28 research outputs found
ENV-653: PRODUCTION OF BIOSURFACTANT BY RHODOCOCCUS ERYTHROPOLIS SP. CULTIVATED IN A NOVEL FISH WASTE COMPOST EXTRACT SUBSTRATE
- Publication venue
- Scholarship@Western
- Publication date
- 01/06/2016
- Field of study
Compost generated through fish waste composting could provide an effective source of nutrient-rich organic matter for microbial growth, leading to the production of valuable products such as biosurfactants. Existing biosurfactant production is a relative expensive process and raw materials contribute about 30% of the production cost. Utilizing waste streams such as fish waste compost (FWC) as a substrate is an economically viable alternative. In this study, biosurfactant was produced by Rhodococcus erythropolis sp. P6-4P, a strain isolated from the North Atlantic Ocean. Biosurfactant production with FWC extract was compared with other soluble and insoluble carbon and nitrogen sources using emulsification assay and surface tension measurement. FWC extract showed good potential as an unconventional source of nutrient for microbial growth. The produced biosurfactant under optimum condition obtained via response surface methodology was further characterized for total carbohydrate, total lipid and total protein content. The results provided evidence for using FWC extract as a novel substrate for biosurfactant production
Cerebellar-dependent delay eyeblink conditioning in adolescents with Specific Language Impairment
- Author
- A Diamond
- A Dimitrova
- Adam B. Steinmetz
- BB Burgemeister
- C Logan
- CG Logan
- D Wechsler
- DA McCormick
- DG Lavond
- DS Woodruff-Pak
- DS Woodruff-Pak
- DS Woodruff-Pak
- DVM Bishop
- E Ohlrich
- E Paulesu
- EL Hill
- G Conti-Ramsden
- H Tager-Flusberg
- H Topka
- HC Leiner
- HN Zelaznik
- HW Catts
- I Daum
- J Cohen
- J Herbert
- JA Roberts
- JAG Lum
- JB Tomblin
- JE Steinmetz
- JJ Kim
- JM Coffin
- KA Lindgren
- KM Christian
- LB Leonard
- LD Shriberg
- LL Sears
- M Alarcón
- M Gerwig
- M Gerwig
- M Kjelgaard
- M Rapoport
- Mabel L. Rice
- MC Silveri
- ML Rice
- ML Rice
- ML Rice
- ML Rice
- ML Rice
- ML Rice
- MM Schugens
- N Ramnani
- NA Akshoomoff
- PD Skosnik
- PR Solomon
- R Cromwell
- R Goldman
- R McGlinchey-Berroth
- RF Rogers
- RH Lye
- RL Nicolson
- RL Nicolson
- RL Nicolson
- RW Woodcock
- S Yamaguchi
- SC Vernes
- SM Brown
- SP Perrett
- SR Zubrick
- T Justus
- TA Blaxton
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
Cerebellar impairments have been hypothesized as part of the pathogenesis of Specific Language Impairment (SLI), although direct evidence of cerebellar involvement is sparse. Eyeblink Conditioning (EBC) is a learning task with well documented cerebellar pathways. This is the first study of EBC in affected adolescents and controls. 16 adolescent controls, 15 adolescents with SLI, and 12 adult controls participated in a delay EBC task. Affected children had low general language performance, grammatical deficits but no speech impairments. The affected group did not differ from the control adolescent or control adult group, showing intact cerebellar functioning on the EBC task. This study did not support cerebellar impairment at the level of basic learning pathways as part of the pathogenesis of SLI. Outcomes do not rule out cerebellar influences on speech impairment, or possible other forms of cerebellar functioning as contributing to SLI
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
- Banda Michael
- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
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- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
- Beck Alfred
- Beck Stephen
- Becker Michael
- Bell Emma
- Bell George I.
- Bellard Terell M.
- Bellerby Damian
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- Belter Edward A., Jr.
- Bemrose Richard
- Benard Michael Anthony
- BenKahla Alia
- Benke J
- Benner William
- Bennett James
- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis Véronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
- Bian Xuemeng
- Bieri Tamberlyn
- Bimage Kesha E.
