2,635 research outputs found
The relationship between interpersonal problems, negative cognitions, and outcomes from cognitive behavioral group therapy for depression
Background: Interpersonal functioning is a key determinant of psychological well-being, and interpersonal problems (IPs) are common among individuals with psychiatric disorders. However, IPs are rarely formally assessed in clinical practice or within cognitive behavior therapy research trials as predictors of treatment attrition and outcome. The main aim of this study was to investigate the relationship between IPs, depressogenic cognitions, and treatment outcome in a large clinical sample receiving cognitive behavioral group therapy (CBGT) for depression in a community clinic.Methods: Patients (N=144) referred for treatment completed measures of IPs, negative cognitions, depression symptoms, and quality of life (QoL) before and at the completion of a 12-week manualized CBGT protocol.Results: Two IPs at pre-treatment, âfinding it hard to be supportive of othersâ and ânot being open about problems,â were associated with higher attrition. Pre-treatment IPs also predicted higher post-treatment depression symptoms (but not QoL) after controlling for pre-treatment symptoms, negative cognitions, demographics, and comorbidity. In particular, âdifficulty being assertiveâ and a âtendency to subjugate one's needs' were associated with higher post-treatment depression symptoms. Changes in IPs did not predict post-treatment depression symptoms or QoL when controlling for changes in negative cognitions, pre-treatment symptoms, demographics, and comorbidity. In contrast, changes in negative cognitions predicted both post-treatment depression and QoL, even after controlling for changes in IPs and the other covariates.Limitations: Correlational design, potential attrition bias, generalizability to other disorders and treatments needs to be evaluated.Conclusions: Pre-treatment IPs may increase risk of dropout and predict poorer outcomes, but changes in negative cognitions during treatment were most strongly associated with improvement in symptoms and QoL during CBGT
Effect of restricted access time to pasture on dairy cow milk production, grazing behavior, and dry matter intake
The objective of this experiment was to investigate the effect of restricting pasture access time on milk production and composition, body weight and body condition score change, dry matter intake, and grazing behavior of autumn calving dairy cows in midlactation. Fifty-two (19 primiparous and 33 multiparous) Holstein-Friesian dairy cows (mean calving date, August 17 ± 91.2 d) were randomly assigned to a 4-treatment (n = 13) randomized block design grazing study. The 4 grazing treatments were: (i) full-time access to pasture (22H; control), (ii) 9-h access to pasture (9H), (iii) two 4.5-h periods of access to pasture after both milkings (2 Ă 4.5H), and (iv) two 3-h periods of access to pasture after both milkings (2 Ă 3H). Experimental treatments were imposed from March 7 to April 6, 2007 (31 d). The pregrazing herbage mass of swards offered to all treatments was 1,268 kg of dry matter/ha, and sward organic matter digestibility was 86.4%, indicating high-quality swards conducive to high dry matter intake. Swards where animals had 22H and 2 Ă 4.5H access to pasture had the lowest postgrazing sward heights (3.5 cm), reflecting the greatest levels of sward utilization. After the experimental period, there were no differences in milk production; however, the 2 Ă 3H animals tended to have lower milk protein concentration (â0.17%) compared with 22H animals. Furthermore, dry matter intake of the 9H animals was lower than 22H animals. Although restricting access time to pasture decreased grazing time, animals compensated by increasing their intake/minute and intake/bite. Restricting pasture access time resulted in much greater grazing efficiency, because the 9H, 2 Ă 4.5H, and 2 Ă 3H treatments spent a greater proportion of their time at pasture grazing (81, 81, and 96%, respectively) than 22H animals (42%). Results of this study indicate that allocating animals restricted access to pasture does not significantly affect milk production. This study also found that the total access time should be greater than 6 h and that perhaps needs to be divided into 2 periods
The Origin of B-Type Runaway Stars: Non-LTE Abundances as a Diagnostic
There are two accepted mechanisms to explain the origin of runaway OB-type
stars: the Binary Supernova Scenario (BSS), and the Cluster Ejection Scenario
(CES). In the former, a supernova explosion within a close binary ejects the
secondary star, while in the latter close multi-body interactions in a dense
cluster cause one or more of the stars to be ejected from the region at high
velocity. Both mechanisms have the potential to affect the surface composition
of the runaway star. TLUSTY non-LTE model atmosphere calculations have been
used to determine atmospheric parameters and carbon, nitrogen, magnesium and
silicon abundances for a sample of B-type runaways. These same analytical tools
