50 research outputs found
Valoración de la seguridad en Municipios Turísticos de Sol y Playa con mayor actividad hotelera en México a partir de un análisis multicriterio.
En un contexto vinculado con problemas de inseguridad por el que ha atravesado en diferente medida gran parte del territorio mexicano durante los últimos ocho años, es necesario conocer de qué manera factores asociados a la seguridad pública pueden tratarse con el fin de generar toma de decisiones que ayuden a diseñar o corregir estrategias, sistematizar experiencias o generar diagnósticos que faciliten la implementación de políticas públicas, programas o proyectos en beneficio del sector turístico. El objetivo principal de este estudio es presentar un análisis teórico, conceptual y metodológico a través del método de relaciones de superación (outranking), se aborda el problema de la evaluación de un conjunto de municipios turísticos como un problema de ordenamiento multicriterio. Este modelo compara la seguridad pública en los primeros 18 municipios turísticos de sol y playa de México con la mayor infraestructura hotelera. Como parte de la metodología utilizada, se identifican alternativas y criterios, se caracterizan los indicadores los cuales se concentran y normalizan y con la participación del experto se asignan los pesos que corresponden a las variables. El método empleado para hacer la evaluación y clasificación final de las alternativas es el ELECTRE III, mientras que para la explotación del modelo se utilizó un algoritmo evolutivo multiobjetivo que da como resultado un ranking de los municipios con mejor seguridad pública en orden decreciente. Como parte de los resultados, municipios como Bahía de Banderas (Nuevo Vallarta), se enlistó como uno de los más seguros, mientras que otros como Acapulco y Ensenada su valoración fue menos positiva.
Abstract
In a context related to problems of insecurity that has gone through a large part of Mexican territory in the last eight years, it is necessary to know how factors associated with public security can be treated in order to generate decision making help to design or correct strategies, systematize experiences or generate diagnoses that facilitate the implementation of public policies, programs or projects for the benefit of the tourism sector. The main objective of this study is to present a theoretical, conceptual and methodological analysis through the method of outranking relationships, addressing the problem of the evaluation of a set of tourist municipalities as a problem of multicriteria ordering. This model compares public safety in the first 18 municipalities of sun and beach in Mexico with the largest hotel infrastructure. As part of the methodology used, alternatives and criteria are identified, the indicators are characterized which are concentrated and normalized and with the participation of the expert the weights corresponding to the variables are assigned. The method used to make the final evaluation and classification of the alternatives is the ELECTRE III, while for the exploitation of the model a multiobjective evolutionary algorithm was used that results in a ranking of municipalities with better public safety in decreasing order. As part of the results, municipalities such as Bahía de Banderas (Nuevo Vallarta), was listed as one of the safest, while others such as Acapulco and Ensenada their assessment was less positive.
 
Optimized Architectural Synthesis of Fixed-Point Datapaths
In this paper we address the time-constrained architectural synthesis of fixed-point DSP algorithms using FPGA devices. Optimized fixed-point implementations are obtained by means of considering: (i) a multiple wordlength approach; (ii) a complete datapath formed of wordlength-wise resources (i.e. functional units, multiplexers and registers); and, (iii) a novel resource usage metric that enables the wise distribution of logic fabric and embedded DSP resources. The paper shows: (i) the benefits of applying a multiple wordlength approach to the implementation of fixedpoint datapaths; and (ii) the benefits of a wise use of embedded FPGA resources. The proposed metric enables area improvements up to 54% and the use of a complete fixed-point datapath leads to improvements up to 35%
An Outranking Approach for Gene Prioritization Using Multinetworks