- Bird Christine
- Birditt Brian
- Birney Ewan
- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
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- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
- Blasiar Darin
- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
- Blumer Heather
- Blye Jason
- Blyth Peter R.
- Blöcker Helmut
- Boatright Elizabeth
- Boehm John
- Boen Juanan
- Boguslavskiy Leonid
- Bolton Christel
- Bolund Lars
- Bondoc Marnel
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- Bonnett Ralph
- Bonnin David
- Border Richard
- Borowsky Mark
- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
- Bradley Amanda
- Bradshaw-Cordum Holly
- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
- Branscomb Elbert
- Bray Jason
- Bray-Allen Sarah
- Brettin Thomas
- Bridgeman Anne
- Bridgers Michael
- Brimhall Angela K.
- Brokstein Peter
- Brook Jonathan
- Brooking Shane
- Brottier Philippe
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- Brown Nancy C.
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- Bruno William J.
- Bruskiewich Richard
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- Brüls Thomas
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- Buck David
- Buckingham Judith M.
- Buckle Veronica
- Buczek Donald
- Budd Claire
- Buhay Christian J.
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- Bunker Nathan
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- Burgin Matt
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- Burrell Kevin L.
- Burrill Wayne
- Burrows Christine
- Burton Christine
- Burton John
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- Butler Jon
- Butler Paul
- Caenepeel Sean
- Cahill Patrick
- Cai Tianjing
- Cai Zhen
- Cairns Murray
- Calderon Eliana
- Callen David F.
- Camarata Jody
- Camire David
- Camm Nick
- Campbell Christopher
- Campbell Connie S.
- Campbell Evelyn W.
- Campbell Mary I.
- Campbell Mary L.
- Campo Kevin
- Canning Bruno
- Cao Ting
- Cao Yuzhu
- Caoile Chenier
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- Carder Paul
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- Carrano Anthony V.
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- Carter Nigel
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- Cattolico Laurence
- Cavanna Tamara
- Cavazos Iracema
- Cavazos Sandra R.
- Ceasar Heather
- Cedroni Maria
- Cepeda Mario
- Chacko Joseph
- Chain Patrick
- Chalk Shani
- Challacombe Jean F.
- Chan Ka
- Chan Sheryl N.
- Chan Yee Man
- Chang Jean L.
- Chapman Jarrod
- Chapman Joanna
- Chapple Jeffrey
- Charles Rachel
- Chasteen Leslie A.
- Chavarria Simeon
- Chazaro Bruno
- Chen Baoxian
- Chen Bin
- Chen Chira
- Chen Chong
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- Chen Jie
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- Chen Junbao
- Chen Lihong
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- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
- Chissoe Stephanie
- Chiu Sally
- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
- Chu Joseph
- Chui Connie
- Chung A
- Cinkowsky Michael J.
- Citroen Mieke
- Clack Rob
- Clamp Michele
- Clark Anthea
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- Clark Lynn
- Clark Lynn M.
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- Clegg Shelia
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- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
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- Coffey Alison
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- Coggill Penelope
- Cohn Judith D.
- Colayco Rick
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- Collier Rachael
- Collings Simon
- Collins Francis S.
- Collins John
- Collins Philip
- Collymore Al
- Colman Louise
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- Comstock Robin
- Cong Bin
- Conner Richard
- Connolly Anthony
- Connolly Karen
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- Constance Doug
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- Cook Leanna
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- Cooper Robert
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- Cordray Rebecca
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- Cornell Earl
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- Cotton Sara
- Coulson Alan
- Couronne Olivier
- Courtney Laura P.
- Coville Gez
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- Cox Caroline D.
- Cox Tony
- Coxhill Robert
- Coyle Marcus D.
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- Crane Tom
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- Crawley Matt
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- Critz Paul
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- Cui Hongjuan
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- Cui Peng
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- Cummings Kirsti
- Cummings Paul
- Cummings Stephanie
- Cuomo Christina A.
- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
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- Dathorne Stephanie R.
- Daum Christopher
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- Do Long
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- Dobson Richard
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- Eckenberg Ralph
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- Edionwe Susan Omwanghe Osayanro
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- Emery-Cohen Alexandra J.
