Discovery of a Probable Physical Triple Quasar

We report the discovery of the first known probable case of a physical triple quasar (not a gravitational lens). A previously known double system, QQ 1429-008 at z = 2.076, is shown to contain a third, fainter QSO component at the same redshift within the measurement errors. Deep optical and IR imaging at the Keck and VLT telescopes has failed to reveal a plausible lensing galaxy group or a cluster, and moreover, we are unable to construct any viable lensing model which could lead to the observed distribution of source positions and relative intensities of the three QSO image components. Furthermore, there are hints of differences in broad-band spectral energy distributions of different components, which are more naturally understood if they are physically distinct AGN. Therefore, we conclude that this system is most likely a physical triple quasar, the first such close QSO grouping known at any redshift. The projected component separations in the restframe are ~ 30 - 50 kpc for the standard concordance cosmology, typical of interacting galaxy systems. The existence of this highly unusual system supports the standard picture in which galaxy interactions lead to the onset of QSO activity.Comment: Submitted to ApJL, LaTeX, 13 pages, 4 eps figures, all include

The Mass Function of Main Sequence Stars in NGC6397 from Near IR and Optical High Resolution HST Observations

We have investigated the properties of the stellar mass function in the globular cluster NGC6397 using a large set of HST observations that include WFPC2 images in V and I, obtained at ~4' and 10' radial distances, and a series of deep images in the J and H bands obtained with the NIC2 and NIC3 cameras of NICMOS pointed to regions located ~4.5' and ~3.2' from the center. These observations span the region from ~1 to ~3 times the cluster's half-light radius. All luminosity functions, derived from color magniutde diagrams, increase with decreasing luminosity up to a peak at M_I~8.5 or M_H~7 and then precipitously drop well before photometric incompleteness becomes significant. Within the observational uncertainties, at M_I~12 or M_H~10.5 (~0.09 Msun) the luminosity functions are compatible with zero. By applying the best available mass- luminosity relation appropriate to the metallicity of NGC6397 to both the optical and IR data, we obtain a mass function that shows a break in slope at \~0.3 Msun. No single exponent power-law distribution is compatible with these data, regardless of the value of the exponent. We find that a dynamical model of the cluster can simultaneously reproduce all the luminosity functions observed throughout the cluster only if the IMF rises as m**-1.6 in the range 0.8-0.3 Msun and then drops as m**0.2 below ~0.3 Msun. Adopting a more physical log-normal distribution for the IMF, all these data taken together imply a best fit distribution with characteristic mass m_c~0.3 and sigma~1.8.Comment: 18 pages, 6 figures (ps). Accepted for publication in Ap

RANKL Signaling Sustains Primary Tumor Growth in Genetically Engineered Mouse Models of Lung Adenocarcinoma.

NSCLC is the leading cause of cancer mortality. Recent retrospective clinical analyses suggest that blocking the receptor activator of NF-κB (RANK) signaling pathway inhibits the growth of NSCLC and might represent a new treatment strategy. Receptor activator of NF-κB gene (RANK) and receptor activator of NF-κB ligand gene (RANKL) expression in human lung adenocarcinoma was interrogated from publicly available gene expression data sets. Several genetically engineered mouse models were used to evaluate treatment efficacy of RANK-Fc to block RANKL, with primary tumor growth measured longitudinally using microcomputed tomography. A combination of RANKL blockade with cisplatin was tested to mirror an ongoing clinical trial. In human lung adenocarcinoma data sets, RANKL expression was associated with decreased survival and KRAS mutation, with the highest levels in tumors with co-occurring KRAS and liver kinase B1 gene (LKB1) mutations. In Kras <sup>LSL-G12D/WT</sup> , Kras <sup>LSL-G12D/WT</sup> ; Lkb1 <sup>Flox/Flox</sup> and Kras <sup>LSL-G12D/WT</sup> ; p53 <sup>Flox/Flox</sup> mouse models of lung adenocarcinoma, we monitored an impaired progression of tumors upon RANKL blockade. Despite elevated expression of RANKL and RANK in immune cells, treatment response was not associated with major changes in the tumor immune microenvironment. Combined RANK-Fc with cisplatin revealed increased efficacy compared with that of single agents in p53- but not in Lkb1-deficient tumors. RANKL blocking agents impair the growth of primary lung tumors in several mouse models of lung adenocarcinoma and suggest that patients with KRAS-mutant lung tumors will benefit from such treatments

A G1-like globular cluster in NGC 1023

The structure of a very bright (MV = -10.9) globular cluster in NGC 1023 is analyzed on two sets of images taken with the Hubble Space Telescope. From careful modeling of King profile fits to the cluster image, a core radius of 0.55+/-0.1 pc, effective radius 3.7+/-0.3 pc and a central V-band surface brightness of 12.9+/-0.5 mag / square arcsec are derived. This makes the cluster much more compact than Omega Cen, but very similar to the brightest globular cluster in M31, G1 = Mayall II. The cluster in NGC 1023 appears to be very highly flattened with an ellipticity of about 0.37, even higher than for Omega Cen and G1, and similar to the most flattened clusters in the Large Magellanic Cloud.Comment: 14 pages, 3 figures, 1 table. Accepted for AJ, Oct 200

