Elastik Zemine Oturan Fonksiyonel Derecelendirilmiş Kare Bir Plağın Statik Yükler Altında Davranışı

Konferans Bildirisi -- Teorik ve Uygulamalı Mekanik Türk Milli Komitesi, 2015Conference Paper -- Theoretical and Applied Mechanical Turkish National Committee, 2015Bu çalışmada, elastik zemine oturan fonksiyonel derecelendirilmiş (FD) kare bir plağın statik davranışı Ritz yöntemi ile Kirchhoff-Love plak teorisi çerçevesinde incelenmiştir. Ritz yönteminin uygulanması için plak yer değiştirme fonksiyonu kuvvet serisine açılmıştır. Sınır koşulları yer değiştirme fonksiyonuna yardımcı bir fonksiyon ilave edilmesiyle sağlatılmıştır. Çalışmada, farklı malzeme kompozisyonları, farklı sınır koşulları ve elastik zemin parametresinin plağın yer değiştirmeleri ve eksenel normal gerilmeler üzerindeki etkisi incelenmiştir.In this study, the static behavior of a functionally graded (FG) square plate resting on the elastic foundation is investigated via Ritz method within the framework of Kirchhoff-Love plate theory. In order to apply Ritz method, the trial function for the deflection of the plate is expressed in the polynomial form. Boundary conditions are satisfied by adding an auxiliary function to the trial function. The effects of various material compositions, boundary conditions and the parameter of elastic foundation on the deflection and axial normal stress of the plate are examined

A new word-based compression model allowing compressed pattern matching

In this study a new semistatic data compression model that has a fast coding process and that allows compressed pattern matching is introduced. The name of the proposed model is chosen as tagged word-based compression algorithm (TWBCA) since it has a word-based coding and word-based compressed matching algorithm. The model has two phases. In the first phase a dictionary is constructed by adding a phrase, paying attention to word boundaries, and in the second phase compression is done by using codewords of phrases in this dictionary. The first byte of the codeword determines whether the word is compressed or not. By paying attention to this rule, the CPM process can be conducted as word based. In addition, the proposed method makes it possible to also search for the group of consecutively compressed words. Any of the previous pattern matching algorithms can be chosen to use in compressed pattern matching as a black box. The duration of the CPM process is always less than the duration of the same process on the texts coded by Gzip tool. While matching longer patterns, compressed pattern matching takes more time on the texts coded by compress and end-tagged dense code (ETDC). However, searching shorter patterns takes less time on texts coded by our approach than the texts compressed with compress. Besides this, the compression ratio of our algorithm has a better performance against ETDC only on a file that has been written in Turkish. The compression performance of TWBCA is stable and does not vary over 6% on different text files

Is there a difference between normotensive and hypertensive patients in terms of blood parameters and cardiovascular diseases?

Objectives: It has been stated in various studies that there is a difference in some blood parameters between hypertensive and normotensive patients for a long time. Mean platelet volume (MPV), and red blood cell distribution width (RDW), have been studied in hypertensive patient groups in many studies. Hypertension is a classic risk factor for ischemic stroke and myocardial ischemia, as known. In our study, we examined whether there was a difference between hypertensive patient groups and normotensive patients in terms of blood parameters such as MPV and RDW, and the incidence of stroke and myocardial infarction.Methods: Blood samples and twenty-four-hour ambulatory blood pressure monitoring (ABPM) results of 552 patients admitted to our outpatient clinic with a pre-diagnosis of hypertension were retrospectively analyzed. According to ABPM results, we divided the study participants into four groups; dippers, non-dippers, extreme dippers, and normotansives. Complete blood count and biochemical test results were found in the database of our hospital for all patients and differences between groups were investigated.Results: One hundred seventy three normotensives (Group 1) (mean age, 47.4 ± 15.4 years), 210 non-dippers (Group 2) (mean age, 53.8 ± 15.8 years), 67 extreme dippers (Group 3) (mean age, 49.1 ± 15.9 years) and 102 dippers (Group 4) (mean age, 52.2 ± 12.5 years). Daytime mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) and night-time mean SBP and DBP were significantly different in groups (Group 1: 117 [90-193] mmHg and 71 [55-87] mmHg; Group 2: 137 [107-188] mmHg and 83 [107-188] mmHg; Group 3: 143 [115-193] mmHg and 88 [56-122] mmHg; and Group 4: 140.5 [116-173] mmHg and 76 [55-124] mmHg), p < 0.001; respectively. MPV and RDW levels were different in all four groups (p < 0.001). We found a significant difference in the rates of stroke and coronary artery disease between the four groups (p = 0.018 and p = 0.002, respectively). In the ROC curve analysis MPV had sensitivity of %77. 8 and specificity of 78. 1% for stroke when the cut-off value MPV was 9.25 (Area under curve: 0.808, 95% confidence interval: 0.726-0.889, p < 0.001).Conclusions: In our study, MPV and RDW levels and the rates of stroke and cardiovascular disease were significantly higher in non-dipper patients compared to other groups

