Observation of HandiMathKey appropriation phase by disabled students in a middle school

The mathematical input in text editors by disabled students is demanding both at the functional level (motor disorder) and at the cognitive level (attention, visual-spatial, memory) and generates fatigability little productive and effective gain. To reduce these demands, HandiMathKey, a mathematical keyboard software was designed by applying a usercentered method. The aim of paper is to report how different disabled students have appropriated HandiMathKey in a middle school by an observation carried out by a multidisciplinary team. The hypothesis is that HandiMathKey can be learned and used by all students with disabilities

Invest Ophthalmol Vis Sci

Purpose: To analyze the association between skin autofluorescence (sAF), estimating tissue accumulation of advanced glycation end-products (AGEs), and open angle glaucoma (OAG) in an elderly population. Methods: The Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes (ALIENOR) study is an on-going epidemiologic population-based study on age-related eye diseases. In 2009 to 2010, 624 subjects, aged 74 years or older, were recruited. All subjects underwent a complete eye examination, including optic disc color photography and spectral-domain optical coherence tomography (SD-OCT) examination. Sociodemographic and medical history data were collected using standardized questionnaires. Glaucoma diagnosis was made using optic nerve head retinophotography and International Society for Epidemiologic and Geographical Ophthalmology criteria. sAF was measured with a noninvasive autofluorescence reader in 467 subjects. Results: Of subjects, 455 had complete data, 424 were classified as controls, and 31 classified as OAG. Mean age was 82.3 +/- 4.3 years, mean and median sAF were 2.8 +/- 0.7 and 2.7 arbitrary units (AU), respectively. In a multivariate analysis, higher sAF values (>/=2.7 AU) were associated with OAG (odds ratio [OR] = 2.28, 95% Confidence Interval [CI]: 1.03; 5.04). Other variables significantly associated with OAG were age (OR = 1.10, 95%CI: 1.00; 1.21), glaucoma family history (OR = 2.83, 95%CI: 1.14; 7.01) and smoking (1-20 pack-years [OR = 3.31, 95%CI: 1.18; 9.26]; >/=20 pack-years [OR = 3.85, 95%CI: 1.42; 10.46]). Conclusions: Higher level of sAF, which may act as a long-term biomarker of metabolic memory, and smoking are independently associated with an increased risk of glaucoma. Long-term accumulation of AGEs, a marker of oxidative stress, could play a role in the pathogenesis of glaucomatous chronic optic neuropathy

The N-Terminal Domain of the Arenavirus L Protein Is an RNA Endonuclease Essential in mRNA Transcription

Arenaviridae synthesize viral mRNAs using short capped primers presumably acquired from cellular transcripts by a ‘cap-snatching’ mechanism. Here, we report the crystal structure and functional characterization of the N-terminal 196 residues (NL1) of the L protein from the prototypic arenavirus: lymphocytic choriomeningitis virus. The NL1 domain is able to bind and cleave RNA. The 2.13 Å resolution crystal structure of NL1 reveals a type II endonuclease α/β architecture similar to the N-terminal end of the influenza virus PA protein. Superimposition of both structures, mutagenesis and reverse genetics studies reveal a unique spatial arrangement of key active site residues related to the PD…(D/E)XK type II endonuclease signature sequence. We show that this endonuclease domain is conserved and active across the virus families Arenaviridae, Bunyaviridae and Orthomyxoviridae and propose that the arenavirus NL1 domain is the Arenaviridae cap-snatching endonuclease

Changer la fiscalité en Belgique ? Pourquoi ? Comment ? Vers un système fiscal plus équitable et plus efficace

Dans le contexte actuel, il semble opportun de clarifier la situation en ce qui concerne les principes fiscaux belges et de proposer des pistes de solutions si ces derniers s'avèrent inappropriés. D'où la problématique de ce mémoire : "Changer la fiscalité en Belgique ? Pourquoi ? Comment ? " Avec cette question de recherche : " Quelles solutions envisager pour améliorer l'équité et l'efficacité du système fiscal belge ? "Master [120] en sciences de gestion, Université catholique de Louvain, 201

Fractal simulation of urbanization for the analysis of vulnerability to natural hazards

International audienceSince 50 years, mountain areas are affected by important land cover/use changes characterized by the decrease of pastoral activities, reforestation and urbanization with the development of tourism activities and infrastructures. These natural and anthropogenic transformations have an impact on the socio-economic activities but also on the exposure of the communities to natural hazards.In the context of the ANR Project SAMCO which aims at enhancing the overall resilience of societies on theimpacts of mountain risks, the objective of this research was to help to determine where to locate new residential developments for different scenarios of land cover/use (based on the Prelude European Project) for the years 2030 and 2050. The Planning Support System (PSS), called MUP-City, based on a fractal multi-scale modeling approach is used because it allows taking into account local accessibility to some urban and rural amenities (Tannier et al., 2012). For this research, an experiment is performed on a mountain area in the French Alps (Barcelonnette Basin) to generate three scenarios of urban development with MUP-City at the scale of 1:10:000. The results are assessed by comparing the localization of residential developments with urban areas predicted by land cover and land use scenarios generated by cellular automata modelling (LCM and Dyna-clue) (Puissant et al., 2015). Based on these scenarios, the evolution of vulnerability is estimated

