Formação de professores: letramento para docência em matemática

Neste trabalho objetivamos socializar a experiência de formação docente realizada através da articulação entre professores alfabetizadores de uma escola da rede pública estadual de Mato Grosso e acadêmicos da Licenciatura em Matemática do IFMT/Brasil, de julho a dezembro de 2016. Neste projeto de extensão, a temática abordada foi o letramento matemático. A partir de Imbernón (2010), Gonçalves (2010), Kleiman (2008), Nóvoa (1992), e Soares (2006), entendemos que é desafio da formação continuada, através do letramento matemático, garantir condições e conhecimentos para que os docentes possam pensar, propor e construir um currículo matemático significativo aos alunos; assim como é desafio da formação inicial oportunizar aos futuros docentes vivências de situações que possibilitem a experimentação, o estudo e a reflexão sobre inovações metodológicas para o ensino de matemática. Nesta perspectiva, formamos um grupo de estudos, realizando encontros mensais para aprofundamento de elementos teóricos, de experimentação de materiais didático-pedagógicos e de reflexão sobre a prática e os saberes docentes. Foram resultados deste projeto de formação docente: a prática de um trabalho colaborativo; a troca de experiências; a reflexão sobre a prática docente; mudanças nas práticas de algumas professoras da escola, propiciando melhores condições de aprendizagem matemática aos seus alunos

Expression of non-TLR pattern recognition receptors in the spleen of BALB/c mice infected with Plasmodium yoelii and Plasmodium chabaudi chabaudi AS

The spleen plays a crucial role in the development of immunity to malaria, but the role of pattern recognition receptors (PRRs) in splenic effector cells during malaria infection is poorly understood. In the present study, we analysed the expression of selected PRRs in splenic effector cells from BALB/c mice infected with the lethal and non-lethal Plasmodium yoelii strains 17XL and 17X, respectively, and the non-lethal Plasmodium chabaudi chabaudi AS strain. The results of these experiments showed fewer significant changes in the expression of PRRs in AS-infected mice than in 17X and 17XL-infected mice. Mannose receptor C type 2 (MRC2) expression increased with parasitemia, whereas Toll-like receptors and sialoadhesin (Sn) decreased in mice infected with P. chabaudi AS. In contrast, MRC type 1 (MRC1), MRC2 and EGF-like module containing mucin-like hormone receptor-like sequence 1 (F4/80) expression decreased with parasitemia in mice infected with 17X, whereas MRC1 an MRC2 increased and F4/80 decreased in mice infected with 17XL. Furthermore, macrophage receptor with collagenous structure and CD68 declined rapidly after initial parasitemia. SIGNR1 and Sn expression demonstrated minor variations in the spleens of mice infected with either strain. Notably, macrophage scavenger receptor (Msr1) and dendritic cell-associated C-type lectin 2 expression increased at both the transcript and protein levels in 17XL-infected mice with 50% parasitemia. Furthermore, the increased lethality of 17X infection in Msr1 -/- mice demonstrated a protective role for Msr1. Our results suggest a dual role for these receptors in parasite clearance and protection in 17X infection and lethality in 17XL infection.CNPqCNPqFAPESP [01/09401-0]FAPESPEuropean CommunityEuropean Community [242095]Spanish Ministry of Science and InnovationSpanish Ministry of Science and Innovation [SAF2009-07760

Family and Community Health Medical Residency Program for Hypertense Care

The objective of the present study was to evaluate the care provided to patients with systemic arterial hypertension by comparing the basic health units (BHU) of the municipality of Gurupi-TO with and without the family and community health residency program. This is a descriptive, cross-sectional and retrospective research conducted in twelve BHUs. Project approved by the research ethics committee of the University of Gurupi, in which health servants answered the QualiAB assessment and monitoring instrument and the data were tested by the chi-square test to verify if there is a difference in care considering p≤5%. or 0,05. Of the 21 items analyzed, 14 obtained better levels in UBS with MRPFCH. Therefore, it is concluded that BHU with MRPFCH, as single health system policies, have better quality in the care of hypertension