Cytotoxic activity and docking studies of 2-arenoxybenzaldehyde N-acyl hydrazone and 1,3,4-oxadiazole derivatives against various cancer cell lines

To understand whether previously synthesized novel hydrazone and oxadiazole derivatives have promising anticancer effects, docking studies and in vitro toxicity assays were performed on A-549, MDA-MB-231, and PC-3 cell lines. The antiproliferative properties of the compounds were investigated using molecular docking experiments. Each compound's best-docked poses, binding affinity, and receptor-ligand interaction were evaluated. Compounds' molecular weights, logPs, TPSAs, abilities to pass the blood-brain barrier, GI absorption qualities, and CYPP450 inhibition have been given. When the activities of these molecules were examined in vitro, for the A-549 cell line, hydrazone 1e had the minimum IC50 value of 13.39 mu M. For the MDA-MB-231 cell line, oxadiazole 2l demonstrated the lowest IC50 value, with 22.73 mu M. For PC-3, hydrazone 1d showed the lowest C50 value of 9.38 mu M. The three most promising compounds were determined as compounds 1e, 1d, and 2a based on their minimum IC50 values, and an additional scratch assay was performed for A-549 and MDA-MB-231 cells, which have high migration capacity, for the three most potent molecules; it was determined that these molecules did not show a significant antimetastatic effect

Predictive Values of Inflammation Indexes in Predicting Mortality in Patients with COVID 19 Hospitalized in General Intensive Care Unit

Objective: Causing a global pandemic, the coronavirus disease 2019 (COVID-19) has caused millions of people to become infected and many more to die. In this study we aimed to investigate whether routinely evaluated clinical and laboratory values ??can predict the mortality of patients with COVID-19 disease.Materials and Methods: In our study, routine laboratory parameters of 89 patients hospitalized in the general intensive care unit with the diagnosis of COVID 19 were retrospectively analyzed. The aggregate index of systemic inflammation (AISI) and other inflamatuar values were calculated from blood tests in patients with positive COVID-19 polymerase chain reaction test and with ground-glass opacity on lung tomography. Patients were divided into two groups as those who died (non-survivors) and those who were discharged (survivors)during the intensive care follow-ups. Results: In our study, in 48 patients who died during follow-up, the indexes of AISI, other inflamatuar paramaters and the biochemical parameters such as troponin I, d-dimer, ferritin and procalcitonin were significantly higher than in discharged patients. Hypertension and higher AISI and ferritin levels were statistically associated with reduced survival in Cox regression analysis (Hazard ration (HR): 3.176; 95% Confident interval (CI): 1.122-8.991, p=0.03, HR: 1.114; 95% CI: 1.060-1.348, p=0.042, HR=1.072;95% CI: 1.014-1.242, p=0.011, respectively.Conclusion: Inflammation indexes derived from blood tests and acute phase reactants such as ferritin can guide us in planning the treatment strategy and risk stratification in patients with COVID-19 in intensive care follow-ups.

