Osnivanje montažnog brodogradilišta na obali Dunava

U ovom diplomskom radu razmotrena je ideja osnivanja jednog montažnog brodogradilišta na obali Dunava. Najprije je dan pregled unutarnje plovidbe po rijekama Hrvatske i Europe te je prikazan potencijalni smjer razvoja nekih europskih prometnih pravaca. Tu su dana i ograničenja u plovidbi pojedinim dijelovima dunavskog plovnog puta. Potom je napravljen kratak pregled ponude i kapaciteta aktivnih brodogradilišta smještenih na obalama Dunava. S obzirom na prethodno navedena ograničenja u plovidbi Dunavom i na trenutni izgled europske riječne trgovačke flote brodova, u trećem je poglavlju predložen mogući proizvodni program potencijalnog brodogradilišta. U četvrtom poglavlju navedene su aktivne tvrtke u Hrvatskoj, s težištem na Istočnoj Slavoniji s kojima bi se mogla ostvariti suradnja za potrebe kompletiranja brodova čija bi se montaža obavljala u našem brodogradilištu. Konačno, u posljednjem poglavlju dan je opći plan brodogradilišta te je opisana sva potrebna infrastruktura i tijek proizvodnog procesa

Konceptualni projekt brodogradilišta na Dunavu

U članku je prezentiran konceptualni projekt fleksibilnog montažnog brodogradilišta na Dunavu. Uvodno su razmatrane značajke i ograničenja plovnih putova u Europi i Hrvatskoj te su dane procjene razvoja prometa u unutrašnjoj plovidbi. Nadalje, prikazani su karakteristični riječni i manji morski brodovi koji bi se mogli uključiti u proizvodni program brodogradilišta. Analizirani su industrijski kapaciteti firmi u regiji s kojima bi brodogradilište moglo surađivati, a prema tome je definiran osnovni koncept prevladavajući montažnog brodogradilišta. Lokacija novog brodogradilišta definirana je prema konfiguraciji terena te obzirom na socijalno industrijske značajke područja regije. Predloženi konceptualni projekt brodogradilišta na Dunavu sadrži tlocrt, raspored radnih prostora, tokove materijala te princip predaje broda vodi

Faktori povezani s alergijskim rinitisom kod disfoničnih profesionalnih korisnika glasa

Objective. The aim of the present study was to investigate the frequency of allergic rhinitis in dysphonic professional voice users and to assess the correlation between allergic rhinitis and demographic characteristics (sex, ages and years in occupation) and presence of laryngopharyngeal reflux, as comorbidity health condition. Methods. A total of 104 male and female dysphonic patients who came to the Department of Otorhinolaryngology, Health Centre Kragujevac, Serbia because of the presence of dysphonia symptoms and who used their voice more than 4 hours per day at job were included in the study. The patients underwent rigid or transnasal fiberoptic laryngoscopy with videostroboscopy to assess the causes of dysphonia. Descriptive analysis, Pearson Chi-Square Tests and Binary Logistic regression were carried out using the SPSS 19.0 statistical software package. Results. Frequency of allergic rhinitis in dysphonic professional voice users was 44.2%. The patients were 1.1 times more likely to have allergic rhinitis with each passing year of life. Allergic rhinitis is with each year in occupation 0.89 times less frequent and 0.035 times less often in patients with laryngopharyngeal reflux. Conclusion. In dysphonic professional voice users, it has been found that allergic rhinitis occurs rarely with each year in occupation, which means that allergic rhinitis is not a predisposing factor for developing dysphonia, but year in occupation are a protective factor when it comes to the appearance of allergic rhinitis in the examined population.Cilj. Cilj ovog rada bio je da se analizira učestalost alergijskog rinitisa kod profesionalnih korisnika glasa sa disfonijom, kao i povezanost između alergijskog rinitisa, demografskih karakteristika (pol, starost i dužina radnog staža) i laringofaringealnog refluksa u ispitivanoj populaciji. Metode. U studiju su uključena ukupno 104 ispitanika muškog i ženskog pola, koji su upućeni u Odeljenje za otorinolaringologiju Doma zdravlja Kragujevac, Srbija, zbog prisustva simptoma disfonije, a zaposleni su na poslovima koji zahtevaju upotrebu glasa više od četiri sata dnevno. Kod ispitanika je primenjena rigidna endovideostroboskopija ili transnazalna fibrooptička laringoskopija da bi se utvrdio uzrok disfonija. Statistička obrada podataka učinjena je primenom deskriptivne metode, Pirsonovog x2 testa i binarne logističke regresije, korišćenjem standardnog statističkog softverskog paketa SPSS 13.0. Rezultati. U ispitivanoj populaciji alergijski rinitis, identifikovan je kod 44,2% profesionalnih korisnika glasa sa disfonijom. U populaciji obuhvaćenoj istraživanjem alergijski rinitis se sa svakom godinom života 1,1 puta češće ispoljava, dok se sa svakom godinom radnog staža 0,89 puta ređe dijagnostikuje. Kod ispitivanih disfoničnih profesionalnih korisnika glasa, kod kojih je ustanovljen laringofaringealni refluks, alergijski rinitis je 0,035 puta ređe prisutan. Zaključak. Kod disfoničnih profesionalnih korisnika glasa, ustanovljeno je da se alergijski rinitis ređe javlja sa svakom godinom radnog staža, što znači da alergijski rinitis nije predisponirajući faktor za nastanak disfonije, već su godine radnog staža protektivni faktor kada je u pitanju pojava alergijskog rinitisa u ispitivanoj populaciji

