Безотходное использование углей

В работе сравниваются расчетная и аналитическая зольность отходов углеобогащения. Рассматриваются возможные пути и необходимость в сокращении отходов использования угля. Предложена модель безотходного использования углей.In this work the calculated and analytical ash contents of coal enrichment waste are compared. Possible ways and necessity in reducing coal waste are studied. The model for the non-waste use of coals is proposed

Prolactin

During an oral glucose tolerance test (OGTT) glucose and insulin levels were measured in 26 patients with prolactin-producing pituitary tumours without growth hormone excess. Basal glucose and insulin levels did not differ from the values of an age-matched control group. After glucose load the hyperprolactinaemic patients showed a decrease in glucose tolerance and a hyperinsulinaemia. Bromocriptine (CB 154), which suppressed PRL, improved glucose tolerance and decreased insulin towards normal in a second OGTT. — Human PRL or CB 154 had no significant influence on insulin release due to glucose in the perfused rat pancreas. — These findings suggest a diabetogenic effect of PRL. CB 154 might be a useful drug in improving glucose utilization in hormone-active pituitary tumours

Эколого-технологические основы формирования визуальной среды города (на примере многофункционального здания г. Томска)

Процессы урбанизации, которые особо ускорились в ХХ веке, вызывают большой интерес у представителей различных наук и у самих горожан, поскольку бурный рост городского населения превращается в глобальную проблему и сильно меняет городскую среду. В ходе роста и развития городов концептуально иной становится окружающая человека среда с новым пониманием ценностей жизни, красоты и гармонии. Как показывает действительность и многочисленные исследования - естественная связь человека с природой значительно ослабевает именно в городах. Это в значительной мере оказывает влияние на психоэмоциональное и физическое состояние горожан. Изучая визуальную среду современного города, мы можем существенным образом обогатить эстетическую составляющую и несколько смягчить негативные последствия урбанизации.The rapid growth of the urban population presents a global challenge and ultimately augments the urban environment. While cities growth and develop, the environment with new understandings of values, beauty and harmony becomes conceptually different. In most cities, the natural connection of individuals with nature has significantly weakened. Their everyday environment is an artificial urban environment. In cities a special lifestyle different from the style of life in the countryside is formed, affecting to a large extent the physical and especially the mental health of the citizens. Through exploring the visual environment of the modern city, we can significantly enrich the aesthetic component and mitigate the negative effects of anthropogenic impact, creating a favorable habitat

Influência do gesso e do cimento Portland nas propriedades de compósitos contendo partículas de madeira

A utilização da madeira como estrutura temporária, nos canteiros de obra, contribui para o aumento do volume de resíduo de construção e demolição (RCD) gerado e, por isso, compósitos de madeira têm se tornado uma alternativa para o reaproveitamento desses resíduos. Neste sentido, o presente artigo tem como objetivo verificar a influência da substituição de teores de gesso por cimento Portland em compósitos de gesso-madeira. Os resíduos de madeira (compensado, eucalipto e pínus) foram coletados, moídos, tratados e secos. Foi utilizado o gesso de pega lenta e o cimento Portland, com uma relação aglomerante/madeira de 1:0,15 (em massa), e relação água/aglomerante de 0,70. Os teores de substituição do gesso por cimento Portland foram de 5%, 10%, 15% e 20%, em massa. As partículas de madeira foram caracterizadas, e os compósitos produzidos foram ensaiados no estado fresco e produzidos corpos de prova prismáticos para realização de ensaios nas idades de 7 e 28 dias). Os resultados indicaram que a substituição do gesso por cimento Portland contribuiu para a aceleração do tempo de fim de pega e para a diminuição das resistências mecânicas quando comparado aos compósitos de referência, isto porque, na presença dos dois aglomerantes, o fator de compatibilidade das espécies utilizadas pode ter sido alterado

Physiological Properties of Cholinergic and Non-Cholinergic Magnocellular Neurons in Acute Slices from Adult Mouse Nucleus Basalis