ATLANTIC-PRIMATES: a dataset of communities and occurrences of primates in the Atlantic Forests of South America

Primates play an important role in ecosystem functioning and offer critical insights into human evolution, biology, behavior, and emerging infectious diseases. There are 26 primate species in the Atlantic Forests of South America, 19 of them endemic. We compiled a dataset of 5,472 georeferenced locations of 26 native and 1 introduced primate species, as hybrids in the genera Callithrix and Alouatta. The dataset includes 700 primate communities, 8,121 single species occurrences and 714 estimates of primate population sizes, covering most natural forest types of the tropical and subtropical Atlantic Forest of Brazil, Paraguay and Argentina and some other biomes. On average, primate communities of the Atlantic Forest harbor 2 ± 1 species (range = 1–6). However, about 40% of primate communities contain only one species. Alouatta guariba (N = 2,188 records) and Sapajus nigritus (N = 1,127) were the species with the most records. Callicebus barbarabrownae (N = 35), Leontopithecus caissara (N = 38), and Sapajus libidinosus (N = 41) were the species with the least records. Recorded primate densities varied from 0.004 individuals/km 2 (Alouatta guariba at Fragmento do Bugre, Paraná, Brazil) to 400 individuals/km 2 (Alouatta caraya in Santiago, Rio Grande do Sul, Brazil). Our dataset reflects disparity between the numerous primate census conducted in the Atlantic Forest, in contrast to the scarcity of estimates of population sizes and densities. With these data, researchers can develop different macroecological and regional level studies, focusing on communities, populations, species co-occurrence and distribution patterns. Moreover, the data can also be used to assess the consequences of fragmentation, defaunation, and disease outbreaks on different ecological processes, such as trophic cascades, species invasion or extinction, and community dynamics. There are no copyright restrictions. Please cite this Data Paper when the data are used in publications. We also request that researchers and teachers inform us of how they are using the data. © 2018 by the The Authors. Ecology © 2018 The Ecological Society of Americ

ATLANTIC EPIPHYTES: a data set of vascular and non-vascular epiphyte plants and lichens from the Atlantic Forest

Epiphytes are hyper-diverse and one of the frequently undervalued life forms in plant surveys and biodiversity inventories. Epiphytes of the Atlantic Forest, one of the most endangered ecosystems in the world, have high endemism and radiated recently in the Pliocene. We aimed to (1) compile an extensive Atlantic Forest data set on vascular, non-vascular plants (including hemiepiphytes), and lichen epiphyte species occurrence and abundance; (2) describe the epiphyte distribution in the Atlantic Forest, in order to indicate future sampling efforts. Our work presents the first epiphyte data set with information on abundance and occurrence of epiphyte phorophyte species. All data compiled here come from three main sources provided by the authors: published sources (comprising peer-reviewed articles, books, and theses), unpublished data, and herbarium data. We compiled a data set composed of 2,095 species, from 89,270 holo/hemiepiphyte records, in the Atlantic Forest of Brazil, Argentina, Paraguay, and Uruguay, recorded from 1824 to early 2018. Most of the records were from qualitative data (occurrence only, 88%), well distributed throughout the Atlantic Forest. For quantitative records, the most common sampling method was individual trees (71%), followed by plot sampling (19%), and transect sampling (10%). Angiosperms (81%) were the most frequently registered group, and Bromeliaceae and Orchidaceae were the families with the greatest number of records (27,272 and 21,945, respectively). Ferns and Lycophytes presented fewer records than Angiosperms, and Polypodiaceae were the most recorded family, and more concentrated in the Southern and Southeastern regions. Data on non-vascular plants and lichens were scarce, with a few disjunct records concentrated in the Northeastern region of the Atlantic Forest. For all non-vascular plant records, Lejeuneaceae, a family of liverworts, was the most recorded family. We hope that our effort to organize scattered epiphyte data help advance the knowledge of epiphyte ecology, as well as our understanding of macroecological and biogeographical patterns in the Atlantic Forest. No copyright restrictions are associated with the data set. Please cite this Ecology Data Paper if the data are used in publication and teaching events. © 2019 The Authors. Ecology © 2019 The Ecological Society of Americ

Involvement of BRAF, PIK3CA and AKT1 oncogenes and let-7 tumor supressor gene in malignant tranformation and progression oh thyroid cancer.

