Comparing and contrasting the cognitive effects of hippocampal and ventromedial prefrontal cortex damage: A review of human lesion studies.

The hippocampus and ventromedial prefrontal cortex (vmPFC) are closely connected brain regions whose functions are still debated. In order to offer a fresh perspective on understanding the contributions of these two brain regions to cognition, in this review we considered cognitive tasks that usually elicit deficits in hippocampal-damaged patients (e.g., autobiographical memory retrieval), and examined the performance of vmPFC-lesioned patients on these tasks. We then took cognitive tasks where performance is typically compromised following vmPFC damage (e.g., decision making), and looked at how these are affected by hippocampal lesions. Three salient motifs emerged. First, there are surprising gaps in our knowledge about how hippocampal and vmPFC patients perform on tasks typically associated with the other group. Second, while hippocampal or vmPFC damage seems to adversely affect performance on so-called hippocampal tasks, the performance of hippocampal and vmPFC patients clearly diverges on classic vmPFC tasks. Third, although performance appears analogous on hippocampal tasks, on closer inspection, there are significant disparities between hippocampal and vmPFC patients. Based on these findings, we suggest a tentative hierarchical model to explain the functions of the hippocampus and vmPFC. We propose that the vmPFC initiates the construction of mental scenes by coordinating the curation of relevant elements from neocortical areas, which are then funneled into the hippocampus to build a scene. The vmPFC then engages in iterative re-initiation via feedback loops with neocortex and hippocampus to facilitate the flow and integration of the multiple scenes that comprise the coherent unfolding of an extended mental event

Scene processing following damage to the ventromedial prefrontal cortex

It has been suggested that the mental construction of scene imagery is a core process underpinning functions such as autobiographical memory, future thinking and spatial navigation. Damage to the ventromedial prefrontal cortex in humans can cause deficits in all of these cognitive domains. Moreover, it has also been reported that patients with ventromedial prefrontal cortex lesions are impaired at imagining fictitious scenes, although they seem able to describe specific scenes from autobiographical events. In general, not much is known about how ventromedial prefrontal cortex patients process scenes. Here, we deployed a recently-developed task to provide insights into this issue, which involved detecting either semantic (e.g. an elephant with butterflies for ears) or constructive (e.g. an endless staircase) violations in scene images. Identifying constructive violations typically provokes the formation of internal scene models in healthy control participants. We tested patients with bilateral ventromedial prefrontal cortex damage, brain-damaged control patients and healthy control participants. We found no evidence for statistically significant differences between the groups in detecting either type of violation. These results suggest that an intact ventromedial prefrontal cortex is not necessary for some aspects of scene processing, with implications for understanding its role in functions such as autobiographical memory and future thinking

Molecular diversity and distribution of marine fungi across 130 European environmental samples.

Journal ArticleEnvironmental DNA and culture-based analyses have suggested that fungi are present in low diversity and in low abundance in many marine environments, especially in the upper water column. Here, we use a dual approach involving high-throughput diversity tag sequencing from both DNA and RNA templates and fluorescent cell counts to evaluate the diversity and relative abundance of fungi across marine samples taken from six European near-shore sites. We removed very rare fungal operational taxonomic units (OTUs) selecting only OTUs recovered from multiple samples for a detailed analysis. This approach identified a set of 71 fungal 'OTU clusters' that account for 66% of all the sequences assigned to the Fungi. Phylogenetic analyses demonstrated that this diversity includes a significant number of chytrid-like lineages that had not been previously described, indicating that the marine environment encompasses a number of zoosporic fungi that are new to taxonomic inventories. Using the sequence datasets, we identified cases where fungal OTUs were sampled across multiple geographical sites and between different sampling depths. This was especially clear in one relatively abundant and diverse phylogroup tentatively named Novel Chytrid-Like-Clade 1 (NCLC1). For comparison, a subset of the water column samples was also investigated using fluorescent microscopy to examine the abundance of eukaryotes with chitin cell walls. Comparisons of relative abundance of RNA-derived fungal tag sequences and chitin cell-wall counts demonstrate that fungi constitute a low fraction of the eukaryotic community in these water column samples. Taken together, these results demonstrate the phylogenetic position and environmental distribution of 71 lineages, improving our understanding of the diversity and abundance of fungi in marine environments.Gordon and Betty Moore FoundationDeutsche ForschungsgemeinschaftMarie Curie International Outgoing FellowshipMarie Curie Intra-European FellowshipEMBO Long-Term fellowshi