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- Evans Gareth
- Evans John
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- Eveleth Gerald
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- Fujiyama Asao
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- Georgescu Anca
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- Hamilton Matt
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- Hamlett John
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- Hammond Sian
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- Harbes Brandy A.
- Harding Adam
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- Hawkins Trevor
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- Hewitt Stephen
- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
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- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
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- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
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- Holden Jane
- Holdgate Janet
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- Holmes Sarah
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- Hosoda Kei
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- Hou Shunfang
- Hou Xiaodi
- Houde Nathan
- Howard Philip
- Howard Stephanie R.
- Howden Philip
- Howe Kevin
- Howell Gareth
- Howell Latoya Lynette
- Howells Sally Lucinda
- Hsu Fan
- Hu George
- Hu Jie
- Hu Songnian
- Huang Fang
- Huang Guyang
- Huang Katherine
- Huang Mei
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- Huang Wei
- Huang Wei
- Huang Wei
- Huang Zhengping
- Hubbard Timothy
- Huber James W.
- Huckle Elizabeth
- Hue Heather
- Hughes Jaime
- Hughes Jennifer
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- Hulme Bill
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- Hynds Christopher
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- Iliev Ilian
- Imbro Paula
- Imo Kelvin C.
- Inacio Nicole
- Inagaki Naomi
- Ince Michael
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- Isherwood Judith
- Ishibashi Akiko
- Ishikawa Sabine K.
- Ishizaki Hinako
- Isozaki Emi
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- Ito Fumiaki
- Ito Noriko
- Itoh Takehiko
- Iwakawa Shinobu
- Iwatate Mariko
- Iwatsu Mikiko
- Iyer Vivek
- Izatt Janet
- Izmajlowicz Monica
- Izumiyama Tomohiro
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- Jackson Terri
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- Jaeger Sara
- Jaffe David B.
- Jahn Niels
- Jaklevic Joseph
- Jaklevic Michael
- James Kent W.
- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
- Jeffery Kim
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- Jekosch Kerstin
- Jenkins Lee
- Jett Jamie
- Jewett Phillip E.
- Jia Jia
- Jia Jia
- Jia Nan
- Jia Xingchang
- Jiang Lu
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- Jimenez Alberto
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- Jones Myrna D.
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- Kou Zhaohui
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- Lorensuhewa Lorna M.
- Lou Yunian
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- Lowenstein Michael G.
- Lowry Stephen
- Lozado Ryan J.
- Lu Lingfeng
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- Lucier Raymond L.
- Ludeman Thom
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- MacLean Christine
- Madabhushi Ramki
- Madu Renita C.
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- McMurray Kimberly L.
- McNinch Jenny
- McPherson John
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- Murayama Yuji
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- Nair Seema R.
- Naka Maho
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- Nakato Eriko
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- Nankervis Colin E.
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- Nazareth Lynne V.
- Neal Dearl D.
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- Nguyen Ngoc Bich
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- Nusbaum Chad
- Nwaokelemeh Ogechi O.
- Nwokenkwo Stanley
- O\u27Donnell Paula
- O\u27Donovan Daniel
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- O\u27Loughlin Jennifer
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- Oinn Tom
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- Okui Michiyo
- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
- Olarnpunsagoon Alisa
- Olivas Jason
- Oliver Hayley
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- Olsen Anne S.
- Olson Maynard V.
- Omotosho Bamidele
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- Oviedo Rodolfo J.
- Ow David
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- Parkin Kim
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- Pasternak Shiran
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- Patel Vishal V.
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- Paul Heidie A.
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- Pearman Charlene
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- Pennacchio Len A.
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- Percy Chantel
- Perez Agapito
- Perez Lesette M.
- Perito Andrew
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- Qin Xiang
- Quail Michael
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- Quiles Miyo M.
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- Ridler Kerry
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- Sonnhammer Erik
- Sonnhammer Erik
- Sorelle Richard P.
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- Sudbrak Ralf
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- Sutherland Grant R.
- Sutherland Robert D.
- Sutton Angelica E.
- Svatek Amanda F.
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- Tatum Owatha I.
