Multi-service resource queue with the multy-component Poisson arrivals

In many papers devoted to telecommunication systems, multiservice queueing models with heterogeneous customer arrivals are given. As a rule, there is streaming traffic, corresponding to the audio and video conference, and elastic traffic, corresponding to the data and file transmission. Different types of traffic require different quality of service, therefore the multi-service systems are also differentiated service systems. Such papers are aimed at developing a framework for estimating the quality of service indicators in new generation multi-service networks. This paper considers a multiservice resource queueing system with three Poisson arrivals, one of which is splitting. The equation for the probabilities distribution of the total resource amounts on the system blocks is compiling by the dynamic screening method, and using the characteristic function of the stationary distribution, the solution is obtaining. The numerical characteristics of the system performance are obtained by the method of moments using characteristic function. A numerical example shows that arrivals intensity growing increases optimal total resource amounts on system blocks in the system with limited resources, and the splitting arrivals affect the correlation between total resource amounts

Chronic obstructive pulmonology disease in gastro-intestinal pathology patients (literature review)

The objective of this paper is to analyze recent studies on correlation between stomach pathology and respiratory apparatus. It presents gastro-intestinal pathology impact on characteristic and chronic obstructive pulmonology disease cource weight and describes some digestive apparatus pathology conerned with para-endocrine system disfunction.Представлен анализ литературных данных о взаимосвязи патологии органов пищеварения и дыхания. Приведены данные о влиянии гастроинтестинальной патологии, в том числе дисфункции энтероэндокринной системы, на особенности и тяжесть течения хронической обструктивной болезни легких

Synthesis and antifungal activity of sulfides, sulfoxides, and sulfones based on (1S)-(-)-β-pinene

Attachment of 2-mercaptoethanol and thioglycolic acid methyl ester to the double bond of (1S)-(-)-β-pinene yielded pinane sulfides with the cis configuration. Oxidation of sulfides with m-chloroperbenzoic acid yielded the corresponding sulfoxides and sulfones. The resulting compounds were screened for antimycotic activity and the dynamics of changes in antifungal properties in sulfides-sulfoxide-sulfone series were studied. © 2010 Springer Science+Business Media, Inc

Antifungal activity of oligochitosans (short chain chitosans) against some Candida species and clinical isolates of Candida albicans: Molecular weight-activity relationship

A series of oligochitosans (short chain chitosans) prepared by acidic hydrolysis of chitosan and characterized by their molecular weight, polydispersity and degree of deacetylation were used to determine their anticandidal activities. This study has demonstrated that oligochitosans show a high fungistatic activity (MIC 8-512 μg/ml) against Candida species and clinical isolates of Candida albicans, which are resistant to a series of classic antibiotics. Flow cytometry analysis showed that oligochitosan possessed a high fungicidal activity as well. For the first time it was shown that even sub-MIC oligochitosan concentration suppressed the formation of C. albicans hyphal structures, cause severe cell wall alterations, and altered internal cell structure. These results indicate that oligochitosan should be considered as a possible alternative/additive to known anti-yeast agents in pharmaceutical compositions. © 2014 Elsevier Masson SAS. All rights reserved

Protein-energy status and quality of life at patients HCV - related cirrhosis class A

The purpose of the present work was studying of laws, protein-energy insufficiency (PEI) and indicators of quality of life (QL) at sick virus (HCV) hepatic cirrhosis (HC) class A in the course of antiviral therapy. Object and methods of research: It is spent randomized, prospective, controllable, open research of parameters PEI and indicators QL of sixty patients with virus (HCV) by hepatic cirrhosis class A in the course of antiviral therapy (AVT) with enteral food (EF) and without it. Indicators PEI (an index of weight of a body, a circle of muscles of a shoulder, skinny - a fatty fold on triceps and albumin of blood whey) were analyzed; quality of life of patients was estimated by a method of questioning with application of questionnaire SF - 36. Results: At sick virus (HCV) HC class A protein- energy insufficiency meets already to AVT in 14,8 % of cases. Antiviral therapy sick HCV HC class A is accompanied by increase in relative frequency PEI in group to 61,5 % of patients. An enteral food reduces relative frequency PEI in the course of AVT to 21,4 %, p = 0,0035. Lowered base (before treatment) indicators QL at sick virus (HCV) HC class A in the course of AVT worsens. Indicators of ‘a physical component of health» (SF - 36) and PEI have authentic positive communication (r> 0,46, p 0,46, р < 0,01). Энтеральное питание предотвращает ухудшение «физического компонента здоровья» (SF - 36) в процессе пртивовирусной терапии, р Заключение: В процессе ПВТ больных HCV ЦП класса А усугубление БЭН тре`бует проведения мониторинга её показателей и превентивное назначение энтерального питания

Features of antifungal therapy during long-lasting infectious process: a clinical case of fungal keratitis and profile of antifungal sensitivity based on assessing biofilm formation

