RELAÇÕES DE GÊNERO E DESEMPENHO MOTOR DE ALUNOS SUBMETIDOS A QUESTIONÁRIO E TESTE DE EUROFIT.

O gnero conduz meninos e meninas a manifestarem vrios tipos de comportamento diante da sociedade, comportamentos esses que interferem no desempenho motor. Sendo assim o objetivo deste estudo foi investigar se h uma diferena nas relaes de gnero e desempenho motor entre meninos e meninas, atravs do Eurofit e do questionrio de identidade de gnero, ao mesmo tempo analisando se existem laos tericos que apontam essa interferncia no desempenho. Foi realizada uma pesquisa com 28 estudantes de ambos os sexos do 9 ano do ensino fundamental de uma escola do municpio de Parintins/AM. As caractersticas de gnero foram obtidas atravs de um questionrio, e o desempenho motor atravs dos testes de Eurofit. Os resultados da analise apontam que os meninos foram superiores na maioria dos testes. Palavras Chave: Relaes de Gnero; Desempenho Motor; Testes Eurofit

Antiproliferative Activity Of Flavonoids From Croton Sphaerogynus Baill. (euphorbiaceae).

Croton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil. A lyophilized crude EtOH extract from leaves of C. sphaerogynus, obtained by maceration at room temperature (seven days), was suspended in methanol and partitioned with hexane. The purified MeOH phase was fractionated over Sephadex LH-20 yielding five fractions (F1-F5) containing flavonoids, as characterized by HPLC-DAD and HPLC-MS analyses. The antiproliferative activity of the crude EtOH extract, MeOH and hexane phases, and fractions F1-F5 was evaluated on in vitro cell lines NCI-H460 (nonsmall cell lung), MCF-7 (breast cancer), and U251 (glioma). The MeOH phase showed activity (mean log GI50 0.54) higher than the hexane phase and EtOH extract (mean log GI50 1.13 and 1.19, resp.). F1 exhibited activity against NCI-H460 (nonsmall cell lung) (GI50 1.2 μg/mL), which could be accounted for the presence of flavonoids and/or diterpenes. F4 showed moderate activity (mean log GI50 1.05), while F5 showed weak activity (mean log GI50 1.36). It is suggested that the antiproliferative activity of the crude EtOH extract and MeOH phase is accounted for a synergistic combination of flavonoids and diterpenes.201521280

Antiproliferative activity of flavonoids from croton Sphaerogynus baill. (euphorbiaceae)

Croton sphaerogynus is a shrub from the Atlantic Rain Forest in southeastern Brazil. A lyophilized crude EtOH extract from leaves of C. sphaerogynus, obtained by maceration at room temperature (seven days), was suspended in methanol and partitioned with hexane. The purified MeOH phase was fractionated over Sephadex LH-20 yielding five fractions (F1-F5) containing flavonoids, as characterized by HPLC-DAD and HPLC-MS analyses. The antiproliferative activity of the crude EtOH extract, MeOH and hexane phases, and fractions F1-F5 was evaluated on in vitro cell lines NCI-H460 (nonsmall cell lung), MCF-7 (breast cancer), and U251 (glioma). The MeOH phase showed activity (mean log GI(50) 0.54) higher than the hexane phase and EtOH extract (mean log GI(50) 1.13 and 1.19, resp.). F1 exhibited activity against NCI-H460 (nonsmall cell lung) (GI(50) 1.2 mu g/mL), which could be accounted for the presence of flavonoids and/or diterpenes. F4 showed moderate activity (mean log GI(50) 1.05), while F5 showed weak activity (mean log GI(50) 1.36). It is suggested that the antiproliferative activity of the crude EtOH extract and MeOH phase is accounted for a synergistic combination of flavonoids and diterpenes2015COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPsem informação2012/10079-

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

A Model to Describe Spatial and Temporal Variation of Phosphorus Mass and Fluxes in Tree Islands of Shark River Slough in the Everglades

A numerical model has been developed to study the temporal and spatial variations of Phosphorus mass and fluxes around the tree islands of Shark River Slough in the Everglades. The developed model is based on a conceptualization of physical, chemical and biological processes that consider advective and diffusive transport of dissolved Phosphorus, adsorption on to soil, input from rainfall and external sources, and Phosphorus cycling in biomass. The biomass related processes are Phosphorus uptake, release as litter, transport as suspended litter and release from the decomposition of the deposited litter. The water flow and transport of dissolved Phosphorus in the numerical model are implemented originally in the simulator MODHMS. However, the transport equations for dissolved Phosphorus were also coded separately, as well as the balance equation for suspended litter particles and deposited litter. The parameterization of the model was conducted by using the data collected by Ross et al. [2004] in three tree islands of Shark River Slough, as well as other parameters reported among the literature. The model was calibrated in three phases. Initially, Manning coefficients were adjusted from surface water velocity data collected by Bazante et al. [2004]. Then the calibration of several groundwater flow parameters was performed from water table data collected at wells by Ross et al. [2004]. In the third phase, the Phosphorus input rate from external sources and the initial concentration of Phosphorus were calibrated by assuming that the average surveyed Phosphorus concentration in soil pore water remains approximately constant over a 10 year period. The quantitative assessment of the spatial distribution and temporal variations of Phosphorus mass and fluxes around tree islands obtained from the developed model corroborate the negative effect of the rainfall events on Phosphorus accumulation in the head of the tree island. However, the possible positive effect of the ET driven water flows on Phosphorous accumulation was found not as relevant as hypothesed by other authors in the literature. According to the model results, most of the Phosphorus transport in the tree islands occurs as suspended particles in surface water, even though the transport of dissolved Phosphorus in pore water cannot be neglected around the head of the island. The model results also suggest that an input of Phosphorus from external sources (e.g., animal activity such as bird guano and other sources) is needed to preserve the average Phosphorus levels in the head and in the whole tree island. Finally, Phosphorus accumulation and losses in certain areas of the tree island suggest changes in vegetation that need to be investigated in future work. The developed model can be used as a predicting tool to gain insight into the potential effects of restoration scenarios in tree islands environments. The model could be run for hypothetical future conditions and contribute to provide quantitative information for conservation and restoration efforts in the Everglades and similar wetlands