Confirmation of two extended objects along the line of sight to PKS1830-211 with ESO-VLT adaptive optics imaging

We report on new high-resolution near-infrared images of the gravitationally lensed radio source PKS1830-211, a quasar at z=2.507. These adaptive optics observations, taken with the Very Large Telescope (VLT), are further improved through image deconvolution. They confirm the presence of a second object along the line of sight to the quasar, in addition to the previously known spiral galaxy. This additional object is clearly extended in our images. However, its faint luminosity does not allow to infer any photometric redshift. If this galaxy is located in the foreground of PKS1830-211, it complicates the modeling of this system and decreases the interest in using PKS1830-211 as a means to determine H0 via the time delay between the two lensed images of the quasar.Comment: Accepted in A&A Letter

Globular clusters and dwarf galaxies in Fornax - I. Kinematics in the cluster core from multi-object spectroscopy

We acquired radial velocities of a significant number of globular clusters (GCs) on wide fields between galaxies in the nearby Fornax cluster of galaxies, in order to derive their velocity dispersion radial profile and to probe the dynamics of the cluster. We used FLAMES on the VLT to obtain accurate velocities for 149 GCs, within a ~500x150 kpc strip centered on NGC 1399, the Fornax central galaxy. These objects are at the very bright tail (M_V < -9.5) of the GC luminosity function, overlapping the so-called ``ultra-compact dwarfs'' magnitude range. Eight of the brightest FLAMES-confirmed members indeed show hints of resolution in the subarcsecond pre-imaging data we used for selecting the ~500 targets for FLAMES spectroscopy. Ignoring the GCs around galaxies by applying 3d_25 diameter masks, we find 61 GCs of 20.0 < V < 22.2 lying in the intra-cluster (IC) medium. The velocity dispersion of the population of ICGCs is 200 km/s at ~150 kpc from the central NGC 1399 and rises to nearly 400 km/s at 200 kpc, a value which compares with the velocity dispersion of the population of dwarf galaxies, thought to be infalling from the surroundings of the cluster.Comment: To be published in A&A Letters. 4 pages, 3 figures, 3 table

Detection of ionized gas in the globular cluster 47 Tucanae

We report the detection of ionized intracluster gas in the globular cluster 47 Tucanae. Pulsars in this cluster with a negative period derivative, which must lie in the distant half of the cluster, have significantly higher measured integrated electron column densities than the pulsars with a positive period derivative. We derive the plasma density within the central few pc of the cluster using two different methods which yield consistent values. Our best estimate of n_e = (0.067+-0.015)/cm^3 is about 100 times the free electron density of the ISM in the vicinity of 47 Tucanae, and the ionized gas is probably the dominant component of the intracluster medium.Comment: 5 pages, 3 included figures, accepted for publication by ApJ Letter

The Consistency of Fermi-LAT Observations of the Galactic Center with a Millisecond Pulsar Population in the Central Stellar Cluster

I show that the spectrum and morphology of a recent Fermi-LAT observation of the Galaxy center are consistent with a millisecond pulsar population in the nuclear Central stellar cluster of the Milky Way. The Galaxy Center gamma-ray spectrum is consistent with the spectrum of four of eight globular clusters that have been detected in the gamma-ray. A dark matter annihilation interpretation cannot be ruled out, though no unique features exist that would require this conclusion.Comment: 5 pages, 1 figure; v3: matches version to appear in JCA

Palomar 13: An Unusual Stellar System in the Galactic Halo

We have measured Keck/HIRES radial velocities for 30 candidate red giants in the direction of Palomar 13: an object traditionally cataloged as a compact, low-luminosity globular cluster. From a sample of 21 confirmed members, we find a systemic velocity of 24.1 km/s and a projected, intrinsic velocity dispersion of 2.2 km/s. Although small, this dispersion is several times larger than that expected for a globular cluster of this luminosity and central concentration. Taken at face value, this dispersion implies a mass-to-light ratio of ~ 40 (in solar units) based on the best-fit King-Michie model. The surface density profile of Palomar 13 also appears to be anomalous among Galactic globular clusters -- depending upon the details of background subtraction and model-fitting, Palomar 13 either contains a substantial population of "extra-tidal" stars, or it is far more spatially extended than previously suspected. The full surface density profile is equally well-fit by a King-Michie model having a high concentration and large tidal radius, or by a NFW model. We examine -- and tentatively reject -- a number of possible explanations for the observed characteristics of Palomar 13 (e.g., velocity "jitter" among the red giants, spectroscopic binary stars, non-standard mass functions, modified Newtonian dynamics), and conclude that the two most plausible scenarios are either catastrophic heating during a recent perigalacticon passage, or the presence of a massive dark halo. Thus, the available evidence suggests that Palomar 13 is either a globular cluster which is now in the process of dissolving into the Galactic halo, or a faint, dark-matter-dominated stellar system (ABRIDGED).Comment: 31 pages, 13 postscript figures and 1 color gif image. Also available at http://www.physics.rutgers.edu/ast/ast-rap.html. Accepted for publication in the Astrophysical Journa