Scale-invariant cellular automata and self-similar Petri nets

Two novel computing models based on an infinite tessellation of space-time are introduced. They consist of recursively coupled primitive building blocks. The first model is a scale-invariant generalization of cellular automata, whereas the second one utilizes self-similar Petri nets. Both models are capable of hypercomputations and can, for instance, "solve" the halting problem for Turing machines. These two models are closely related, as they exhibit a step-by-step equivalence for finite computations. On the other hand, they differ greatly for computations that involve an infinite number of building blocks: the first one shows indeterministic behavior whereas the second one halts. Both models are capable of challenging our understanding of computability, causality, and space-time.Comment: 35 pages, 5 figure

Prosopographische und diplomatische Ergänzungen zum Codex B des Ioannes Prodromos-Klosters bei Serrhai

Die Studie widmete sich dem Klerus der spätbyzantinischen Metropolis Serrhai (ca. 1270 bis 1360). Rezente Forschungen haben ergeben, dass die bisher bekannten prosopographischen Informationen zu vielen Mitgliedern des Klerus der Metropolis Serrhai einer Revision bedürfen. Dies wurde mittels dieser Arbeit geleistet.The study is concerned on the clerics of the late Byzantine metropolis Serrhai. Recent research work has shown many mistakes on biographic details of many clerics. This Diplomarbeit-thesis has been written to correct those mistakes giving a modern view of research

Pedestrian Wayfinding Under Consideration of Visual Impairment, Blindness, and Deafblindness: A Mixed-Method Investigation Into Individual Experiences and Supporting Elements

In this report we discuss to-date findings of a project that aimed at assessing individual and environmental affordances in the context of human pedestrian wayfinding of visually impaired, blind, and deafblind travelers in public spaces. Our project afforded collaboration, co-design, and co-creation of knowledge between the investigators, partners at the American Printing House of the Blind and GoodMaps, the Portland State University Digital City Testbed Center, and members of the disability community. The objective of the project was to better understand how different wayfinding aids, that is, wayfinding apps, tactile maps, and verbal route descriptions, are employed by visually impaired, blind, and deafblind travelers. On that account, we examined individual wayfinding behavior and experiences of visually impaired travelers who were tasked with the completion of a set of unfamiliar outdoor/indoor routes on the campus of Portland State University. Our methodology incorporated both qualitative and quantitative methods to evaluate the efficacy of wayfinding behavior, in general, and specifically route completion performance across a set of three routes and wayfinding aids. We expect that the insights garnered from our project drive forward the development of standards and innovation in mobile wayfinding in relation to best practices for technology-mediated pedestrian wayfinding of visually impaired, blind, and deafblind travelers in public spaces

Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion

Data Availability: All relevant data are available from the Gene Expression Omnibus at the following accession number: GSE97755. Funding: This work was funded by the German Research Council (DFG) Graduation College 685, Dr. Jekyll and Mr. Hyde: A systems approach to the therapy of nosocomial infections caused by Candida albicans: a commensal organism switches to a deadly pathogen/ PTJ (FKZ: 0315409BBMBF), the Dr. Manfred Plempel-foundation, the Dr. Siegried Stettendorf-Foundation, the InfectERA Program (FunComPath; BMBF FKZ 031L0001A), the Integrated Research and Treatment Center for Sepsis Control and Care (CSCC) project CanBac (BMBF, FKZ: 01EO1002), and the German Research Council (DFG) GZ:HE7565/1-1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Lie algebroid morphisms, Poisson Sigma Models, and off-shell closed gauge symmetries

Chern-Simons gauge theories in 3 dimensions and the Poisson Sigma Model (PSM) in 2 dimensions are examples of the same theory, if their field equations are interpreted as morphisms of Lie algebroids and their symmetries (on-shell) as homotopies of such morphisms. We point out that the (off-shell) gauge symmetries of the PSM in the literature are not globally well-defined for non-parallelizable Poisson manifolds and propose a covariant definition of them as left action of some finite-dimensional Lie algebroid. Our approach allows to avoid complications arising in the infinite dimensional super-geometry of the BV- and AKSZ-formalism. This preprint is a starting point in a series of papers meant to introduce Yang-Mills type gauge theories of Lie algebroids, which include and generalize the standard YM theory, the PSM, and gerbes.Comment: 24 page

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation

Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported by a Vici grant of the Netherlands Organisation for Scientific Research. AJPB and DMM were funded by STRIFE, ERC-2009-AdG-249793 and AJPB additionally by FINSysB, PITN-GA-2008-214004 and the BBSRC [BB/F00513X/1]. MDL was supported by the MRC (MR/J008230/1). GDB and SV were funded by the Wellcome Trust (086558) and TB and MK were funded by the Deutsche Forschungsgemeinschaft (Bi 696/3-1; Bi 696/5-2; Bi 696/10-1). MS was supported by the Deutsche Forschungsgemeinschaft (Sch 897/1-3) and the National Institute of Dental and Craniofacial Research (R01 DE017514-01). TDK and RKSM were funded by the National Institute of Health (AR056296, AI101935) and the American Lebanese Syrian Associated Charities (ALSAC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD