An embedded distributed tool for transportation systems health assessment

International audienceThis article presents an embedded distributed tool for health assessment of complex systems. The presented architecture is based on a solving method for embedded technical diagnostics and prognostics. This tool provides services enabling the evaluation of the health status of complex systems. Diagnostic services provide information for the maintenance decision support system that leads to reduce the periods of unavailability and determine if their future mission can be carried out. The diagnostic and prognostic functions are detailed and the exchanged data are specified. An example shows the feasibility of the proposed architecture and demonstrates the correctness of the developed algorithms

Unpacking distinction within mobility : social prestige and international students

Author thanks the Social Sciences and Humanities Research Council of Canada (SSHRC) for their funding on this projecThis paper investigates the complex ways in which young people engage in social distinction within international mobility. The study offers novel conceptual and empirical insights by examining how distinction and social advantage is reproduced through short‐term student mobility from the Global North to the Global South. In doing so, it elucidates the iterative process of distinction‐making within mobility and argues that young mobile people negotiate a tension between different forms of distinction. Specifically, it unpacks and conceptualises distinction into dual categories—collective and individual—and suggests that students alternate and waver between these categories in order to both validate and elevate their position within a mobility hierarchy. The paper also considers how particular places are viewed as more distinctive and affording greater gains in cultural and symbolic capital. It concludes with future interrogations and ways forward for research on international mobility and distinction.PostprintPeer reviewe

Large-Scale Sleep Condition Analysis Using Selfies from Social Media

Sleep condition is closely related to an individual's health. Poor sleep conditions such as sleep disorder and sleep deprivation affect one's daily performance, and may also cause many chronic diseases. Many efforts have been devoted to monitoring people's sleep conditions. However, traditional methodologies require sophisticated equipment and consume a significant amount of time. In this paper, we attempt to develop a novel way to predict individual's sleep condition via scrutinizing facial cues as doctors would. Rather than measuring the sleep condition directly, we measure the sleep-deprived fatigue which indirectly reflects the sleep condition. Our method can predict a sleep-deprived fatigue rate based on a selfie provided by a subject. This rate is used to indicate the sleep condition. To gain deeper insights of human sleep conditions, we collected around 100,000 faces from selfies posted on Twitter and Instagram, and identified their age, gender, and race using automatic algorithms. Next, we investigated the sleep condition distributions with respect to age, gender, and race. Our study suggests among the age groups, fatigue percentage of the 0-20 youth and adolescent group is the highest, implying that poor sleep condition is more prevalent in this age group. For gender, the fatigue percentage of females is higher than that of males, implying that more females are suffering from sleep issues than males. Among ethnic groups, the fatigue percentage in Caucasian is the highest followed by Asian and African American.Comment: 2017 International Conference on Social Computing, Behavioral-Cultural Modeling, & Prediction and Behavior Representation in Modeling and Simulation (SBP-BRiMS'17

Exploring our practitioner and parent partnerships

The study presented here is underpinned by Froebel’s pedagogy and principles; acknowledging the importance and value of the relationship between children, family members and practitioners, and the role of play as a central, integrating element in children’s development and learning (Froebel, c1826, trans 1912). For Froebel, parents and family members form the basis for a child’s understandings and interactions, which reiterates that an effective partnership essentially involves the engagement of parents and practitioners in order to support all children educationally, socially and emotionally

Young children's cognitive achievement: home learning environment, language and ethnic background

For decades, research has shown differences in cognitive assessment scores between White and minority ethnic group(s) learners as well as differences across different minority ethnic groups. More recent data have indicated that the home learning environment and languages spoken can impact cognitive assessment and other corollary outcomes. This study uses the Millennium Cohort Study to jointly assess how minority ethnic group, home learning environment and home languages predict child cognitive assessment scores. Regression analyses were conducted using two assessment measures. The following is hypothesised: (1) cognitive achievement scores vary by minority ethnic group, (2) more home learning environment in early childhood leads to higher cognitive development scores and (3) English only in the home yields the highest cognitive scores while no English in the home yields the lowest. Findings reveal that there are differences in cognitive scores along ethnic group categories although there are also some unexpected findings. Home learning environment does not play as large a role as was predicted in raising the assessment scores overall for learners while speaking English in the home does, irrespective of ethnic background

A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes

Copyright @ 2012, American Society for Microbiology.Human coronaviruses are associated with upper respiratory tract infections that occasionally spread to the lungs and other organs. Although airway epithelial cells represent an important target for infection, the respiratory epithelium is also composed of an elaborate network of dendritic cells (DCs) that are essential sentinels of the immune system, sensing pathogens and presenting foreign antigens to T lymphocytes. In this report, we show that in vitro infection by human coronavirus 229E (HCoV-229E) induces massive cytopathic effects in DCs, including the formation of large syncytia and cell death within only few hours. In contrast, monocytes are much more resistant to infection and cytopathic effects despite similar expression levels of CD13, the membrane receptor for HCoV-229E. While the differentiation of monocytes into DCs in the presence of granulocyte-macrophage colony-stimulating factor and interleukin-4 requires 5 days, only 24 h are sufficient for these cytokines to sensitize monocytes to cell death and cytopathic effects when infected by HCoV-229E. Cell death induced by HCoV-229E is independent of TRAIL, FasL, tumor necrosis factor alpha, and caspase activity, indicating that viral replication is directly responsible for the observed cytopathic effects. The consequence of DC death at the early stage of HCoV-229E infection may have an impact on the early control of viral dissemination and on the establishment of long-lasting immune memory, since people can be reinfected multiple times by HCoV-229E

Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction

Fetal growth restriction (FGR) is a significant risk factor for stillbirth, neonatal complications and adulthood morbidity. Compared with those of appropriate weight for gestational age (AGA), FGR babies have smaller placentas with reduced activity of amino acid transporter systems A and L, thought to contribute to poor fetal growth. The amino acids glutamine and glutamate are essential for normal placental function and fetal development; whether transport of these is altered in FGR is unknown. We hypothesised that FGR is associated with reduced placental glutamine and glutamate transporter activity and expression, and propose the mammalian target of rapamycin (mTOR) signaling pathway as a candidate mechanism. FGR infants [individualised birth weight ratio (IBR) < 5th centile] had lighter placentas, reduced initial rate uptake of 14C-glutamine and 14C-glutamate (per mg placental protein) but higher expression of key transporter proteins (glutamine: LAT1, LAT2, SNAT5, glutamate: EAAT1) versus AGA [IBR 20th–80th]. In further experiments, in vitro exposure to rapamycin inhibited placental glutamine and glutamate uptake (24 h, uncomplicated pregnancies) indicating a role of mTOR in regulating placental transport of these amino acids. These data support our hypothesis and suggest that abnormal glutamine and glutamate transporter activity is part of the spectrum of placental dysfunction in FGR

Comparing eDNA metabarcoding and conventional pelagic netting to inform biodiversity monitoring in deep ocean environments

The performance of environmental DNA (eDNA) metabarcoding has rarely been evaluated against conventional sampling methods in deep ocean mesopelagic environments. We assessed the biodiversity patterns generated with eDNA and two co-located conventional methods, oblique midwater trawls and vertical multinets, to compare regional and sample-level diversity. We then assessed the concordance of ecological patterns across water column habitats and evaluated how DNA markers and the level of sampling effort influenced the inferred community. We found eDNA metabarcoding characterized regional diversity well, detecting more taxa while identifying similar ecological patterns as conventional samples. Within sampling locations, eDNA metabarcoding rarely detected taxa across more than one replicate. While more taxa were found in eDNA than oblique midwater trawls within sample stations, fewer were found compared to vertical multinets. Our simulations show greater eDNA sampling effort would improve concordance with conventional methods. We also observed that using taxonomic data from multiple markers generated ecological patterns most similar to those observed with conventional methods. Patterns observed with Exact Sequence Variants were more stable across markers suggesting they are more powerful for detecting change. eDNA metabarcoding is a valuable tool for identifying and monitoring biological hotspots but some methodological adjustments are recommended for deep ocean environments

Mort neuronale induite par un coronavirus humain

Les coronavirus humains (HCoV) sont des pathogènes respiratoires causant le plus fréquemment le rhume mais aussi des pneumonies et l’exacerbation de l’asthme. Nous avons démontré que la souche OC43 (HCoV-OC43) peut également être associée à des maladies neurodégénératives. En effet, HCoV-OC43 a la capacité d’infecter et de se répliquer dans les cellules du système nerveux central où le neurone est la cible principale, provoquant ainsi la mort de cette cellule essentielle. Or, la mort des neurones suite à l’infection semble être induite via différentes voies métaboliques et par divers facteurs cellulaires associés à ces voies; dont entre autres les protéines Bax, AIF et RIP1/3. De plus, la glycoprotéine de surface S semble également être impliquée dans la régulation de la mort cellulaire puisque certains virus portant des mutations de cette protéine augmentent la mort neuronale. Nous avons précédemment démontré que Bax et AIF sont activés suite à l’infection d’une lignée neuronale humaine (LA-N-5). De plus, les protéines RIP1/3 auraient un rôle à jouer dans la mort des neurones utilisés dans des modèles de maladies neurologiques. En utilisant le modèle cellulaire LA-N-5 de neurones humains, nous avons démontré que Bax ne semble pas jouer un rôle important dans la mort neuronale alors que AIF et RIP1/3 demeurent des candidats intéressants pouvant expliquer l’activation des processus de mort cellulaire. En effet, suite à l’infection de cellules LA-N-5, les niveaux en ARNm des protéines RIP1/3 augmentent de façon significative. De plus, en utilisant des inhibiteurs chimiques de la protéine RIP1, la mortalité cellulaire induite par l’infection des neurones est atténuée. Par une approche d’ARN interférant (ARNi), l’expression des protéines AIF et RIP1/3 sera diminuée afin de déterminer si ces protéines jouent véritablement un rôle dans la mort neuronale induite par l’infection. Cette étude tente de clarifier les mécanismes impliqués dans la mort des neurones infectés par HCoV-OC43, de comprendre l’importance de la protéine virale S dans le processus et d’établir un lien entre l’infection et la dégénérescence de neurones.</p

On the interplay between hypothermia and reproduction in a high arctic ungulate

For free-ranging animals living in seasonal environments, hypometabolism (lowered metabolic rate) and hypothermia (lowered body temperature) can be effective physiological strategies to conserve energy when forage resources are low. To what extent such strategies are adopted by large mammals living under extreme conditions, as those encountered in the high Arctic, is largely unknown, especially for species where the gestation period overlaps with the period of lowest resource availability (i.e. winter). Here we investigated for the first time the level to which high arctic muskoxen (Ovibos moschatus) adopt hypothermia and tested the hypothesis that individual plasticity in the use of hypothermia depends on reproductive status. We measured core body temperature over most of the gestation period in both free-ranging muskox females in Greenland and captive female muskoxen in Alaska. We found divergent overwintering strategies according to reproductive status, where pregnant females maintained stable body temperatures during winter, while non-pregnant females exhibited a temporary decrease in their winter body temperature. These results show that muskox females use hypothermia during periods of resource scarcity, but also that the use of this strategy may be limited to non-reproducing females. Our findings suggest a trade-of between metabolically driven energy conservation during winter and sustaining foetal growth, which may also apply to other large herbivores living in highly seasonal environments elsewhere.publishedVersio