Developing a Questionnaire for Iranian Women's Attitude on Medical Ethics in Vaginal Childbirth

Background: Vaginal delivery is one of the challenging issues in medical ethics. It is important to use an appropriate instrument to assess medical ethics attitudes in normal delivery, but the lack of tool for this purpose is clear. Objectives: The aim of this study was to develop and validate a questionnaire for the assessment of women’s attitude on medical ethics application in normal vaginal delivery. Patients and Methods: This methodological study was carried out in Iran in 2013 - 2014. Medical ethics attitude in vaginal delivery questionnaire (MEAVDQ) was developed using the findings of a qualitative data obtained from a grounded theory research conducted on 20 women who had vaginal childbirth, in the first phase. Then, the validation criteria of this tool were tested by content and face validity in the second phase. Exploratory factor analysis was used for construct validity and reliability was also tested by Cronbach’s alpha coefficient in the third phase of this study. SPSS version 13 was used in this study. The sample size for construct validity was 250 females who had normal vaginal childbirth. Results: In the first phase of this study (tool development), by the use of four obtained categories and nine subcategories from grounded theory and literature review, three parts (98-items) of this tool were obtained (A, B and J). Part A explained the first principle of medical ethics, part B pointed to the second and third principles of medical ethics, and part J explained the fourth principle of medical ethics. After evaluating and confirming its face and content validity, 75 items remained in the questionnaire. In construct validity, by the employment of exploratory factor analysis, in parts A, B and J, 3, 7 and 3 factors were formed, respectively; and 62.8%, 64% and 51% of the total variances were explained by the obtained factors in parts A, B and J, respectively. The names of these factors in the three parts were achieved by consideration of the loading factor and medical ethics principles. The subscales of MEAVDQ showed significant reliability. In parts A, B and J, Cronbach’s alpha coefficients were 0.76, 0.72 and 0.68, respectively and for the total questionnaire, it was 0.72. The results of the test–retest were satisfactory for all the items (ICC = 0.60 - 0.95). Conclusions: The present study showed that the 59-item MEAVDQ was a valid and reliable questionnaire for the assessment of women’s attitudes toward medical ethics application in vaginal childbirth. This tool might assist specialists in making a judgment and plan appropriate for women in vaginal delivery management

Effects of N-Acetylcysteine on auditory brainstem response threshold shift in rabbits exposed to noise and carbon monoxide

Problem statement: Noise Induced Hearing Loss (NIHL) is one of the most important occupational disease in worldwide. NIHL has been found to be potentiated by simultaneous Carbon monoxide (CO) exposure. Exposure to noise plus CO is common in occupational and environmental settings. Free radicals have been implicated in cochlear damage resulting from exposure to noise and due to CO hypoxia This study examined whether N-Acetylcysteine (NAC) administration cause attenuation of Auditory Brainstem Response (ABR) threshold shifts resulting from noise exposure and noise plus CO exposure. Approach: Forty-two rabbits were divided into seven groups including control, noise+ saline, noise+ CO +saline, noise+ NAC, noise+ CO+ NAC, CO+ NAC and NAC alone. ABR was assessed before exposure, 1 hour and 14 days post exposure. Results: The administration of 325 mg kg-1 of NAC prior, following and post exposure to noise or noise plus CO recovered permanent ABR threshold shift at 1 and 2 kHz almost to the baseline and provided significant attenuation in permanent ABR threshold shift at 4 and 8 kHz in subjects which were exposed to noise but it did not block the potentiating of threshold elevation by CO exposure (extra threshold loss by combined exposure) at 4 and 8 kHz. Conclusion: NAC provides protective effect against hearing loss resulting from noise exposure and simultaneous exposure to noise plus CO. © 2010 Science Publications

Immune and bioinformatics identification of T cell and B cell epitopes in the protein structure of SARS-CoV-2: A systematic review