Neste estudo, geramos ensaios de espectrometria de massa para detecção de 111 mutações nos genes RET, BRAF, NRAS, HRAS, KRAS, PIK3CA e AKT1 e avaliamos inúmeras linhagens celulares e tumores tiroidianos. Mostramos que as mutações dos genes BRAF e RAS refletem prognósticos distintos e que as mutações BRAF são altamente prevalentes em câncer metastático. Mutações dos genes PIK3CA e AKT1, esta última sendo reportada pela primeira vez no câncer de tiróide, são relativamente frequentes neste câncer. Avaliamos ainda a função do microRNA let-7 neste câncer. Mostramos que a ativação do rearranjo RET/PTC3 em células de tiróide PCCl3 reduz a expressão de let-7. Além disso, a transfecção deste microRNA em células TPC-1, que apresentam o rearranjo RET/PTC1, inibe a fosforilação de ERK, o crescimento celular e modula a expressão de genes do ciclo celular e diferenciação. Estes dados contribuem na aplicação de terapias dirigidas a efetores das vias PI3K e MAPK no câncer de tiróide, além de salientar o envolvimento do miRNA let-7 como um gene supressor tumoral nesta doença.In this study, we designed an assay panel for genotyping 111 mutations by mass spectrometry in RET, BRAF, NRAS, HRAS, KRAS, PIK3CA, AKT1 and other related genes in many thyroid cancer cell lines and tumors. We show that patients with BRAF and RAS mutations have distinct prognosis and that BRAF mutations are highly prevalent in metastatic thyroid cancers. Mutations of PIK3CA and AKT1, the latter not previously described in this disease, are comparatively frequent in thyroid cancers. In addition, we evaluated the role of let-7 microRNA in this cancer. We show that RET/PTC3 activation in PCCl3 thyroid cells reduces let-7 expression. Moreover, transfection of let-7 in TPC-1 cells, which harbor RET/PTC1 rearrangement, inhibits MAPK activation, reduces cell growth and modulates the expression of cell cycle and differentiation genes. These findings may contribute to the design of therapies directed at MAPK and PI3K effectors and to highlight the function of let-7 as tumor suppressor gene in thyroid cancer

Accuracy Comparison between Frameless Biopsy and Frame-Based Biopsy: A Retrospective Study of a Case Series

Objective To compare the efficacy and safety of frameless and frame-based techniques for biopsies of intracranial lesions in an exclusive assistance service at a public health center in Brazil (SUS)

SISTEMA CONSTRUTIVO LIGHT STEEL FRAMING: AVALIAÇÃO DO DESEMPENHO DE PLACAS DE MADEIRA RECONSTITUÍDA

Taking into account the transversal actions of the Light Steel Framing (LSF) constructive system, the structural performance depends on the shearing behavior of Wall sheathing, depending on the elasticity and transversal deformation modules, among other factors. Thus, the objective of this work was to determine, from the structural plywood closing plates, the modulus of elasticity in the longitudinal and transverse directions, through three-point bending flexural static test, according the requirements of NBR 9533 (ABNT, 2012), and compare them with similar research results that used Oriented Strand Board (OSB) panels in bracing the LSF system. After analyzing the results of the modulus of elasticity found in those studies in which OSB plates were used, and compared with the results of the currently research, it was concluded that it is possible to use the structural plywood in the LSF construction system, highlighting even a superior performance.Levando em conta as ações transversais do sistema construtivo Light Steel Framing (LSF), o desempenho estrutural depende do comportamento ao cisalhamento das chapas de fechamento das paredes, em função dos módulos de elasticidade e de deformação transversal, entre outros fatores. Assim, o objetivo deste trabalho foi determinar o módulo de elasticidade nas direções longitudinal e transversal, das chapas de fechamento em compensado estrutural, por meio de ensaios à flexão estática em três pontos, nos quais foram seguidas as prescrições da NBR 9533 (ABNT, 2012), e compará-lo com resultados de pesquisas similares que usaram chapas Oriented Strand Board (OSB) no contraventamento do sistema LSF. Após análise dos resultados dos valores obtidos dos módulos de elasticidade em pesquisas que foram utilizadas chapas de OSB, e comparados com os resultados da presente pesquisa concluiu-se que é possível utilizar o compensado estrutural no sistema construtivo LSF destacando-se inclusive um desempenho superior