were used by Hunter et al. (2009) for their analysis of 50 B-type open cluster
Galactic stars (i.e. non-runaways). Effective temperatures were deduced using
the silicon-ionization balance technique, surface gravities from Balmer line
profiles and microturbulent velocities derived using the Si spectrum. The
runaways show no obvious abundance anomalies when compared with stars in the
open clusters. The runaways do show a spread in composition which almost
certainly reflects the Galactic abundance gradient and a range in the
birthplaces of the runaways in the Galactic disk. Since the observed Galactic
abundance gradients of C, N, Mg and Si are of a similar magnitude, the
abundance ratios (e.g., N/Mg) are, as obtained, essentially uniform across the
sample
Doublecortin-expressing cell types in temporal lobe epilepsy
Doublecortin (DCX) is widely regarded as a marker of immature and migrating neurons during development. While DCX expression persists in adults, particularly in the temporal lobe and neurogenic regions, it is unknown how seizures influence its expression. The aim of the present study was to explore the distribution and characteristics of DCX-expressing cells in surgical and postmortem samples from 40 adult and paediatric patients, with epilepsy and with or without hippocampal sclerosis (HS), compared to post mortem controls. The hippocampus (pes and body), parahippocampal gyrus, amygdala, temporal pole and temporal cortex were examined with DCX immunohistochemistry using four commercially-available DCX antibodies, labelled cells were quantified in different regions of interest as well as their co-expression with cell type specific markers (CD68, Iba1, GFAP, GFAPâ, nestin, SOX2, CD34, OLIG2, PDGFRÎČ, NeuN) and cell cycle marker (MCM2). Histological findings were compared with clinical data, as well as gene expression data obtained from the temporal cortex of 83 temporal lobe epilepsy cases with HS. DCX immunohistochemistry identified immature (Nestin-/NeuN-) neurons in layer II of the temporal neocortex in patients with and without epilepsy. Their number declined significantly with age but was not associated with the presence of hippocampal sclerosis, seizure semiology or memory dysfunction. DCX+ cells were prominent in the paralaminar nuclei and periamygdalar cortex and these declined with age but were not significantly associated with epilepsy history. DCX expressing cells with ramified processes were prominent in all regions, particularly in the hippocampal subgranular zone, where significantly increased numbers were observed in epilepsy samples compared to controls. DCX ramified cells co-expressed Iba1, CD68 and PDGFRÎČ, and less frequently MCM2, OLIG2 and SOX2, but no co-localization was observed with CD34, nestin or GFAP/GFAP â. Gene expression data from neocortical samples in patients with TLE and HS supported ongoing DCX expression in adults. We conclude that DCX identifies a range of morphological cell types in temporal lobe epilepsy, including immature populations, glial and microglial cell types. Their clinical relevance and biological function requires further study but we show some evidence for alteration with age and in epilepsy
Early-type stars observed in the ESO UVES Paranal Observatory Project - V. Time-variable interstellar absorption
The structure and properties of the diffuse interstellar medium (ISM) on
small scales, sub-au to 1 pc, are poorly understood. We compare interstellar
absorption-lines, observed towards a selection of O- and B-type stars at two or
more epochs, to search for variations over time caused by the transverse motion
of each star combined with changes in the structure in the foreground ISM. Two
sets of data were used: 83 VLT- UVES spectra with approximately 6 yr between
epochs and 21 McDonald observatory 2.7m telescope echelle spectra with 6 - 20
yr between epochs, over a range of scales from 0 - 360 au. The interstellar
absorption-lines observed at the two epochs were subtracted and searched for
any residuals due to changes in the foreground ISM. Of the 104 sightlines
investigated with typically five or more components in Na I D, possible
temporal variation was identified in five UVES spectra (six components), in Ca
II, Ca I and/or Na I absorption-lines. The variations detected range from 7\%
to a factor of 3.6 in column density. No variation was found in any other
interstellar species. Most sightlines show no variation, with 3{\sigma} upper
limits to changes of the order 0.1 - 0.3 dex in Ca II and Na I. These
variations observed imply that fine-scale structure is present in the ISM, but
at the resolution available in this study, is not very common at visible
wavelengths. A determination of the electron densities and lower limits to the
total number density of a sample of the sightlines implies that there is no
striking difference between these parameters in sightlines with, and sightlines
without, varying components.Comment: 19 pages, 11 figures, accepted for publication in MNRA
Spectral transitions in networks
