Feminist Friendship as an Affective Engagement through the Arts: A Decolonial and Posthuman Becoming-with Rebeca Lane\u27s \u3cem\u3eAlma Mestiza\u3c/em\u3e

This paper considers friendship as an affective terrain of feminist alliance among subjects that belong to territories with a colonial record responding to the colonial/modern gender system (Lugones 2007) through the arts. Friendship is here conceptualized as an engagement of feminist solidarity unfolding within theoretical and practical models of change and resistance against the logics of cultural imperialism (Lugones and Spelman 1983). Turning friendship into a polyphonic feminist reaction, this work is conducted by acknowledging the need to foster dialogues where different authorial voices and feminist positionalities meet, reflect, and speak. The paper settles the encounter between its authors in conversation with Guatemalan feminist rapper Rebeca Lane and her song Alma Mestiza ( Mestiza Soul, 2016), which triggers both a critical examination of decolonial artistic practices with a feminist commitment, and a situated response of auto-phenomenographic poetry (Lykke 2018) . In this light, the present paper is born out of the authors\u27 will to pose their friendship as an affective commitment to formulate critical and artistic accounts of a feminist nature displaying a decolonial awareness, while incorporating a posthuman approach becoming-with artistic material (Straube 2014)

Evaluación institucional de contenidos y proyectos de investigación en un CPI: Caso de estudio (2013-2022)

Purpose. Intra and inter-institutional content were evaluated in a CPI case study through the transdisciplinary use of organizational up-down/bottom-up approaches and automated content analysis tools. Methodology. A CPI case study established a system of intra (program and research projects) and inter (national issues) contents during 2013-2022. It was structured from an up-down/bottom-up perspective and evaluated using automated content analysis tools. Reliability and validity were established based on a system of heuristic rules and similarity analysis among groups of documents. Theoretical and practical Findings. As a theoretical contribution (Scientia), an inter and intra- institutional content model was developed based on up-down/bottom-up evaluation systems. In the practical contribution (Praxis), areas of opportunity were identified to improve academic alignment and orientation processes. Transdisciplinary and sustainable innovation originality. An innovative and transdisciplinary theoretical-methodological tool was developed, integrating Mexican laws related to national issues, programs, and research projects from a CPI case study. These were structured and evaluated using up-down/bottom-up organizational perspectives and massive document analysis. This achievement resulted in an evaluation system that improves the integration and sustainability of current academic evaluation systems. Conclusions and limitations. Content generation is an essential part of academic production in HEIs and CPIs, thus making its evaluation indispensable. Furthermore, combining content analysis and statistical methods is necessary as avenues for transdisciplinary innovation that foster fair and sustainable academic production and evaluation systems.Objetivo. Se evaluó el contenido intra e inter institucional de un CPI caso de estudio, a través del uso transdisciplinario de análisis organizacionales up-down/bottom-up y herramientas de contenido automatizado. Metodología. Se fundamentó un sistema de contenidos intra (programa y proyectos de investigación) e inter (problemas nacionales) en un CPI caso de estudio en el periodo 2013-2022, el cual fue estructurado desde una perspectiva up-down/bottom-up y evaluado por medio de herramientas de análisis de contenido automatizado. La confiabilidad y validez se estableció de acuerdo a un sistema de reglas heurísticas y de análisis de similitud entre grupo de documentos. Hallazgos Teóricos y Prácticos. Como contribución teórica (Scientia), se desarrolló un modelo de contenido inter e intra institucional basado en sistemas de evaluación up-down/bottom-up. En la práctica (Praxis), se identificaron áreas de oportunidad para mejorar los procesos de alineación y de orientación académica. Originalidad desde el punto de vista transdisciplinar y de innovación sostenible. Se desarrolló una herramienta teórico-metodología innovadora y transdisciplinaria que integró leyes mexicanas relacionadas a problemas nacionales, así como programas y proyectos de investigación de un CPI caso de estudio, estructurados y evaluados entorno a perspectivas organizacionales up-down/bottom- up y a través del análisis masivo de documentos. Logrando un sistema de evaluación que contribuye a mejorar la integración y sostenibilidad de los sistemas actuales de evaluación académica. Conclusiones y limitaciones. La generación de contenido es una parte esencial de la producción académica en IES y CPIs, por lo que es indispensable evaluarla. Así también, es necesario combinar análisis de contenido y métodos estadísticos como vías de innovación transdisciplinar que fomenten sistemas de producción y evaluación académica más justas y sostenibles