Among infectious diseases, opportunistic mycoses hold a special place. There has been accumulating a lot of evidence regarding the clinical and epidemiological aspects of infection caused by Fusarium spp., which global incidence rate among microbial keratitis ranges from 2 to 40% depending on the geographical location of the country. Colonizing mucous membranes, fungi can exist not only in the form of plankton, but form biofilms after surface attachment, which leads to elevated resistance to multiple antifungal agents. Here we describe a clinical case of fungal keratitis due to Fusarium solani by determining profile of the antifungal sensitivity for isolated fungal strains, by taking into account their potential for biofilm formation. We used an F. solani culture isolated from the patient as well as F. solani test culture obtained from the Russian National Collection of Microorganisms. While determining the sensitivity of fungal planktonic cultures to antifungal agents from the azole group (fluconazole, voriconazole), amphotericin B and terbinafine, it was revealed that antimycotics amphotericin B and voriconazole exerted a marked antifungal activity against clinical isolate, whereas the plankton F. solani test culture was more sensitive to all groups of antifungal agents. Due to a long-lasting progressive course of the infectious process and the high biofilm-forming ability of the clinical strain F. solani, the activity of antifungal agents on biofilm cells was modeled and examined in vitro. It was shown that regarding to the fungal biofilms, value of the minimally inhibitory concentration exceeded those for planktonic cultures by 100-fold. The mechanisms of action for antifungal agents on vital parameters of fungal cell structures were analyzed by using confocal laser scanning microscopy after staining samples with propidium iodide and acridine orange for 15 min to detect changes between intact and damaged cell surface. It was found that within the biofilm fungal cells preserved viability even after exposure to high concentrations of antifungals. In addition, despite the fungicidal drug activity at substantial concentrations acting on the biofilm cell membrane, the cell nuclei remained viable. Owing to the presence ot the mechanism of resistance in mycelial fungi shown in the study, it is necessary to take into account and investigate characteristics of biofilms in terms of drug sensitivity that will allow to optimize a choice of antimicrobial therapy

The Sozofity of Volyn Region (Ukraine)

Уперше здійснено аналіз созологічного статусу раритетних судинних рослин Волинської області порівняно з природоохоронними списками Республіки Білорусь та Польщі. Незважаючи на наявність Полісся в зазначених регіонах, їх раритетні види відрізняються ступенем ризику, що необхідно враховувати при викладанні дисциплін ботанічного циклу і проведенні польових практик у виші. Представлено матеріали про 96 видів судинних рослин Волинської області, що перебувають під охороною Червоної книги України, проведено порівняльний аналіз охоронного статусу видів рослин області та двох сусідніх держав. The first conducted analysis of the sozologichal status of rare vascular plants of Volyn region compared to the nature protection’s lists of Belarus and Poland. Despite the presence of Polesie at the regions, their rare species differ in the degree of risk that must be considered at Botanical cycle’s subjects and field university’s practices. The materials of 96 species of vascular plants of the Volyn region, under the protection of the Red Book of Ukraine, are presented. The comparative analysis of the conservation status of species and the two neighboring states was carried out.Роботу виконано на кафедрі ботаніки СНУ ім. Лесі Українк

Synthesis and antifungal activity of monoterpenoids of the carane series

The antifUngal activity of terpenoids of the carane series was studied; an interaction was found between the structures of these compounds and their antifungal properties. The actions of several terpenoids on the adhesive activity and enzyme systems of the fungus Candida albicans were studied. © 2012 Springer Science+Business Media, Inc

КЛИНИКО-МОРФОЛОГИЧЕСКАЯ ХАРАКТЕРИСТИКА ЭНТЕРОЭНДОКРИННОЙ СИСТЕМЫ У БОЛЬНЫХ ХРОНИЧЕСКИМ ОБСТРУКТИВНЫМ БРОНХИТОМ

Introduction. Comorbidity greatly contributes to progression and severity of chronic obstructive pulmonary disease (COPD). The aim of this study was to describe the nature and severity of gastrointestinal paraendocrine disorders in patients with COPD.Methods. This cross-sectional open randomized controlled study included 84 patients with COPD. We measured blood serotonin concentration and performed immunohistochemical investigation of gastrointestinal APUD cells.Results. Our results suggested an effect of gastrointestinal disease on the severity of COPD. Hyperserotoninemia and structural and functional disorders in enteroendocrine system were noted even in patients with mild COPD.Conclusion. The severity of bronchial obstruction could correlate with functional activity of serotonin-producing enteroendocrine cells.В прогрессировании и тяжести течения хронической обструктивной болезни легких (ХОБЛ) придается значение сопутствующей патологии. С целью установления характера и тяжести поражения параэндокринной системы гастроинтестинальной зоны у пациентов с различными стадиями ХОБЛ проведено одномоментное исследование, в которое были включены пациенты (n = 84) с ХОБЛ. Выполнено исследование уровня серотонина крови, иммуногистохимическое исследование апудоцитов гастроинтестинальной зоны. Получены данные о влиянии гастроинтестинальной патологии на тяжесть течения ХОБЛ. Установлено, что тяжесть бронхообструктивного синдрома коррелирует с функциональной активностью серотонинпродуцирующих энтероэндокриноцитов