The beginning of 2020 was marked as the emergence of a COVID-19 outbreak caused by a new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there is no vaccine or approved treatment for this infectious virus so the invention of an efficient vaccine is certainly a high priority. Some studies have employed several techniques to facilitate the combination of the immunoinformatics approach and comparative genomic approach in order to determine the potential peptides for designing the T-cell epitope-based peptide vaccine using the 2019-nCoV envelope protein as a target. Via screening the bioimmunoinformatic SARS-CoV2 derived B-cell and T-cell epitopes within the basic immunogenic of SARS-CoV2 proteins, we presented a set of inferred B-cell and T-cell epitopes from the spike (S) and nucleocapsid (N) proteins with high antigenicity and without allergenic property or toxic effects. Our findings provide a screened set of epitopes that can be introduced as potential targets for developing peptide vaccines against the SARS-CoV-2 virus

Differences in maladaptive schemas between patients suffering from chronic and acute posttraumatic stress disorder and healthy controls

War, as a stressor event, has a variety of acute and chronic negative consequences, such as posttraumatic stress disorder (PTSD). In this context, early maladaptive schema-based problems in PTSD have recently become an important research area. The aim of this study was to assess early maladaptive schemas in patients with acute and chronic PTSD.; Using available sampling methods and diagnostic criteria, 30 patients with chronic PTSD, 30 patients with acute PTSD, and 30 normal military personnel who were matched in terms of age and wartime experience were selected and assessed with the Young Schema Questionnaire-Long Form, Beck Depression Inventory second version (BDI-II), the Beck Anxiety Inventory (BAI), and the Impact of Events Scale (IES).; Both acute and chronic PTSD patients, when compared with normal military personnel, had higher scores for all early maladaptive schemas. Additionally, veterans suffering from chronic PTSD, as compared with veterans suffering from acute PTSD and veterans without PTSD, reported more impaired schemas related, for instance, to Self-Control, Social Isolation, and Vulnerability to Harm and Illness.; The results of the present study have significant preventative, diagnostic, clinical, research, and educational implications with respect to PTSD

Hexagonal Smoothness-Increasing Accuracy-Conserving Filtering

Discontinuous Galerkin (DG) methods are a popular class of numerical techniques to solve partial differential equations due to their higher order of accuracy. However, the inter-element discontinuity of a DG solution hinders its utility in various applications, including visualization and feature extraction. This shortcoming can be alleviated by postprocessing of DG solutions to increase the inter-element smoothness. A class of postprocessing techniques proposed to increase the inter-element smoothness is SIAC filtering. In addition to increasing the inter-element continuity, SIAC filtering also raises the convergence rate from order k+1k+1 to order 2k+12k+1 . Since the introduction of SIAC filtering for univariate hyperbolic equations by Cockburn et al. (Math Comput 72(242):577–606, 2003), many generalizations of SIAC filtering have been proposed. Recently, the idea of dimensionality reduction through rotation has been the focus of studies in which a univariate SIAC kernel has been used to postprocess a two-dimensional DG solution (Docampo-Sánchez et al. in Multi-dimensional filtering: reducing the dimension through rotation, 2016. arXiv preprint arXiv:1610.02317). However, the scope of theoretical development of multidimensional SIAC filters has never gone beyond the usage of tensor product multidimensional B-splines or the reduction of the filter dimension. In this paper, we define a new SIAC filter called hexagonal SIAC (HSIAC) that uses a nonseparable class of two-dimensional spline functions called hex splines. In addition to relaxing the separability assumption, the proposed HSIAC filter provides more symmetry to its tensor-product counterpart. We prove that the superconvergence property holds for a specific class of structured triangular meshes using HSIAC filtering and provide numerical results to demonstrate and validate our theoretical results

Statistical Properties of the Square Map Modulo a Power of Two

The square map is one of the functions that is used in cryptography. For instance, the square map is used in Rabin encryption scheme, block cipher RC6 and stream cipher Rabbit, in different forms. In this paper we study a special case of the square map, namely the square function modulo a power of two. We obtain probability distribution of the output of this map as a vectorial Boolean function. We find probability distribution of the component Boolean functions of this map. We present the joint probability distribution of the component Boolean functions of this function. We introduce a new function which is similar to the function that is used in Rabbit cipher and we compute the probability distribution of the component Boolean functions of this new map

