Sex differences in endothelial function in porcine coronary arteries: a role for H2O2and gap junctions?

BACKGROUND AND PURPOSE: Cardiovascular risk is higher in men and postmenopausal women compared with premenopausal women. This may be due to sex differences in endothelial function. Here, sex differences in endothelial function of porcine coronary arteries (PCAs) were investigated. EXPERIMENTAL APPROACH: Distal PCAs were studied under myographic conditions and after precontraction with U46619. Concentration-response curves to bradykinin were constructed in the presence of a range of inhibitors. KEY RESULTS: In male and female PCAs, bradykinin produced comparable vasorelaxant responses. Inhibition of NO and prostanoid synthesis produced greater inhibition in males compared with females. Removing H2O2 with PEG-catalase reduced the maximum relaxation in the absence, but not the presence of L-NAME and indomethacin in females, and had no effect in males. Blocking gap junctions with 100 muM carbenoxolone or 18α-glycyrrhetinic acid further inhibited the endothelium-derived hyperpolarization (EDH-mediated response in females but not in males. In female PCAs, the maximum EDH-mediated response was reduced by inhibiting SKCa with apamin and by inhibiting IKCa with TRAM-34, or with both. In male PCAs, at maximum bradykinin concentration, the EDH-mediated response was reduced in the presence of apamin but not TRAM-34. Western blot did not detect any differences in connexins 40 or 43 or in IKCa expression between male and female PCAs. CONCLUSIONS AND IMPLICATIONS: H2O2 mediated some part of endothelium-dependent vasorelaxation in female PCAs and EDH was more important in females, with differences in the contribution of gap junctions and IKCa channels. These findings may contribute to understanding vascular protection in premenopausal women

Lagrangian description of world-line deviations

We introduce a Lagrangian which can be varied to give both the equation of motion and world-line deviations of spinning particles simultaneously.Comment: to appear in IJT

Limitations of light delay and storage times in EIT experiments with condensates

We investigate the limitations arising from atomic collisions on the storage and delay times of probe pulses in EIT experiments. We find that the atomic collisions can be described by an effective decay rate that limits storage and delay times. We calculate the momentum and temperature dependence of the decay rate and find that it is necessary to excite atoms at a particular momentum depending on temperature and spacing of the energy levels involved in order to minimize the decoherence effects of atomic collisions.Comment: 4 pages RevTeX, 4 figures. Send correspondence to [email protected]

Equine nutrition: a survey of perceptions and practices of horse owners undertaking a massive open online course in equine nutrition

An online survey was designed to ascertain the following information: demographics, current feeding practices, and perceptions and knowledge of equine nutrition, including nutrition-related disorders. Response rate was 34% (6,538 respondents). More than 80% of respondents were horse owners or caretakers, with the majority owning between one and five horses (75%) aged 5 years and older (74%). Most kept their horses for pleasure (54%), with 33% using them mostly for competition and 13% using them for an equal mix of both pleasure and competition. Concentrates were fed by the majority (87%), and more than 70% stated that their horses had some access to pasture. Over half of respondents (60%) regularly monitored their horses' weight, with most doing this monthly. Weight tapes were most commonly used (62%), although many reported to guess the weight of their horse(s) with very few (5%) using weight scales. Under half (46%) stated that they regularly used body condition scoring (BCS), many did not use BCS at all (24%), and some did not know what BCS was (10%). Of those that did use BCS, most (36%) did this monthly, with others weekly (25%), daily (14%), and when they remembered (15%). Overall knowledge of nutrition was reported by most as average (median, 3 on Likert scale—average); however, respondents were less knowledgeable on the management of nutrition-related disorders

Feshbach resonances in a quasi-2D atomic gas

Strongly confining an ultracold atomic gas in one direction to create a quasi-2D system alters the scattering properties of this gas. We investigate the effects of confinement on Feshbach scattering resonances and show that strong confinement results in a shift in the position of the Feshbach resonance as a function of the magnetic field. This shift, as well as the change of the width of the resonance, are computed. We find that the resonance is strongly damped in the thermal gas, but in the condensate the resonance remains sharp due to many-body effects. We introduce a 2D model system, suited for the study of resonant superfluidity, and having the same scattering properties as the tightly confined real system near a Feshbach resonance. Exact relations are derived between measurable quantities and the model parameters.Comment: 8 pages, 2 figure

North Pacific Surgical Association A booming economy means a bursting trauma system: association between hospital admission for major injury and indicators of economic activity in a large Canadian health region

Abstract BACKGROUND: Injury epidemiology fluctuates with economic activity in many countries. These relationships remain unclear in Canada. METHODS: The annual risk of admission for major injury (Injury Severity Score R12) to a highvolume, level-1 Canadian trauma center was compared with indicators of economic activity over a 16-year period using linear regression

Geodesic deviation in pp-wave spacetimes of quadratic curvature gravity

We write the equation of geodesic deviations in the spacetime of $pp$-waves in terms of the Newman-Penrose scalars and apply it to study gravitational waves in quadratic curvature gravity. We show that quadratic curvature gravity $pp$-waves can have a transverse helicity-0 polarization mode and two transverse helicity-2 general relativity-like wave polarizations. A concrete example is given in which we analyze the wave polarizations of an exact impulsive gravitational wave solution to quadratic curvature gravity.Comment: 16 pages, no figures, accepted in Physical Review

Bayesian Nonparametric Inverse Reinforcement Learning

Inverse reinforcement learning (IRL) is the task of learning the reward function of a Markov Decision Process (MDP) given the transition function and a set of observed demonstrations in the form of state-action pairs. Current IRL algorithms attempt to find a single reward function which explains the entire observation set. In practice, this leads to a computationally-costly search over a large (typically infinite) space of complex reward functions. This paper proposes the notion that if the observations can be partitioned into smaller groups, a class of much simpler reward functions can be used to explain each group. The proposed method uses a Bayesian nonparametric mixture model to automatically partition the data and find a set of simple reward functions corresponding to each partition. The simple rewards are interpreted intuitively as subgoals, which can be used to predict actions or analyze which states are important to the demonstrator. Experimental results are given for simple examples showing comparable performance to other IRL algorithms in nominal situations. Moreover, the proposed method handles cyclic tasks (where the agent begins and ends in the same state) that would break existing algorithms without modification. Finally, the new algorithm has a fundamentally different structure than previous methods, making it more computationally efficient in a real-world learning scenario where the state space is large but the demonstration set is small