ESR, raman and conductivity studies on fractionated poly(2-methoxyaniline-5-sulfonic acid)

Synthesis methods used to produce poly(2-methoxyaniline-5-sulfonic acid) (PMAS), a water soluble, self-doped conducting polymer, have been shown to form two distinctly different polymer fractions with molecular weights of approximately 2 kDa and 8 -10 kDa. The low molecular weight (LMWT) PMAS fraction is redox inactive and non-conducting while the high molecular weight (HMWT) PMAS is electro-active with electrical conductivities of 0.94 0.05 S cm-1. Previous investigations have illustrated the different photochemical and electrochemical properties of these fractions, but have not correlated these properties with the structural and electronic interactions that drive them. Incomplete purification of the PMAS mixture, typically via bag dialysis, has been shown to result in a mixture of approximately 50:50 HMWT:LMWT PMAS with electrical conductivity significantly lower at approximately 0.10 to 0.26 S cm-1. The difference between the electrical conductivities of these fractions has been investigated by the controlled addition of the non-conducting LMWT PMAS fraction into the HMWT PMAS composite film with the subsequent electronic properties investigated by solid-state ESR and Raman spectroscopies. These studies illustrate strong electronic intereactions of the insulating LMWT PMAS with the emeraldine salt HMWT PMAS to substantially alter the population of the electronic charge carriers in the conducting polymer. ESR studies on these mixtures, when compared to HMWT PMAS, exhibited a lower level of electron spin in the presence of LMWT PMAS indicative of the the formation of low spin bipolarons without a change the oxidation state of the conducting HMWT fraction

Teaching early numeracy to students with autism using a school staff delivery model

Mathematics is one of the core school subjects in the UK and an emphasis is placed on developing pupils’ mathematical competencies throughout all key stages. Despite that, the attainment of students with disabilities in mathematics remains low. The current study explored ways in which the Teaching Early Numeracy to children with Developmental Disabilities (TEN-DD) programme could be implemented by teaching staff in a special school in the UK to improve the numeracy skills of students with autism. Adaptations to the delivery of the programme were made during the study as a result of continued collaboration with the participating school. The findings suggest that it may be feasible to implement the TEN-DD programme using a school staff delivery model and it may help learners improve their early numeracy skills. Practical aspects of TEN-DD’s implementation highlighted the need to incorporate more systematic adaptations for minimally verbal students, as well as for learners who might need additional training with prerequisite skills

Early ultraviolet emission in the Type Ia supernova LSQ12gdj: No evidence for ongoing shock interaction

We present photospheric-phase observations of LSQ12gdj, a slowly-declining, UV-bright Type Ia supernova. Classified well before maximum light, LSQ12gdj has extinction-corrected absolute magnitude $M_B = -19.8$, and pre-maximum spectroscopic evolution similar to SN 1991T and the super-Chandrasekhar-mass SN 2007if. We use ultraviolet photometry from Swift, ground-based optical photometry, and corrections from a near-infrared photometric template to construct the bolometric (1600-23800 \AA) light curve out to 45 days past $B$-band maximum light. We estimate that LSQ12gdj produced $0.96 \pm 0.07$ $M_\odot$ of $^{56}$Ni, with an ejected mass near or slightly above the Chandrasekhar mass. As much as 27% of the flux at the earliest observed phases, and 17% at maximum light, is emitted bluewards of 3300 \AA. The absence of excess luminosity at late times, the cutoff of the spectral energy distribution bluewards of 3000 \AA, and the absence of narrow line emission and strong Na I D absorption all argue against a significant contribution from ongoing shock interaction. However, up to 10% of LSQ12gdj's luminosity near maximum light could be produced by the release of trapped radiation, including kinetic energy thermalized during a brief interaction with a compact, hydrogen-poor envelope (radius $< 10^{13}$ cm) shortly after explosion; such an envelope arises generically in double-degenerate merger scenarios.Comment: 18 pages, 10 figures, accepted to MNRAS; v2 accepted version. Spectra available on WISEReP (http://www.weizmann.ac.il/astrophysics/wiserep/). Natural-system photometry and bolometric light curve available as online tables in MNRAS versio