- Taudien Stefan
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- Taylor Ruth
- Taylor Sam
- Taylor Susan
- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
- Turney Kathryn
- Tynan Katherine
- Ueland Stephanie
- Ueng Samantha
- Ukegbu Ogechi Nkemdirim
- Ulanovsky Levy E.
- Un Chun
- Ung Quyen
- Upson Darren
- Urban Jeremy B.
- Ureta-Vidal Abel
- Ureta-Vidal Abel
- Usmani Kamran
- Ustaszewska Anna
- Uyama Nozomi
- Valas Ruben E.
- Valdez Michelle
- Valle Duane
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- Vargas Michelle
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- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
- Vastrik Imre
- Vaudin Mark
- Veil Rose
- Veklerov Eugene
- Velasco Nelson
- Velasquez Lisa
- Venkataranan Vijay
- Vera Virginia A.
- Verduzco Daniel
- Vergez Lisa
- Vico Virginie
- Viknaraja Ramya
- Villasana Donna M.
- Vine Wendy
- Viswanathan Vijay
- Vo Andy
- Vo Nu
- Voak Paul
- Vollenhoven David
- Wada Hiromi
- Wagner Mark
- Wagner-McPherson Caryn
- Waldron Lenee
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- Walker Davian L.
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- Wall Melanie
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- Wallis Michelle
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- Wan Ma
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- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
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- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
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- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
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- Wang Lijun
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- Wang Mei
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- Wang Shu
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- Wang Wenjun
- Wang Xiaoling
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- Wang Xuegang
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- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
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- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
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- White Scott P.
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- Wickremasinghe Manosha I.
- Widaa Sara
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- Wincker Patrick
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- Witt James
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- Woods Eric
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- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
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- Wright Debbie
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- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
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- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
A saturated map of common genetic variants associated with human height
- Author
- Abecasis GR
- Adair LS
- Adams HHH
- Aguilar-Salinas CA
- Ahluwalia TS
- Akiyama M
- Al-Mulla F
- Allison MA
- Alvarez M
- Andersen MK
- Ani A
- Appadurai V
- Arbeeva L
- Arias JD
- Arnett DK
- Asselbergs FW
- Assimes TL
- Asvold BO
- Attia J
- Auton A
- Banas B
- Bandinelli S
- Bartell E
- Bennett DA
- Bergler T
- Berndt SI
- Bharadwaj D
- Bhaskar S