The earliest evidence of true lambdoid craniosynostosis: the case of “Benjamina”, a Homo heidelbergensis child

Background The authors report the morphological and neuroimaging findings of an immature human fossil (Cranium 14) diagnosed with left lambdoid synostosis. Discussion The skull was recovered at the Sima de los Huesos site in Atapuerca (Burgos, Spain). Since the human fossil remains from this site have been dated to a minimum age of 530,000 years, this skull represents the earliest evidence of craniosynostosis occurring in a hominid. A brief historical review of craniosynostosis and cranial deformation is provided

Effect of textile dyes on activity and differential regulation of laccase genes from Pleurotus ostreatus grown in submerged fermentation

Additional file 1: Figure S1. Growth of P. ostreatus and pH profile in submerged fermentations in BMF (●black circle), BBF (■ black square) and AYF (♦black diamond) media. The error bars represent the standard deviation of three different fermentation runs. Figure S2. Genorm analysis of the expression stability of 4 reference genes. Figure S3. Variability of Cp values of 4 reference genes tested under the 3 different fermentation conditions using NormFinder. Table S1. Identifiers and product lengths of reference genes primers used in this study

Rendimiento diagnóstico de repetir la biopsia guiada por ultrasonido endoscópico después de una primera biopsia negativa en pacientes con lesiones no pancreáticas

ResumenIntroducciónEl ultrasonido endoscópico has sido un método útil para la evaluación de la enfermedad pancreatobiliar por más de una década, sin embargo no es un escenario raro el encontrar resultados patológicos no concluyentes en el tejido obtenido para el diagnóstico. Entre los factores que alteran el rendimiento diagnóstico se encuentran la experiencia del endosonografista, el volumen de procedimientos realizados, el tipo, el tamaño y la localización, entre otros. El objetivo del presente estudio fue evaluar el rendimiento diagnóstico de la segunda USE-BAAF en las lesiones no pancreáticas.Material y métodosSe realizó un estudio retrospectivo y transversal. Se incluyeron pacientes >18 años a los que se les realizó USE-BAAF durante el periodo de 8 años.ResultadosSe realizaron 150 procedimientos en 132 pacientes con lesiones no pancreáticas. Finalmente, el diagnóstico se logró por USE-BAAF en 114/132 pacientes, para un rendimiento diagnóstico global de 86.63%. En total, la mediana (intervalo mínimo-máximo) de biopsias fue de 1 (1-5). El rendimiento diagnóstico de la primera USE-BAAF fue de 77.3% (102/132). Se realizó una segunda biopsia en 16/132 (12.1%) pacientes. Con la segunda USE-BAAF se observó un aumento del rendimiento global a 113/132 pacientes (11/16=68.7%; global 85.6%). No se observaron complicaciones.ConclusiónEl repetir la USE-BAAF en lesiones no pancreáticas es necesario en pacientes con una primera negativa USE-BAAF, ya que mejora el rendimiento diagnóstico.AbstractIntroductionEndoscopic ultrasound has been a useful method for the evaluation of pancreatobiliary pathology for more than a decade, however it is not unusual to find inconclusive pathological results in tissue obtained for diagnosis. The factors affecting diagnostic performance include; endosonographist experience, the volume of procedures performed, type, size and location, amongst others. The aim of this study was to evaluate the diagnostic performance of the second EUS-FNA in non-pancreatic lesions.Material and methodsA retrospective cross-sectional study that includedpatients>18 years who underwent EUS-FNA over a period of 8 years.Results150 procedures were performed in 132 patients with non-pancreatic lesions. Finally, the diagnosis was obtained by EUS-FNA in 114/132 patients for a diagnostic yield of 86.6%. In total, the biopsy median (minimum/maximum interval) was 1 (1-5). The diagnostic yield of the first EUS-FNA was 77.3% (102/132). With the second EUS-FNA 11/16 patients had a histological diagnosis (11/16=68.7%; global 85.6%). No complications were reported.ConclusionRepeat EUS-FNA in patients with non-pancreatic lesions is necessary in patients with a first negative EUS-FNA because it improves the diagnostic yield

