An elastoplastic model for unsaturated expansive soils based on shakedown concept

It is important to model the behaviour of unsaturated expansive soils subjected to hydromechanical loadings, because these wetting and drying cycles alter significantly their hydromechanical behaviour which may cause a huge differential settlement on the foundations of individual buildings, pavements, dams, etc. From experimental observations, these expansive soils can generally reach a final equilibrium state at the end of the suction cycles where the soil behaviour can be supposed elastic. In this context, this paper presents an analytical method based on shakedown concept for the hydromechanical behaviour of expansive soils. The required parameters of the shakedown-based model are calibrated by the experimental results obtained for bentonite/sand mixtures subjected to cyclic suction loadings in an oedometric test. The comparison between the experimental results and the modeling demonstrates the capacity of the proposed shakedown-based model to simulate the hydromechanical behaviour of unsaturated expansive soils

Roll, Roll, Roll your Root:A Comprehensive Analysis of the First Ever DNSSEC Root KSK Rollover

The DNS Security Extensions (DNSSEC) add authenticity and integrity to the naming system of the Internet. Resolvers that validate information in the DNS need to know the cryptographic public key used to sign the root zone of the DNS. Eight years after its introduction and one year after the originally scheduled date, this key was replaced by ICANN for the first time in October 2018. ICANN considered this event, called a rollover, "an overwhelming success" and during the rollover they detected "no significant outages". In this paper, we independently follow the process of the rollover starting from the events that led to its postponement in 2017 until the removal of the old key in 2019. We collected data from multiple vantage points in the DNS ecosystem for the entire duration of the rollover process. Using this data, we study key events of the rollover. These events include telemetry signals that led to the rollover being postponed, a near real-time view of the actual rollover in resolvers and a significant increase in queries to the root of the DNS once the old key was revoked. Our analysis contributes significantly to identifying the causes of challenges observed during the rollover. We show that while from an end-user perspective, the roll indeed passed without major problems, there are many opportunities for improvement and important lessons to be learned from events that occurred over the entire duration of the rollover. Based on these lessons, we propose improvements to the process for future rollovers

An elastoplastic model for unsaturated expansive soils based on shakedown concept

It is important to model the behaviour of unsaturated expansive soils subjected to hydromechanical loadings, because these wetting and drying cycles alter significantly their hydromechanical behaviour which may cause a huge differential settlement on the foundations of individual buildings, pavements, dams, etc. From experimental observations, these expansive soils can generally reach a final equilibrium state at the end of the suction cycles where the soil behaviour can be supposed elastic. In this context, this paper presents an analytical method based on shakedown concept for the hydromechanical behaviour of expansive soils. The required parameters of the shakedown-based model are calibrated by the experimental results obtained for bentonite/sand mixtures subjected to cyclic suction loadings in an oedometric test. The comparison between the experimental results and the modeling demonstrates the capacity of the proposed shakedown-based model to simulate the hydromechanical behaviour of unsaturated expansive soils

Environ Int

BACKGROUND: Pesticides exposures could be implicated in the excess of Central Nervous System (CNS) tumors observed in farmers, but evidence concerning individual pesticides remains limited. Carbamate derivative pesticides, including herbicides and fungicides (i.e. (thio/dithio)-carbamates), have shown evidence of carcinogenicity in experimental studies in animals. In the French AGRICAN cohort, we assessed the associations between potential exposures to carbamate herbicides and fungicides and the incidence of CNS tumors, overall and by histological subtype. METHODS: AGRICAN enrolled 181,842 participants involved in agriculture. Incident CNS tumors were identified by linkage with cancer registries from enrollment (2005-2007) until 2013. Individual exposures were assessed by combining information on lifetime periods of pesticide use on crops and the French crop-exposure matrix PESTIMAT, for each of the 14 carbamate and thiocarbamate herbicides and the 16 carbamate and dithiocarbamate fungicides registered in France since 1950. Associations were estimated using proportional hazard models with age as the underlying timescale, adjusting for gender, educational level and smoking. RESULTS: During an average follow-up of 6.9years, 381 incident cases of CNS tumors occurred, including 164 gliomas and 134 meningiomas. Analyses showed increased risks of CNS tumors with overall exposure to carbamate fungicides (Hazard Ratio, HR=1.88; 95% CI: 1.27-2.79) and, to a lesser extent, to carbamate herbicides (HR=1.44; 95% CI: 0.94-2.22). Positive associations were observed with specific carbamates, including some fungicides (mancozeb, maneb, metiram) and herbicides (chlorpropham, propham, diallate) already suspected of being carcinogens in humans. CONCLUSIONS: Although some associations need to be corroborate in further studies and should be interpreted cautiously, these findings provide additional carcinogenicity evidence for several carbamate fungicides and herbicides