We study the level spacing distribution p(s) in the spectrum of random
networks. According to our numerical results, the shape of p(s) in the
Erdos-Renyi (E-R) random graph is determined by the average degree , and
p(s) undergoes a dramatic change when is varied around the critical point
of the percolation transition, =1. When > 1, the p(s) is described by
the statistics of the Gaussian Orthogonal Ensemble (GOE), one of the major
statistical ensembles in Random Matrix Theory, whereas at =1 it follows the
Poisson level spacing distribution. Closely above the critical point, p(s) can
be described in terms of an intermediate distribution between Poisson and the
GOE, the Brody-distribution. Furthermore, below the critical point p(s) can be
given with the help of the regularised Gamma-function. Motivated by these
results, we analyse the behaviour of p(s) in real networks such as the
Internet, a word association network and a protein protein interaction network
as well. When the giant component of these networks is destroyed in a node
deletion process simulating the networks subjected to intentional attack, their
level spacing distribution undergoes a similar transition to that of the E-R
graph.Comment: 11 pages, 5 figure
A De Novo Mutation in COL1A1 in a Holstein Calf with Osteogenesis Imperfecta Type II
Osteogenesis imperfecta (OI) type II is a genetic connective tissue disorder characterized by bone fragility, severe skeletal deformities and shortened limbs. OI usually causes perinatal death of affected individuals. OI type II diagnosis in humans is established by the identification of heterozygous mutations in genes coding for collagens. The purpose of this study was to characterize the pathological phenotype of an OI type II-affected neonatal Holstein calf and to identify the causative genetic variant by whole-genome sequencing (WGS). The calf had acute as well as intrauterine fractures, abnormally shaped long bones and localized arthrogryposis. Genetic analysis revealed a private heterozygous missense variant in COL1A1 (c.3917T>A) located in the fibrillar collagen NC1 domain (p.Val1306Glu) that most likely occurred de novo. This confirmed the diagnosis of OI type II and represents the first report of a pathogenic variant in the fibrillar collagen NC domain of COL1A1 associated to OI type II in domestic animals. Furthermore, this study highlights the utility of WGS-based precise diagnostics for understanding congenital disorders in cattle and the need for continued surveillance for rare lethal genetic disorders in cattle
Optic radiation tractography and vision in anterior temporal lobe resection.
Anterior temporal lobe resection (ATLR) is an effective treatment for refractory temporal lobe epilepsy but may result in a contralateral superior visual field deficit (VFD) that precludes driving in the seizure-free patient. Diffusion tensor imaging (DTI) tractography can delineate the optic radiation preoperatively and stratify risk. It would be advantageous to incorporate display of tracts into interventional magnetic resonance imaging (MRI) to guide surgery
The VLT-FLAMES Tarantula Survey X: Evidence for a bimodal distribution of rotational velocities for the single early B-type stars
Aims: Projected rotational velocities (\vsini) have been estimated for 334
targets in the VLT-FLAMES Tarantula survey that do not manifest significant
radial velocity variations and are not supergiants. They have spectral types
from approximately O9.5 to B3. The estimates have been analysed to infer the
underlying rotational velocity distribution, which is critical for
understanding the evolution of massive stars.
Methods: Projected rotational velocities were deduced from the Fourier
transforms of spectral lines, with upper limits also being obtained from
profile fitting. For the narrower lined stars, metal and non-diffuse helium
lines were adopted, and for the broader lined stars, both non-diffuse and
diffuse helium lines; the estimates obtained using the different sets of lines
are in good agreement. The uncertainty in the mean estimates is typically 4%
for most targets. The iterative deconvolution procedure of Lucy has been used
to deduce the probability density distribution of the rotational velocities.
Results: Projected rotational velocities range up to approximately 450 \kms
and show a bi-modal structure. This is also present in the inferred rotational
velocity distribution with 25% of the sample having \ve100\,\kms
and the high velocity component having \ve\,\kms. There is no
evidence from the spatial and radial velocity distributions of the two
components that they represent either field and cluster populations or
different episodes of star formation. Be-type stars have also been identified.
Conclusions: The bi-modal rotational velocity distribution in our sample
resembles that found for late-B and early-A type stars. While magnetic braking
appears to be a possible mechanism for producing the low-velocity component, we
can not rule out alternative explanations.Comment: to be publisged in A&
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