Helicobacter pylori infection in amniotic fluid may cause hyperemesis gravidarum

Objectives: Limited data are available from recent trials involving pregnant women to guide Helicobacter pylori infection diagnosis. There are no data about the presence of H. pylori in the amniotic fluid as well. Furthermore, the relation between amniotic fluid H. pylori and hyperemesis gravidarum (HG) has not been characterized yet. Materials and Methods: This is a prospective study conducted after obtaining approval from the Ethics Committee. Pregnant women undergoing amniocentesis were enrolled in the study. The stool antigen test assessed the presence of H. pylori in amniotic fluid. A perinatologist independently performed an amniocentesis. The obtained amniotic liquid was sent to the laboratory to evaluate H. pylori infection by stool H. pylori antigen assay. We determined the rate of H. pylori in amniotic fluid and assessed relations between H. pylori infection and pregnancy outcome, including HG. Results: Between May and September 2017, we enrolled 48 pregnant women who underwent amniocentesis to detect possible fetal malformations. Patients were divided into two groups regarding the HG status. There were significant differences between the groups in terms of H. pylori infection presence. Among them, 28 (58.3%) were found to have a positive H. pylori test in their amniotic fluid. The rate of HG was significantly higher (71.4%) in patients who tested positive for H. pylori in amniocentesis than the H. pylori-negative group (20%), (p<0.001). Conclusions: The study’s main new finding is that presence of H. pylori in the amniotic fluid is possible. Our data suggest that H. pylori-infected amniotic fluid is associated with the experience of past HG. The current study may have important implications for HG detection and help identify patients who would benefit from future preventive strategies. © 2020 Global Research Online. All rights reserved

Effect of circumcision for the prevention of recurrent urinary tract infection

ıdrar yolu enfeksiyonu çocukluk çağında önemli bir problem olup tedavi edilmezse etken mikroorganizma alt üriner sistemden yukarıya doğru çıkarak böbrek yetmezliğine kadar ilerleyen bir seyir izleyebilir. Önemli bir idrar yolu enfeksiyonu kaynağı sünnet derisidir. Çalışmamızın amacı sünnetin idrar yolu enfeksiyonunu önlemedeki etkinliğinin araştırılmasıdır. Çalışma grubumuzu, yineleyen idrar yolu enfeksiyonu bulguları ile başvuran sünnet olmamış erkek çocuklar oluşturdu. Hastalardan idrar kültürü alınıp enfeksiyon varsa, antibiyoterapi uygulandı. Antibiyoterapi sonrasında idrar yolu enfeksiyonu yineleyen çocuklara Ultrasonografi, Miksion Sisto Üretrografisi, ıntra Venöz Pyelografi veDMSAgibi ileri görüntüleme tetkikleri yapıldıktan sonra sünnet uygulanıp, hastalar sünnet sonrası idrar kültürü ile tekrar değerlendirildi. Çalışmamızda toplam 12 hasta olup ortalama yaş 2.4 idi. Hastaların idrarlarında E.Coli, Pseudomonas, Proteus, Stafilokok, Enterokok Klebsiella ve Salmonella gibi mikroorganizmalar üredi. Hastaların biri dışında hiçbirinde sünnet sonrası idrar kültüründe üreme olmadı. Yineleyen idrar yolu enfeksiyonu olan sünnetsiz çocuklarda sünnet derisi taşıyıcılığı araştırılmalı ve sünnetin tedavinin bir parçası olduğu düşünülmelidir.Urinary tract infection (UTI) is an important problem of childhood and if left untreated, the microorganisms may migrate from the lower urinary system to upper levels, leading to chronic renal failure. A UTI source of considerable importance is preputial skin. This study was performed to identify the role of circumcision on prevention of recurrent UTI. Study group consisted of uncircumcised male children diagnosed as recurrent UTI. Following diagnostic tests such as ultrasonography, voiding cystourethrography, intravenous pyelography and DMSA, circumcision was performed. Postcircumcision evaluation was made by urine culture. Total number of patients in our study group was 12 with a mean age of 2.4 years. Urine cultures before circumcision revealed microorganisms such as E. Coli, Pseudomonas, Proteus, Staphylococcus, Enterococcus, Klebsiella and Salmonella species. None of the urine cultures revealed a microbial growth in patients at the postcircumcision period. In uncircumcised children with recurrent urinary tract infections, the carrier state of preputial skin must be investigated, and circumcision must be accounted for as a step of treatment procedur

Retrospective Analysis of Lymphangitis Carcinomatosa Regarding Primer Tumor Spectrum and Computer Tomography Features