The minimum-error discrimination via Helstrom family of ensembles and Convex Optimization

Using the convex optimization method and Helstrom family of ensembles introduced in Ref. [1], we have discussed optimal ambiguous discrimination in qubit systems. We have analyzed the problem of the optimal discrimination of N known quantum states and have obtained maximum success probability and optimal measurement for N known quantum states with equiprobable prior probabilities and equidistant from center of the Bloch ball, not all of which are on the one half of the Bloch ball and all of the conjugate states are pure. An exact solution has also been given for arbitrary three known quantum states. The given examples which use our method include: 1. Diagonal N mixed states; 2. N equiprobable states and equidistant from center of the Bloch ball which their corresponding Bloch vectors are inclined at the equal angle from z axis; 3. Three mirror-symmetric states; 4. States that have been prepared with equal prior probabilities on vertices of a Platonic solid. Keywords: minimum-error discrimination, success probability, measurement, POVM elements, Helstrom family of ensembles, convex optimization, conjugate states PACS Nos: 03.67.Hk, 03.65.TaComment: 15 page

Measurement of peripheral dose to the pelvic region and the associated risk for cancer development after breast intraoperative electron radiation therapy

This study aimed to measure the received dose to the pelvic region of patients during breast intraoperative electron radiation therapy (IOERT). Furthermore, we compared the findings with those of external beam radiation therapy. Finally, secondary ovarian and uterus cancer risks following breast IOERT were estimated. In the current study, the received dose to the pelvic surface of 18 female patients during breast IOERT boosts were measured by thermoluminescent dosimeter (TLD-100) chips. All patients were treated with 12 Gy given in a single fraction. To estimate the dose to the ovary and uterus of the patients, conversion coefficients for depth from the surface dose were obtained in a Rando phantom. Given the received dose to the pelvic region of the patients, secondary ovarian and uterus cancer risks following breast IOERT were estimated. The received doses to the ovary and uterus surface of the patients were 0.260 ±0.155 mGy to 31.460 ±6.020 mGy and 0.485 ±0.122 mGy to 22.387 ±15.476 mGy, respectively. Corresponding intra-pelvic (ovary and uterus) regional doses were 0.012 ±0.007 mGy to 1.479 ±0.283 mGy and 0.027 ±0.001 mGy to 1.164 ±0.805 mGy, respectively. Findings demonstrated that the ratio of the received dose by the pelvic surface to the regional dose during breast IOERT was much less than external beam radiation therapy. The mean of the secondary cancer risks for the ovary in 8 and 10 MeV electron beam energies were 135.722 ±117.331 �10 -6 and 69.958 ±28.072 �10 -6 , and for the uterus were 17.342 ±10.583 �10 -6 and 2.971 ±3.604 �10 -6 , respectively. According to our findings, the use of breast IOERT in pregnant patients can be considered as a safe radiotherapeutic technique, because the received dose to the fetus was lower than 50 mGy. Furthermore, IOERT can efficiently reduce the unnecessary dose to the pelvic region and lowers the risk of secondary ovarian and uterus cancer following breast irradiation. © 2019 Society for Radiological Protection. Published on behalf of SRP by IOP Publishing Limited. All rights reserved

Cryptographic Properties of Addition Modulo 2n2^n

The operation of modular addition modulo a power of two is one of the most applied operations in symmetric cryptography. For example, modular addition is used in RC6, MARS and Twofish block ciphers and RC4, Bluetooth and Rabbit stream ciphers. In this paper, we study statistical and algebraic properties of modular addition modulo a power of two. We obtain probability distribution of modular addition carry bits along with conditional probability distribution of these carry bits. Using these probability distributions and Markovity of modular addition carry bits, we compute the joint probability distribution of arbitrary number of modular addition carry bits. Then, we examine algebraic properties of modular addition with a constant and obtain the number of terms as well as algebraic degrees of component Boolean functions of modular addition with a constant. Finally, we present another formula for the ANF of the component Boolean functions of modular addition modulo a power of two. This formula contains more information than representations which are presented in cryptographic literature, up to now