- Bielak LF
- Biino G
- Bisgaard H
- Boehnke M
- Boerwinkle E
- Boger CA
- Bollepalli S
- Bonnelykke K
- Bonnycastle LL
- Boomsma DI
- Borglum AD
- Borja JB
- Bork-Jensen J
- Bouchard C
- Bowden DW
- Bradfield JP
- Bradford Y
- Brandslund I
- Braund PS
- Brody JA
- Brumpton B
- Burgdorf KS
- Buring JE
- Cade BE
- Cai H
- Cai QY
- Campbell A
- Canadas-Garre M
- Catamo E
- Caulfield MJ
- Chai JF
- Chai XR
- Chambers JC
- Chandak GR
- Chang LC
- Chang YC
- Chanock SJ
- Chasman DI
- Chaturvedi N
- Chen CH
- Chen SH
- Chen YDI
- Chen ZM
- Cheng CY
- Chesi A
- Cho YS
- Choi SH
- Christofidou P
- Christophersen IE
- Chung RH
- Ciullo M
- Cocca M
- Cole JW
- Collins FS
- Concas MP
- Cooper RS
- Couture C
- Cruz M
- Cucca F
- Cuellar-Partida G
- Cupples LA
- Cutler MJ
- Damrauer SM
- Danning R
- Dantoft TM
- Daw EW
- de Borst GJ
- de Groot LCPGM
- De Jager PL
- de Kleijn DPV
- de Silva HJ
- Dedoussis GV
- Degenhard F
- Delgado GE
- Delitala A
- Deloukas P
- Demirkan A
- den Hollander AI
- Deng X
- Devineni P
- Dietl A
- Dimitriou M
- Dimitrov L
- Dorajoo R
- Du SF
- Easton DF
- Ekici AB
- Elders PJM
- Eliasen AU
- Eliassen AH
- Ellinor PT
- Elmstahl S
- Engmann JE
- Erdmann J
- Esko T
- Evans MK
- Fairhurst-Hunter Z
- Farmaki AE
- Fatkin D
- Faul JD
- Feenstra B
- Feitosa MF
- Fernandez-Lopez JC
- Ferreira T
- Ferrucci L
- Ford I
- Forer L
- Fornage M
- Francescatto M
- Franke A
- Franks PW
- Frayling TM
- Freedman BI
- Freitag-Wolf S
- Fuchsberger C
- Galesloot TE
- Gao Y
- Gao ZS
- Gasparini P
- Geller F
- Giannakopoulou O
- Gieger C
- Girotto G
- Giulianini F
- Gjesing AP
- Goddard ME
- Goel A
- Golightly YM
- Gonzalez-Villalpando C
- Gordon SD
- Gordon-Larsen P
- Gorski M
- Graff M
- Graham SE
- Grallert H
- Grant SFA
- Grarup N
- Griffiths L
- Grove J
- Gudnason V
- Guo XQ
- Gustafsson S
- Haessler J
- Haiman C
- Hakonarson H
- Hansen T
- Hansen TF
- Hart LMT
- Hartman CA
- Hattersley AT
- Havulinna AS
- Haworth SJ
- Hayward C
- He J
- Heard-Costa N
- Hebbar P
- Heckbert SR
- Heid IM
- Heng CK
- Hengstenberg C
- Hewitt AW
- Highland HH
- Hindy G
- Hirschhorn JN
- Hishigaki H
- Ho YLA
- Hofer E
- Holliday E
- Horn K
- Hornsby WE
- Hottenga JJ
- Hoyng CB
- Huang HY
- Huang J
- Huang PL
- Huang W
- Huerta-Chagoya A
- Huffman JE
- Hung YJ
- Hunt SC
- Huo SF
- Hveem K
- Hwang MY
- Hypponen E
- Iacono WG
- Ichihara S
- Iha H
- Ikeda DD
- Ikram MA
- Isasi CR
- Isono M
- Jackson AU
- Jackson RD
- Jager S
- Jansen IE
- Jarvelin MR
- Ji YJ
- Jiang YX
- Jin ZB
- Jockel KH
- Johansson I
- Jonas JB
- Jonsson A
- Jorgensen T
- Joshi PK
- Jousilahti P
- Jukema JW
- Justice AE
- Kahonen M
- Kalafati IP
- Kamatani Y
- Kanai M
- Kang KD
- Kanoni S
- Kaprio J
- Karaderi T
- Kardia SLR
- Karhus LL
- Karpe F
- Kasturiratne A
- Kato N
- Katsuya T
- Kawaguchi T
- Kee F
- Kember RL
- Kentistou KA
- Kessler T
- Khera AV
- Khor CC
- Kiemeney LALM
- Kim BJ
- Kim EK
- Kim HL
- Kim HN
- Kim YJ
- Kirchhof P
- Kivimaki M
- Kleber ME
- Knol MJ
- Koh WP
- Koistinen HA
- Kolovou GD
- Kooner JS
- Kooperberg C
- Kottgen A
- Kovacs P
- Kraaijeveld A
- Kraft P
- Krauss RM
- Kumari M
- Kurbasic A
- Kutalik Z
- Laakso M
- Lange LA
- Langenberg C
- Launer LJ
- Lauzon M
- Le Marchand L
- Le P
- Lea R
- Lee H
- Lee JY
- Lee NR
- Lehtimaki T
- Leonard HL
- Lettre G
- Li HX
- Li LM
- Li SCA
- Li XH
- Li XY
- Liang JJ
- Lieb W
- Lin HH
- Lin K
- Lin SY
- Lin X
- Lind L
- Lindgren CM
- Linneberg A
- Liu CT
- Liu J
- Liu JJ
- Liu XP
- Lo KS
- Locke AE
- Loeffler M
- Loh PR
- London B
- Long JR
- Loos RJF
- Lores-Motta L
- Luan JA
- Lubitz SA
- Lull K
- Lye SJ
- Lyssenko V
- Lyytikainen LP
- Machado M
- Mackey DA
- Magi R
- Magnusson PKE
- Mahajan A
- Malden DE
- Mamakou V
- Mangino M
- Manichaikul A
- Marcus GM
- Marouli E
- Marten J
- Martin NG
- Marz W
- Matsuda F
- Mattheisen M
- Mavarani L
- McCarthy MI
- McDaid AF
- McGarrah RW
- McGue M
- McKnight AJ
- Medina-Gomez C
- Medland SE
- Meidtner K
- Melendez TL
- Mellstrom D
- Mercader JM
- Metspalu A
- Miao JK
- Milaneschi Y
- Miller JE
- Millwood IY
- Mishra PP
- Mitchell BD
- Mitchell P
- Mitchell RE
- Mohlke KL
- Mollehave LT
- Mook-Kanamori DO
- Moore A
- Morgan A
- Morris AD
- Mucci LA
- Mucha S
- Mukamel RE
- Munroe PB
- Munz M
- Nakatochi M
- Nalls MA
- Nazarian S
- Nelson AE
- Nelson CP
- Nethander M
- Neville MJ
- Newton-Cheh C
- Ng MCY
- Nho CW
- Nielsen AA
- Nielsen CS
- Nolte IM
- Nongmaithem SS
- Noordam R
- North KE
- Nothen MM
- Ntalla I
- Nutile T
- O'Donnell CJ
- Ohlsson C
- Okada Y
- Oldehinkel AJ
- Orozco L
- Pahkala K
- Pajukanta P
- Palmer CNA
- Pandit A
- Parna K
- Parra EJ
- Pattaro C
- Pauper M
- Pedersen O
- Pennell CE
- Penninx BWJH
- Perusse L
- Peters A
- Petersen ERB
- Petersen LV
- Peyser PA
- Pitkanen N
- Polasek O
- Porteous DJ
- Posthuma D
- Poveda A
- Power C
- Pramstaller PP
- Preuss MH
- Province MA
- Pyarajan S
- Qi QB
- Qu J
- Rader DJ
- Raffield LM
- Raghavan S
- Raitakari OT
- Rakugi H
- Ralhan S
- Rallidis LS
- Ramirez J
- Rao DC
- Rasheed A
- Raven D
- Rayner NW
- Redline S
- Reilly DF
- Reiner AP
- Rhee SY
- Ridker PM
- Rienstra M
- Ripatti S
- Ritchie MD
- Rivadeneira F
- Riveros C
- Roden DM
- Rohde R
- Rosendaal FR
- Rotter JI
- Rudan I
- Rueger S
- Ruggiero D
- Ruotsalainen SE
- Rutters F
- Ryan KA
- Sabanayagam C
- Sabater-Lleal M
- Sakaue S
- Saleheen D
- Salomaa V
- Samani NJ
- Sanghera DK
- Sattar N
- Saxena R
- Schmidt B
- Schmidt H
- Schmidt R
- Scholz M
- Schulze MB
- Schunkert H
- Scott LJ
- Scott RJ
- Sendamarai A
- Sever P
- Shen BT
- Shi JCZ
- Shin JH
- Shiroma EJ
- Shoemaker MB
- Shu XO
- Sidore C
- Sidorenko J
- Sim X
- Simonsick EM
- Sims M
- Singh JR
- Singleton AB
- Sinner MF
- Sitlani CM
- Slieker RKC
- Smit RAJ
- Smith AV
- Smith JA
- Smith JG
- Smyth LJ
- Snieder H
- Southam LE
- Spector TD
- Spracklen CN
- Stampfer MJ
- Stark KJ
- Stefansson K
- Steinthorsdottir V
- Strachan DP
- Sun L
- Sun YV
- Tabara Y
- Tai ES
- Takeuchi F
- Tallapragada D
- Tang H
- Tardif JC
- Taylor KD
- Tayo BO
- Tcheandjieu C
- Terzikhan N
- Tesolin P
- Teumer A
- Thanaraj TA
- Theusch E
- Thompson DJ
- Thorleifsson G
- Thorsteinsdottir U
- Timmers PRHJ
- Timpson NJ
- Tonjes A
- Tremblay A
- Trompet S
- Tuomi T
- Tuomilehto J
- Turman C
- Tusie-Luna MT
- Uitterlinden AG
- Vaccargiu S
- van Dam RM
- van der Harst P
- van der Laan SW
- van der Most PJ
- Van der Velde N
- van Duijn CM
- van Klinken JB
- van Schoor NM
- van Setten J
- Vedantam S
- Verma SS
- Verweij N
- Veturi Y
- Vidal PM
- Visscher PM
- Vitart V
- Volker U
- Vollenweider P
- Volzke H
- Vrieze S
- Wacher-Rodarte NH
- Walker M
- Walters RG
- Wang CA
- Wang CL
- Wang LH
- Wang YX
- Wang Z
- Wareham NJ
- Warren HR
- Watanabe RM
- Watkins H
- Wei WB
- Weir DR
- Werge TM
- Wickremasinghe AR
- Widen E
- Wielscher M
- Wiggins KL
- Wilkens LR
