Provisioning Spot Market Cloud Resources to Create Cost-effective Virtual Clusters

Infrastructure-as-a-Service providers are offering their unused resources in the form of variable-priced virtual machines (VMs), known as "spot instances", at prices significantly lower than their standard fixed-priced resources. To lease spot instances, users specify a maximum price they are willing to pay per hour and VMs will run only when the current price is lower than the user's bid. This paper proposes a resource allocation policy that addresses the problem of running deadline-constrained compute-intensive jobs on a pool of composed solely of spot instances, while exploiting variations in price and performance to run applications in a fast and economical way. Our policy relies on job runtime estimations to decide what are the best types of VMs to run each job and when jobs should run. Several estimation methods are evaluated and compared, using trace-based simulations, which take real price variation traces obtained from Amazon Web Services as input, as well as an application trace from the Parallel Workload Archive. Results demonstrate the effectiveness of running computational jobs on spot instances, at a fraction (up to 60% lower) of the price that would normally cost on fixed priced resources.Comment: 14 pages, 4 figures, 11th International Conference on Algorithms and Architectures for Parallel Processing (ICA3PP-11); Lecture Notes in Computer Science, Vol. 7016, 201

Myocardial T1 mapping and extracellular volume quantification in patients with left ventricular non-compaction cardiomyopathy

Aims: From pathophysiological mechanisms to risk stratification and management, much debate and discussion persist regarding left ventricular non-compaction cardiomyopathy (LVNC). This study aimed to characterize myocardial T1 mapping and extracellular volume (ECV) fraction by cardiovascular magnetic resonance (CMR), and investigate how these biomarkers relate to left ventricular ejection fraction (LVEF) and ventricular arrhythmias (VA) in LVNC. Methods and results: Patients with LVNC (n = 36) and healthy controls (n = 18) were enrolled to perform a CMR with T1 mapping. ECV was quantified in LV segments without late gadolinium enhancement (LGE) areas to investigate diffuse myocardial fibrosis. Patients with LVNC had slightly higher native T1 (1024 ± 43 ms vs. 995 ± 22 ms, P = 0.01) and substantially expanded ECV (28.0 ± 4.5% vs. 23.5 ± 2.2%, P < 0.001) compared to controls. The ECV was independently associated with LVEF (β = -1.3, P = 0.001). Among patients without LGE, VAs were associated with higher ECV (27.7% with VA vs. 25.8% without VA, P = 0.002). Conclusion: In LVNC, tissue characterization by T1 mapping suggests an extracellular expansion by diffuse fibrosis in myocardium without LGE, which was associated with myocardial dysfunction and VA, but not with the amount of non-compacted myocardium

Developing a Cost-Effective Virtual Cluster on the Cloud

The Cloud provides highly democratic access to computer services on a pay-per-use basis. A fact that has encouraged many researchers to adopt the Cloud for the processing of large computational tasks and data storage. This has been used in the past for single research endeavours or as mechanism for coping with excessive load on conventional computational resources (clusters). In this paper we investigate, through the use of simulation, the applicability of running an entire computer cluster on the Cloud. We investigate a number of policy decisions which can be made over such a virtual cluster to reduce the running cost and the effect these policies have on the users of the cluster

The zebrafish reference genome sequence and its relationship to the human genome

Zebrafish have become a popular organism for the study of vertebrate gene function. The virtually transparent embryos of this species, and the ability to accelerate genetic studies by gene knockdown or overexpression, have led to the widespread use of zebrafish in the detailed investigation of vertebrate gene function and increasingly, the study of human genetic disease. However, for effective modelling of human genetic disease it is important to understand the extent to which zebrafish genes and gene structures are related to orthologous human genes. To examine this, we generated a high-quality sequence assembly of the zebrafish genome, made up of an overlapping set of completely sequenced large-insert clones that were ordered and oriented using a high-resolution high-density meiotic map. Detailed automatic and manual annotation provides evidence of more than 26,000 protein-coding genes, the largest gene set of any vertebrate so far sequenced. Comparison to the human reference genome shows that approximately 70% of human genes have at least one obvious zebrafish orthologue. In addition, the high quality of this genome assembly provides a clearer understanding of key genomic features such as a unique repeat content, a scarcity of pseudogenes, an enrichment of zebrafish-specific genes on chromosome 4 and chromosomal regions that influence sex determination