Magnetic Polarity Stratigraphy and \u3csup\u3e40\u3c/sup\u3eK-\u3csup\u3e40\u3c/sup\u3eAR Dating of Late Miocene and Early Pliocene Continental Deposits, Catamarca Province, NW Argentina

Magnetostratigraphic and 40K-40Ar data on a 2300 m thick sequence of continental sediments at Puerta de Corral Quemado in Catamarca Province, NW Argentina permit calibration of land mammal faunas of late Tertiary (Huayquerian and Montehermosan) age. The sequence represents (from oldest to youngest) the Chiquimil A, Araucanense, and Corral Quemado Formations. Paleomagnetic samples were collected from 99 stratigraphic levels. Strong-field thermomagnetic and isothermal remanent magnetization experiments indicate that the dominant ferrimagnetic mineral is magnetite. Progressive alternating-field (AF) and themal demagnetization of the natural remanent magnetism (NRM) demonstrates that AF demagnetization to 20 mT peak field is sufficient to isolate the primary NRM which is of depositional origin. The resulting paleomagnetic data provide a well-defined magnetic polarity zonation, although sampling is less dense in the upper half of the section. 40K-40Ar data obtained from mineral separates of four tuffs within the section allow reliable age determinations for those levels. The combined magnetostratigraphic and 40K-40Ar data allow the magnetic polarity zonation to be correlated with the magnetic polarity time scale. This correlation indicates a nearly constant rate of sediment accumulation between ~8.0 Ma and 3.5 Ma. The boundary between the Araucanense and Corral Quemado Formations approximates the boundary between the Huayquerian and Montehermosan land mammal age faunas at this locality. The data presented here allow the boundary between the Araucanense and Corral Quemado Formations to be dated at 6.4 Ma. Combined with geochronologic data from similar age rocks and faunas from San Carlos, Mendoza Province, west-central Argentina, the geochronologic data from Puerta de Corral Quemado allow the Huayquerian-Monteher-mosan land mammal age boundary to be placed tentatively at 6.0 Ma. A specimen of the fossil land mammal Cyonasua (family Procyonidae) from unit 14 of the Araucanense Formation is dated at 7.0 to 7.5 Ma. This specimen is the earliest known representative of this North American group in South America and represents the oldest dated participant in the Great American Faunal Interchange on that continent

Geochronology of Type Santacrucian (Middle Tertiary) Land Mammal Age, Patagonia, Argentina

Mammal-bearing lacustrine and tuffaceous sediments from three localities of the Santa Cruz Formation, type fauna of the Santacrucian Land Mammal Age, in Patagonia, southern Argentina, are calibrated by radioisotope dating with the aid of magnetostratigraphy. The strata range from about 17.6 Ma to perhaps 16.0 Ma, and are thus of late-early Miocene age. The Santacrucian Land Mammal Age ranges from about 18.0 Ma to about 15.0 Ma

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the relevant cellular sources of IL-10, as well as the pathways responsible for IL-10 induction, remain unclear. In this study, we traced IL-10 production over the course of chronic lymphocytic choriomeningitis virus (LCMV) infection in an IL-10 reporter mouse line. Using this model, we demonstrated that virus-specific T cells with reduced inflammatory function, particularly Th1 cells, display elevated and sustained IL-10 expression during chronic LCMV infection. Furthermore, ablation of IL-10 from the T cell compartment partially restored T cell function and reduced viral loads in LCMV-infected animals. We found that viral persistence is needed for sustained IL-10 production by Th1 cells and that the transcription factor BLIMP-1 is required for IL-10 expression by Th1 cells. Restimulation of Th1 cells from LCMV-infected mice promoted BLIMP-1 and subsequent IL-10 expression, suggesting that constant antigen exposure likely induces the BLIMP-1/IL-10 pathway during chronic viral infection. Together, these data indicate that effector T cells self-limit their responsiveness during persistent viral infection via an IL-10-dependent negative feedback loop.This work was supported by an Australian NHMRC Overseas Biomedical Postdoctoral Fellowship (to I.A. Parish); a Yale School of Medicine Brown-Coxe Postdoctoral Fellowship (to I.A. Parish); the Alexander von Humboldt Foundation (SKA2010, to P.A. Lang); a CIHR grant (to P.S. Ohashi); and by the Howard Hughes Medical Institute and NIH grant RO1AI074699 (to S.M. Kaech). P.S. Ohashi holds a Canada Research Chair in Autoimmunity and Tumor immunity

Mobile Object Tracking in Panoramic Video and LiDAR for Radiological Source-Object Attribution and Improved Source Detection