Procena težine simptoma alergijskog rinitisa vizuelnom analognom skalom

Objective. To examine the characteristics of patients with allergic rhinitis and assess the severity of symptoms by using a visual analog scale. Methods. A prospective study was carried out among allergic rhinitis patients, who were referred by the primary care physician to the ENT Department of Health Centre Kragujevac. The assessment of severity of symptoms was performed using visual analog scale (overall influence of all nasal or nasal and ocular symptoms, VAS score of 0 'nasal or nasal and ocular symptoms do not bother' to 10 'nasal or nasal and ocular symptoms are extremely bothered') during the first examination. Data was statistically analysed with descriptive statistical methods, t-test, x2 test and logistic regression using by standard statistical software package (SPSS for Windows, version 19.0). Results. Among our respondents there were 34.3% (37/108) males and 65.7% (71/108) females. Average age of all patients was 29 ± 15,1. Average duration of disease in the sample studied was 7,2 ± 16,2 years. The majority of our participants were classified as having moderate to severe persistent allergic rhinitis. Severity of disease has a greater impact on the VAS score of disease duration. Average VAS score of all participants were 6,9±4,2. It was found that the severity of the disease and the presence of ocular symptoms in patients with allergic rhinitis have an impact on the VAS score (p lt 0,0001) while the use of therapy and sensitization to inhalant allergens did not have such impact. Conclusion. Visual analog scale is a simple quantitative method to assess the severity of allergic rhinitis.Cilj. Proceniti težinu simptoma metodom vizuelne analogne skale kod obolelih od alergijskog rinitisa. Metode: Sprovedena je prospektivna studija u kojoj su analizirani oboleli od alergijskog rinitisa, koje su izabrani lekari upućivali na ORL odeljenje specijalističko-konsultativne službe Doma zdravlja 'Kragujevac'. Težina simptoma procenjena je vizuelnom analognom skalom (ukupan uticaj svih nazalnih ili nazalnih i okularnih simptoma, VAS skor od nula - 'nazalni ili nazalni i okularni simptomi uopšte ne smetaju', do 10 - 'nazalni ili nazalni i okularni simptomi izuzetno smetaju') prilikom prvog pregleda. Statistički značajnim smatrane su vrednosti za p lt 0,05. Podaci su statistički obrađeni primenom deskriptivnog metoda, t-testa, X2-testa i logističke regresije standardnim statističkim paketom (SPSS za Windows, verzija 19.0). Rezultati. Među našim ispitanicima bilo je 34,3% (37/108) osoba muškog pola, dok je osoba ženskog pola bilo 65,7% (71/108). Starost svih ispitanika bila je 29 ± 15,1. Prosečna dužina trajanja bolesti u ispitivanom uzorku bila je 7,2 ± 16,2 godine. Najviše ispitanika imalo je umereno do težak perzistentan oblik bolesti. Prosečna vrednost VAS skora za sve ispitanike bila je 6,9 ± 4,2. Primenom logističke regresije ustanovljeno je da težina bolesti ima veći uticaj na VAS skor od trajanja bolesti. Utvrđeno je da težina bolesti i prisustvo okularnih simptoma kod obolelih od alergijskog rinitisa ima veći uticaj na VAS skor (p lt 0,0001), dok primena terapije i senzibilizacija na inhalatorne alergene nema. Zaključak. Vizuelna analogna skala je jednostavan kvantitativan metod za procenu težine alergijskog rinitisa