The synthetic molecule stauprimide impairs cell growth and migration in triple-negative breast cancer

Stauprimide, a semi-synthetic derivative of staurosporine, is known mainly for its potent differentiation-enhancing properties in embryonic stem cells. Here, we studied the effects of stauprimide in cell growth and migration of triple-negative breast cancer cells in vitro, evaluating its potential antitumoral activity in an orthotopic mouse model of breast cancer in vivo. Our results from survival curves, EdU incorporation, cell cycle analysis and annexin-V detection in MDA-MB-231 cells indicated that stauprimide inhibited cell proliferation, arresting cell cycle in G2/M without induction of apoptosis. A decrease in the migratory capability of MDA-MB-231 was also assessed in response to stauprimide. In this work we pointed to a mechanism of action of stauprimide involving the modulation of ERK1/2, Akt and p38 MAPK signalling pathways, and the downregulation of MYC in MDA-MB-231 cells. In addition, orthotopic MDA-MB-231 xenograft and 4T1 syngeneic models suggested an effect of stauprimide in vivo, increasing the necrotic core of tumors and reducing metastasis in lung and liver of mice. Together, our results point to the promising role of stauprimide as a putative therapeutic agent in triple-negative breast cancer.MRI experiments were performed in the ICTS “NANBIOSIS”, more specifically in the U28 Unit at the Andalusian Centre for Nanomedicine & Biotechnology (BIONAND). Cell cultures were performed in the Cell Culture Service at the Central Support Services of Research (SCAI) of the University of Málaga. // Partial funding for open access charge: Universidad de Málaga / CBUA

Riesgo quirúrgico tras resección pulmonar anatómica en cirugía torácica. Modelo predictivo a partir de una base de datos nacional multicéntrica

Introduction: the aim of this study was to develop a surgical risk prediction model in patients undergoing anatomic lung resections from the registry of the Spanish Video-Assisted Thoracic Surgery Group (GEVATS). Methods: data were collected from 3,533 patients undergoing anatomic lung resection for any diagnosis between December 20, 2016 and March 20, 2018. We defined a combined outcome variable: death or Clavien Dindo grade IV complication at 90 days after surgery. Univariate and multivariate analyses were performed by logistic regression. Internal validation of the model was performed using resampling techniques. Results: the incidence of the outcome variable was 4.29% (95% CI 3.6-4.9). The variables remaining in the final logistic model were: age, sex, previous lung cancer resection, dyspnea (mMRC), right pneumonectomy, and ppo DLCO. The performance parameters of the model adjusted by resampling were: C-statistic 0.712 (95% CI 0.648-0.750), Brier score 0.042 and bootstrap shrinkage 0.854. Conclusions: the risk prediction model obtained from the GEVATS database is a simple, valid, and reliable model that is a useful tool for establishing the risk of a patient undergoing anatomic lung resection

SARS-CoV-2 Infection in Multiple Sclerosis

To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. Retrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations between MS characteristics and COVID-19 course and for identifying risk factors for a fatal outcome. Of the 326 patients analyzed, 120 were cases confirmed by real-time PCR, 34 by a serologic test, and 205 were suspected. Sixty-nine patients (21.3%) developed severe infection, 10 (3%) critical, and 7 (2.1%) died. Ambulatory patients were higher in relapsing MS forms, treated with injectables and oral first-line agents, whereas more severe cases were observed in patients on pulsed immunosuppressors and critical cases among patients with no therapy. Severe and critical infections were more likely to affect older males with comorbidities, with progressive MS forms, a longer disease course, and higher disability. Fifteen of 33 patients treated with rituximab were hospitalized. Four deceased patients have progressive MS, 5 were not receiving MS therapy, and 2 were treated (natalizumab and rituximab). Multivariate analysis showed age (OR 1.09, 95% CI, 1.04-1.17) as the only independent risk factor for a fatal outcome. This study has not demonstrated the presumed critical role of MS therapy in the course of COVID-19 but evidenced that people with MS with advanced age and disease, in progressive course, and those who are more disabled have a higher probability of severe and even fatal diseas