INTRODUCTION: Lymphangitis carcinomatosis (LC) is used to describe the metastatic involvement of pulmonary lymphatic canals and perilymphatic connective tissue by primary tumor cells and commonly occurs secondary to primary tumors, mostly adenocarcinomas, originated from breast, lung, gastrointestinal system cancers. Common findings in lung computed tomography (CT) are interlobular septal thickening and increased reticular/reticulonodular density. In this study, we aim to present the primary tumor spectrum and most frequent computed tomography findings of patients with LC. METHODS: In this double-centered study 63 patients, who had lung CT examination due to prediagnosis of LC, were retrospectively investigated. 41 patients with final diagnosis of LC due to findings upon Positron emission tomography/Computed tomography (PET/CT), ultrasonography, CT scan, endoscopic, bronchoscopic and cytopathologic investigations and/or clinical manifestations are ultimately included RESULTS: In 41 patients with LC, lung in 11 cases, esophagus in 7 cases, colon in 6 cases, stomach in 4 cases, pancreas in 3 cases, breast in 2 cases, bladder in 2 cases, thyroid in 2 cases and singly larynx, kidney, prostate and bone marrow in 4 cases were respectively revealed as primary tumor origins. Most frequent lung CT findings were increased reticular/reticulonodular and nodular densities, thickenings of interlobular septa, mediastinal and hilar lymphadenopathies, pleural and/or pericardial effusions, atelectasis, ground-glass opacities. Extrapulmonary involvement was detected in 14 patients DISCUSSION AND CONCLUSION: LC occurs with metastatic involvement of pulmonary lymphatics in patients with primary malignancy, especially adenocarcinomas. In CT, the reticular, reticulonodular, and noduler pattern (most common pulmonary parenchymal changes) and mediastinal lymphadenopathies (LAP) are the most common findgs. Pulmonary CT examination is accepted as the most important radiological modality in diagnosis and follow up of LC

Clinical outcomes and treatment patterns of primary central nervous system lymphoma: Multicenter retrospective analysis

Objectives: Primary central nervous system lymphoma (PCNSL) is a rare malignant disease with poor prognosis. Its low incidence leads to challenges in decision-making for treatment. As a matter of fact, there is still no consensus on the appropriate treatment modalities. In this context, the objective of this study is to investigate and comparatively assess the efficacies of several treatment modalities in the treatment of PCNSL. Methods: Thirty-four patients diagnosed with PCNSL at 5 different hematology centers between 2007 and 2021 were included in the study. Patients’ data from all five centers were collected retrospectively. Since ibrutinib is not approved for this indication in Turkey, consent for off-label use of ibrutinib is obtained from each patient. Ethics committee ap-proval was obtained on June 9, 2021 with decision number 2021/18-05. Results: The median age of the patients was 59 (min.: 22, max.: 78) years. The male-to-female ratio was 1.26/1. Nineteen (55.9%) patients had Eastern Cooperative Oncology Group (ECOG) performance score of ≥2. Fifteen (44.1%) patients had normal lactate dehydrogenase (LDH) levels and only 14.7% of the patients had B symptoms at the time of diagnosis. Magnetic resonance imaging (MRI) revealed a single mass lesion in 14 (41.2%) patients. As an induction therapy, meth-otrexate-based regimen was administered in 29 (85.3%) patients. Only 14 of the 34 patients received 4 or more cycles of high-dose methotrexate (MTX). About 32.4% of the patients received radiation therapy (RT) during follow-up as a part of induction therapy. Five patients received only RT due to poor performance status. Ibrutinib was administered in 5 patients for refractory disease. It was determined that four or more cycles of MTX treatment increased progression-free survival (PFS) (p=0.031) and overall survival (OS) (p=0.012). Moreover, RT improved PFS (p=0.023). Considering that the complete response achieved by induction therapy influences long-term survival, achievement of the best response to the treatment regimens administered in combination with new agents may prolong survival (PFS: p=0.01, OS: p=0.023). Conclusion: The findings of this study indicate that the initial response to treatment is crucial. Additionally, it was found that high-dose MTX treatment should be administered for 4 cycles or more in order to achieve the best results. Furthermore, it was determined that ibrutinib monotherapy was well-tolerated in our patients with relapsed/refractory disease, with excellent clinical benefits. In conclusion, a combination therapy consisting of high-dose MTX, ibrutinib, and rituximab appears to be a promising initial treatment approach in appropriate patients