Algorithmic Approaches to Game-theoretical Modeling and Simulation

This paper deals with a methodology of computer modeling and simulation of market competitive situations using game theory. The situations are thematically focused mostly to models of commodity markets but the applications of the methodology can be wider. This methodology covers the whole modeling work, including a primary specification of a problem, making an abstract model, making a simulation model, design of a state space of the problem and the simulator itself. As a whole, the methodology represents a complete framework for implementation of computer models of commodity markets suitable for their further analysis and prediction of their future evolution. The main contribution of the paper consists in the algorithmic implementation of computer processing of large strategic game.Market models, non-cooperative game theory, modeling and simulation, artificial intelligence

GAL Framework

GAL (GIS or GRASS? Abstraction Layer) Framework is meant to be multiplatform OpenSource library with certain tools and subsidiary daemons for easy implementation of distributed modules for GIS GRASS in static or dynamic programming languages. This article aims to present some ideas behind this library and bait a fresh meat for this project since its complexity needs more spread development team not just single person. Project homepage can be found at http://gal-framework.no-ip.org

GAL Framework – Current State of the Project

The GAL (GIS Abstraction Layer) Framework is a component-architecture-oriented1 remote procedure call (RPC) library with implementations of GIS-related subsystems communicating using the library and a set of demonstrational and testing tools utilizing that services. It doesn’t aim to be a full-featured solution for GIS application construction but a proposal for possible incremental GRASS GIS2 modernization. This article summarizes current state of the project, it’s history, application and potential and also presents options for further advancement and areas of possible participation. Only a concern of other developers or users and the time may transform this idea into something practically usable

Heating Solution in the Family House

Předmětem této bakalářské práce byl návrh stavebně konstrukčního řešení rodinného domu s obytným podkrovím a rovněž také návrh vytápění se dvěma variantami zdroje tepla. Jako první řešení bylo zvoleno vytápění kondenzační technologií, ve formě plynového kondenzačního kotle a jako druhá možnost bylo navrženo tepelné čerpadlo na bázi systému vzduch-voda. Díky schopnosti těchto zdrojů tepla pracovat v nízkoteplotním režimu a také faktem, že konstrukce byly navrženy na doporučené hodnoty součinitele prostupu tepla, bylo v celém objektu zvoleno podlahové vytápění bez otopných těles napojených na otopnou soustavu. Dále byla řešena příprava teplé vody, a to pomocí externího nepřímotopného zásobníku. Bakalářská práce byla rozdělena do třech hlavních částí. První z nich je technická zpráva, další je přílohová část s výpočty a technickými listy, a nakonec výkresová část stavebně konstrukčního řešení a vytápění. Projekt, který obsahuje tato práce byl zpracován ve stupni dokumentace pro provádění staveb.Subject of this bachelor thesis was a structural design of two-story detached house and also the design of heating system in this house with two versions of heat sources. Condensing technology heating, in form of a gas condensing boiler was chosen as the first solution, and as a second solution, it was chosen a heat pump with air-water system. Thanks to the properties of these heat sources, that they are allowing to operate on low temperature mode and also by the fact that the construction was designed to achieve recomended values of heat transfer coefficient, which allowed to implement floor heating system without radiators connected to the heating systém. Furthermore, the preparation of hot water was solved by using an external indirect heating tank. This bachelor thesis was divided into four main parts. The first of them is a technical report, followed by an economic evaluation of two variants of heat sources. Next is the appendix part with calculations and technical sheets and finally the drawing part of the construction design and heating. The thesis that contains this work was developed at the stage of detail design documentation.229 - Katedra prostředí staveb a TZBvýborn

Heating the guest house with an LPG heat source

Předmětem této diplomové práce byl návrh architektonicko-stavebního řešení penzionu a také návrh vytápění, způsob ohřevu teplé vody a odběrného plynového zařízení. Jako zdroj tepelné energie byl v objektu uvažován LPG spalovaný v plynovém kondenzačním kotli umístěném v objektu. Z tohoto důvodu tato práce řeší také návrh tlakové stanice LPG včetně vnitřních a vnějších rozvodů domovního plynovodu. Pro objekt byl také vyhotoven průkaz energetické náročnosti budovy. Diplomové práce byla rozdělena do třech hlavních částí. První z nich je technická zpráva, další je přílohová část s výpočty a technickými listy, a nakonec výkresová část stavebně konstrukčního řešení, vytápění a odběrného plynového zařízení. Projekt, který obsahuje tato práce byl zpracován ve stupni dokumentace pro provádění staveb.The subject of this diploma thesis was the design of the architectural and constructional solution of the guesthouse and also the design of the heating system, the method of hot water heating and the gas consumption equipment. As a source of heat energy in the building was considered LPG burned in a gas condensing boiler located in the building. Therefore, this work also addresses the design of the LPG pressure station including the internal and external distribution of the domestic gas pipeline. An energy performance certificate for the building was also prepared. The thesis has been divided into three main parts. The first is the technical report, the next is the appendix part with calculations and technical sheets, and finally the drawing part of the structural design, heating and gas consumer equipment. The project containing this work was prepared at the stage of documentation for the execution of the construction.229 - Katedra prostředí staveb a TZBvýborn