High-throughput experimental techniques such as genome-wide association studies have been instrumental in the identification of disease-associated genes. These methods often produce large lists of disease candidate genes which are time-consuming and expensive to experimentally validate. Computational gene prioritization methods are required to identify relevant genes from a larger pool of candidates. Research has shown that the integration of diverse “omic” evidence can reduce the candidate-gene search space. In this paper we present a general framework that integrates “omic” data using a multinetwork approach and topological analysis to prioritize disease-candidate genes. Specifically, we propose a data integration method within a multicriteria decision analysis context using aggregation mechanisms based on decision rules identifying positive and negative criteria for judging gene-candidates ranks. The proposed multinetwork disease gene prioritization method is applied to the prioritization of disease genes in ovarian cancer progression. Using this approach we uncovered known ovarian cancer genes GSTA1, ERBB2, IL1A, MAGEB2, along with significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways ErbB signaling and pathways in cancer. Relatively high predictive performance (area under Receiver Operating Characteristic [ROC] curve 0.704) was observed when classifying epithelial ovarian high-grade serous carcinoma cancer early and late stage RNA-Seq expression profiles from individuals using 10-fold cross-validation
Heterotrophic Kinetic Study and Nitrogen Removal of a Membrane Bioreactor System Treating Real Urban Wastewater under a Pharmaceutical Compounds Shock: Effect of the Operative Variables
Numerous studies have analyzed the viability of the biodegradation and removal of
different compounds of emerging concern in biological systems for wastewater treatment. However,
the effect on the heterotrophic biomass of organic matter removal is sometimes missed. The aim
of the present research was to study the effect of the addition of a mix of three pharmaceuticals
(carbamazepine, ciprofloxacin, and ibuprofen) on the behavior of the biomass in two different
membrane-based biological systems treating urban wastewater. The present research studied a
membrane bioreactor (MBR) pilot plant operating at a similar mixed liquor suspended solids (MLSS)
concentration (about 5.5 g/L). This system works as an MBR and is combined with a moving bed
biofilm reactor (MBBR-MBR) to treat real urban wastewater at 6 and 10 h of hydraulic retention time
(HRT) under three different shocks of pharmaceuticals with increasing concentrations. In all cases,
the organic matter removal was, in average terms, higher than about 92% of biochemical oxygen
demand on the fifth day (BOD5), 79% of chemical oxygen demand (COD), and 85% of total organic
carbon (TOC). Nevertheless, the removal is higher in the MBBR-MBR technology under the same
HRT and the MLSS is similar. Moreover, the removal increased during the shock of pharmaceutical
compounds, especially in the MBR technology. From a kinetic perspective, MBBR-MBR is more
suitable for low HRT (6 h) and MBR is more effective for high HRT (10 h). This could be due to the fact
that biofilm systems are less sensitive to hostile environments than the MBR systems. The removal of
N-NH4
+ decreased considerably when the pharmaceutical compounds mix was introduced into the
system until no removal was detected in cycle 1, even when biofilm was present.This research was funded by EMASAGRA, project number C-4265-00
The Burden of Hidradenitis Suppurativa Signs and Symptoms in Quality of Life: Systematic Review and Meta-Analysis
Hidradenitis suppurativa (HS) is a chronic, recurrent and debilitating inflammatory skin
disease of the hair follicle that usually presents as painful, deep-seated inflamed lesions in the apocrine
gland-bearing areas of the body. HS patients suffer from uncomfortable signs and symptoms, such as
pain, pruritus, malodour and suppuration, which may impair patients’ quality of life (QoL). Although
HS patients frequently experience these signs and symptoms, they are only occasionally assessed
by clinicians and, unexpectedly, the scientific evidence available is limited and heterogeneous. The
aim of this study is to summarize the evidence regarding the impact of HS signs and symptoms
on QoL to serve as a basis for future research and help clinicians to consider them in the daily
care of HS patients. A systematic review and meta-analysis were conducted following PRISMA
Guidelines. The following search algorithm was used: (hidradenitis or “acne inversa”) and (pain
or itch or odour or malodour or suppuration or oozing or drainage) and (“quality of life”). The
literature search identified 836 references, 17 of them met the eligible criteria and were included
for analysis, representing 4929 HS patients. Mean age of the participants was 36.28 years and there
was a predominance of female sex among study participants. The BMI of the population was in
the range of over-weight and about two out five patients were active smokers. Studies included