Seed quality of the facelia-variety NS Priora grown in Serbia

Phacelia has been used for seed production and as a forage crops, either on its own or in a mix with peas or vetch to provide forage and honey production as a source of high quality nectar and pollen. The experiment was carried out in 2016, in the fields of the Institute of Field and Vegetable Crops in Bački Petrovac, in Serbia, with variety NS Priora. NS Priora had plant flowering continualy over 60 days and had high, good quality grain yield. NS Priora variety had average nitrogen content is 3.21%, protein content was 20.06% and the average thousand seeds weight was 1.42 g. Phacelia is presently very intensively used in organic agriculture and for sowing of arable land temporarily excluded from production which achieves high yields

Osnivanje montažnog brodogradilišta na obali Dunava

U ovom diplomskom radu razmotrena je ideja osnivanja jednog montažnog brodogradilišta na obali Dunava. Najprije je dan pregled unutarnje plovidbe po rijekama Hrvatske i Europe te je prikazan potencijalni smjer razvoja nekih europskih prometnih pravaca. Tu su dana i ograničenja u plovidbi pojedinim dijelovima dunavskog plovnog puta. Potom je napravljen kratak pregled ponude i kapaciteta aktivnih brodogradilišta smještenih na obalama Dunava. S obzirom na prethodno navedena ograničenja u plovidbi Dunavom i na trenutni izgled europske riječne trgovačke flote brodova, u trećem je poglavlju predložen mogući proizvodni program potencijalnog brodogradilišta. U četvrtom poglavlju navedene su aktivne tvrtke u Hrvatskoj, s težištem na Istočnoj Slavoniji s kojima bi se mogla ostvariti suradnja za potrebe kompletiranja brodova čija bi se montaža obavljala u našem brodogradilištu. Konačno, u posljednjem poglavlju dan je opći plan brodogradilišta te je opisana sva potrebna infrastruktura i tijek proizvodnog procesa

Microwave-assisted immobilization of lipase from Candida rugosa on Eupergit (R) supports

BACKGROUND: Immobilization of lipase (triacylglycerol acylhydrolase EC 3.1.1.3) from Candida rugosa on Eupergite (R) C and Eupergit (R) C 250L was performed under microwave irradiation in order to reduce immobilization time. Lipase loading, hydrolytic activity, esterification activity and operational stability in organic solvent of immobilized lipase preparation were determined. RESULTS: The microwave-assisted procedure resulted in a 29% lower lipase loadings, compared with immobilized lipase obtained without microwaves. In hydrolytic activity assay, lipase immobilized under microwaves exhibited a 23% higher specific activity. Slight activation of lipase by microwave-assisted immobilization was observed, since specific activity was around 5% higher than for free lipase. Lipase of highest activity was obtained after 2 min immobilization on Eupergit (R) C. The same preparation exhibited high esterification activity in organic medium and a half life of 212 h was determined in multiple use assay. CONCLUSION: The application of microwave irradiation leads to reduction of immobilization time from 2 days to only 2 min. The immobilized lipase obtained has prospects for further application due to its high retained activity and stability

Chemical modification of Purolite A109 for application in lipase immobilization

Modern industry recognizes enzymes as important catalysts for batch production of food, drugs and cosmetics. Because of their price and poor technical characteristics in free form, enzymes are mostly used as immobilized derivative. Therefore, there is a constant need for new and improved supports, possessing sufficient amount of active groups on it's surface to interact with enzyme, but on the other side chemically inert to the reaction media. Mechanical stability and price range are as much important as chemical stability. The aim of this study was to investigate properties of modified ionic resin Purolite A109 for lipase immobilization. Purolite A109 is polystyrenic (styrene-divinylbenzene copolymer), macro porous anion exchange resin with primary amine weak base functional groups. It's advantages could be low price, and excellent mechanical and chemical characteristics. Modification of this resin was performed using cyanuric chloride (CTC) and epychlorhydrine. In both cases FTIR spectroscopy confirmed that modification process was successful. Lipase from Candida rugosa was immobilized on both modified supports. Approximately 30% of proteins was bound to both carrier. Hydrolytic activity of both, free and immobilized lipase was determined, and based on these results activity retention after immobilization process was calculated. Results showed that significantly higher activity retention was obtained in case of CTC-Purolite – 67 %. Thermal stabilities of these two immobilized enzymes on 65 °C were compared to thermal stability of free enzyme. Relative activity of free enzyme decreased below 50% of initial activity within 30 min. On the other hand, both immobilized enzymes showed significant thermal stability. Relative activity of epoxy-Purolite dropped below 50 % of initial activity within 3 hours, while CTCPurolite dropped below 50 % of initial activity within 5 hours