956 research outputs found
Programmable Matter Research based on 4D printing
Department of Materials Science EngineeringAs a concept suggested by Skylar Tibbits of MIT in 2013, 4D printing is a field with many new possibilities. 4D printing produces programmable matter that responds to exterior stimuli and changes its structure or properties into the shape designed in advance, through 3D printing. One of the advantages of 4D printing is that a motion can be realized in a simple constitution in order for a certain material to move even without a complicated driving mechanism like a motor. This paper first explains 3D printing and 4D printing and then deals with 4D printing using the properties of Poly-Lactic Acid (PLA), which is a shape memory polymer, and 4D printing using a bistable structure. In the case of 4D printing using PLA, we applied the properties that the shape is restored to the original form at a state higher than glass temperature to 3D printing and tested what structure of 4D printing would be possible in the future. In the case of the bistable structure, we made the basic elements of a mechanical bistable structure in order for 4D printing using Shape Memory Polymer (SMP) to produce more efficiently, and prepared the ground that can realize the diversified and complicated mechanical movements.ope
Ru-Catalyzed, cis-Selective Living Ring-Opening Metathesis Polymerization of Various Monomers, Including a Dendronized Macromonomer, and Implications to Enhanced Shear Stability
An unsaturated polymer’s cis/trans-olefin content has a significant influence on its properties. For polymers obtained by ring-opening metathesis polymerization (ROMP), the cis/trans-olefin content can be tuned by using specific catalysts. However, cis-selective ROMP has suffered from narrow monomer scope and lack of control over the polymerization (giving polymers with broad molecular weight distributions and prohibiting the synthesis of block copolymers). Herein, we report the versatile cis-selective controlled living ROMP of various endo-tricyclo[4.2.2.0^(2,5)]deca-3,9-diene and various norbornene derivatives using a fast-initiating dithiolate-chelated Ru catalyst. Polymers with cis-olefin content as high as 99% could be obtained with high molecular weight (up to M_n of 105.1 kDa) and narrow dispersity (<1.4). The living nature of the polymerization was also exploited to prepare block copolymers with high cis-olefin content for the first time. Furthermore, owing to the successful control over the stereochemistry and narrow dispersity, we could compare cis- and trans-rich polynorbornene and found the former to have enhanced resistance to shear degradation
Sopungyangjae-Tang Inhibits Development of Dermatitis in Nc/Nga Mice
Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). Activation of the nuclear factor-κB (NF-κB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-κB activation, which may be essential for TARC expression in TNF-α/IFN-γ treated keratinocytes. The inhibitory effect of SYT on NF-κB activation and TARC production might be associated with the anti-dermatitic effects of SYT
COORDINATIVE PATTERNS BETWEEN CARVING TURN AND SKIDDING TURN DURING ALPINE SKIING
The purpose of this study was to investigate the coordinative patterns between segments and ski using the continuous relative phase (CRP) on anteroposterior and vertical axis during carving and skidding turn. Fourteen alpine ski instructors were participated in this study. Eight inertial measurement units were used to collect segment kinematic data. Each skier was asked to perform ten carving turns and ten skidding turns on the groomed 15° slope, respectively. CRP angles between all segments and ski were significantly increased during carving turn on the vertical axis. On the other hand, CRP angles between all segments and ski were significantly increased during skidding turn on anteroposterior axis. Therefore, skiers should perform the anti-phase movements of the lower spine-ski, pelvis-ski, thigh-ski and shank-ski on the vertical axis during the carving turn and the in-phase movements of the lower spine-ski, pelvis-ski, thigh-ski and shank-ski on the anteroposterior axis during skidding turn
Dark to light! A new strategy for large Stokes shift dyes: coupling of dark donor with tunable high quantum yield acceptors
10.1039/c4sc01821dChemical Science5124812-481
The Occurrence and Speed of CMEs Related to Two Characteristic Evolution Patterns of Helicity Injection in Their Solar Source Regions
Long-term (a few days) variation of magnetic helicity injection was
calculated for 28 solar active regions which produced 47 CMEs to find its
relationships with the CME occurrence and speed using SOHO/MDI line-of-sight