The basal forebrain is a series of nuclei that provides cholinergic input to much of the forebrain. The most posterior of these nuclei, nucleus basalis, provides cholinergic drive to neocortex and is involved in arousal and attention. The physiological properties of neurons in anterior basal forebrain nuclei, including medial septum, the diagonal band of Broca and substantia innominata, have been described previously. In contrast the physiological properties of neurons in nucleus basalis, the most posterior nucleus of the basal forebrain, are unknown.Here we investigate the physiological properties of neurons in adult mouse nucleus basalis. We obtained cell-attached and whole-cell recordings from magnocellular neurons in slices from P42-54 mice and compared cholinergic and non-cholinergic neurons, distinguished retrospectively by anti-choline acetyltransferase immunocytochemistry. The majority (70-80%) of cholinergic and non-cholinergic neurons were silent at rest. Spontaneously active cholinergic and non-cholinergic neurons exhibited irregular spiking at 3 Hz and at 0.3 to 13.4 Hz, respectively. Cholinergic neurons had smaller, broader action potentials than non-cholinergic neurons (amplitudes 64+/-3.4 and 75+/-2 mV; half widths 0.52+/-0.04 and 0.33+/-0.02 ms). Cholinergic neurons displayed a more pronounced slow after-hyperpolarization than non-cholinergic neurons (13.3+/-2.2 and 3.6+/-0.5 mV) and were unable to spike at high frequencies during tonic current injection (maximum frequencies of approximately 20 Hz and >120 Hz).Our results indicate that neurons in nucleus basalis share similar physiological properties with neurons in anterior regions of the basal forebrain. Furthermore, cholinergic and non-cholinergic neurons in nucleus basalis can be distinguished by their responses to injected current. To our knowledge, this is the first description of the physiological properties of cholinergic and non-cholinergic neurons in the posterior aspects of the basal forebrain complex and the first study of basal forebrain neurons from the mouse

Concanavalin A—induced liver cell damage: Activation of intracellular pathways triggered by tumor necrosis factor in mice☆☆☆

AbstractBackground & Aims: Concanavalin A (con A) induces tumor necrosis factor (TNF)-dependent hepatocyte apoptosis resembling immune-mediated fulminant hepatic failure in humans. Intracellular pathways originating at the TNF receptor are either linked to apoptosis, nuclear factor (NF)-κB translocation, or Jun kinase (JNK) activation. The aim of this study was to study TNF-dependent pathways after con A injection in vivo. Methods: Con A, con A plus anti-TNF, and control buffer were injected into BALB/c mice. Immunofluorescence, Western blot, Northern blot, gel shift, Erk, and JNK activity and DNA fragmentation experiments were performed at different time points after injection. Results: DNA fragmentation in hepatocytes was increased 4–24 hours after con A injection. JNK was activated maximally (>20-fold) directly after con A injection, whereas binding and nuclear translocation of NF-κB was maximal after 4 hours. All pathways were blocked by anti-TNF. JNK activation was specific because related ERK 1 + 2 were not activated after con A. High nuclear expression of c-Jun was already evident 1 hour after con A injection; however, in contrast to JNK, anti-TNF treatment did not block c-Jun nuclear expression and DNA binding. Conclusions: In the con A model, activation of TNF-dependent pathways is associated with apoptosis of hepatocytes. Their modulation in vivo may have implications to develop new therapeutic strategies to prevent apoptosis.GASTROENTEROLOGY 1998;114:1035-104

The EASL–Lancet Liver Commission: protecting the next generation of Europeans against liver disease complications and premature mortality

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Sleep-wake sensitive mechanisms of adenosine release in the basal forebrain of rodents : an in vitro study

Adenosine acting in the basal forebrain is a key mediator of sleep homeostasis. Extracellular adenosine concentrations increase during wakefulness, especially during prolonged wakefulness and lead to increased sleep pressure and subsequent rebound sleep. The release of endogenous adenosine during the sleep-wake cycle has mainly been studied in vivo with microdialysis techniques. The biochemical changes that accompany sleep-wake status may be preserved in vitro. We have therefore used adenosine-sensitive biosensors in slices of the basal forebrain (BFB) to study both depolarization-evoked adenosine release and the steady state adenosine tone in rats, mice and hamsters. Adenosine release was evoked by high K+, AMPA, NMDA and mGlu receptor agonists, but not by other transmitters associated with wakefulness such as orexin, histamine or neurotensin. Evoked and basal adenosine release in the BFB in vitro exhibited three key features: the magnitude of each varied systematically with the diurnal time at which the animal was sacrificed; sleep deprivation prior to sacrifice greatly increased both evoked adenosine release and the basal tone; and the enhancement of evoked adenosine release and basal tone resulting from sleep deprivation was reversed by the inducible nitric oxide synthase (iNOS) inhibitor, 1400 W. These data indicate that characteristics of adenosine release recorded in the BFB in vitro reflect those that have been linked in vivo to the homeostatic control of sleep. Our results provide methodologically independent support for a key role for induction of iNOS as a trigger for enhanced adenosine release following sleep deprivation and suggest that this induction may constitute a biochemical memory of this state