SNPs at miR-155 binding sites of TYRP1 explain discrepancy between mRNA and protein and refine TYRP1 prognostic value in melanoma

International audienceBACKGROUND: We previously demonstrated an inverse correlation between tyrosinase-related protein 1 (TYRP1) mRNA expression in melanoma metastases and patient survival. However, TYRP1 protein was not detected in half of tissues expressing mRNA and did not correlate with survival. Based on a study reporting that 3' untranslated region (UTR) of TYRP1 mRNA contains two miR-155-5p (named miR-155) binding sites exhibiting single-nucleotide polymorphisms (SNPs) that promote (matched miRNA-mRNA interaction) mRNA decay or not (mismatched), we aimed to investigate the role of miR-155 in the regulation of TYRP1 mRNA expression and protein translation accounting for these SNPs. METHODS: The effect of miR-155 on TYRP1 mRNA/protein expression was evaluated in two melanoma cell lines harbouring matched or mismatched miR-155-TYRP1 mRNA interaction after transfection with pre-miR-155. In parallel, 192 skin and lymph node melanoma metastases were examined for TYRP1 mRNA/protein, miR-155 and SNPs and correlated with patient survival. TYRP1 mRNA, SNPs at its 3'UTR and miR-155 were analysed by RT-qPCR, whereas TYRP1 protein was evaluated by western blot in cell lines and by immunohistochemistry in metastatic tissues. RESULTS: The miR-155 induced a dose-dependent TYRP1 mRNA decay and hampered its translation into protein in the line with the 'match' genotype. In melanoma metastases, TYRP1 mRNA inversely correlated with miR-155 expression but not with TYRP1 protein in the 'match' group, whereas it positively correlated with protein but not with miR-155 in the 'mismatch' group. Consequently, in the latter group, TYRP1 protein inversely correlated with survival. CONCLUSION: Polymorphisms in 3'UTR of TYRP1 mRNA can affect TYRP1 mRNA regulation by miR-155 and its subsequent translation into protein. These SNPs can render TYRP1 mRNA and protein expression nonsusceptible to miR-155 activity and disclose a prognostic value for TYRP1 protein in a subgroup of melanoma patients. These data support the interest in the prognostic value of melanogenic markers and propose TYRP1 to refine prognosis in patients with advanced diseas

J Neurooncol

Inverse association between allergic conditions and glioma risk has been consistently reported in epidemiological studies with little attention paid to potential environmental confounders; the association with meningioma risk is less consistent. We examined the association between allergy history and risk of glioma and meningioma in adults using data from the CERENAT (CEREbral tumors: a NATional study) multicenter case-control study carried out in 4 areas in France in 2004-2010. Participants' histories of doctor-diagnosed allergic asthma, eczema, rhinitis/hay fever and other allergic conditions were collected at onset through a detailed questionnaire delivered in a face-to-face interview. Conditional logistic regression for matched sets was adjusted for participants' educational level and mobile phone use. A total of 273 glioma cases, 218 meningioma cases and 982 matched controls selected from the local electoral rolls were analyzed. A significant inverse association was found between glioma and a history of any allergy (OR 0.52, 95% CI 0.36-0.75), with a dose-effect relationship with the number of allergic conditions reported (p-trend = 0.001) and a particularly strong association with hay fever/allergic rhinitis (OR 0.46, 95% CI 0.30-0.72). Interestingly, associations with glioma risk were more pronounced in women. For meningioma, no association was observed with overall or specific allergic conditions. Our findings confirmed the inverse association between allergic conditions and glioma risk but questioned the role of allergy in meningioma risk. Future research is needed to clarify the biological mechanism of overall allergy and allergic rhinitis on glioma and to confirm the different effect by gender