- Willemsen G
- Willer CJ
- Willett WC
- Wilson JF
- Winkler TW
- Winsvold BS
- Wong A
- Wong TY
- Woo JT
- Wood AR
- Wright AF
- Wu JY
- Wu Y
- Wuttke M
- Xia R
- Xie T
- Xu HC
- Yajnik CS
- Yamamoto K
- Yang J
- Yang JY
- Yao J
- Yengo L
- Yin XY
- Yokota M
- Young H
- Young KL
- Yousri NA
- Yu L
- Yuan JM
- Zeggini E
- Zemel BS
- Zeng LY
- Zhang WH
- Zhang XY
- Zhao JH
- Zhao W
- Zheng W
- Zhou W
- Zhu XF
- Zimmermann ME
- Zmuda JM
- Zoledziewska M
- Zonderman AB
- Zwart JA
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/11/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes(1). Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel(2)) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries.A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants
A saturated map of common genetic variants associated with human height.
- Author
- 't Hart LM
- 23andMe Research Team
- Abecasis GR
- Adair LS
- Adams HHH
- Aguilar-Salinas CA
- Ahluwalia TS
- Akiyama M
- Al-Mulla F
- Allison MA
- Alvarez M
- Andersen MK
- Ani A
- Appadurai V
- Arbeeva L
- Arias JD
- Arnett DK
- Asselbergs FW
- Assimes TL
- Attia J
- Auton A
- Banas B
- Bandinelli S
- Bartell E
- Bennett DA
- Bergler T
- Berndt SI
- Bharadwaj D
- Bhaskar S
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- DiscovEHR (DiscovEHR and MyCode Community Health Initiative)
- Dorajoo R
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- eMERGE (Electronic Medical Records and Genomics Network)
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- Understanding Society Scientific Group
- VA Million Veteran Program
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- Zimmermann ME
- Zmuda JM
- Zoledziewska M
- Zonderman AB
- Zwart J-A
- Åsvold BO
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 12/10/2022
- Field of study
Common single-nucleotide polymorphisms (SNPs) are predicted to collectively explain 40-50% of phenotypic variation in human height, but identifying the specific variants and associated regions requires huge sample sizes1. Here, using data from a genome-wide association study of 5.4 million individuals of diverse ancestries, we show that 12,111 independent SNPs that are significantly associated with height account for nearly all of the common SNP-based heritability. These SNPs are clustered within 7,209 non-overlapping genomic segments with a mean size of around 90 kb, covering about 21% of the genome. The density of independent associations varies across the genome and the regions of increased density are enriched for biologically relevant genes. In out-of-sample estimation and prediction, the 12,111 SNPs (or all SNPs in the HapMap 3 panel2) account for 40% (45%) of phenotypic variance in populations of European ancestry but only around 10-20% (14-24%) in populations of other ancestries. Effect sizes, associated regions and gene prioritization are similar across ancestries, indicating that reduced prediction accuracy is likely to be explained by linkage disequilibrium and differences in allele frequency within associated regions. Finally, we show that the relevant biological pathways are detectable with smaller sample sizes than are needed to implicate causal genes and variants. Overall, this study provides a comprehensive map of specific genomic regions that contain the vast majority of common height-associated variants. Although this map is saturated for populations of European ancestry, further research is needed to achieve equivalent saturation in other ancestries
