477 research outputs found

    Examining the Effects of Exposure to Nature on Well-Being: Implications for College Campuses

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    Humans attraction to the natural environment stems from our evolutionary tendencies. Biophilia is defined by E.O. Wilson as the “innate tendency to focus on life and lifelike processes (Wilson, 1984, p. 1).” Recent studies have shown that spending time outside in nature is beneficial to physical and mental health as well as well-being. Nature is filled with intriguing things such as animals, plants, fresh air and other aspects which can help an individual replenish. Some of these benefits include stress reduction, opportunities and motivation to complete tasks. Research indicates that adults who work in offices would perform better if they had views of natural landscape painting or even a window which faced nature. This paper will provide a review of research on how nature affects human well-being and mental health. The findings in this paper can be beneficial to college students and those assisting them in a number of ways. Based on the available research literature, this paper concludes with a set of recommendations of how attention to the influence of nature can enhance the quality of campus life and the literature. As mostly young individuals transitioning into the adult world, it would help influence their well-being in a positive way that will promote creativity and motivation

    Bauhinia Rhapsody : the literary journal of Lingnan University 2018-2019

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    Editor\u27s Note The Lingnan Literary Journal itself, the book you have now in your hands, is a work of Lingnan University students. That which we write and leave behind is how we communicate with the future, and it is in this way that the students of Lingnan, here during the 2018-2019 academic year, will continue to have impact long after they have left the campus here in Tuen Mun, nestled against the foothills of Hong Kong’s mountains. The work you see here is that of my own students, from either of my two classes, Arts, Creative Writing & Journalism, taught in the Fall and Spring of my time here, and Journalism Principles & Social Media, taught only in the Spring. Save for Mary Garcia who designed the covers, the editorial team came from my Fall class. There is also the writing and visual efforts of students I have never met in person, but which spoke to all of us. Others I met along the way at numerous events on campus, engaging them in conversation and asking them to submit their work. The team also recruited, through passive means like posters, and through setting up tables on campus. Still other constributions came from Professor Ingham’s class, gifting us with interesting intertextual work based on songs and poems, a favorite method of his for inspiring his students’ creativity. Mike’s deep desire to engage with his students, in and out of the classroom, was also something that inspired me to always try to give more and reach out to students across the spectrum at Lingnan. I believe through my efforts and the efforts of so many others, the journal as you see it now represents a broad range of Lingnan’s diverse student body, locals and exchange students alike.https://commons.ln.edu.hk/eng_studentjournal/1003/thumbnail.jp

    Using Cold Atoms to Measure Neutrino Mass

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    We propose a beta decay experiment based on a sample of ultracold atomic tritium. These initial conditions enable detection of the helium ion in coincidence with the beta. We construct a two-dimensional fit incorporating both the shape of the beta-spectrum and the direct reconstruction of the neutrino mass peak. We present simulation results of the feasible limits on the neutrino mass achievable in this new type of tritium beta-decay experiment.Comment: 10 pages, 5 figure

    Doing gender locally: The importance of ‘place’ in understanding marginalised masculinities and young men’s transitions to ‘safe’ and successful futures

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    Observable anxieties have been developing about the position of boys and young men in contemporary society in recent years. This is expressed as a crisis of masculinity, in which place is often implicitly implicated, but is rarely considered for its role in the shaping of young men’s practices, trajectories and aspirations. Drawing on research conducted with young people who accessed a range of social care support services, this article argues that transition means different things for young men in different locales and that local definitions of masculinity are required to better understand young men’s lives and the opportunities available to them. The authors argue that home life, street life, individual neighbourhoods, regions and nations all shaped the young men’s identities and the practices they (and the staff working with them) drew on in order to create successful futures and ‘safe’ forms of masculinity. It is suggested that this place-based approach has the potential to re-shape the ‘crisis’ discourse surrounding masculinity and the anxieties associated with young men

    Identifying Low pH Active and Lactate-Utilizing Taxa within Oral Microbiome Communities from Healthy Children Using Stable Isotope Probing Techniques

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    <div><h3>Background</h3><p>Many human microbial infectious diseases including dental caries are polymicrobial in nature. How these complex multi-species communities evolve from a healthy to a diseased state is not well understood. Although many health- or disease-associated oral bacteria have been characterized <em>in vitro</em>, their physiology within the complex oral microbiome is difficult to determine with current approaches. In addition, about half of these species remain uncultivated to date with little known besides their 16S rRNA sequence. Lacking culture-based physiological analyses, the functional roles of uncultivated species will remain enigmatic despite their apparent disease correlation. To start addressing these knowledge gaps, we applied a combination of Magnetic Resonance Spectroscopy (MRS) with RNA and DNA based Stable Isotope Probing (SIP) to oral plaque communities from healthy children for <em>in vitro</em> temporal monitoring of metabolites and identification of metabolically active and inactive bacterial species.</p> <h3>Methodology/Principal Findings</h3><p>Supragingival plaque samples from caries-free children incubated with <sup>13</sup>C-substrates under imposed healthy (buffered, pH 7) and diseased states (pH 5.5 and pH 4.5) produced lactate as the dominant organic acid from glucose metabolism. Rapid lactate utilization upon glucose depletion was observed under pH 7 conditions. SIP analyses revealed a number of genera containing cultured and uncultivated taxa with metabolic capabilities at pH 5.5. The diversity of active species decreased significantly at pH 4.5 and was dominated by <em>Lactobacillus</em> and <em>Propionibacterium</em> species, both of which have been previously found within carious lesions from children.</p> <h3>Conclusions/Significance</h3><p>Our approach allowed for identification of species that metabolize carbohydrates under different pH conditions and supports the importance of Lactobacilli and Propionibacterium in the development of childhood caries. Identification of species within healthy subjects that are active at low pH can lead to a better understanding of oral caries onset and generate appropriate targets for preventative measures in the early stages.</p> </div

