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Synthesis and antifungal activity of sulfides, sulfoxides, and sulfones based on (1S)-(-)-β-pinene
Authors
Gavrilov V.
Glushko N.
+6 more
Gnezdilov O.
Klimovitskii E.
Lisovskaya S.
Lodochnikova O.
Nikitina L.
Startseva V.
Publication date
1 January 2010
Publisher
Abstract
Attachment of 2-mercaptoethanol and thioglycolic acid methyl ester to the double bond of (1S)-(-)-β-pinene yielded pinane sulfides with the cis configuration. Oxidation of sulfides with m-chloroperbenzoic acid yielded the corresponding sulfoxides and sulfones. The resulting compounds were screened for antimycotic activity and the dynamics of changes in antifungal properties in sulfides-sulfoxide-sulfone series were studied. © 2010 Springer Science+Business Media, Inc
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Last time updated on 07/05/2019