IDENTIFICATION OF TEMPORAL SCALING BEHAVIOUR OF FLOOD: A STUDY OF FRACTALS
- Author
- Publication venue
- 'World Scientific Pub Co Pte Lt'
- Publication date
- Field of study
Modeling the Sorption of Ni2+ and Co2+ on Saprist Peat Using the Response Surface Methodology
- Publication venue
- Hindawi Publishing Corporation
- Publication date
- 01/01/2015
- Field of study
A detailed study of the sorption of Ni2+ and Co2+ from simulated wastewater on saprist peat is presented. The significantly decomposed peat possessed a strong sorptive capacity that was maintained over a wide range of pH. With a metal concentration range of 50 to 200 mg/L, pH range of 3 to 10, peat dose of 2 to 40 g/L, and contact time of 12 to 24 h, batch experiments were conducted based on a four-factor Box-Behnken response surface design. The percentage removals of Ni2+ and Co2+ were analyzed using analysis of variance. Second order response surface models were developed with the significant factors and their interactions to predict the percentage sorption of Ni2+ and Co2+ independently. The prediction equations were verified with additional data not used in developing the equations. The study showed that the saprist peat could be a potential industrial metal adsorbent and the percentage of uptake of Ni2+ and Co2+ could be accurately predicted using the second order response surface models developed. Ni2+ uptake was greater for the two metals and reached a maximum value at just below a neutral pH and Co2+ uptake continued to increase from pH > 5, with higher uptake percentage at pH 10
Corrigendum to ‘Neurology of COVID-19 in Singapore (vol 418, 117118, 2020)
- Author
- Ahmad Aftab
- Angon Jasmyn
- Chiew Hui Jin
- De Silva Deidre Anne
- Goh Yihui
- Hoe Rebecca Hui Min
- Hui Andrew Che-Fai
- Ker Justin Ruixin
- Koh Jasmine Shimin
- Lim Tchoyoson Choie Cheio
- Lye David Chien Boon
- Ng Kay Wei Ping
- Pang Yu Zhi
- Prakash Kumar M
- Quek Amy May Lin
- Saini Monica
- Seet Christopher Ying Hao
- Tan Benjamin Yong Qiang
- Tan Kevin
- Thomas Terrence
- Tu Tian Ming
- Umapathi Thirugnanam
- Yeo Leonard Leong Litt
- Yong Ming Hui
- Yu Wai-Yung
- Publication venue
- 'Elsevier BV'
- Publication date
- 26/11/2021
- Field of study
10.1016/j.jns.2021.117406JOURNAL OF THE NEUROLOGICAL SCIENCES42
Mapping the human genetic architecture of COVID-19
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
Correlation between antimicrobial resistance and faecal contamination in small urban streams and bathing waters
- Author
- Ahlstrom
- Argudin
- Aurora Gitto
- Baral
- Bedri
- Canton
- Cassini
- Chave
- Dick
- Ellis
- Environment Agency
- EU
- Fewtrell
- Goto
- Gourmelon
- Gregory M.P. O'Hare
- Huddleston
- Hughes
- Hurlimann
- Jayne H. Stephens
- John J. O'Sullivan
- Kapoor
- Karkman
- Kay
- Laura Sala-Comorera
- Leonard
- Liam J. Reynolds
- Lu
- Lye
- Marathe
- Maravic
- Marti
- Marti
- Marti
- Milledge
- Molina
- Niamh A. Martin
- Olds
- O’Neill
- Paule-Mercado
- Pehrsson
- Pei
- Proia
- Rizzo
- Rodriguez-Mozaz
- Rowe Taitt
- Rutledge
- Rutledge
- Sercu
- Servais
- Seurinck
- Seurinck
- Sidrach-Cardona
- Szekeres
- Tomova
- Tristan M. Nolan
- WHO
- WHO
- Wiedenmann
- Wim G. Meijer
- Xi
- Xu
- Zhou
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study