68 research outputs found

    Comparative study on seasonal variation in hydro-chemical parameters of Ganga River water using comprehensive pollution index (CPI) at Rishikesh (Uttarakhand) India

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    The assessment of the Ganga River System at Rishikesh was investigated at five different sites for three different seasons (summer, winter and monsoon) using comprehensive pollution index (CPI), considering 10 physicochemical parameters such as conductivity, turbidity, total dissolved solids, dissolved oxygen, biochemical oxygen demand, chemical oxygen demand, total hardness, Cl, phosphate and sulphate. The CPI was found to be 0.54–2.47, which indicates the variation in pollution level of the River Ganga. The variation in pollution index value clearly shows that water quality was slightly polluted in winter (0.54–0.72) and summer (0.64–0.88) whereas high contamination (1.68–2.47) was observed during monsoon season. Among various sampling stations, Pashulok Barrage (Site 5) was more contaminated than other sites. All the studied parameters were under the permissible limit of W.H.O. (2011) except turbidity, total solids and suspended solids which were higher than the permissible limit. This study also illustrates the correlation between parameters by developing correlation matrix. The result of this study clearly elucidates that the water quality is getting contaminated as we moved from upstream to downstream of river and helps to understand the potential effects of water quality on drinking, irrigation and other purposes

    Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis

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    Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect. Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity

    Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis

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    Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life.We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries.The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect.Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity

    Cause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation : Data From ROCKET AF

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    M. Kaste on työryhmän ROCKET AF Steering Comm jäsen.Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intention-to-treat population. The median age was 73 years, and the mean CHADS(2) score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P= 75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, approximate to 7 in 10 deaths were cardiovascular, whereasPeer reviewe

    Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: A multi-cohort analysis

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    Differences in health status by socioeconomic position (SEP) tend to be more evident at older ages, suggesting the involvement of a biological mechanism responsive to the accumulation of deleterious exposures across the lifespan. DNA methylation (DNAm) has been proposed as a biomarker of biological aging that conserves memory of endogenous and exogenous stress during life. We examined the association of education level, as an indicator of SEP, and lifestyle-related variables with four biomarkers of age-dependent DNAm dysregulation: the total number of stochastic epigenetic mutations (SEMs) and three epigenetic clocks (Horvath, Hannum and Levine), in 18 cohorts spanning 12 countries. The four biological aging biomarkers were associated with education and different sets of risk factors independently, and the magnitude of the effects differed depending on the biomarker and the predictor. On average, the effect of low education on epigenetic aging was comparable with those of other lifestyle-related risk factors (obesity, alcohol intake), with the exception of smoking, which had a significantly stronger effect. Our study shows that low education is an independent predictor of accelerated biological (epigenetic) aging and that epigenetic clocks appear to be good candidates for disentangling the biological pathways underlying social inequalities in healthy aging and longevity

    Hydrochemical characteristics and planktonic composition assessment of River Henwal in Himalayan Region of Uttarakhand using CPI, Simpson's and Shannon-Weaver Index

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    In this present study seasonal water quality of River Henwal was conducted in term of the physico-chemical parameters, heavy metals, and plankton composition at four different sites of Chamba, Distt, Tehri Garhwal to observe pollution grade of River Henwal, situated in newly carved state of Uttarakhand. One site was considered as control site out of four and low concentration of physicochemical parameters was observed at it. For this purpose, comprehensive pollution index (CPI) was used, in view of the physiochemical parameters such as conductivity, turbidity, dissolved oxygen, total solids, total hardness (TH), total phosphate, chloride etc. and heavy metals (Fe, Cu, Zn, Cr etc.). Besides this, Simpson index (D) and Shannon-Weaver index (H) and Taxon Evenness (E) are used to depict the planktonic density, diversity and evenness in Henwal river. The CPI value (4.70-10.31) classifies the water quality in severely polluted condition of river water. Highest value was at Khadi. Blue green algae and protozoa were the most abundant group was recorded at all four sites. The highest Simpson (4.74), Shannon-Weiner index (1.58) and taxon evenness (0.46) was at Nagni during monsoon and lowest was at control site (D = 4.37, H = 1.54 and E = 0.43) during winter. Negative correlation was found between turbidity and plankton
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