magnetograms. As a result, we found that the 47 CMEs can be categorized into
two different groups by two characteristic evolution patterns of helicity
injection in their source active regions which appeared for about 0.5-4.5 days
before their occurrence: (1) a monotonically increasing pattern with one sign
of helicity (Group A; 30 CMEs in 23 active regions) and (2) a pattern of
significant helicity injection followed by its sign reversal (Group B; 17 CMEs
in 5 active regions). We also found that CME speed has a correlation with
average helicity injection rate with linear correlation coefficients of 0.85
and 0.63 for Group A and Group B, respectively. In addition, these two CME
groups show different characteristics as follows: (1) the average CME speed of
Group B (1330km/s) is much faster than that of Group A (870km/s), (2) the CMEs
in Group A tend to be single events, whereas those in Group B mainly consist of
successive events, and (3) flares related to the CMEs in Group B are relatively
more energetic and impulsive than those in Group A. Our findings therefore
suggest that the two CME groups have different pre-CME conditions in their
source active regions and different CME characteristics.Comment: 25 pages, 7 figures, accepted for publication in Ap
Preparation and evaluation of polymeric microparticulates for improving cellular uptake of gemcitabine
Ji-Ho Lim1,*, Sung-Kyun You1,*, Jong-Suep Baek1, Chan-Ju Hwang1, Young-Guk Na1, Sang-Chul Shin2, Cheong-Weon Cho11College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Gungdong, Yuseonggu, Daejeon, South Korea, 2College of Pharmacy, Chonnam National University, Buggu, Gwangju, South Korea *These authors contributed equally to this workBackground: Gemcitabine must be administered at high doses to elicit the required therapeutic response because of its very short plasma half-life due to rapid metabolism. These high doses can have severe adverse effects.Methods: In this study, polymeric microparticulate systems of gemcitabine were prepared using chitosan as a mucoadhesive polymer and Eudragit L100-55 as an enteric copolymer. The physicochemical and biopharmaceutical properties of the resulting systems were then evaluated.Results: There was no endothermic peak for gemcitabine in any of the polymeric gemcitabine microparticulate systems, suggesting that gemcitabine was bound to chitosan and Eudragit L100-55 and its crystallinity was changed into an amorphous form. The polymeric gemcitabine microparticulate system showed more than 80% release of gemcitabine in 30 minutes in simulated intestinal fluid. When mucin particles were incubated with gemcitabine polymeric microparticulates, the zeta potential of the mucin particles was increased to 1.57 mV, indicating that the polymeric gemcitabine microparticulates were attached to the mucin particles. Furthermore, the F53 polymeric gemcitabine microparticulates having 150 mg of chitosan showed a 3.8-fold increased uptake of gemcitabine into Caco-2 cells over 72 hours compared with gemcitabine solution alone.Conclusion: Overall, these results suggest that polymeric gemcitabine microparticulate systems could be used as carriers to help oral absorption of gemcitabine.Keywords: gemcitabine, polymeric microparticulates, mucoadhesive, enteric coating, cellular uptake, oral absorptio
Theoretical Estimation of Cannulation Methods for Left Ventricular Assist Device Support as a Bridge to Recovery
Left ventricular assist device (LVAD) support under cannulation connected from the left atrium to the aorta (LA-AA) is used as a bridge to recovery in heart failure patients because it is non-invasive to ventricular muscle. However, it has serious problems, such as valve stenosis and blood thrombosis due to the low ejection fraction of the ventricle. We theoretically estimated the effect of the in-series cannulation, connected from ascending aorta to descending aorta (AA-DA), on ventricular unloading as an alternative to the LA-AA method. We developed a theoretical model of a LVAD-implanted cardiovascular system that included coronary circulation. Using this model, we compared hemodynamic responses according to various cannulation methods such as LA-AA, AA-DA, and a cannulation connected from the left ventricle to ascending aorta (LV-AA), under continuous and pulsatile LVAD supports. The AA-DA method provided 14% and 18% less left ventricular peak pressure than the LA-AA method under continuous and pulsatile LVAD conditions, respectively. The LA-AA method demonstrated higher coronary flow than AA-DA method. Therefore, the LA-AA method is more advantageous in increasing ventricular unloading whereas the AA-DA method is a better choice to increase coronary perfusion
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