780 research outputs found
Higgsino Dark Matter in a SUGRA Model with Nonuniversal Gaugino Masses
We study a specific SUGRA model with nonuniversal gaugino masses as an
alternative to the minimal SUGRA model in the context of supersymmetric dark
matter. The lightest supersymmetric particle in this model comes out to be a
Higgsino dominated instead of a bino dominated lightest neutralino. The thermal
relic density of this Higgsino dark matter is somewhat lower than the
cosmologically favoured range, which means it may be only a subdominant
component of the cold dark matter. Nonetheless, it predicts favourable rates of
indirect detection, which can be seen in square-km size neutrino telescopes.Comment: Version to appear in Phys. Rev. D. A few references added in the
bibliography and a comment added in Section 2. LaTex, 16 pages, 4 figure
International Emission Policy with Lobbying and Technological Change
I examine the implementation of emission policy in a union of countries. Production in any country incurs emissions that pollute all over the union, but efficiency in production can be improved by research and development (R&D). I compare four cases: laissez-faire, Pareto optimal policy, lobbying with centrally-determined emission quotas and lobbying with emission trade. The main findings are as follows. With emission quotas, the growth rate is socially optimal, but welfare sub-optimal. Emission trade speeds up growth from the initial position of laissez-faire, but slows down from the initial position of centrally-determined emission quotas
Gaugino Mass Nonuniversality and Dark Matter in SUGRA, Strings and D Brane Models
The effects of nonuniversality of gaugino masses on dark matter are examined
within supersymmetric grand unification, and in string and D brane models with
R parity invariance. In SU(5) unified models nonuniversality in the gaugino
sector can be generated via the gauge kinetic energy function which may depend
on the 24, 75 and 200 dimensional Higgs representations. We also consider
string models which allow for nonuniversality of gaugino masses and D brane
models where nonuniversality arises from embeddings of the Standard Model gauge
group on five branes and nine branes. It is found that with gaugino mass
nonuniversality the range of the LSP mass can be extended much beyond the range
allowed in the universal SUGRA case, up to about 600 GeV even without
coannihilation effects in some regions of the parameter space. The effects of
coannihilation are not considered and inclusion of these effects may further
increase the allowed neutralino mass range. Similarly with the inclusion of
gaugino mass nonuniversality, the neutralino-proton () cross-section
can increase by as much as a factor of 10 in some of regions of the parameter
space. An analysis of the uncertainties in the quark density content of the
nucleon is given and their effects on cross-section are discussed.
The predictions of our analysis including nonuniversality is compared with the
current limits from dark matter detectors and implications for future dark
matter searches are discussed.Comment: Revised version, 23 pages, Latex, and 7 figure
Supersymmetric Dark Matter and Yukawa Unification
An analysis of supersymmetric dark matter under the Yukawa unification
constraint is given. The analysis utilizes the recently discovered region of
the parameter space of models with gaugino mass nonuniversalities where large
negative supersymmetric corrections to the b quark mass appear to allow
unification for a positive sign consistent with the and constraints. In the present analysis we use the
revised theoretical determination of ()
in computing the difference which takes account of
a reevaluation of the light by light contribution which has a positive sign.
The analysis shows that the region of the parameter space with
nonuniversalities of the gaugino masses which allows for unification of Yukawa
couplings also contains regions which allow satisfaction of the relic density
constraint. Specifically we find that the lightest neutralino mass consistent
with the relic density constraint, unification for SU(5) and
unification for SO(10) in addition to other constraints lies in the region
below 80 GeV. An analysis of the maximum and the minimum neutralino-proton
scalar cross section for the allowed parameter space including the effect of a
new determination of the pion-nucleon sigma term is also given. It is found
that the full parameter space for this class of models can be explored in the
next generation of proposed dark matter detectors.Comment: 28 pages,nLatex including 5 fig
Hadronic Total Cross-sections Through Soft Gluon Summation in Impact Parameter Space
The Bloch-Nordsieck model for the parton distribution of hadrons in impact
parameter space, constructed using soft gluon summation, is investigated in
detail.
Its dependence upon the infrared structure of the strong coupling constant
is discussed, both for finite as well as singular, but integrable,
. The formalism is applied to the prediction of total proton-proton
and proton-antiproton cross-sections, where screening, due to soft gluon
emission from the initial valence quarks, becomes evident.Comment: 20 pages, Latex2e, input FEYNMAN,12 postscipt figures. Submitted to
PR
An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
Until recently, effective therapies for advanced endometrial cancer progressing to a platinum-based combination were lacking. In this setting, immunotherapy with anti PD-1/PDL-1 monoclonal antibodies is rising as a new paradigm in particular for patients with microsatellites instability/mismatch repair deficiency. In this case report, we describe an exceptional and rapid response to dostarlimab in a platinum refractory endometrial cancer patient with high disease burden harboring a mismatch repair deficiency
AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons
Functional as well as structural alterations in mitochondria size, shape and distribution are precipitating, early events in progression of Alzheimer's Disease (AD). We reported that a 20\u201322 kDa NH2-tau fragment (aka NH2htau), mapping between 26 and 230 amino acids of the longest human tau isoform, is detected in cellular and animal AD models and is neurotoxic in hippocampal neurons. The NH2htau \u2013but not the physiological full-length protein\u2013 interacts with A\u3b2 at human AD synapses and cooperates with it in inhibiting the mitochondrial ANT-1-dependent ADP/ATP exchange. Here we show that the NH2htau also adversely affects the interplay between the mitochondria dynamics and their selective autophagic clear- ance. Fragmentation and perinuclear mislocalization of mitochondria with smaller size and density are early found in dying NH2htau-expressing neurons. The specific effect of NH2htau on quality control of mitochondria is accompanied by (i) net reduction in their mass in correlation with a general Parkin- mediated remodeling of membrane proteome; (ii) their extensive association with LC3 and LAMP1 autoph- agic markers; (iii) bioenergetic deficits and (iv) in vitro synaptic pathology. These results suggest that NH2htau can compromise the mitochondrial biology thereby contributing to AD synaptic deficits not only by ANT-1 inactivation but also, indirectly, by impairing the quality control mechanism of these organelles
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