The addition of contextual sensors to mobile radiation sensors provides valuable information about radiological source encounters that can assist in adjudication of alarms. This study explores how computer-vision based object detection and tracking analyses can be used to augment radiological data from a mobile detector system. We study how contextual information (streaming video and LiDAR) can be used to associate dynamic pedestrians or vehicles with radiological alarms to enhance both situational awareness and detection sensitivity. Possible source encounters were staged in a mock urban environment where participants included pedestrians and vehicles moving in the vicinity of an intersection. Data was collected with a vehicle equipped with 6 NaI(Tl) 2 inch times 4 inch times 16 inch detectors in a hexagonal arrangement and multiple cameras, LiDARs, and an IMU. Physics-based models that describe the expected count rates from tracked objects are used to correlate vehicle and/or pedestrian trajectories to measured count-rate data through the use of Poisson maximum likelihood estimation and to discern between source-carrying and non-source-carrying objects. In this work, we demonstrate the capabilities of our source-object attribution approach as applied to a mobile detection system in the presence of moving sources to improve both detection sensitivity and situational awareness in a mock urban environment

Impact of HIV-Associated Conditions on Mortality in People Commencing Anti-Retroviral Therapy in Resource Limited Settings

To identify associations between specific WHO stage 3 and 4 conditions diagnosed after ART initiation and all cause mortality for patients in resource-limited settings (RLS). DESIGN, SETTING: Analysis of routine program data collected prospectively from 25 programs in eight countries between 2002 and 2010

Incidence of WHO stage 3 and 4 conditions following initiation of Anti-Retroviral Therapy in resource limited settings

To determine the incidence of WHO clinical stage 3 and 4 conditions during early anti-retroviral therapy (ART) in resource limited settings (RLS)

Thermal Cycle Testing of the Powersphere Engineering Development Unit

During the past three years the team of The Aerospace Corporation, Lockheed Martin Space Systems, NASA Glenn Research Center, and ILC Dover LP have been developing a multifunctional inflatable structure for the PowerSphere concept under contract with NASA (NAS3-01115). The PowerSphere attitude insensitive solar power-generating microsatellite, which could be used for many different space and Earth science purposes, is ready for further refinement and flight demonstration. The development of micro- and nanosatellites requires the energy collection system, namely the solar array, to be of lightweight and small size. The limited surface area of these satellites precludes the possibility of body mounting the solar array system for required power generation. The use of large traditional solar arrays requires the support of large satellite volumes and weight and also requires a pointing apparatus. The current PowerSphere concept (geodetic sphere), which was envisioned in the late 1990 s by Mr. Simburger of The Aerospace Corporation, has been systematically developed in the past several years.1-7 The PowerSphere system is a low mass and low volume system suited for micro and nanosatellites. It is a lightweight solar array that is spherical in shape and does not require a pointing apparatus. The recently completed project culminated during the third year with the manufacturing of the PowerSphere Engineering Development Unit (EDU). One hemisphere of the EDU system was tested for packing and deployment and was subsequently rigidized. The other hemisphere was packed and stored for future testing in an uncured state. Both cured and uncured hemisphere components were delivered to NASA Glenn Research Center for thermal cycle testing and long-term storage respectively. This paper will discuss the design, thermal cycle testing of the PowerSphere EDU

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.

© 2014 Haider et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Improved usage of the repertoires of pancreatic ductal adenocarcinoma (PDAC) profiles is crucially needed to guide the development of predictive and prognostic tools that could inform the selection of treatment options

KELT-18b: Puffy Planet, Hot Host, Probably Perturbed

We report the discovery of KELT-18b, a transiting hot Jupiter in a 2.87-day orbit around the bright ( V = 10.1), hot, F4V star BD+60 1538 (TYC 3865-1173-1). We present follow-up photometry, spectroscopy, and adaptive optics imaging that allow a detailed characterization of the system. Our preferred model fits yield a host stellar temperature of K and a mass of , situating it as one of only a handful of known transiting planets with hosts that are as hot, massive, and bright. The planet has a mass of , a radius of , and a density of , making it one of the most inflated planets known around a hot star. We argue that KELT-18b’s high temperature and low surface gravity, which yield an estimated ∼600 km atmospheric scale height, combined with its hot, bright host, make it an excellent candidate for observations aimed at atmospheric characterization. We also present evidence for a bound stellar companion at a projected separation of ∼1100 au, and speculate that it may have contributed to the strong misalignment we suspect between KELT-18\u27s spin axis and its planet’s orbital axis. The inferior conjunction time is 2457542.524998 ± 0.000416 (BJD TDB ) and the orbital period is 2.8717510 ± 0.0000029 days. We encourage Rossiter–McLaughlin measurements in the near future to confirm the suspected spin–orbit misalignment of this system