FOCUSING ON CENTRALITY MEASURE IN EMERGENCY MEDICAL SERVICES

Emergency Medical Services (EMS) attracted many researchers because the demand of EMS was increasing over time. One of the major concerns of EMS is the response time and ambulance despatching is one of the vital factors which affects the response time. This paper focuses on the problem of ambulance despatching when many emergency calls emerge in a short time, which exists under the condition of catastrophic natural or manmade disasters. We modify a new method for ambulance despatching by centrality measure, this method constructs a nearest-neighbor coupled emergency call network and then prioritize those calls by the score of fitness, where the score of fitness considers two factors: centralized measure a call by the emergency call network and the closest policy which means despatching to the closest call site. This method is testified by a series of simulation experiments on the real topology road network of Hong Kong Island which contains 8 hospitals. These analyses demonstrate the real situation and proof the potential of centrality measure in reducing response time of EMS

Effects of pH on the PtRu/C catalyst prepared by microwave-assisted ethylene glycol process

PtRu nanoparticles supported on the carbon, with different mean particle sizes, were synthesized by microwave-assisted ethylene glycol process, the effects of pH on the PtRu/C catalyst were mainly investigated. UV-Vis spectroscopy, energy dispersive X-ray analysis, transmission electron microscopy, and X-ray diffraction were applied to characterize the PtRu nanoparticles. The solution pH had important influence on the metal particle size. TEM results indicated that the PtRu mean particle size decreased from 3.5 nm to 1.5 nm with the increase of pH value. However, when pH value reached 11.0, the metal loading of synthesized catalyst decreased distinctly because the metal nanoparticles were protected in solution. The results showed that the PtRu/C catalyst synthesized at pH ca 9.0, with appropriate particle sizes (2.4 nm) and homogenous dispersed particles, had the highest electrocatalytic activity for methanol electrooxidation among all the synthesized catalysts

Search for new physics via CP violation in $B_{d,s} \to l^+ l^-

It is shown that in the approximation of $|\frac{q}{p}|$=1 the CP violation in $B^0_{d,s} \to l^+ l^-$ decays vanishes in SM. In a 2HDM with CP violating phases and MSSM the CP asymmetries depend on the parameters of models and can be as large as 40% for $B^0_d$ and 3% for $B^0_s$. An observation of CP asymmetry in the decays would unambiguously signal the existence of new physics.Comment: shortened version, latex, 10 pages, 2 figures, comments adde

Neoadjuvant chemoimmunotherapy achieved a pathologic complete response in stage IIIA lung adenocarcinoma harboring RET fusion: a case report

Neoadjuvant chemoimmunotherapy has demonstrated significant benefit for resectable non-small-cell lung cancer (NSCLC) excluding known EGFR/ALK genetic alterations. Recent evidence has shown that neoadjuvant chemoimmunotherapy could be clinically valuable in resectable localized driver gene-mutant NSCLC, though the data still lack robust support, especially for rare oncogenic mutations. Here, we report a patient with stage IIIA lung adenocarcinoma with a RET fusion gene and high expression of PD-L1 who underwent neoadjuvant chemoimmunotherapy and successfully attained a pathologic complete response. The patient has survived for 12 months with no recurrence or metastases after surgery. Our case suggests that this treatment strategy may be an alternative therapeutic option for resectable RET fusion-positive NSCLC patients

The Promising Process to Distinguish Supersymmetric Models with Large tanβ\beta from the Standard Model: B→Xsμ+μ−B\to X_s{\mu}^{+}{\mu}^{-}

It is shown that in supersymmetric models (SUSYMs) the large supersymmetric contributions to $B \to X_s{\mu}^{+}{\mu}^{-}$ come from the Feynman diagrams which consist of exchanging neutral Higgs bosons (NHBs) and the chargino-stop loop and are proportional to $m_b m_{\mu}$tan$^3\beta/m_{h}^2$ when tan$\beta$ is large and the mass of the lightest neutral Higgs boson m$_h$ is not too large (say, less than 150 Gev). Numerical results show that the branching ratios of $B \to X_s{\mu}^{+}{\mu}^{-}$ can be enhanced by more than 100% compared to the standard model (SM) and the backward-forward asymmetry of lepton is significantly different from that in SM when tan$\beta \geq 30$.Comment: 8 pages, including 2 figure

Direction finding and mutual coupling estimation for uniform rectangular arrays

A novel two-dimensional (2-D) direct-of-arrival (DOA) and mutual coupling coefficients estimation algorithm for uniform rectangular arrays (URAs) is proposed. A general mutual coupling model is first built based on banded symmetric Toeplitz matrices, and then it is proved that the steering vector of a URA in the presence of mutual coupling has a similar form to that of a uniform linear array (ULA). The 2-D DOA estimation problem can be solved using the rank-reduction method. With the obtained DOA information, we can further estimate the mutual coupling coefficients. A better performance is achieved by our proposed algorithm than those auxiliary sensor-based ones, as verified by simulation results

Screening biomarkers for Sjogren’s Syndrome by computer analysis and evaluating the expression correlations with the levels of immune cells

BackgroundSjögren’s syndrome (SS) is a systemic autoimmune disease that affects about 0.04-0.1% of the general population. SS diagnosis depends on symptoms, clinical signs, autoimmune serology, and even invasive histopathological examination. This study explored biomarkers for SS diagnosis.MethodsWe downloaded three datasets of SS patients’ and healthy pepole’s whole blood (GSE51092, GSE66795, and GSE140161) from the Gene Expression Omnibus (GEO) database. We used machine learning algorithm to mine possible diagnostic biomarkers for SS patients. Additionally, we assessed the biomarkers’ diagnostic value using the receiver operating characteristic (ROC) curve. Moreover, we confirmed the expression of the biomarkers through the reverse transcription quantitative polymerase chain reaction (RT-qPCR) using our own Chinese cohort. Eventually, the proportions of 22 immune cells in SS patients were calculated by CIBERSORT, and connections between the expression of the biomarkers and immune cell ratios were studied.ResultsWe obtained 43 DEGs that were mainly involved in immune-related pathways. Next, 11 candidate biomarkers were selected and validated by the validation cohort data set. Besides, the area under curves (AUC) of XAF1, STAT1, IFI27, HES4, TTC21A, and OTOF in the discovery and validation datasets were 0.903 and 0.877, respectively. Subsequently, eight genes, including HES4, IFI27, LY6E, OTOF, STAT1, TTC21A, XAF1, and ZCCHC2, were selected as prospective biomarkers and verified by RT-qPCR. Finally, we revealed the most relevant immune cells with the expression of HES4, IFI27, LY6E, OTOF, TTC21A, XAF1, and ZCCHC2.ConclusionIn this paper, we identified seven key biomarkers that have potential value for diagnosing Chinese SS patients