Statistical Analysis of Consequences Caused by the Collisions of Soaring Drops of Organic Coal-Water Fuel

The paper examines the processes of collision of the soaring organic coal - water fuel (OCWF) drops in the specialized combustion chamber in case of direct injection of suspension with the subsequent crushing, decay and coagulation. High speed video registration is used. The fuel composition is prepared with the use of a coal conversion waste (filter-cake "G"), turbine oil waste, water and a plasticizer. The statistical analysis of consequences of impingement of OCWF drops at their movement in an oxidizer flotation (temperature is about 800-840 K) with their following deformation is carried out. The conditions when the processes of coagulation, disintegration or crushing of drops are dominated are established

Superconductivity in TTF[Ni(dmit)2]2 films

We report on the observation of a superconducting transition in a fiber-like film of the TTF[Ni(dmit)2]2 phase electrodeposited on silicon substrates. Superconductivity is evidenced by a broad drop of the resistance below 0.8K under the application of a hydrostatic pressure of 7.7 kbar. Zero resistance is not reached due to the contribution of inter-fiber resistance. Superconductivity is confirmed by the application of a magnetic field perpendicular to the plane of the film. The critical field determined on the film is in agreement with that obtained in bulk single crystals

The HTLV-1 Tax interactome

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far

Experimental Investigation of Droplet Evaporation of Suspension Based on Water with Subsurface Admixtures in a Flame Area

The influence of typical mixtures (clay, sand, soil, silt) on integral characteristics of droplet evaporation of suspension based on water in high-temperature (about 1100 K) gases was investigated experimentally by the optical methods and high-speed (to 10{5} frames per second) video recording system. The significant intensification of heat up and evaporation of suspension droplets was defined when varying the relative mass fraction of admixtures within the range γ=0−0.1 for a sand, γ=0−0.01 for clay, ground, and silt

Étude téphrostratigraphique et bio-climatique du Tardiglaciaire et de l’Holocène de la Laguna Salinas, Pérou méridional

La présente étude est une contribution à la connaissance de l'évolution de l'environnement tardiglaciaire et holocène des régions andines. En raison de la présence de volcans à proximité de la ville d'Arequipa (800 000 habitants), l'accent est mis sur la récurrence de l'activité volcanique et il est démontré que sept téphras majeures ont recouvert la région après le dernier maximum glaciaire. La Laguna Salinas est une dépression fermée d'origine volcano-tectonique du département d'Arequipa (Pérou méridional) qui constitue un piège sédimentaire dont des carottes ont été extraites des niveaux couvrant les quinze derniers millénaires. L'ensemble des analyses multidisciplinaires (téphras, pollen, diatomées, datation au 14C) réalisées sur ces carottes et des coupes accessibles autour de la lagune ont conduit à rétablissement d'un modèle stratigraphique actuellement unique pour le Tardiglaciaire et l'Holocène du Pérou méridional.This study is a contribution to the Late glacial and Holocene environmental changes in the Andean Cordillera. Due to the presence of volcanoes near Arequipa city (800,000 inhabitants), particular importance is given to the frequency of volcanic activity and it is demonstrated that seven major tephras have covered the area after the last glacial maximum. Laguna Salinas is a volcano-tectonic closed basin in the Arequipa Department (southern Peru) which acts as a sediment trap in which cores were taken that correspond to the last 15,000 years. A multidisciplinary research (tephras, pollen, diatoms, 14C-dating) of a core as well as tephrostratigraphical investigations of nearby roadcuts have allowed to realize the first chronostratigraphical model for the Late Glacial and Holocene periods of southern Peru.Die vorliegende Arbeit stellt einen Beitrag zur Kenntniss von Unweltverânderungen im Spat und Postglazial in den Anden dar. Da die sudperuanische Stadt Arequipa (800 000 Einwohner) zwischen Vulkanen eingebettet ist, wird beim Studium dieser Region ein bezonderer Akzent auf den Ruckgang der vulkanischen Aktivitàt und Fôrdertâtigkeit gelegt. Dabei haben sich fur die Zeit seit dem letzten Hochglazial sieben Haupttephren ergeben. Die Laguna Salinas erstreckt sich im sudperuanischen Département Arequipa in einem vulkano-tecktonishen Becken, das als eigentliche Sedimentfalle wirkt. Darin wurden in einer Kernbohrung Proben genommen, die zeitlich die letzten 15 000 Jahre abstecken. Tephralagen, Pollen, Diatomeen, l4C-Alter wurden multidisziplinar untersucht. Zusammen mit dem Studium umliegender Aufschlusse konnte eine stratigraphische Pionniermodell bzw Referenzprofil fur Sùdperu entwickelt werden

