Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne–azide cycloaddition

AbstractThe synthesis of 1,2,3-triazoles was developed employing sequential copper azide–alkyne cycloaddition, tosylation, sodium azide, and copper azide–alkyne steps. This approach allowed the synthesis of two and three 1,2,3-triazole rings. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology

The second generation of optimized beam orbit measurement (BOM) system of LEP: hardware and performance description

The BOM System with its 504 Beam Position Monitors and 40 Processing Electronics Stations, distributed along the 27 km of the LEP tunnel, has been optimized for all beam conditions and modes of operation. The description of the Beam Position Monitors (or PU) behavior in the tunnel is given. The guiding approaches for obtaining both main aspects of the critical BOM performances were: a) high reliability, since most of the electronics is not accessible during operation, and b) resolution, precision and stability of the signal processing equipment for the management of the LEP optics, polarization and energy calibration. The finalized analog signal processing chains, both Wide-Band and Narrow-Band, are described. Since local memories allow for the recording of data at each bunch passage during more than 1000 revolutions, it can be followed by a powerful digital signal processing allowing for many modes of beam observation. Examples are presented of beam and machine behavior studies. The BOM System has been a key instrument for the success of LEP operation

Control Modules for Scintillation Counters in the SPS Experimental Areas

The hardware used in the SPS Experimental Areas to control the beam instrumentation electronics and mechanics of the particle detectors is based on CAMAC and NIM modules. The maintenance of this hardware now presents very serious problems. The modules used to operate the Experimental Areas are numerous and older than 20 years so many of them cannot be repaired any more and CAMAC is no longer well supported by industry. The fast evolution of technology and a better understanding of the detectors allow a new equipment-oriented approach, which is more favourable for maintenance purposes and presents fewer data handling problems. VME and IP Modules were selected as standard components to implement the new electronics to control and read out the particle detectors. The first application implemented in this way concerns the instrumentation for the Scintillation Counters (formerly referred to as triggers). The fundamental options and the design features will be presented

Real time display of the vertical beam sizes in LEP using the BEXE X-ray detector and fast VME based computers

Fast X-ray detectors based on CdTe photoconductors have been installed in LEP since the beginning of its operation in 1989. The angular divergence of the high energy photons from the synchrotron radiation (x-rays) and the narrow spacing of the 64 photoconductors of the detector allow a good measurement of vertical beam profiles down to an rms beam size of 300 mm. This paper presents some specific parameters and experimental results of an upgrade program in which the local processing power of the front-end electronics has been increased by a factor 50. Such a powerful tool has allowed a real time display of the time evolution of the vertical beam sizes. An online correlation plot between the electron and positron beam sizes (turn by turn) is also displayed. These online video images are available in the LEP control room and are used in daily operation for luminosity optimisation

Luminosity and Beam Measurements used for Performance Optimisation in the LEP Collider

The vertical beam-beam parameter in LEP reached 0.083 in 1999. In order to achieve and maintain this high performance a number of different observables are continuously monitored and optimised. The beam sizes are measured using X-ray detectors and UV telescopes. The luminosity is determined directly with tungsten-silicon calorimeters and indirectly through an accurate measurement of the beam lifetime. The tune shift is measured from the tune spectrum in collision. Beam-beam deflection scans provide information about the beam sizes and separation at the interaction points. The different measurements are shortly reviewed and their resolution and time response is analysed. Their use for the optimisation of LEP is described

Combined Treatment of Heterocyclic Analogues and Benznidazole upon Trypanosoma cruzi In Vivo

Chagas disease caused by Trypanosoma cruzi is an important cause of mortality and morbidity in Latin America but no vaccines or safe chemotherapeutic agents are available. Combined therapy is envisioned as an ideal approach since it may enhance efficacy by acting upon different cellular targets, may reduce toxicity and minimize the risk of drug resistance. Therefore, we investigated the activity of benznidazole (Bz) in combination with the diamidine prodrug DB289 and in combination with the arylimidamide DB766 upon T. cruzi infection in vivo. The oral treatment of T.cruzi-infected mice with DB289 and Benznidazole (Bz) alone reduced the number of circulating parasites compared with untreated mice by about 70% and 90%, respectively. However, the combination of these two compounds decreased the parasitemia by 99% and protected against animal mortality by 100%, but without providing a parasitological cure. When Bz (p.o) was combined with DB766 (via ip route), at least a 99.5% decrease in parasitemia levels was observed. DB766+Bz also provided 100% protection against mice mortality while Bz alone provided about 87% protection. This combined therapy also reduced the tissular lesions induced by T. cruzi infection: Bz alone reduced GPT and CK plasma levels by about 12% and 78% compared to untreated mice group, the combination of Bz with DB766 resulted in a reduction of GPT and CK plasma levels of 56% and 91%. Cure assessment through hemocultive and PCR approaches showed that Bz did not provide a parasitological cure, however, DB766 alone or associated with Bz cured ≥13% of surviving animals

Immune-neuroendocrine and metabolic disorders in human and experimental T. cruzi infection: New clues for understanding Chagas disease pathology

Studies in mice undergoing acute Trypanosoma cruzi infection and patients with Chagas disease, led to identify several immune-neuroendocrine disturbances and metabolic disorders. Here, we review relevant findings concerning such abnormalities and discuss their possible influence on disease physiopathology.Fil: González, Florencia Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Villar, Silvina Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Pacini, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Perez, Ana Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentin