Centre for Applied Linguistics at the University of Warwick

The Centre for Applied Linguistics was established in 1983 and has grown from a relatively small teaching unit to a large centre engaged in a wide variety of activities under the broad heading of Applied Linguistics. Our work includes English language teaching, teacher education, undergraduate and postgraduate teaching in applied linguistics, development of teaching and research resources, and small- and large-scale research

Effects of moderate electric fields on the post-harvest preservation of chestnuts

Ohmic heating (OH) was evaluated as a post-harvest technology to improve chestnuts shelf-life (Castanea sativa Mill.) by controlling molds and insect larvae proliferation. Chestnuts were processed by OH at 35, 45, and 55 °C and compared with untreated fruits and the conventional hydrothermal technology (HT - 50 °C for 45 min), which is the process currently used by the chestnut industry. Shelf-life studies were carried out at different atmospheric conditions for 60 days: (i) 25 °C and 40% relative humidity (RH); (ii) 5 °C and 70% RH. The results show that the OH conducted at 55 °C (OH-55 °C), combined with storage at 5 °C, was more effective in controlling molds and larvae growth than the other treatments. Moreover, under these conditions, chestnuts shelf-life could be extended for 60 days without substantial changes in the fruits color and texture. After the OH-55 °C treatment, lower losses of some nutrients and vitamin C were registered compared to HT. This study demonstrates for the first time that OH has the potential to be used by the chestnut industry for the post-harvest disinfestation of this fruit.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2020 unit and BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. Enrique Pino-Hernández is a recipient of a fellowship supported by an advanced doctoral training program (call NORTE-69-2015-15), funded by the European Social Fund under the scope of Norte2020 – Programa Operacional Regional do Norte (NORTE-08-5369-FSE 000036). Ricardo N. Pereira and Luís Abrunhosa acknowledge FCT for their Assistant Research contract obtained under CEEC Individual 2017: reference CEECIND/02903/2017 and CEECIND/00728/2017, respectively.info:eu-repo/semantics/publishedVersio

Combining pulse-based features for rejecting far-field speech in a HMM-based Voice Activity Detector

ABSTRACT 1.-Introduction The advantages of using Automatic Speech Recognition are obvious for several types of applications. Speech Recognition becomes difficult when the main speaker is in noisy environments, for example in bars, where many far-field speakers are speaking almost all the time. This factor contributes to a reduction in the speech recognizer success rate that can lead to an unsatisfactory experience for the user. If there are too many recognition mistakes, the user is forced to correct the system which takes too long, it is a nuisance, and the user will finally reject the system. With the purpose of solving this problem a Robust Voice Activity Detector is proposed in this work. The VAD is able to select speech frames (noise frames are discarded). This frame information is sent to the Speech Recognizer and only speech pronunciations are processed, so the VAD tries to avoid Speech Recognizer mistakes coming from noisy frames. If the VAD works well, the Speech Recognizer does too. In summary, it is very common to find, in mobile phone scenarios, many situations in which the target speaker is situated in open environments surrounded by far-field interfering speech from other speakers. In this ambiguous case, VAD systems can detect far-field speech as coming from the user, increasing the speech recognition error rate. Generally, detection errors caused by background voices mainly increase word insertions and substitutions, leading to significant dialogue misunderstandings. This work tries to solve these speech-based application problems in which far-field speech can be wrongly considered as main speaker speech. In [1] a spectrum sensing scheme to detect the presence of the primary user for cognitive radio systems is proposed (very similar to the VAD proposed in this paper) being able to distinguish between main speaker speech and far-field speech. Moreover the system implemented in In several previous works, similar measurements, like those considered in this work, have been used for dereverberation techniques. I

Do new cancer drugs offer good value for money? The perspectives of oncologists, health care policy makers, patients, and the general population

