Interactive displays in medical art

Medical illustration is a field of visual communication with a long history. Traditional medical illustrations are static, 2-D, printed images; highly realistic depictions of the gross morphology of anatomical structures. Today medicine requires the visualization of structures and processes that have never before been seen. Complex 3-D spatial relationships require interpretation from 2-D diagnostic imagery. Pictures that move in real time have become clinical and research tools for physicians. Medical illustrators are involved with the development of interactive visual displays for three different, but not discrete, functions: as educational materials, as clinical and research tools, and as data bases of standard imagery used to produce visuals. The production of interactive displays in the medical arts is examined

The religious element in the popular ballads.

The present study of the religious element in the popular ballads is based largely on Mr. George L. Kittredge\u27s edition of Mr. Francis J. Child\u27s collection of English and Scottish popular ballads, the completeness of which, up to this time, has not been disputed.* Mr. Kittredge has printed in his volume one or more versions of every ballad which Mr. Child has given as an authentic folk ballad (omitting Nos. 33, 279, 281, 290 and 291), besides including a few of somewhat doubtful origin. It has not been judged necessary for the purposes of this article to discuss more than one version of any ballad, except in cases where a significant development of thought or custom is brought out by the different versions; consequently Mr. Kittredge\u27s single volume has been found most convenient and adequate. The numbers and names of ballads to which this paper refers are those used by both Mr. Child and Mr. Kittredge. The notes of both of these scholars have been consulted and quoted frequently and freely. The present work makes no claim to originality, but purposes to consider the ballads from one standpoint, their relation to the Christian religion and church, applying to the whole series the same touchstone, and grouping the facts which this test brings out under suitable headings

Destination Ventures, Ltd. v. F.C.C. and Moser v. F.C.C.: How Much Should the Telephone Consumer Protection Act Restrict Your Phone, Fax and Computer?

The Ninth Circuit upheld the constitutionality of the Telephone Consumer Protection Act (hereinafter TCPA ) in two February 1995 decisions: Destination Ventures, Ltd. v. F.C.C. and Moser v. F.C.C. Destination Ventures marked the first examination of the TCPA by any United States Court of Appeals. In that case, the Ninth Circuit held that the TCPA ban on unsolicited facsimile (hereinafter fax ) advertising was a constitutional regulation of commercial speech since the provision reasonably fit the government interest in preventing advertisement cost-shifting to the consumer. Five days later, in Moser, the same three-judge panel reversed a district court decision and upheld the TCPA\u27s bar of prerecorded telephone sales messages. The Ninth Circuit held that automated telemarketing threatens residential privacy which justifies narrowly tailored statutory restrictions on such marketing methods. This comment examines and attempts to reconcile these two Ninth Circuit decisions with prior Supreme Court holdings involving constitutional challenges to commercial speech regulations. It concludes that both Destination Ventures and Moser are consistent with the Constitution and with the Congress\u27 desire to avoid advertising cost-shifting. However, it suggests that the court exaggerated or overemphasized the harms caused by telemarketing and unsolicited fax advertising in upholding the corresponding regulations. Finally, it recommends that the TCPA be expanded to encompass other types of unsolicited faxing and to restrict advertising on the Internet

The Proposal in an Engineering Context: A Field Study of Document Development.

The specific goal of this field study was to develop an empirically-based description of engineering proposals as they are developed and used in their natural context; this goal was designed to provide a data base for further study addressing the general research interest of why the descriptions of proposals in technical writing textbooks vary so significantly from the types of proposals produced and used in an nonacacemic environment, specifically engineering. Using strategies borrowed and adapted from sociological and anthropological research methodologies, the study focused on collecting field-based data through interviews, field notes, questionnaires, and artifacts about the form, content, structure, and use of proposals by an engineering firm in state, federal, and municipal projects. Analysis of the data confirmed the discrepancy between the characterization of proposals in textbooks and the configuration and function of proposals in the study\u27s context. The staging framework, taxonomy, and lexicon developed for the proposals used by the firm highlighted four major focuses for further study: (1) a correlation between textbook and practice to develop more empirically-based guidelines for instruction; (2) a re-evaluation of the concept of audience as a fluid term that should be partitioned into more meaningful sub-categories such as user, use, function, or purpose in a specific context; (3) an analysis of the function of language in academic and nonacademic contexts to avoid arbitrary, meaningless, or unilateral labels; (4) a longitudinal study to analyze the evolution of content as controlled by form, use, and context

Destination Ventures, Ltd. v. F.C.C. and Moser v. F.C.C.: How Much Should the Telephone Consumer Protection Act Restrict Your Phone, Fax and Computer?

The Ninth Circuit upheld the constitutionality of the Telephone Consumer Protection Act (hereinafter TCPA ) in two February 1995 decisions: Destination Ventures, Ltd. v. F.C.C. and Moser v. F.C.C. Destination Ventures marked the first examination of the TCPA by any United States Court of Appeals. In that case, the Ninth Circuit held that the TCPA ban on unsolicited facsimile (hereinafter fax ) advertising was a constitutional regulation of commercial speech since the provision reasonably fit the government interest in preventing advertisement cost-shifting to the consumer. Five days later, in Moser, the same three-judge panel reversed a district court decision and upheld the TCPA\u27s bar of prerecorded telephone sales messages. The Ninth Circuit held that automated telemarketing threatens residential privacy which justifies narrowly tailored statutory restrictions on such marketing methods. This comment examines and attempts to reconcile these two Ninth Circuit decisions with prior Supreme Court holdings involving constitutional challenges to commercial speech regulations. It concludes that both Destination Ventures and Moser are consistent with the Constitution and with the Congress\u27 desire to avoid advertising cost-shifting. However, it suggests that the court exaggerated or overemphasized the harms caused by telemarketing and unsolicited fax advertising in upholding the corresponding regulations. Finally, it recommends that the TCPA be expanded to encompass other types of unsolicited faxing and to restrict advertising on the Internet

Inhibition of lipoprotein lipase by the receptor-binding domain of apolipoprotein E

AbstractA synthetic peptide (residues 139–153) corresponding to the receptor-binding domain of apolipoprotein E (ApoE) was tested for lipoprotein lipase (LPL) inhibitory properties. In systems using both natural and synthetic substrates, inhibition of LPL was observed. Using the synthetic substrate, 50% inhibition was observed at 50 μM while high concentrations completely inhibited LPL activity. These studies suggest an additional functional role for the receptor-binding domain of ApoE — modulation of LPL activity

Iodine-123 labeled reboxetine analogues for imaging of noradrenaline transporter in brain using single photon emission computed tomography

Preliminary investigation of the radioiodinated (S,S)-reboxetine analogue, 123I-INER, in baboons showed this tracer to have promise for imaging the noradrenaline transporter (NAT) using single photon emission computed tomography (SPECT). More recently, the radioiodinated (R,S)-stereoisomer of 123I-INER, 123I-NKJ64, has been synthesized and preliminary evaluation in rats has been reported. This article reports the brain distribution and pharmacokinetic properties of 123I-NKJ64 in baboons and compares results with 123I-INER data in the same species. SPECT studies were conducted in two ovariectomized adult female baboons using two different protocols: (1) bolus of 123I-INER or 123I-NKJ64; and (2) bolus plus constant infusion of 123I-NKJ64 with reboxetine (2.0 mg/kg) administration at equilibrium. Following bolus injection, both radiotracers rapidly and avidly entered the baboon brain. The regional brain accumulation of 123I-NKJ64 did not match the known distribution of NAT in baboon brain, contrasting with previous results obtained in rats. Conversely, the regional distribution of 123I-INER was consistent with known distribution of NAT in baboon brain. No displacement of 123I-NKJ64 was observed following administration of reboxetine. This contrasts with previous data obtained for 123I-INER, where 60% of specific binding was displaced by a lower dose of reboxetine. These data suggest that 123I-NKJ64 may lack affinity and selectivity for NAT in baboon brain and 123I-INER is the most promising iodinated reboxetine analogue developed to date for in vivo imaging of NAT in brain using SPECT. This study highlights the importance of species differences during radiotracer development and the stereochemical configuration of analogues of reboxetine in vivo. Synapse, 2012. -® 2012 Wiley Periodicals, In