acyclic, as well as along any subgraph of this directed graph. This method
simultaneously generalizes standard persistent homology, zigzag persistence and
multidimensional persistence to arbitrary directed acyclic graphs, and it also
allows the study of more general families of topological spaces or point-cloud
data. We give an algorithm to compute the persistent homology groups
simultaneously for all subgraphs which contain a single source and a single
sink in arithmetic operations, where is the number of vertices in
the graph. We then demonstrate as an application of these tools a method to
overlay two distinct filtrations of the same underlying space, which allows us
to detect the most significant barcodes using considerably fewer points than
standard persistence.Comment: Revised versio
Polarised target for Drell-Yan experiment in COMPASS at CERN, part I
In the polarised Drell-Yan experiment at the COMPASS facility in CERN pion
beam with momentum of 190 GeV/c and intensity about pions/s interacted
with transversely polarised NH target. Muon pairs produced in Drel-Yan
process were detected. The measurement was done in 2015 as the 1st ever
polarised Drell-Yan fixed target experiment. The hydrogen nuclei in the
solid-state NH were polarised by dynamic nuclear polarisation in 2.5 T
field of large-acceptance superconducting magnet. Large helium dilution
cryostat was used to cool the target down below 100 mK. Polarisation of
hydrogen nuclei reached during the data taking was about 80 %. Two oppositely
polarised target cells, each 55 cm long and 4 cm in diameter were used.
Overview of COMPASS facility and the polarised target with emphasis on the
dilution cryostat and magnet is given. Results of the polarisation measurement
in the Drell-Yan run and overviews of the target material, cell and dynamic
nuclear polarisation system are given in the part II.Comment: 4 pages, 2 figures, Proceedings of the 22nd International Spin
Symposium, Urbana-Champaign, Illinois, USA, 25-30 September 201
Boundedness of Pseudodifferential Operators on Banach Function Spaces
We show that if the Hardy-Littlewood maximal operator is bounded on a
separable Banach function space and on its associate space
, then a pseudodifferential operator
is bounded on whenever the symbol belongs to the
H\"ormander class with ,
or to the the Miyachi class
with ,
. This result is applied to the case of
variable Lebesgue spaces .Comment: To appear in a special volume of Operator Theory: Advances and
Applications dedicated to Ant\'onio Ferreira dos Santo
Analytical and clinical evaluation of an electrochemiluminescence immunoassay for the determination of CA 125
The CA 125 II assay on the Elecsys(R) 2010 analyzer was evaluated in an
international multicenter trial. Imprecision studies yielded within-run
CVs of 0.8-3.3% and between-day CVs of 2.4-10.9%; CVs for total
imprecision in the manufacturer's laboratory were 2.4-7.8%. The linear
range of the assay extended to at least 4500 kilounits/L (three decades).
Interference from triglycerides (10.3 mmol/L), bilirubin (850 micromol/L),
hemoglobin (1.1 mmol/L), anticoagulants (plasma), and several widely used
drugs was undetectable. Method comparisons with five other CA 125 II
assays showed good correlation but differences in standardization. A 95th
percentile cutoff value of 35 kilounits/L was calculated from values
measured in 593 apparently healthy (pre- and postmenopausal) women. In 95%
of patients with benign gynecological diseases CA 125 was </=190
kilounits/L; 63% of patients with newly diagnosed ovarian carcinoma had
values >190 kilounits/L. A comparison of CA 125 values obtained with the
Elecsys test and with other common CA 125 tests in monitored patients
being treated for ovarian cancer showed identical patterns. In conclusion,
the Elecsys CA 125 II assay is linear over a broad range, yields precise
and accurate results, is free from interferences, and compares well with
other assays
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