Evaluation of nitrous oxide emission by soybean inoculated with Bradyrhizobium strains commonly used as inoculants in South America

Aims: The purpose of this work was to analyze the agronomic and environmental performance of soybean plants inoculated with the Bradyrhizobium strains widely used as soybean biofertilizers in South America and to determine if these strains possess any functional or taxonomic trait associated with the NO emission. Methods: Bradyrhizobium japonicum E109 and CPAC 15, B. diazoefficiens USDA 110 and CPAC 7, and B. elkanii SEMIA 5019 and SEMIA 587 were used to inoculate soybean seeds. The field experiment was carried out in a soil without history of soybean cultivation in the Argentinian Humid Pampa. The natural N abundance method was applied to estimate N-fixation, and NO production was evaluated using gas chromatography. Among other physiological parameters, shoot dry weight, shoot N content, and crop yield were estimated after harvest. Results: B. japonicum inoculation produced the greatest increases in soybean growth and crop yield but also led to higher NO emissions compared to all other inoculated treatments. Plants inoculated with B. diazoefficiens released the lowest amount of NO, and their growth and yield were the least affected. Inoculation with B. elkanii resulted in intermediate NO emission fluxes and crop yield compared with B. japonicum and B. diazoefficiens. Conclusions: We found that soybean inoculation with strains of B. japonicum and B. elkanii that lack the nosZ gene led to the highest NO emissions under field conditions, but also to the highest crop yield, while inoculation with strains that carry out complete denitrification, nosZ-containing B. diazoefficiens, showed lower NO emission and lower crop yield.To the Instituto de Investigaciones Agrobiotecnológicas (INIAB); Universidad Nacional de Río Cuarto (UNRC); Consejo Nacional de Investigaciones Científcas y Tecnológicas (CONICET), Fondo Nacional de Ciencia y Tecnología (FONCyT); Instituto Nacional de Tecnología Agropecuaria (INTA). FC is Researcher of CONICET at the UNRC. DT and FD are Postdoc and PhD students at the UNRC granted by CONICET. MOC is a former PhD student at the UNRC granted by CONICET. To Mariano Cicchino from INTA Chascomús, who was in charge of sowing and yield estimation at R8. To Juan Pedro Ezquiaga from INTA Castelar, for their contribution to N2O measurements

Statistical mixing and aggregation in Feller diffusion

We consider Feller mean-reverting square-root diffusion, which has been applied to model a wide variety of processes with linearly state-dependent diffusion, such as stochastic volatility and interest rates in finance, and neuronal and populations dynamics in natural sciences. We focus on the statistical mixing (or superstatistical) process in which the parameter related to the mean value can fluctuate - a plausible mechanism for the emergence of heavy-tailed distributions. We obtain analytical results for the associated probability density function (both stationary and time dependent), its correlation structure and aggregation properties. Our results are applied to explain the statistics of stock traded volume at different aggregation scales.Comment: 16 pages, 3 figures. To be published in Journal of Statistical Mechanics: Theory and Experimen

The progenitor and early evolution of the Type IIb SN 2016gkg

We report initial observations and analysis on the Type IIb SN~2016gkg in the nearby galaxy NGC~613. SN~2016gkg exhibited a clear double-peaked light curve during its early evolution, as evidenced by our intensive photometric follow-up campaign. SN~2016gkg shows strong similarities with other Type IIb SNe, in particular with respect to the \he~emission features observed in both the optical and near infrared. SN~2016gkg evolved faster than the prototypical Type~IIb SN~1993J, with a decline similar to that of SN~2011dh after the first peak. The analysis of archival {\it Hubble Space Telescope} images indicate a pre-explosion source at SN~2016gkg's position, suggesting a progenitor star with a $\sim$mid F spectral type and initial mass $15-20$\msun, depending on the distance modulus adopted for NGC~613. Modeling the temperature evolution within $5\,\rm{days}$ of explosion, we obtain a progenitor radius of $\sim\,48-124$\rsun, smaller than that obtained from the analysis of the pre-explosion images ($240-320$\rsun).Comment: 7 pages, 5 figures. Submitted to ApJ Letter