patients with mild to moderate HS, with a mean disease duration of 13.69 years. The HS signs and
symptoms assessed were pain, pruritus, malodour and suppuration. Overall, the higher intensity
of a sign or symptom correlated with poorer general QoL or specific QoL dimensions including
sexual distress, anxiety, depression and sleep. The most frequently employed tool to assess QoL was
the Dermatology Life Quality Index (DLQI). DLQI was used in 52.9% of the studies (9/17) with a
mean value of 10.70 (2.16 SD). The scores employed to assess signs and symptoms severity were
subjective and varied between studies, being the numerical rating scale (NRS) for each of the most
used symptoms. The mean NRS value for pain was 3.99 and the mean NRS for pruritus was 4.99. In
conclusion, we have summarized, categorized and analyzed the scientific evidence regarding signs
and symptoms in HS patients and their impairment in QoL. Their assessment should be thorough
and included during routine evaluation of HS patients to motivate therapeutic modifications and
increase patients’ health
Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age
We would like to thank all the individuals who generously shared their time
to participate in this research. The results of this study are part of the PhD work of Trinidad
Montero-Vilchez.Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients. A cross-sectional study was conducted including 162 participants, 81 AD patients and 81 healthy volunteers. Skin barrier function parameters, such as transepidermal water loss (TEWL), erythema, temperature, stratum corneum hydration (SCH), pH, and elasticity, were evaluated. Healthy volunteers were evaluated on the volar forearm. AD patients were measured on two regions: on an eczematous lesion on the volar forearm and on a non-involved area 5 cm from the affected area. TEWL was lower on healthy skin than uninvolved AD skin (9.98 vs. 25.51 g center dot m(-2)center dot h(-1), p < 0.001) and AD eczematous lesions (9.98 vs. 28.38 g center dot m(-2)center dot h(-1), p < 0.001). SCH was lower on AD eczematous lesions than uninvolved AD skin (24.23 vs. 39.36 AU, p < 0.001) and healthy skin (24.23 vs. 44.36 AU, p < 0.001). Elasticity was lower on AD eczematous lesions than uninvolved AD skin (0.69 vs. 0.74, p = 0.038) and healthy skin (0.69 vs. 0.77, p = 0.014). A negative correlation was found between age and elasticity in all the population (r = -0.383, p < 0.001). This correlation was stronger in AD patients (r = -0.494, p < 0.001) than in controls (r = -0.266, p = 0.092). After conducting a linear regression model in AD patients adjusted by age, sex, and SCORing Atopic Dermatitis (SCORAD), it was found that elasticity was impaired by an increasing age (beta = -0.004, p < 0.001) and a higher SCORAD (beta = -0.003, p < 0.001). The skin barrier function is impaired by age and AD, reflected mainly in poor elasticity values in older AD patients
TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis
The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10−4, OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10−5, OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS
XVI International Congress of Control Electronics and Telecommunications: "Techno-scientific considerations for a post-pandemic world intensive in knowledge, innovation and sustainable local development"
Este título, sugestivo por los impactos durante la situación de la Covid 19 en el mundo, y que en Colombia lastimosamente han sido muy críticos, permiten asumir la obligada superación de tensiones sociales, políticas, y económicas; pero sobre todo científicas y tecnológicas.
Inicialmente, esto supone la existencia de una capacidad de la sociedad colombiana por recuperar su estado inicial después de que haya cesado la perturbación a la que fue sometida por la catastrófica pandemia, y superar ese anterior estado de cosas ya que se encontraban -y aún se encuentran- muchos problemas locales mal resueltos, medianamente resueltos, y muchos sin resolver: es decir, habrá que rediseñar y fortalecer una probada resiliencia social existente - producto del prolongado conflicto social colombiano superado parcialmente por un proceso de paz exitoso - desde la tecnociencia local; como lo indicaba Markus Brunnermeier - economista alemán y catedrático de economía de la Universidad de Princeton- en su libro The Resilient Society…La cuestión no es preveerlo todo sino poder reaccionar…aprender a recuperarse rápido.This title, suggestive of the impacts during the Covid 19 situation in the world, and which have unfortunately been very critical in Colombia, allows us to assume the obligatory overcoming of social, political, and economic tensions; but above all scientific and technological.