Numerical modeling of the effects of water flow, sediment transport and vegetation growth on the spatiotemporal patterning of the ridge and slough landscape of the Everglades wetland

A numerical model has been developed to simulate the spatiotemporal patterning of the ridge and slough landscape in wetlands, characterized by crests (ridges) and valleys (sloughs) that are elongated parallel to the direction of water flow. The model formulation consists of governing equations for integrated surface water and groundwater flow, sediment transport, and soil accretion, as well as litter production by vegetation growth. The model simulations show how the spatial pattern self-organizes over time with the generation of ridges and sloughs through sediment deposition and erosion driven by the water flow field. The spatial and temporal distributions of the water depth, flow rates and sediment transport processes are caused by differential flow due to vegetation and topography heterogeneities. The model was parameterized with values that are representative of the Everglades wetland in the southern portion of the Florida peninsula in the USA. Model simulation sensitivity was tested with respect to numerical grid size, lateral vegetation growth and the rate of litter production. The characteristic wavelengths of the pattern in the directions along and perpendicular to flow that are simulated with this model develop over time into ridge and slough shapes that resemble field observations. Also, the simulated elevation differences between the ridges and sloughs are of the same order of those typically found in the field. The width of ridges and sloughs was found to be controlled by a lateral vegetation growth distance parameter in a simplified formulation of vegetation growth, which complements earlier modeling results in which a differential peat accretion mechanism alone did not reproduce observations of ridge and slough lateral wavelengths. The results of this work suggest that ridge and slough patterning occurs as a result of vegetation's ability to grow laterally, enhancing sediment deposition in ridge areas, balanced by increased sediment erosion in slough areas to satisfy flow continuity. The interplay between sediment transport, water flow and vegetation and soil dynamic processes needs to be explored further through detailed field experiments, using a model formulation such as the one developed in this work to guide data collection and interpretation. This should be one of the focus areas of future investigations of pattern formation and stability in ridge and slough areas

Catalytic carbon deposition-oxidation over Ni, Fe and Co catalysts : a new indirect route to store and transport gas hydrocarbon fuels.

In this work, a new two-step route to store and transport associated natural gas, promoted by Ni, Fe and Co supported catalyst was presented. Initially, CH4 is converted into carbon deposits (M/C composite), being Fe catalyst the most active catalyst. In Step 2, M/C composite reacts with H2O producing H2, CO and CH4. TPO experiments showed that efficiency and selectivity of oxidation depends on the metal. Ni catalyst produced mainly H2 and CO, while Fe system was more selective to convert carbon into CH4. The formation of C2 and C3 compounds suggests the presence of a Fischer Tropsch like process

Becas de Verano 2012 del Instituto Balseiro – Informes

El programa de Becas de Verano del Instituto Balseiro ofrece a estudiantes universitarios avanzados o recientemente egresados de carreras de grado en Ciencias o Ingenierías la posibilidad de realizar una pasantía durante el mes de febrero. El objetivo de la misma es familiarizarse con técnicas experimentales y colaborar en tareas de investigación en laboratorios del Centro Atómico Bariloche. Anualmente, 15 estudiantes son seleccionados y reciben ayuda económica completa. Cada participante elige un único tema de investigación entre una serie de propuestas y es guiado por un grupo de investigadores del Centro Atómico Bariloche. La pasantía finaliza con la entrega de un informe y la presentación de un póster en el que se detallan los resultados obtenidos a lo largo del mes de trabajo

Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence

Background: The malaria parasite Plasmodium falciparum exhibits abundant genetic diversity, and this diversity is key to its success as a pathogen. Previous efforts to study genetic diversity in P. falciparum have begun to elucidate the demographic history of the species, as well as patterns of population structure and patterns of linkage disequilibrium within its genome. Such studies will be greatly enhanced by new genomic tools and recent large-scale efforts to map genomic variation. To that end, we have developed a high throughput single nucleotide polymorphism (SNP) genotyping platform for P. falciparum. Results: Using an Affymetrix 3,000 SNP assay array, we found roughly half the assays (1,638) yielded high quality, 100% accurate genotyping calls for both major and minor SNP alleles. Genotype data from 76 global isolates confirm significant genetic differentiation among continental populations and varying levels of SNP diversity and linkage disequilibrium according to geographic location and local epidemiological factors. We further discovered that nonsynonymous and silent (synonymous or noncoding) SNPs differ with respect to within-population diversity, inter-population differentiation, and the degree to which allele frequencies are correlated between populations. Conclusions: The distinct population profile of nonsynonymous variants indicates that natural selection has a significant influence on genomic diversity in P. falciparum, and that many of these changes may reflect functional variants deserving of follow-up study. Our analysis demonstrates the potential for new high-throughput genotyping technologies to enhance studies of population structure, natural selection, and ultimately enable genome-wide association studies in P. falciparum to find genes underlying key phenotypic traits.National Institutes of Health (U.S.)Broad Institute of Harvard and MITBurroughs Wellcome FundBill & Melinda Gates FoundationNational Institute of Allergy and Infectious Diseases (U.S.). Microbial Sequencing CenterEllison Medical FoundationFogarty International CenterExxon Mobil FoundationNational Center for Research Resources (U.S.) (Grant U54 RR020278