    The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts

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    The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation. It negatively regulates osteoblast activity, and, as such, its inhibition is a potential means to prevent bone loss. Dasatinib is a new dual Src/Bcr-Abl tyrosine kinase inhibitor initially developed for the treatment of chronic myeloid leukemia. It has also shown promising results in preclinical studies in various solid tumors. However, its effects on the differentiation of human osteoblasts have never been examined.Journal ArticleResearch Support, Non-U.S. Gov'tSCOPUS: ar.jinfo:eu-repo/semantics/publishe

    Limitations of Tc99m-MIBI-SPECT Imaging Scans in Persistent Primary Hyperparathyroidism

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    In primary hyperparathyroidism (PHPT) the predictive value of technetium 99m sestamibi single emission computed tomography (Tc99m-MIBI-SPECT) for localizing pathological parathyroid glands before a first parathyroidectomy (PTx) is 83-100%. Data are scarce in patients undergoing reoperative parathyroidectomy for persistent hyperparathyroidism. The aim of the present study was to determine the value of Tc99m-MIBI-SPECT in localizing residual hyperactive parathyroid tissue in patients with persistent primary hyperparathyroidism (PHPT) after initial excision of one or more pathological glands. We retrospectively evaluated the localizing accuracy of Tc99m-MIBI-SPECT scans in 19 consecutive patients with persistent PHPT who had a scan before reoperative parathyroidectomy. We used as controls 23 patients with sporadic PHPT who had a scan before initial surgery. In patients with persistent PHPT, Tc99m-MIBI-SPECT accurately localized a pathological parathyroid gland in 33% of cases before reoperative parathyroidectomy, compared to 61% before first PTx for sporadic PHPT. The Tc99m-MIBI-SPECT scan accurately localized intra-thyroidal glands in 2 of 7 cases and a mediastinal gland in 1 of 3 cases either before initial or reoperative parathyroidectomy. Our data suggest that the accuracy of Tc99m-MIBI-SPECT in localizing residual hyperactive glands is significantly lower before reoperative parathyroidectomy for persistent PHPT than before initial surgery for sporadic PHPT. These findings should be taken in consideration in the preoperative workup of patients with persistent primary hyperparathyroidis

    Hyaluronan Binding Motifs of USP17 and SDS3 Exhibit Anti-Tumor Activity

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    BACKGROUND: We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specifically deubiquitinates Lys-63 branched polyubiquitination of SDS3 resulting in negative regulation of histone deacetylase (HDAC) activity in cancer cells. Furthermore, USP17 and SDS3 mutually interact with each other to block cell proliferation in HeLa cells but the mechanism for this inhibition in cell proliferation is not known. We wished to investigate whether the HABMs of USP17 were responsible for tumor suppression activity. METHODOLOGY/PRINCIPAL FINDINGS: Similarly to USP17, we have identified that SDS3 also has three consecutive HABMs and shows direct binding with hyaluronan (HA) using cetylpyridinium chloride (CPC) assay. Additionally, HA oligosaccharides (6-18 sugar units) competitively block binding of endogenous HA polymer to HA binding proteins. Thus, administration of HA oligosaccharides antagonizes the interaction between HA and USP17 or SDS3. Interestingly, HABMs deleted USP17 showed lesser interaction with SDS3 but retain its deubiquitinating activity towards SDS3. The deletion of HABMs of USP17 could not alter its functional regulation on SDS3-associated HDAC activity. Furthermore, to explore whether HABMs in USP17 and SDS3 are responsible for the inhibition of cell proliferation, we investigated the effect of USP17 and SDS3-lacking HABMs on cell proliferation by soft agar, apoptosis, cell migration and cell proliferation assays. CONCLUSIONS: Our results have demonstrated that these HABMs in USP17 and its substrate SDS3 are mainly involved in the inhibition of anchorage-independent tumor growth

    The Generationing of Power: A Comparison of Child-Parent and Sibling Relations in Scotland

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    The paper concentrates on an exploration of power relations within families. The paper discusses parental power in relation to legitimacy, household resources and children’s anticipated reactions of adult discipline. The nature of sibling power is highlighted before exploring the reciprocal expectations of sibling and child-parent interactions. The paper ends by suggesting that the generationing of power relations can lead to differing degrees of backstage and frontstage performances within the home
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