Space Telescope Imaging Spectrograph Parallel Observations of the Planetary Nebula M94-20

The planetary nebula M94--20 in the Large Magellanic Cloud was serendipitously observed with the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope as part of the Hubble Space Telescope Archival Pure Parallel Program. We present spatially resolved imaging and spectral data of the nebula and compare them with ground based data, including detection of several emission lines from the nebula and the detection of the central star. We find the total H alpha + [NII] flux = 7.3e-15 erg s^-1 cm^-2 and we estimate the magnitude of the central star to be m_V = 26.0 +/- 0.2. Many other H alpha sources have been found in M31, M33 and NGC 205 as well. We discuss the use of the parallel observations as a versatile tool for planetary nebula surveys and for other fields of astronomical research.Comment: Latex, 14 pages, 2 JPEG figures, 2 tables. PASP Research Note, June 1999, in pres

Altered Anesthetic Sensitivity of Mice Lacking Ndufs4, a Subunit of Mitochondrial Complex I

RDP and AQ were supported by the Howard Hughes Medical Institute (HHMI). AQ was a recipient of MICINN postdoctoral mobility program fellowship from the Spanish Ministerio de Ciencia e Innovación. PGM and MMS were supported by National Institutes of Health (NIH) grant GM58881. These studies were also supported in part by the Mitochondrial Research Guild. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABAA and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role of these receptors as sole effectors of general anesthesia. Findings in C. elegans and in children reveal that defects in mitochondrial complex I can cause hypersensitivity to volatile anesthetics. Here, we tested a knockout (KO) mouse with reduced complex I function due to inactivation of the Ndufs4 gene, which encodes one of the subunits of complex I. We tested these KO mice with two volatile and two non-volatile anesthetics. KO and wild-type (WT) mice were anesthetized with isoflurane, halothane, propofol or ketamine at post-natal (PN) days 23 to 27, and tested for loss of response to tail clamp (isoflurane and halothane) or loss of righting reflex (propofol and ketamine). KO mice were 2.5 - to 3- fold more sensitive to isoflurane and halothane than WT mice. KO mice were 2-fold more sensitive to propofol but resistant to ketamine. These changes in anesthetic sensitivity are the largest recorded in a mammal

Improving accuracy and efficiency of mutual information for multi-modal retinal image registration using adaptive probability density estimation

Mutual information (MI) is a popular similarity measure for performing image registration between different modalities. MI makes a statistical comparison between two images by computing the entropy from the probability distribution of the data. Therefore, to obtain an accurate registration it is important to have an accurate estimation of the true underlying probability distribution. Within the statistics literature, many methods have been proposed for finding the 'optimal' probability density, with the aim of improving the estimation by means of optimal histogram bin size selection. This provokes the common question of how many bins should actually be used when constructing a histogram. There is no definitive answer to this. This question itself has received little attention in the MI literature, and yet this issue is critical to the effectiveness of the algorithm. The purpose of this paper is to highlight this fundamental element of the MI algorithm. We present a comprehensive study that introduces methods from statistics literature and incorporates these for image registration. We demonstrate this work for registration of multi-modal retinal images: colour fundus photographs and scanning laser ophthalmoscope images. The registration of these modalities offers significant enhancement to early glaucoma detection, however traditional registration techniques fail to perform sufficiently well. We find that adaptive probability density estimation heavily impacts on registration accuracy and runtime, improving over traditional binning techniques. © 2013 Elsevier Ltd

Defining quality physical education: an analysis of international documents

Abstract presented at the 2014 AAHPERD National Convention and Exposition, 2-4 April 2014, St. Louis, United State

Proficiency deficiency: mastery of fundamental movement skills and skill components in overweight and obese children

The purpose of this observational study was to compare the mastery of 12 fundamental movement skills (FMS) and skill components between a treatment-seeking sample of overweight/obese children and a reference sample from the United States. Mastery of six locomotor and six object-control skills (24 components in each subdomain) were video-assessed by one assessor using the test of gross motor development-2 (TGMD-2). The 153 overweight/obese children (mean ± s.d. age = 8.3 ± 1.1 years, BMI z-score = 2.78 ± 0.69, 58% girls, 77% obese) were categorized into age groups (for the underhand roll and strike: 7–8 years and 9–10 years; all other FMS: 6–7 years and 8–10 years) and mastery prevalence rates were compared with representative US data (N = 876) using χ2 analysis. For all 12 skills in all age groups, the prevalence of mastery was lower among overweight/obese children compared with the reference sample (all P < 0.05). This was consistent for 18 locomotor and upto 21 object-control skill components (all P < 0.05). Differences were largest for the run, slide, hop, dribble, and kick. Specific movement patterns that could be targeted for improvement include positioning of the body and feet, the control or release of an object at an optimal position, and better use of the arms to maintain effective force production during the performance of FMS. Physical activity programs designed for overweight and obese children may need to address deficiencies in FMS proficiency to foster the movement capabilities required for participation in health-enhancing physical activity

Objectively measured sedentary behavior in secondary school physical education lessons

Abstract presented at the 2014 Global Summit on the Physical Activity of Children, held in Toronto, May 19-22, 2014

Host movement dominates the predicted effects of climate change on parasite transmission between wild and domestic mountain ungulates

Climate change is shifting the transmission of parasites, which is determined by host density, ambient temperature and moisture. These shifts can lead to increased pressure from parasites, in wild and domestic animals, and can impact the effectiveness of parasite control strategies. Understanding the interactive effects of climate on host movement and parasite life histories will enable targeted parasite management, to ensure livestock productivity and avoid additional stress on wildlife populations. To assess complex outcomes under climate change, we applied a gastrointestinal nematode transmission model to a montane wildlife–livestock system, based on host movement and changes in abiotic factors due to elevation, comparing projected climate change scenarios with the historic climate. The wildlife host, Alpine ibex (Capra ibex ibex), undergoes seasonal elevational migration, and livestock are grazed during the summer for eight weeks. Total parasite infection pressure was more sensitive to host movement than to the direct effect of climatic conditions on parasite availability. Extended livestock grazing is predicted to increase parasite exposure for wildlife. These results demonstrate that movement of different host species should be considered when predicting the effects of climate change on parasite transmission, and can inform decisions to support wildlife and livestock health.<br/

A Search for Wolf-Rayet Stars in the Small Magellanic Cloud

We conducted an extensive search for Wolf-Rayet stars (W-Rs) in the SMC, using the same interference filter imaging techniques that have proved successful in finding W-Rs in more distant members of the Local Group. Photometry of some 1.6 million stellar images resulted in some 20 good candidates, which we then examined spectroscopically. Two of these indeed proved to be newly found W-Rs, bringing the total known in the SMC from 9 to 11. Other finds included previously unknown Of-type stars (one as early as O5f?p)),the recovery of the Luminous Blue Variable S18, and the discovery of a previously unknown SMC symbiotic star. More important, however, is the fact that there does not exist a significant number of W-Rs waiting to be discovered in the SMC. The number of W-Rs in the SMC is a factor of 3 lower than in the LMC (per unit luminosity), and we argue this is the result of the SMC's low metallicity on the evolution of the most massive stars.Comment: Accepted by Astrophysical Journal. Postscript version available via ftp.lowell.edu/pub/massey/smcwr.ps.gz Revised version contains slightly revised spectral types for the Of stars but is otherwise unchange