SISTEMA CONSTRUTIVO LIGHT STEEL FRAMING: AVALIAÇÃO DO DESEMPENHO DE PLACAS DE MADEIRA RECONSTITUÍDA

Taking into account the transversal actions of the Light Steel Framing (LSF) constructive system, the structural performance depends on the shearing behavior of Wall sheathing, depending on the elasticity and transversal deformation modules, among other factors. Thus, the objective of this work was to determine, from the structural plywood closing plates, the modulus of elasticity in the longitudinal and transverse directions, through three-point bending flexural static test, according the requirements of NBR 9533 (ABNT, 2012), and compare them with similar research results that used Oriented Strand Board (OSB) panels in bracing the LSF system. After analyzing the results of the modulus of elasticity found in those studies in which OSB plates were used, and compared with the results of the currently research, it was concluded that it is possible to use the structural plywood in the LSF construction system, highlighting even a superior performance.Levando em conta as ações transversais do sistema construtivo Light Steel Framing (LSF), o desempenho estrutural depende do comportamento ao cisalhamento das chapas de fechamento das paredes, em função dos módulos de elasticidade e de deformação transversal, entre outros fatores. Assim, o objetivo deste trabalho foi determinar o módulo de elasticidade nas direções longitudinal e transversal, das chapas de fechamento em compensado estrutural, por meio de ensaios à flexão estática em três pontos, nos quais foram seguidas as prescrições da NBR 9533 (ABNT, 2012), e compará-lo com resultados de pesquisas similares que usaram chapas Oriented Strand Board (OSB) no contraventamento do sistema LSF. Após análise dos resultados dos valores obtidos dos módulos de elasticidade em pesquisas que foram utilizadas chapas de OSB, e comparados com os resultados da presente pesquisa concluiu-se que é possível utilizar o compensado estrutural no sistema construtivo LSF destacando-se inclusive um desempenho superior

Efeito da solução de Ringer com lactato sobre os equilíbrios hidroeletrolítico e acidobase de equinos, ovelhas e bezerros sadios

O objetivo deste trabalho foi investigar os efeitos da solução de Ringer com lactato (SRL) sobre os equilíbrios hidroeletrolítico e acidobase de equinos, ovelhas e bezerros hígidos. Equinos adultos (n=6), ovelhas adultas (n=6) e bezerros (n=5) receberam a SRL em volume correspondente a 10% do peso corporal, administrada por infusão contínua intravenosa durante quatro (ovelhas e bezerros) ou seis (equinos) horas. Amostras de sangue venoso e de urina foram colhidas antes do início da infusão, na metade do volume infundido, ao término da infusão e duas (ovelhas e bezerros) ou três (equinos) horas após. Foram determinados valores de pH sanguíneo e urinário, de pCO2, HCO3- e BE no sangue, de Na+, K+, Cl- e SID no soro, de AG, PPT, Atot e lactato L no plasma e das excreções fracionadas urinárias de Na+, K+, Cl- e lactato L. A SRL provocou hemodiluição e não afetou os equilíbrios eletrolítico e acidobase nas três espécies estudadas, não sendo capaz de promover aumento da reserva alcalina. Por outro lado, deve ser considerada segura para a terapia de manutenção com infusão de grandes volumes porque não provoca desequilíbrios eletrolíticos