Perfluorinated and polyfluorinated substances in ski waxes

Perfluorinated and polyfluorinated compounds (PFAS) represent a group of thousands of anthropogenically produced substances. The strong bonding of carbon and fluorine gives these compounds unique properties, which have been used in ski waxes, among other applications. There is limited data on the specific PFAS used in wax production. This is due not only to the difficulty of analysis but also to the reluctance of manufacturers to disclose this information. The application of ski waxes has been associated with increased PFAS concentrations in the blood and some lung problems. Because of their persistence in ski areas, PFAS can be found in snow, soil, animals and plants. Although there is a gradual ban on the production and use of these substances, the issue of PFAS in ski waxes continues. This paper focuses on particular aspects of the issue. Key words: perfluorinated and polyfluorinated substances, PFAS, PFOA, ski waxesPerfluorované a polyfluorované sloučeniny (PFAS) představují skupinu tisíců antropogenně vytvořených látek. Silná vazba uhlíku a fluoru dává těmto sloučeninám jedinečné vlastnosti, kterých bylo využito mimo jiné v lyžařských voscích. Existují omezená data o konkrétních PFAS užívaných při výrobě vosků. Důvodem je nejen náročná analýza, ale také neochota výrobců tyto informace sdělit. Aplikace lyžařských vosků je spojována se zvýšenými koncentracemi PFAS v krvi a některými plicními problémy. Kvůli perzistentnosti se PFAS v lyžařských oblastech dají nalézt ve sněhu, půdě, zvířatech i na rostlinách. Přestože dochází k postupnému zakazování výroby a užívání těchto látek, problematika PFAS v lyžařských voscích přetrvává. Tato práce se zaměřuje na jednotlivé aspekty celé problematiky. Klíčová slova: perfluorované a polyfluorované sloučeniny, PFAS, PFOA, lyžařské voskyInstitute for Environmental StudiesÚstav pro životní prostředíFaculty of SciencePřírodovědecká fakult

Identification of Dynamics of Movement of the Differential Mobile Robotic Platform Controlled by Fuzzy Controller

Mobile robots with differential chassis are very often used because of simple construction and a smaller number of drive and sensors elements. For practical applications, it is necessary to know the kinematic and dynamic structure of the differential mobile robot. This paper deals with identification of the dynamics of the differential robotic platform, using differential kinematics. Electro-optical rpm sensors obtain required values such as speed of the driven wheels. Identification of dynamic system is used to determine the dynamic characteristics of power subsystem of developed EN 20 robot, whose control subsystem is created by single-chip microcontroller. Response of the dynamic system is monitored along with the peripheral velocity of the right and left drive wheels. Incremental encoders that work on optics principle measure the speeds of both wheels. It was necessary to calibrate the sensors and obtain constants for precise speed determination. The monitored system with the dumped oscillation characteristic is approximated by a system with the inertia of the 2nd order. Dynamic system parameters are found. The system approximation is suitable for given evolution of circumferential speeds of the right and left wheels. This is confirmed by the quantitative determination coefficients R2. The equations for calculating peripheral velocities of driving wheels are applied to the system of the differential equations for the differential chassis. A mathematical model of the mobile robot EN20 was obtained for testing control algorithms, where a robot is equipped with sensory systems and it is designed for interior conditions. Fuzzy controller with 49 interference rules is used to control the mobile robot. The real mobile robot path matches the path determined according to simulation model

Paclitaxel-loaded biodegradable ROS-sensitive nanoparticles for cancer therapy

Source at https://doi.org/10.2147/IJN.S208938. Background: Reactive oxygen species (ROS), such as hydrogen peroxide and superoxide, trigger biodegradation of polymer-based nanoparticles (NPs) bearing pinacol-type boronic ester groups. These NPs may selectively release their cargo, in this case paclitaxel (PTX), at the high levels of ROS present in the intracellular environment of inflamed tissues and most tumors. Purpose: The main objective was to determine anti-tumor efficacy of PTX-loaded ROS-sensitive NPs and to examine whether macrophage infiltration had any impact on treatment efficacy. Methods: NPs were synthesized and their characteristics in the presence of H2O2 were demonstrated. Both confocal microscopy as well as flow cytometry approaches were used to determine degradation of ROS-sensitive NPs. HeLa cells were cultured in vitro and used to establish tumor xenografts in nude mice. In vivo experiments were performed to understand toxicity, biodistribution and anti-tumor efficacy of the NPs. Moreover, we performed immunohistochemistry on tumor sections to study infiltration of M1 and M2 subsets of macrophages. Results: We demonstrated that PTX delivered in NPs containing a ROS-sensitive polymer exhibits a better anti-tumor efficacy than PTX in NPs containing ROS-non-sensitive polymer, free PTX or Abraxane® (nab-PTX). The biodistribution revealed that ROS-sensitive NPs exhibit retention in liver, spleen and lungs, suggesting a potential to target cancer metastasizing to these organs. Finally, we demonstrated a correlation between infiltrated macrophage subsets and treatment efficacy, possibly contributing to the efficient anti-tumor effects. Conclusion: Treatment with ROS-sensitive NPs containing PTX gave an improved therapeutic effect in HeLa xenografts than their counterpart, free PTX or nab-PTX. Our data revealed a correlation between macrophage infiltration and efficiency of the different antitumor treatments, as the most effective NPs resulted in the highest infiltration of the anti-tumorigenic M1 macrophages