833 research outputs found
Highly turbulent solutions of LANS-alpha and their LES potential
We compute solutions of the Lagrangian-Averaged Navier-Stokes alpha-model
(LANS) for significantly higher Reynolds numbers (up to Re 8300) than have
previously been accomplished. This allows sufficient separation of scales to
observe a Navier-Stokes (NS) inertial range followed by a 2nd LANS inertial
range. The analysis of the third-order structure function scaling supports the
predicted l^3 scaling; it corresponds to a k^(-1) scaling of the energy
spectrum. The energy spectrum itself shows a different scaling which goes as
k^1. This latter spectrum is consistent with the absence of stretching in the
sub-filter scales due to the Taylor frozen-in hypothesis employed as a closure
in the derivation of LANS. These two scalings are conjectured to coexist in
different spatial portions of the flow. The l^3 (E(k) k^(-1)) scaling is
subdominant to k^1 in the energy spectrum, but the l^3 scaling is responsible
for the direct energy cascade, as no cascade can result from motions with no
internal degrees of freedom. We verify the prediction for the size of the LANS
attractor resulting from this scaling. From this, we give a methodology either
for arriving at grid-independent solutions for LANS, or for obtaining a
formulation of a LES optimal in the context of the alpha models. The fully
converged grid-independent LANS may not be the best approximation to a direct
numerical simulation of the NS equations since the minimum error is a balance
between truncation errors and the approximation error due to using LANS instead
of the primitive equations. Furthermore, the small-scale behavior of LANS
contributes to a reduction of flux at constant energy, leading to a shallower
energy spectrum for large alpha. These small-scale features, do not preclude
LANS to reproduce correctly the intermittency properties of high Re flow.Comment: 37 pages, 17 figure
Three regularization models of the Navier-Stokes equations
We determine how the differences in the treatment of the subfilter-scale
physics affect the properties of the flow for three closely related
regularizations of Navier-Stokes. The consequences on the applicability of the
regularizations as SGS models are also shown by examining their effects on
superfilter-scale properties. Numerical solutions of the Clark-alpha model are
compared to two previously employed regularizations, LANS-alpha and Leray-alpha
(at Re ~ 3300, Taylor Re ~ 790) and to a DNS. We derive the Karman-Howarth
equation for both the Clark-alpha and Leray-alpha models. We confirm one of two
possible scalings resulting from this equation for Clark as well as its
associated k^(-1) energy spectrum. At sub-filter scales, Clark-alpha possesses
similar total dissipation and characteristic time to reach a statistical
turbulent steady-state as Navier-Stokes, but exhibits greater intermittency. As
a SGS model, Clark reproduces the energy spectrum and intermittency properties
of the DNS. For the Leray model, increasing the filter width decreases the
nonlinearity and the effective Re is substantially decreased. Even for the
smallest value of alpha studied, Leray-alpha was inadequate as a SGS model. The
LANS energy spectrum k^1, consistent with its so-called "rigid bodies,"
precludes a reproduction of the large-scale energy spectrum of the DNS at high
Re while achieving a large reduction in resolution. However, that this same
feature reduces its intermittency compared to Clark-alpha (which shares a
similar Karman-Howarth equation). Clark is found to be the best approximation
for reproducing the total dissipation rate and the energy spectrum at scales
larger than alpha, whereas high-order intermittency properties for larger
values of alpha are best reproduced by LANS-alpha.Comment: 21 pages, 8 figure
Cognitive Information Processing
Contains reports on four research projects.National Science Foundation (Grant SED76-81985)Associated Press (Grant)Providence Gravure, Inc. (Grant)Taylor Publishing Company (Grant
Cognitive Information Processing
Contains reports on four research projects.Associated Press (Grant)Providence Gravure, Inc. (Grant)Taylor Publishing Company (Grant
Novel insights by 4D Flow imaging on aortic flow physiology after valve-sparing root replacement with or without neosinuses
This study was undertaken to evaluate the flow dynamics in the aortic root after valve-sparing root replacement with and without neosinuses of Valsalva reconstruction, by exploiting the capability of 4D Flow imaging to measure in vivo blood velocity fields and 3D geometric flow patterns
Scalable synthesis and coupling of quaternary alpha-arylated amino acids: alpha-aryl substituents are tolerated in alpha-helical peptides
Cognitive Information Processing
Contains reports on five research projects.National Science Foundation (Grant SED76-81985)Associated Press (Grant)Providence Gravure, Inc. (Grant)Taylor Publishing Company (Grant)Sony Corporation (Grant
Cognitive Information Processing
Contains reports on seven research projects.National Science Foundation (Grant SED76-81985)Graphic Arts Research Foundation (Grant)Providence Gravure, Inc. (Grant)Associated Press (Grant)National Institutes of Health (Grant 1 RO1 GM22547-01)National Institutes of Health (Grant 1 PO1 AG00354-01)Health Sciences Fund (Grant 76-11
Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704
Double hit lymphoma (DHL) and double protein-expressing (MYC and BCL2) lymphomas (DPL) fare poorly with R-CHOP; consolidative autologous stem cell transplant (ASCT) may improve outcomes. S9704, a phase III randomized study of CHOP +/−R with or without ASCT allows evaluation of intensive consolidation. Immunohistochemical analysis identified 27 of 198 patients (13.6%) with MYC IHC overexpression and 20 (74%) harboring concurrent BCL2 overexpression. Four had DHL and 16 had DPL only. With median follow-up 127 months, there is a trend favoring outcomes after consolidative ASCT in DPL and MYC protein overexpressing patients, whereas all DHL patients have died irrespective of ASCT
Tissue registration and exploration user interfaces in support of a human reference atlas
Seventeen international consortia are collaborating on a human reference atlas (HRA), a comprehensive, high-resolution, three-dimensional atlas of all the cells in the healthy human body. Laboratories around the world are collecting tissue specimens from donors varying in sex, age, ethnicity, and body mass index. However, harmonizing tissue data across 25 organs and more than 15 bulk and spatial single-cell assay types poses challenges. Here, we present software tools and user interfaces developed to spatially and semantically annotate ( register ) and explore the tissue data and the evolving HRA. A key part of these tools is a common coordinate framework, providing standard terminologies and data structures for describing specimen, biological structure, and spatial data linked to existing ontologies. As of April 22, 2022, the registration user interface has been used to harmonize and publish data on 5,909 tissue blocks collected by the Human Biomolecular Atlas Program (HuBMAP), the Stimulating Peripheral Activity to Relieve Conditions program (SPARC), the Human Cell Atlas (HCA), the Kidney Precision Medicine Project (KPMP), and the Genotype Tissue Expression project (GTEx). Further, 5,856 tissue sections were derived from 506 HuBMAP tissue blocks. The second exploration user interface enables consortia to evaluate data quality, explore tissue data spatially within the context of the HRA, and guide data acquisition. A companion website is at https://cns-iu.github.io/HRA-supporting-information/
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