Mitochondrial dynamics: quantifying mitochondrial fusion in vitro

Mitochondrial fusion is an essential process for preserving the integrity and stability of mitochondrial DNA; however, regulation of this process remains largely mysterious. In this issue of BMC Biology, Schauss and colleagues describe a simple, reliable, and robust novel assay that allows fusion of mammalian mitochondria to be quantified in vitro

Iron, Ferritin, Transferrin, and Transferrin Receptor in the Adult Rat Retina

PURPOSE. The retina and other tissues need iron to survive. However, the normal iron metabolism in rodent retinas had not been characterized. This study was intended to investigate iron and iron homeostasis protein (ferritin, transferrin [Tf] and transferrin receptor [Tf-R]) distribution in 20-to 55-day-old rat retinas. METHODS. Iron was revealed on retinal sections directly by proton-induced x-ray emission (PIXE) and indirectly by electron microscopy (EM). Ferritin, Tf, and Tf-R proteins were localized by immunohistochemistry. Transferrin expression was localized by in situ hybridization (ISH). Transferrin and ferritin proteins and mRNA were analyzed by Western blot analysis and reverse transcription-polymerase chain reaction (RT-PCR), respectively. RESULTS. Iron is widely and unevenly distributed throughout the adult rat retina. The highest concentration was observed by PIXE in the choroid and the retinal pigmented epithelial cell (RPE) layer, and in inner segments of photoreceptors (IS). Outer segments of photoreceptors (OS) also contain iron. EM studies suggested the presence of iron inclusions inside the photoreceptor discs. Choroid, RPE, and IS showed a strong immunoreactivity for ferritin. Transferrin accumulated mainly in the IS and OS areas and in RPE cells but can also be detected slightly in retinal capillaries. Western blot analysis for Tf and ferritin confirmed their presence in the adult neural retina. By RT-PCR, H-and L-chains of ferritin and Tf mRNAs were expressed in neural retina, but the main sites of Tf synthesis observed by ISH were the RPE and choroid cell layers. Tf-R immunoreactivity was detected in the ganglion cell layer, inner nuclear layer, outer plexiform layer, IS, RPE, and choroid. These results were similar for all stages studied. CONCLUSIONS. For the first time, the present study characterized both iron and iron homeostasis proteins in rodent retinas. In the outer retina, iron and ferritin shared the same distribution patterns. In contrast, Tf, mainly synthesized by RPE cells and detected in OS and IS areas, probably helps to transport iron to photoreceptors through their Tf-R. This is a likely pathway for filling iron needs in the outer retina. (Invest Ophthalmol Vis Sci. 2000;41:2343-235

Interaction of HTLV-1 Tax with minichromosome maintenance proteins accelerates the replication timing program

The Tax oncoprotein encoded by the Human T-cell leukemia virus type 1 (HTLV-1) plays a pivotal role in viral persistence and pathogenesis. HTLV-1 infected cells proliferate faster than normal lymphocytes, expand through mitotic division and accumulate genomic lesions. Here, we show that Tax associates with the minichromosome maintenance MCM2-7 helicase complex and localizes to origins of replication. Tax modulates the spatiotemporal program of origin activation and fires supplementary origins at the onset of S phase. Thereby, Tax increases the DNA replication rate, accelerates S phase progression but also generates a replicative stress characterized by the presence of genomic lesions. Mechanistically, Tax favors p300 recruitment and histone hyperacetylation at late replication domains advancing their replication timing in early S phase