Fractal simulation of urbanization for the analysis of vulnerability to natural hazards

International audienceSince 50 years, mountain areas are affected by important land cover/use changes characterized by the decrease of pastoral activities, reforestation and urbanization with the development of tourism activities and infrastructures. These natural and anthropogenic transformations have an impact on the socio-economic activities but also on the exposure of the communities to natural hazards.In the context of the ANR Project SAMCO which aims at enhancing the overall resilience of societies on theimpacts of mountain risks, the objective of this research was to help to determine where to locate new residential developments for different scenarios of land cover/use (based on the Prelude European Project) for the years 2030 and 2050. The Planning Support System (PSS), called MUP-City, based on a fractal multi-scale modeling approach is used because it allows taking into account local accessibility to some urban and rural amenities (Tannier et al., 2012). For this research, an experiment is performed on a mountain area in the French Alps (Barcelonnette Basin) to generate three scenarios of urban development with MUP-City at the scale of 1:10:000. The results are assessed by comparing the localization of residential developments with urban areas predicted by land cover and land use scenarios generated by cellular automata modelling (LCM and Dyna-clue) (Puissant et al., 2015). Based on these scenarios, the evolution of vulnerability is estimated

Fractal simulation of urbanization for the analysis of vulnerability to natural hazards

International audienceSince 50 years, mountain areas are affected by important land cover/use changes characterized by the decrease of pastoral activities, reforestation and urbanization with the development of tourism activities and infrastructures. These natural and anthropogenic transformations have an impact on the socio-economic activities but also on the exposure of the communities to natural hazards.In the context of the ANR Project SAMCO which aims at enhancing the overall resilience of societies on theimpacts of mountain risks, the objective of this research was to help to determine where to locate new residential developments for different scenarios of land cover/use (based on the Prelude European Project) for the years 2030 and 2050. The Planning Support System (PSS), called MUP-City, based on a fractal multi-scale modeling approach is used because it allows taking into account local accessibility to some urban and rural amenities (Tannier et al., 2012). For this research, an experiment is performed on a mountain area in the French Alps (Barcelonnette Basin) to generate three scenarios of urban development with MUP-City at the scale of 1:10:000. The results are assessed by comparing the localization of residential developments with urban areas predicted by land cover and land use scenarios generated by cellular automata modelling (LCM and Dyna-clue) (Puissant et al., 2015). Based on these scenarios, the evolution of vulnerability is estimated

Landslide deformation monitoring with ALOS/PALSAR imagery: A D-InSAR geormorphological interpretation method

International audienceThe objective of this work is to propose a geomorphologically-guided method for theinterpretation of L-band ALOS/PALSAR interferograms created by DifferentialInterferometric Synthetic Aperture Radar (D-InSAR). The interferograms are used to estimatethe deformation pattern of two rapid and large landslides (Poche, La Valette; South EastFrance). The wrapped and unwrapped phase values are interpreted for different movementtypes (rotational, translational, and complex sliding) and two ranges of surface displacementrates. Kinematic sub-units are detected for both landslides, and zones affected by enlargementor retrogression are identified. The InSAR-derived displacement rates are consistent withground-based measurements and with remote estimates of the displacement from C-band andX-band satellite SAR sensors. The results demonstrate the potential of L-bandALOS/PALSAR imagery for the monitoring of active landslides with important changes inthe soil surface state and covered by vegetation

Radar remote sensing observations to monitor landslides and prepare inventories for hazard assessment

Abstract: The creation of a landslide inventory encompassing multi-temporal information needs high quality and high-resolution data source as well as a good knowledge of the field. Visual image interpretation and field surveys are the prevailing methods for landslide inventory mapping while remote sensing techniques have become a widely used source of information for measuring the topography and deformation of the Earth surface (e.g. Berardino et al., 2002). Semi-automatic image analysis methods based on remote sensing techniques are proposed but their quality lacks behind the expert mappings (Guzzetti et al., 2012). Advance processing of SAR images have proven their ability for: (1) landslide detection and mapping (Farina et al., 2006; Cascini et al., 2009; Guzzetti et al., 2012), (2) process monitoring (Hilley et al., 2004; Zhao et al., 2012), (3) hazard assessment (e.g. Nikolaeva et al., 2014) and (4) risk management (Bardi et al., 2014). ..

HandiMathKey, L'innovation au service des élèves pour la saisie mathématiques

FEHAP : Fédération des Établissements Hospitaliers & d'Aide à la PersonnePrésentation HandiMathKey (HMK)Vidéo sur l'utilisation de HandiMathKey par des élèves du Centre pour une scolarité inclusive Jean Lagarde, Ramonvile Saint Agne (31