Background: In oncology, establishing the value of new cancer treatments is challenging. A clear definition of the different perspectives regarding the drivers of innovation in oncology is required to enable new cancer treatments to be properly rewarded for the value they create. The aim of this study was to analyze the views of oncologists, health care policy makers, patients, and the general population regarding the value of new cancer treatments. Methods: An exploratory and qualitative study was conducted through structured interviews to assess participants’ attitudes toward cost and outcomes of cancer drugs. First, the participants were asked to indicate the minimum survival benefit that a new treatment should have to be funded by the Spanish National Health System (NHS). Second, the participants were requested to state the highest cost that the NHS could afford for a medication that increases a patient’s quality of life (QoL) by twofold with no changes in survival. The responses were used to calculate incremental cost-effectiveness ratios (ICERs). Results: The minimum improvement in patient survival means that justified inclusions into the NHS were 5.7, 8.2, 9.1, and 10.4 months, which implied different ICERs for oncologists (€106,000/quality-adjusted life year [QALY]), patients (€73,520/QALY), the general population (€66,074/QALY), and health care policy makers (€57,471/QALY), respectively. The costs stated in the QoL-enhancing scenario were €33,167, €30,200, €26,000, and €17,040, which resulted in ICERs of €82,917/QALY for patients, €75,500/QALY for the general population, €65,000/QALY for oncologists, and €42,600/QALY for health care policy makers, respectively. Conclusion: All estimated ICER values were higher than the thresholds previously described in the literature. Oncologists most valued gains in survival, whereas patients assigned a higher monetary value to treatments that enhanced QoL. Health care policy makers were less likely to pay more for therapeutic improvements compared to the remaining participantsThe study was funded by Eli & Lilly and C

Dysregulation of the endocannabinoid signaling system in the cerebellum and brainstem in a transgenic mouse model of spinocerebellar ataxia type-3.

Spinocerebellar ataxia type-3 (SCA-3) is a rare disease but it is the most frequent type within the autosomal dominant inherited ataxias. The disease lacks an effective treatment to alleviate major symptoms and to modify disease progression. Our recent findings that endocannabinoid receptors and enzymes are significantly altered in the post-mortem cerebellum of patients affected by autosomal-dominant hereditary ataxias suggest that targeting the endocannabinoid signaling system may be a promising therapeutic option. Our goal was to investigate the status of the endocannabinoid signaling system in a transgenic mouse model of SCA-3, in the two CNS structures most affected in this disease cerebellum and brainstem. These animals exhibited progressive motor incoordination, imbalance, abnormal gait, muscle weakness, and dystonia, in parallel to reduced in vivo brain glucose metabolism, deterioration of specific neuron subsets located in the dentate nucleus and pontine nuclei, small changes in microglial morphology, and reduction in glial glutamate transporters. Concerning the endocannabinoid signaling, our data indicated no changes in CB2 receptors. By contrast, CB1 receptors increased in the Purkinje cell layer, in particular in terminals of basket cells, but they were reduced in the dentate nucleus. We also measured the levels of endocannabinoid lipids and found reductions in anandamide and oleoylethanolamide in the brainstem. These changes correlated with an increase in the FAAH enzyme in the brainstem, which also occurred in some cerebellar areas, whereas other endocannabinoid-related enzymes were not altered. Collectively, our results in SCA-3 mutant mice confirm a possible dysregulation in the endocannabinoid system in the most important brain structures affected in this type of ataxia, suggesting that a pharmacological manipulation addressed to correct these changes could be a promising option in SCA-3.This study has been supported by MICINN (SAF2009-11847 and SAF2015-68580-C2-1-R), CIBERNED (CB06/05/0089), "Fundacion Eugenio Rodriguez Pascual" and the Research and Education Component of the Advancing a Healthier Wisconsin Endowment at the Medical College of Wisconsin. Carmen Rodriguez-Cueto was a predoctoral fellow supported by FPI Program-Ministry of Science. Authors are indebted to Yolanda Garcia-Movellan for administrative support

SENSIBILIDAD AL RIESGO EN RATAS (Rattus norvegicus): EFECTO DE LA MAGNITUD DE REFORZADOR Y LA PROBABILIDAD DE REFORZAMIENTO