Initially, this supposes the existence of a capacity of Colombian society to recover its initial state after the disturbance to which it was subjected by the catastrophic pandemic has ceased, and to overcome that previous state of affairs since it was found -and still is find - many local problems poorly resolved, moderately resolved, and many unresolved: that is, an existing social resilience test will have to be redesigned and strengthened - product of the prolonged Colombian social conflict partially overcome by a successful peace process - from local technoscience; As Markus Brunnermeier - German economist and professor of economics at Princeton University - indicates in his book The Resilient Society...The question is not to foresee everything but to be able to react...learn to recover quickly.Bogot
Semilleros de Investigación 2013, n.° 28
"Unijus promueve y apoya el desarrollo e implementación de programas y proyectos de investigación que aporten al conocimiento de la realidad nacional e internacional, de las instituciones jurídicas, políticas y sociales, así como de las teorías jurídicas y políticas que contribuyan a la construcción de nuevas propuestas para la solución de las problemáticas que aquejan la sociedad.
Por tal motivo, es fundamental el apoyo constante a la formación de semilleros de investigación en la Facultad de Derecho, Ciencias Políticas y Sociales de la Sede Bogotá, así como la consolidación de los semilleros ya existentes. En el año 2013, se desarrollaron las Convocatorias No. 01 y 02 de 2013 para la Selección de Semilleros de Investigación de la Facultad de Derecho, Ciencias Políticas y Sociales. Como resultado de dicho proceso fueron seleccionadas trece propuestas de investigación integradas por un total de 47 estudiantes, quienes a su vez se encontraban vinculados a 7 grupos de investigación.""Presentación
Acercamiento a la reforma del Consejo de Seguridad de las Naciones Unidas:
Una mirada a las propuestas de México, Argentina y Brasil
Reflections on Legal Education: an Approach to the Escuela de Derecho Propio Laureano Inampués Cuatín
Iliana Jineth Yepes Acuña, Simón Camilo Hernández Gaona, Paula Alejandra Poveda Cocuy, Francisco Javier Quito Córdoba, Sonia Catalina Villamizar Almeyda
Grupo de investigación en Relaciones Internacionales y Asuntos Globales - RIAG
Intervención en el Bronx: Análisis descriptivo de una apuesta alternativa en política pública de seguridad humana
Intervention in the Bronx: Descriptive Analysis of an alternative bet on Public Policy and human security
Ana María Tarazona Galvis, Carolina Cristancho Zarco, Andrés Felipe Espinosa Zuluaga, Fredy Hernando Caro y Sergio Iván González Machetá
Grupo de Investigación en Seguridad y Defensa -GISDE
Conflictos socioterritoriales en la región Andina Oriental de Colombia: una mirada al campesinado y a las formas contemporáneas de la lucha por la tierra y el territorio
Socio-territorial Conflicts in the East Andes Region of Colombia: A glance at the Peasantry and Contemporary Ways of Struggle for Land and Territory
Catherine Moore Torres, Julián Eduardo Naranjo Vasco
Grupo Interdisciplinario de Estudios Políticos y Sociales - Theseus
Territorios, resistencias y espacialidad en la geopolítica de la globalización
Territory, Strength and Spatiality in the Geopolitics of Globalization
Sindy Katherine Castro Herrera, Camila Andrea Galindo Martínez, Paula Andrea Ricaurte Ávila, Natalia Briceño Hernández, John Freddy Gómez Celi, Ángela Beatriz Torres Tamayo
Grupo Interdisciplinario de Estudios Políticos y Sociales - Theseus
Territorio y construcción de subjetividades en Bogotá. Transferencias entre lo rural y lo urbano en las localidades de Chapinero, Usme y Ciudad Bolívar
Territory and construction of subjectivities in Bogotá. Transfers between the rural and the urban in the localities of Chapinero, Usme and Ciudad Bolívar
Javier Alejandro Jiménez González, David Fernando Salamanca Paternina, Diana Paola López Bojacá
Grupo de Investigación Presidencialismo y Participación
Los jóvenes y la paz: la incógnita de La Habana
Young People and Peace: the Unknown of Havana
Sara Camila Arias Castañeda, Reina Alejandra Jiménez Díaz, Brahiam Fernando Quintana Martínez, Fernando Villada Agudelo
Grupo de investigación Presidencialismo y Participación
Análisis jurídico-crítico de la producción normativa en materia ambiental en el período 2003-2013 con énfasis en el Proyecto de reforma al Código Nacional de Recursos Naturales Renovables
Legal-Critical Analysis of Legislation Production in Environmental Law in the Period of 2003-2013 with an Emphasis on the National Code of Renewable Natural Resources
Diana Sofía Díaz Castro, Natalia Alejandra Rodríguez Vargas, Adriana María Guerrero Arias
Grupo de Investigación en Derechos Colectivos y Ambientales - GIDCA
Conflictividad ambiental por monocultivos de palma aceitera en Tibú, Norte de Santander
Environmental Conflict for Oil Palm Plantations in Tibú, North of Santander
José Agustín Labrador Forero, Carlos Eduardo Olaya Díaz
Grupo de Investigación en Derechos Colectivos y Ambientales - GIDCA
Campañas electorales: lo que se puede y lo que se debería comunicar
Electoral Campaigns: what can be communicated and what should be communicated
Daniela Alvarado Rincón, Freddy Leonardo González Araque y Augusto Federico Padilla
Grupo de investigación Cultura Jurídico Política, Instituciones y Globalización
Tratamiento jurídico-social de la obscenidad en Colombia: Aproximación desde la jurisprudencia de la Corte Constitucional
Legal and social treatment of obscenity in Colombia: Approximation from the jurisprudence of the Constitutional Court
Germán Darío Rodríguez González, Luisa Fernanda Ortiz Rodríguez, Diego Ricardo Cárdenas Nonsoque
Grupo de investigación Cultura Jurídico Política, Instituciones y Globalización
Mujeres indígenas y prácticas de justicia
Indigenous Women and Practices of Justice
Luisa María Ocaña Muñoz, Sibelys Katina Mejía Rodríguez, Viviana Patricia López Rubio, Damaris Alejandra Quintero Leyva
Grupo de investigación Escuela de Justicia Comunitaria de la Universidad Nacional (EJCUN)
Justicia en red: Caminando hacia el empoderamiento y la construcción de ciudadanía para Bogotá
Justice in Network: towards the Empowerment and the Construction of Citizenship in Bogotá
Alejandra Méndez Molano, Jenny Alejandra Tamayo Tamayo
Grupo de investigación Escuela de Justicia Comunitaria de la Universidad Nacional (EJCUN)
Reflexiones sobre la educación legal: Una aproximación a la Escuela de Derecho Propio Laureano Inampués Cuatín
Reflections on Legal Education: an Approach to the Escuela de Derecho Propio Laureano Inampués Cuatín
Krisly Tatiana Amaya Osorio, Juan Sebastián Urdaneta Forero, Miguel Ángel Salas Dorado
Grupo de investigación Escuela de Justicia Comunitaria de la Universidad Nacional (EJCUN)
Semilleros de Investigación 2013
El Instituto Unidad de Investigaciones Jurídico-Sociales Gerardo Molina (Unijus) promueve y apoya el desarrollo e implementación de programas y proyectos de investigación que aporten al conocimiento de la realidad nacional e internacional, de las instituciones jurídicas, políticas y sociales, así como de las teorías jurídicas y políticas que contribuyan a la construcción de nuevas propuestas para la solución de las problemáticas que aquejan la sociedad. Por tal motivo, es fundamental el apoyo constante a la formación de semilleros de investigación en la Facultad de Derecho, Ciencias Políticas y Sociales de la Sede Bogotá, así como la consolidación de los semilleros ya existentes. En el año 2013, se desarrollaron las Convocatorias No. 01 y 02 de 2013 para la Selección de Semilleros de Investigación de la Facultad de Derecho, Ciencias Políticas y Sociales. Como resultado de dicho proceso fueron seleccionadas trece propuestas de investigación integradas por un total de 47 estudiantes, quienes a su vez se encontraban vinculados a 7 grupos de investigación. La presente publicación está compuesta por los artículos que resultaron de los proyectos aprobados. Grupo de investigación Relaciones Internacionales y Asuntos Globales Acercamiento a la reforma del Consejo de Seguridad de las Naciones Unidas: una mirada a las propuestas de México, Argentina y Brasil Busca identificar los factores por los cuales tres países latinoamericanos (Argentina, Brasil y México) —con características históricas similares, que comparten un origen medianamente común y que participan en los espacios de integración regional de la misma—, divergen en sus posiciones con respecto a la reforma del Consejo de Seguridad de la Organización de las Naciones Unidas (ONU). El semillero de investigación estuvo bajo la dirección del profesor Gustavo Adolfo Puyo