En una tarea experimental de elección libre con ratas (Rattus norvegicus)se analizó el efecto de la magnitud de reforzador y la probabilidad de reforzamiento.Se manipuló en cada una de las alternativas de respuesta ambasvariables, igualándose en ambas alternativas la cantidad de reforzador obtenidoal final de la sesión. Inicialmente los animales fueron entrenados en dosposibles alternativas de respuesta de manera secuencial (elección forzada):1) obtener con una alta probabilidad una cantidad de reforzador baja (bajoriesgo) y 2) obtener con una baja probabilidad una magnitud de reforzadoralta (alto riesgo). Tras este entrenamiento, se presentó a los sujetos de manerasimultánea ambas alternativas (elección libre). En general se observópreferencia por la alternativa etiquetada como bajo riesgo. Sin embargo, unanálisis detallado revela un efecto de interacción entre magnitud de reforzador y probabilidad de reforzamiento que arroja luz acerca de la propensión alriesgo que las ratas mostraron en el experiment

Election turnout statistics in many countries: similarities, differences, and a diffusive field model for decision-making

We study in details the turnout rate statistics for 77 elections in 11 different countries. We show that the empirical results established in a previous paper for French elections appear to hold much more generally. We find in particular that the spatial correlation of turnout rates decay logarithmically with distance in all cases. This result is quantitatively reproduced by a decision model that assumes that each voter makes his mind as a result of three influence terms: one totally idiosyncratic component, one city-specific term with short-ranged fluctuations in space, and one long-ranged correlated field which propagates diffusively in space. A detailed analysis reveals several interesting features: for example, different countries have different degrees of local heterogeneities and seem to be characterized by a different propensity for individuals to conform to the cultural norm. We furthermore find clear signs of herding (i.e. strongly correlated decisions at the individual level) in some countries, but not in others.Comment: 15 pages, 9 figures, 7 table

Effects of Orifice Sizes for Uncontrolled Filling Processes in Water Pipelines

[EN] The sizing of air valves during the air expulsion phase in rapid filling processes is crucial for design purposes. Mathematical models have been developed to simulate the behaviour of air valves during filling processes for air expulsion, utilising 1D and 2D schemes. These transient events involve the presence of two fluids with different properties and behaviours (water and air). The effect of air valves under scenarios of controlled filling processes has been studied by various authors; however, the analysis of uncontrolled filling processes using air valves has not yet been considered. In this scenario, water columns reach high velocities, causing part of them to close air valves, which generates an additional peak in air pocket pressure patterns. In this research, a two-dimensional computational fluid dynamics model is developed in OpenFOAM software to simulate the studied situations.Aguirre-Mendoza, AM.; Paternina-Verona, DA.; Oyuela, S.; Coronado-Hernández, OE.; Besharat, M.; Fuertes-Miquel, VS.; Iglesias Rey, PL.... (2022). Effects of Orifice Sizes for Uncontrolled Filling Processes in Water Pipelines. Water. 14(6):1-11. https://doi.org/10.3390/w1406088811114

Through-space hopping transport in an iodine-doped perylene-based metal–organic framework

Electrically conductive metal-organic frameworks (MOFs) have emerged in the past few years as promising materials towards applications in (opto)electronics, electrocatalysis and energy storage, among others. One of the most common strategies for the design of conductive MOFs is based on the use of electroactive organic ligands and their partial oxidation/reduction to increase the number of charge carriers. Although perylene salts were reported as the first molecular conductors, they have been scarcely explored as building blocks for the construction of conductive MOFs. Herein we report the electrical conductivity enhancement of a microporous perylene-based MOF upon partial ligand oxidation by using two-probe single-crystal devices. The origin of the conductivity enhancement is rationalised by means of spectroscopic studies and quantum-chemical calculations, supporting a through-space hopping transport along the herringbone perylene packing. This study opens the way for the design of conductive MOFs based on perylene building blocks.publishe

Surface Morphology Evolution of Chemical Vapor-Deposited Tungsten Films on Si(100)

Chemical vapor deposition (CVD) is used to prepare research-grade heterostructures and to produce the majority of industrially important thin films.[1] In particular, CVD tungsten films are used for many technological applications.[2,3] In CVD an external source maintains a fixed concentration of reactant molecules at a distance above the film surface.[4] Then, gas diffusion drives the molecules through the diffusion layer[2] towards the film surface. At the film interface a reaction must occur before new material is incorporated into the solid. Kinetic studies show that two growth regimes are usually present in CVD. At a low deposition temperature (low rate, regime I) the kinetics is controlled by the surface reaction, whereas at a high temperature (high rate, regime II), mass transport of reactants to, or reaction products from, the surface is the rate-controlling step.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicada