149 research outputs found
Investigation of mRNA ablation strategies in ES cells
- Author
- Publication venue
- The University of Edinburgh
- Publication date
- 01/01/2002
- Field of study
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
- Author
- Abano Nenette
- Abbdul-saheb Mudhar
- Adedoyin Temi
- Adell Victoria
- Adesina Tolu
- Adie Katja
- Adil-Smith Jennifer
- Ahmad Nasar
- Ahmed Ashraf
- Ahmed Iman
- Al-Mayhani Talal
- Al-Shahi Salman Rustam
- Al-Shahi Salman Rustam
- Alam Mohammad Irfan
- Albazzaz Mo
- Ali Ali
- Alipio Francis
- Allen Christopher
- Allison Joanna
- Amey Isobel
- Amis Elaine
- Amlani Sageet
- Amoils Shannon
- Amor Kelly
- Anderson Rosemary
- Andole Sreeman
- Anjum Talat
- Ankolekar Sandeep
- Annamalai Arunkumar
- Anthony Alpha
- Anversha Ajmal
- Anwar Ijaz
- Anwar Sajjad
- Appleton Jason
- Argandona Lucia
- Armitage Jane
- Ashton Amy
- Atkinson Natalie
- Auld Grace
- Avis Joanne
- Aweid Basaam
- Ayres Georgina
- Azhar Khalid
- Bagnall Caroline
- Baig Farrukh
- Baigent Colin
- Bailey Duncan
- Baird Yolanda
- Bakawala Rehana
- Baker John
- Baker Pauline
- Balazikova Olga
- Balian Linda
- Baliga Vidya
- Balitska Olesia
- Ball Julie
- Ball Margaret
- Ballantine Robert
- Bamford John
- Banaras Azra
- Barber Mark
- Barbon Emma
- Barker James
- Barr Charlotte
- Barrie Elizabeth
- Barron Luke
- Barry Adrian
- Bateman Gavin
- Bates Michelle
- Bathula Rajaram
- Battersby-Wood Emma
- Bayliss Pauline
- Beadle Hannah
- Bearne Helen
- Beaty Teresa
- Beaves Emily
- Bell Angela
- Bell Jo
- Bell Murdina
- Bellfield Ruth
- Beranova Eva
- Bergin Adrian
- Bhakri Harbens
- Bhalla Ajay
- Bharaj Kiranjit
- Bhargava Maneesh
- Bhaskaran Biju
- Bhatnagar Priya
- Bhatnagar Priya
- Birchall Kathryn
- Birns Jonathan
- Black Toby
- Blades Alex
- Blair Caroline
- Blair Caroline
- Blair Gordon
- Blane Sujata
- Blank Catrin
- Blight Adrian
- Board Joanne
- Board Sarah
- Bokhari Maria
- Bond Kirsty
- Bowring Angela
- Boxall Cherish
- Breeds Joanna
- Brew Helen
- Brezitski Maria
- Bridger Hayley
- Brodie Fiona
- Brotherton Lucy
- Broughton David
- Brown Claire
- Brown Ellen
- Brown Pauline
- Brown Sarah
- Bruce David
- Buchanan David
- Buck Amanda
- Buckle Steve
- Buckle Steve
- Buckley Clare
- Bunea George
- Burger Ilse
- Burgess Laura
- Burgess Seona
- Burssens Evelyne
- Butler Adrian
- Butler Donna
- Butler Rebecca
- Butterworth-Cowin Nicola
- Button Denise
- Buxton Jean
- Byrne Anthony
- Cageao Julie
- Caine Sarah
- Campbell Robert
- Carpenter Michael
- Carpio Racquel
- Carrie Johanna
- Cassidy Tim
- Causley Chelsea
- Chadbourn Indra
- Chadha Dinesh
- Chamberlain Angela
- Chan kelly
- Chandrakumar Aberami
- Chapman Kath
- Chapman Nicola
- Charles Bethan
- Chatterjee Kausic
- Chaudhry Afnan
- Chauhan Meena
- Chenna Srikanth
- Cherian Suja
- Cheripelli Bharath Kumar
- Chopra Neha
- Choulerton James
- Choy Lillian
- Clarke Brian
- Clarke Caroline
- Clarke Judith
- Clarke Natasha
- Clarke Rebecca
- Clarke Samantha
- Clarkson Emma
- Clay Caroline
- Clayton Susan
- Clayton-Evans Lisa
- Cluckie Gillian
- Cochrane Helen
- Codd Laura
- Cohen David
- Collins Kayleigh
- Connor Lynda
- Constantin Carmen
- Cook Angela
- Cooper Martin
- Copeland Claire
- Cosier Tracey
- Courtauld Gillian
- Couser Mandy
- Coward Lucy
- Cowie Linda
- Cox Chantel
- Cox Chloe
- Cox Penelope
- Crabtree Karen
- Crawford Pam
- Crawford Susan
- Creeden Robyn
- Crisp Sarah
- Cronin Julie
- Crook Luci
- Crosbie Caroline
- Crouch Nichola
- Crown Rachel
- Crowther Hannah
- Cuddy Sarah
- Cuenoud Larissa
- Cullen Claire
- Culmsee Charlotte
- Cunningham James
- Cunningham Mishell
- Cvoro Vera
- Dacey Lynne
- Dakin Katy
- Dallol Bander
- Dangri Puneet
- Datta Prabal
- Davey Richard
- David Anette
- David Owen
- Davies Caroline
- Davies Ruth
- Davies Silvie
- Davis Fiona
- Davis Michelle
- Day Nicola
- Dayal Nilofer
- De Berker Henry
- Deary Ann
- Denic Hayley
- Dennis Martin
- Dennis Martin S
- Denniss Carol
- Devine Joseph
- Devitt Nicola
- Dewar Richard
- Dhakal Mahesh
- Dhar Saikat
- Dickinson Christina
- Dickson Christine
- Dima Sofia
- Dinsmore Lynn
- Dixon Lynn
- Dobson Tracey
- Dodd Angela
- Dodd Emily
- Doherty Mandy
- Doherty Mandy
- Donaldson Denise
- Donnelly Richard
- Doubal Fergus
- Dow Lindsey
- Downham Susan
- Doyle Clare
- Doyle Donna
- Drever Jonathan
- du Plessis Johann C
- du Plessis Johannes
- Dube Judith
- Duberley Stephen
- Dunn Linda
- Dunne Karen
- Durairaj Ramesh
- Durman Helen
- Dutta Dipankar
- Dynan Kevin
- Edwards Mandy
- Egerton Shuna
- Eglinton Charlotte
- Eglinton Charlotte
- El Tawil Salwa
- Elfandi Khaled
- Elliot Jennifer
- Elliott Emma
- Ellis Sam
- Emberson Jonathan
- Emsley Hedley
- England Timothy
- Epstein Daniel
- Erande Renuka
- Erumere Esther
- Esisi Bernard
- Esisi Bernard
- Esson Derek
- Esson Derek
- Evans Rachel
- Evans Sue
- Eveson David
- Ewing Jordan
- Fathima Razik
- Fawcett Michelle
- Feerick Shez
- Fennelly Ruth
- Ferdinand Phillip
- Findlay Paul
- Finlay Sarah
- Finney Kay
- Fitzell Pauline
- Fitzsimmons Paul
- Fletcher Glyn
- Fletcher Jo
- Fong Rosanna
- Foot Jayne
- Foote Leanne
- Ford Gary
- Foster Eliza
- Fotherby Ken
- Fox Charlotte
- Francia Nina
- Francis Jobbin
- Fraser Ruth
- Fraser Ruth
- Fuller Tracy
- Fulton Ailsa
- Furnace Jacqueline
- Gadapa Naveen
- Gainard Glyn
- Gainsborough Nicola
- Gallagher Jill
- Gallagher Louise
- Gallifent Rachel
- Gamble Ed
- Garcia Tatiana
- Gardener Léjeune
- Garfield-Smith Joanne
- Garside Mark
- Gartrell Imogen
- Gascoyne Rachel
- Gattringer Thomas
- Gautam Nikki
- Gaylard Jane
- Gbadamoshi Lukuman
- Geraghty Olivia
- Ghaly George
- Ghatala Rita
- Ghosh Sandip
- Giallombardo Elio
- Gilham Ellie
- Gilmour Danielle
- Gilzeane Nicola
- Glass Jon
- Gleave Laura
- Glover Rachel
- Godfrey Margi
- Goff Anita
- Goorah Neetish
- Gott Valerie
- Gow Heather
- Graham Carol
- Graham Ruth
- Gray Jane
- Green Carole
- Greenwood Richard
- Gregory Bindu
- Greig Jill
- Grimwood Gemma
- Grocott Jeanette
- Grue Rebecca
- Gulliver Diane
- Guo Fenglin
- Gupwell Karin
- Guthrie Lucy Belle
- Guy Helen
- Guyler Paul
- Hague Adam
- Haider Syed
- Hairsine Brigid
- Hakim Eluzai
- Hall Andrea
- Halse Omid
- Handley Dominic
- Hann Gail
- Hannon Niamh
- Hansen Christian
- Haque Mohammad
- Hardwick Anne
- Harkness Kirsty
- Harrington Frances
- Harrington-Davies Yasmin
- Harrison Louise
- Harrison Melanie
- Harrison Thomas
- Harston George
- Harvey Kirsten
- Harvey Miriam
- Hassan Ahamad
- Hassan Hardi
- Havard Diane
- Hayes Anne
- Hayhoe Helen
- Hayman Rachel
- Hays Carole
- Hazel Beth
- Hedstrom Amanda
- Hedstrom Amanda
- Hemsley Anthony
- Henry Margo
- Herman Jane
- Hervey Simon
- Hewitt Jonathan
- Hiden Joanne
- Hogan Caroline
- Hogg Valerie
- Holden Melinda
- Holmes Clare
- Homan Jane
- Hooley Michaela
- Horan Kathleen
- Horton Sarah
- Hostettler Isabel
- Hove Dionne
- Howaniec Laura
- Howard Gabriella
- Howard Joanne
- Howard Peter
- Howcroft Deborah
- Howe Jo
- Huang Xuya
- Huggett Isabel
- Hughes Chloe
- Hughes Claire
- Hughes Tom
- Humphreys Louise
- Humphries Fiona
- Hunt Benjamin
- Hunt Nicholas
- Hunter Annemarie
- Hunter Neil
- Hurford Frances
- Hurley Jennifer
- Hussain Malik
- Hutchison Aidan
- Hyams Benjamin
- Hyatt Lisa
- Imam Javed
- Ingham Andrea
- Ingram Tanya
- Innes Karen
- Iqbal Arshi
- Iqbal Mohammad Shazad
- Irvine Janice
- Ispoglou Sissy
- Ivatts Simone
- Jackson Benjamin
- Jackson Linda
- Jagger Jenny
- Jagpal Baljit
- James Ali
- James Claire
- James Martin
- Jarapa Rowilson
- Jarrett David
- Jeffs Carol
- Jelley Benjamin
- Jenkins Colin
- Jennings-Preece Karla
- Jeyaraj Naomi
- Jha Ratneshwari
- Jinks Emma
- Johnes Mary
- Johnson Sharon
- Jones Ifan
- Jones Ifan
- Jones Kirsty
- Jones Rachael
- Jones Stephanie
- Jones Terry
- Jones Val
- Jordan Carla
- Jose Deepa
- Jose Josin
- Joshi Yogish
- Joshi Yogish
- Joyson Anu
- Jupp Becky
- Justin Frances
- Kakar Puneet
- Kalathil Latheef
- Kalladka Dheeraj
- Kamara Christine
- Kambafwile Mary
- Kane Ingrid
- Kar Arindam
- Keegan Breffni
- Keeling Elizabeth
- Keenan Samantha
- Kelavkar Shyam
- Kelly Christine
- Kelly Debs
- Kelly Jim
- Kelly Siobhan
- Keltos Marketa
- Kennedy James
- Kennedy Kate
- Kenton Antony
- Kerin Lourda
- Kerr Enda
- Kerr Gillian
- Keshvara Rekha
- Khan Mohammad
- Khan Shagufta
- Khan Usman
- Khan Uzma
- Kibutu Faith
- King Sam
- Kingwell Hayley
- Kini Manohar
- Klaasen Katrina
- Knops Kerstin
- Krishnamoorthy Shrivakumar
- Krishnamurthy Ramesh
- Krishnamurthy Vinodh
- Krishnan Kailash
- Krishnan Manju
- Krommyda Magdalini
- Kullane Sagal
- Kumar Balakrishna
- Kumar Pradeep
- Kunhunny Swapna
- Lam Man Yee
- Lambert Caroline
- Landers Geraldine
- Langhorne Peter
- Lasserson Daniel
- Latter Laura
- Law Zhe
- Lawrence Tara
- Lawson Heidi
- Leason Sandra
- Lee Stephanie
- Leggett Jacqui
- Lenti Giulia
- Lerpiniere Christine
- Lerpiniere Christine
- Licenik Radim
- Lindert Ralf
- Little Victoria
- Littleton Edward
- Ljubez Anja
- Loganathan Thayalini
- Longland Barbara
- Lopez Paula
- Lovelock Caroline
- Lowe Gordon
- Lucas Linda
- Lucas Suzanne
- Luder Robert
- Lyjko Sue
- Maanoosi Mehran
- Maatouk Ahmad
- Macaden Ashish
- MacInnes Brian
- MacLennan Beverly
- Macleod Malcolm
- MacLeod Mary
- MacLiver Linda
- MacRaild Allan
- Maddula Mohana
- Madigan Barbara
- Maguire Holly
- Maguire Stuart
- Maiden Susan
- Majis Arshad
- Majmudar Nikhil
- Makawa Linetty
- Mangion David
- Manning Lisa
- Manoj Aravind
- Mardania Rina
- Marigold James Richard
- Markova Skarlet
- Marks Katherine
- Marsden Tracy
- Marshall Sally
- Martin Irene
- Mashate Sheila
- Mason Cathy
- Mate Abhijit
- Mathieson Philip
- Matias Oliver
- Matthews Christopher
- Maund Bev
- McAlpine Christine
- McArdle Damian
- Mcauley Sean
- McCann Stephanie
- McCarron Mark
- McClelland Beverley
- McCormick Katrina
- McCormick Katrina
- McDonald Shanni
- McDonald Susan
- Mcgee Joanne
- McGhee Caroline
- McGill Connor
- McGrath Aileen
- McIlmoyle James
- McKee Jacqueline
- McLoughlin Alison
- McVerry Ferghal
- Mead Denise
- Mead Gillian
- Meir Julie
- Menon Nisha
- Mercer Lily
- Metcalf Kneale
- Miller Keniesha
- Miller Richard
- Milligan Josette
- Minks David
- Minks David P.
- Miriam Skelton
- Mistri Amit
- Mitchell Jennifer
- Mitra Dipayan
- Mitra Dipayan
- Mohammed Niaz
- Mohd Nor Azlisham
- Mokoena Betty
- Moores Andrew
- Moqsith Mohammed
- Morell Jordi
- Moreton Fiona
- Morgan Debbie
- Moroney Helen
- Morse Bethan
- Moseley Sally
- Motherwell Nichola
- Moynihan Barry
- Mpelembue Mushiya
- Mudd Paul
- Muddegowda Girish
- Muir Keith
- Mukherjee Indranil
- Murali Elodie
- Murphy Peter
- Murray Gordon D
- Musarrat Kashif
- Myint Min
- Naeem Muhammad
- Naing Zin
- Nair Anand
- Nallasivan Arumugam
- Nasar Mohammad
- Nasim Ashraf
- Naylor Charde
- Needle Ann
- Nelson Sandra
- Newby David E
- Newton Sophie
- Ng Kheng Xiong
- Ngo David
- Nguyen Vinh
- Ngwako Mmua
- Ni Hlaing
- Nicholas Paul
- Nicolson Anne
- Niranchanan Rangah
- Nisar Nabeela
- Njoku Kelechi
- Nott Claire
- Nott Claire
- Nozedar Tarn
- Nyabadza Sheila
- O'Brien Eoin
- O'Brien Richard
- O'Brien Richard
- O'Connell Susan
- O'Loughlin Victoria
- O'Reilly Joanna
- O'Toole Sarah
- OConnell Janice
- Oji Nnebuife
- Orath Prabakaran Rajalakshmi
- Orefo Chukwuka
- Orugun Enoch
- Osborn Mairead
- Osborne Emily
- Oshodi Anne
- Osman Ahmed
- Ovington Catherine
- Owings Paula
- Owoyele Emmanuelle
- Owusu-Agyei Peter
- Pai Yogish
- Palmer Jeb
- Papavasileiou Vasileios
- Parakramawansha Ruwan
- Parker Richard
- Parry Anthea
- Parry-Jones Adrian
- Pasco Kath
- Patel Bhavini
- Patel Champa
- Patel Farzana
- Patel Krishna
- Patterson Chris
- Paulton Ruth
- Pawley Corinne
- Peixoto Cassilda
- Penge Justin
- Perez Jane
- Perfitt Rebekah
- Perkins Charlotte
- Perry David
- Perry Jack
- Persad Nicola
- Peters Jenny
- Pettitt Kerry
- Phiri Duke
- Pitt-Ford Alexandra
- Pitt-Kerby Tressy
- Plewa Catherine
- Poku Philip
- Ponnambath Suheil
- Poultney Una
- Pound Susan
- Power Michael
- Pressly Vanessa
- Price Fiona
- Proeschel Harald
- Punekar Shuja
- Punter Martin
- Pusalkar Aparna
- Putterill Janet
- Quinn Leanne
- Quinn Outi
- Qureshi Sammie
- Ragab Suzanne
- Raghunathan Senthil
- Rahman Bithi
- Rai Baljinder
- Raj Sonia
- Rajapakse Anoja
- Rajkumar Chakravarthi
- Ramachandran Sankaranarayana
- Ramadan Hawraman
- Ramshaw Alex
- Rana Pratap
- Randall Marc
- Rashed Khalid
- Rashmi Sindhu
- Ravenhill Garth
- Rayessa Rayessa
- Reckless Ian
- Reddan Julie
- Reddan Julie
- Redgrave Jessica
- Redjep Ozlem
- Remegoso Alda
- Richard Bella
- Richards Emma
- Rinkel Gabriel
- Roberts Josh
- Robinson Matthew
- Robinson Naomi
- Rodgers Alicia
- Rodrigues Mark A
- Rodriguez Aryelly
- Roffe Christine
- Roffe Jack
- Roganova Tatjana
- Rogers Emily
- Rogers Gill
- Rojas Javier
- Ross Sarah
- Roughan Caroline
- Rudd Tony
- Rudenko Hannah
- Saada Janak
- Saastamoinen Kari
- Sajid Mahmud
- Sakka Eleni
- Salehin Maqsud
- Salek-Haddadi Afraim
- Salih Isam
- Sally Moore
- Sandercock Peter A G
- Sangombe Mirriam
- Sangster Graeme
- Sanyal Ranjan
- Sarah Procter
- Sarah Procter
- Sattar Naweed
- Sattar Saira
- Saulat Afaq
- Saulat Afaq
- Schofield Christine
- Schulz Ursula
- Schumacher Natasha
- Schwarz Stefan
- Seagrave Samantha
- Sekaran Lakshmanan
- Sesay Juliana
- Sethuraman Sakthivel
- Shackcloth Daniela
- Shah Alex
- Shah Sweni
- Shahmehri Shahrzad
- Sharma Nikhil
- Sharpe Simon
- Shaw Kelly Marie
- Shaw Louise
- Sheikh Saima
- Shekhar Raj
- Shelton Faye
- Shinh Naval
- Shread Ian
- Shukla Avani
- Siddegowda Prasad
- Siddiq Muhammad
- Siddiqui Amber
- Siddiqui Anwer
- Sigsworth Andrew
- Simon Rohan
- Sims Don
- Singh Arun
- Sinha Devesh
- Skinner Helen
- Slade Peter
- Smart Amanda
- Smith Andrew
- Smith Fiona
- Smith Gemma Marie
- Smith Simon
- Smith Wilma
- Smyth Nigel
- Spencer Jayne
- Sprigg Nikola
- Sprigg Nikola
- Srinivasan Meena
- Stafford Samantha
- Stafford Samantha
- Stanners Andrew
- Steele Amy
- Stephen Jacqueline
- Stephens Claire
- Stevens Angela
- Stevens Stephanie
- Stevenson Sarah
- Stewart Kelvin
- Stocks Kathy
- Stone Andrew
- Storton Sharon
- Strain David
- Subramonian Santhosh
- Sudlow Cathie
- Sudlow Cathie L M
- Sukdeo Varthi
- Sullivan Frank
- Sultan Sulaiman
- Suttling Anne
- Sutton Claire
- Sutton Patrick
- Sutton Victoria
- Sword Jane
- Sykes Lucy
- Symonds Stuart
- Szabo Susan
- Tallantyre Emma
- Tanate Alfonso
- Tandy Jane
- Tate Margaret
- Tauro Suzanne
- Tayler Michelle
- Taylor Pat
- Taylor Vicky
- Teal Rachel
- Temple Natalie
- Thant Hlaing
- Thavanesan Kamy
- Thomas Isobel
- Thomas Kelly
- Thomas Philip
- Thomas Sarah
- Thompson Philip
- Thompson Susan
- Thompson Teresa
- Thompson-Jones Helen
- Thomson Audrey
- Thornthwaite Sarah
- Thorpe Kevin
- Tilley Victoria
- Tiwari Divya
- Tomlin Dawn
- Tomlinson Benjamin
- Treadwell Shelley
- Tribbeck Michele
- Trippier Sarah
- Triscott Claire
- Triscott Claire
- Tryambake Dinesh
- Tucker Laura
- Tucker Susan
- Turfrey Jennifer
- Tysoe Sharon
- Ullah Khalil
- Valentine Stacey
- van Someren Chloe
- Varquez Resti
- Vasileiadis Evangelos
- Vassallo Joseph
- Venter Marius
- Veraque Emelda
- Verrion Anna
- Vettimootal Johnson Venetia
- Vickers Carinna
- Walford Jamie
- Walker Allan
- Walker Marion
- Walker Pauli
- Walker Susannah
- Wallace Aine
- Wallace Rebecca
- Wallace Rebecca
- Walstow Deborah
- Walter Deborah
- Walters Ashleigh
- Wani Mushtaq
- Ward Deborah
- Wardlaw Joanna M
- Watchurst Caroline
- Waterfield Kelly
- Waterfield Kelly
- Watson Fran
- Waugh Dean
- Webb Tom
- Webber Adam
- Webster Timothy
- Weinling Marie
- Weir Nic
- Weir Pauline
- Welch Angela
- Werring David
- Werring David J
- Whitcher Alison
- White James
- White Julie
- White Philip M
- White Susan
- Whiteley William
- Whiteley William N
- Whiteman Jessica
- Whiteman Jessica
- Whiting Robert
- Whittamore Katherine
- Wiggam Ivan
- Wilding Peter
- Wilkes Gwendoline
- Wilkinson Mark
- Willberry Angela
- Williams Carol
- Williams Rebecca
- Williams-Yesson Barbara
- Willmot Mark
- Wilson David
- Wilson Duncan
- Wilson Jenny
- Wilson Lisa
- Wilson Sarah
- Wiltshire Alison
- Wood Diane
- Wood Edith
- Wood Lisa
- Woodward Stephen
- Wright Fiona
- Wroath Belinda
- Wynter Inez
- Yadava Rajendra
- Yip Brigitte
- Young Andrew
- Zachariah George
- Zahoor Tajammal
- Zoe Mellor
- Publication venue
- 'Elsevier BV'
- Publication date
- 22/05/2019
- Field of study
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
An investigation in the correlation between Ayurvedic body-constitution and food-taste preference
- Author
- Abdullah M. Al-Beda
- Abolali Mohagheghzadeh
- Adriana Macchi
- Agnete E. Kristoffersen
- Alejandra Ribas
- Aleksandar Vcev
- Alfred Längler
- Ali M. Tamaddon
- Ali Tavakoli
- Amie Steel
- Amir M. Jaladat
- Amir M. Jaladat
- Ana C. Moreno Mazini
- Ana C. Viana Valle
- Ana P. Simões-Wüst
- Ana P. Simões-Wüst
- Ana P. Simões-Wüst
- Andre Tsai
- Anette L. Larsen
- Angelika Eggert
- Anita Rose
- Anita Salamonsen
- Anita Salamonsen
- Anja Thronicke
- Anjali Bhagra
- Anna Nietlispach
- Anne Majumdar
- Anne Ponstein
- Anne Ponstein
- Annemarie Abbing
- Annemarie Abbing
- Antonella Traversi
- Ashry Gad Mohamed
- Ava Lorenc
- Ava Lorenc
- Awais Mian
- Awais Mian
- Ayda Hosseinkhani
- Babak Daneshfard
- Babak Daneshfard
- Beatriz Jimenez
- Benedikt Huber
- Benno Brinkhaus
- Bjørg Evjen
- Bo-Hyung Jang
- Bradley McEwen
- Britta Rutert
- Carel Thijs
- Carmelo Guido
- Carmelo Guido
- Carmen J. Cerda
- Carmen Rocha
- Carolina Moltó-Puigmartí
- Carolyn Szuter
- Carolyn Szuter
- Charlene H. L. Wong
- Chen Bai
- Chiara Cervino
- Chin Lin
- Christine Holmberg
- Christine Lam
- Claudia Iachino
- Cornelia Herbstreit
- Cornelia Kaspar
- Cosette Pharisa
- Daiva Jakubonienė
- Damiano Zemp
- Daniel Krüerke
- Daniela Navarrete Heckersdorf
- Darong Wu
- Darong Wu
- Deja Ostrowski
- Deja Ostrowski
- Diego Lanaro
- Dora Tsui
- Edith Chan
- Eduardo D’Alessandro
- Elham Behmanesh
- Elham Behmanesh
- Elham Behmanesh
- Elham Behmanesh
- Elio Rossi
- Elio Rossi
- Elio Rossi
- Elio Rossi
- Elio Rossi
- Eny Márcia Ruggerini
- Eric T. C. Ziea
- Eric Ziea
- Erik Baars
- Erik Baars
- Ethel Doyle
- Eunji Choi
- Eva Tihanyi
- Evgeniya Sovershaeva
- Fabian Lotz
- Fabiana Quattrone
- Fabio Firenzuoli
- Fabio Firenzuoli
- Fabio Firenzuoli
- Faith Warner
- Farhad Handjani
- Fatemeh Amini
- Fatemeh Amini
- Fatemeh Tabatabaei
- Fatemeh Tabatabei
- Fatemeh Tavakoli
- Federica Sabatini
- Fei Zhen
- Fei Zhen
- Fenna Heyning
- Fernanda Mulinari Fontana
- Filippo Bosco
- Francesco Cerritelli
- Francesco Macrì
- Francislete Melo
- Frauke Musial
- Friedemann Schad
- Gabriele Rotter
- Gabriella Hegyi
- Georg Seifert
- Gerhard Florschutz
- Gholamreza Hatam
- Gianfranco Trapani
- Giuseppe Peloni
- Gokarna Dahal
- Gregor Kaczala
- Guoyan Yang
- Hakima Amri
- Hans de Goeij
- Hans Jeekel
- Harald Gruber
- Harald Matthes
- Harald Walach
- Hasan Sadeghi
- He Yu
- Heike Gerhardt
- Helen Parsons
- Henny Hui
- Hilde Risvoll
- Holger Pelz
- Hye L. Woo
- Hyunchul Jang
- Hyunho Kim
- Héctor Jorquera
- Ingo Bolliger
- Irene Schlingensiepen
- Iva Selke-Krulichova
- Ivna M. Fuchigami
- Jacques Kopferschmitt
- Jafar Abolghasemi
- Jafar Hasanzadeh
- Jan Smit
- Jan Vagedes
- Janet Schloss
- Jang W. Lee
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianping Liu
- Jianxiong Cai
- Jianxiong Cai
- Jin M. Lee
- Jingnan Xu
- Jinhyang Ahn
- Jinsoon Seo
- Jitka Pokladnikova
- Johannes Wildhaber
- Joyce Hsieh
- Justin C. Y. Wu
- Justin C. Y. Wu
- Kamran Bagheri-Lankarani
- Katharina Schnabel
- Katherine Beaven
- Katherine Burke
- Katia Belvedere
- Katia Belvedere
- Katia Vuono
- Kealoha Fox
- Kealoha Fox
- Kjell H. Halvorsen
- Li Zhou
- Li Zhou
- Lily Chan
- Lina Chen
- Linda Nurra
- Lingjia Yin
- Livia Waeber
- Lixin Wang
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Liyan Jia
- Luigi Ciullo
- Luisella Zanino
- Lynda Balneaves
- Mahmood R. Moein
- Mahsa rostami
- Majid Nimrouzi
- Majid Nimrouzi
- Marco Picchi
- Marco Picchi
- Marco Picchi
- Margit Cree
- Maria C. Torri
- Maria T. Borges Neres
- Maria T. Mangini
- Maria Waldenez Oliveira
- Marialessandra Panozzo
- Mariella Di Stefano
- Mariella Di Stefano
- Marisa Gaioli
- Marit Waaseth
- Marta Dell’Orso
- Martien van Dongen
- Martin Schnelle
- Martine Busch
- Maryam Mosaffa-Jahromi
- María L. Alcázar Saldivia
- Matthias Kröz
- Megan Steele
- Mehdi Pasalar
- Mehdi Pasalar
- Mehdi Pasalar
- Meiling Li
- Meng Zhao
- Meng Zhao
- Mia Li
- Michael Heinrich
- Michael Heinrich
- Michael Munday
- Michael Teut
- Min K. Hyun
- Miranda Rodrigo Jacobsen
- Miriam Ortiz
- Mohadeseh Ostovar
- Mohammad E. Zohalinezhad
- Mohammad M. Parvizi
- Mohammad M. Parvizi
- Mohammad M. Zarshenas
- Mohammad R. Namazi
- Mohemmed K. M. Khalil
- Mojgan Tansaz
- Mojtaba Heydari
- Mojtaba Heydari
- Momir Dunjic
- Momir Dunjic
- Monica E. Winnubst
- Morgana Masetti
- Márcia da Silva Jacobsen
- Mónica Galanti
- Mónica Galanti
- Mónica Galanti
- Mónica Mennet
- Namgyeong Go
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nanqi Zhao
- Nasrin Hamidizadeh
- Nicola Brough Phil
- Nicola Robinson
- Nicola Robinson
- Norma Barraza
- Olja Njaradi
- Olja Njaradi
- Pak K. Chan
- Palitha Serasingh
- Pantea Shirooye
- Paolo Fedi
- Patricia Ronan
- Patricia Ronan
- Paulo Caceres Guido
- Pavel Sidorov
- Penny Agent
- Penny Agent
- Petar Papuga
- Peter Heusser
- Pholtan Rajamanoharan
- Pierluigi Quadri
- Pieter Dagnelie
- Po-Hsu Chen
- Raid A. Abutalib
- Ralf Suhr
- Razie N. Meybodi
- Renate Oepen
- Ricardo Monezi
- Ricardo Monezi
- Ricardo Monezi
- Ricardo Monezi
- Robert Kempenich
- Roberto Cardarelli
- Robin S. T. Ho
- Romy Schneider
- Roshanak Mokaberinejad
- Rui M. Da Cunha Faria
- Sam Watts
- Sandra Burnside
- Sarah Croke
- Sarah Stewart-Brown
- Saravanan Sathasivampillai
- Sathyanarayana Badekila
- Sebastian Weiss
- Sebo Damir
- Seyyedali Mozaffarpour
- Seyyedali Mozaffarpour
- Seyyedali Mozaffarpour
- Seyyedali Mozaffarpour
- Shelley Dorazio
- Siaw M. Liew
- Sicheng Wang
- Silvia Villanueva
- Siobhan Carr
- Siobhan Carr
- Solveig Wiesener
- Sonia Baccetti
- Sonia Baccetti
- Sonia Baccetti
- Su Madge
- Su Madge
- Sulaiman AlEidi
- Suleiman Afsharypuor
- Susanne Metzner
- Suzanne Hanser
- Sylvia Binting
- Taoying Lu
- Tido von Schoen-Angerer
- Tiegang Liu
- Tiziana Di Giampietro
- Tommaso Bellandi
- Tommaso Conti
- Torunn Hamran
- Trine Stub
- Trude Giverhaug
- Tu-Hsing Wu
- Ursula von Mandach
- Vahid Tafazoli
- Vahid Tafazoli
- Vincent C. H. Chung
- Vincent C. H. Chung
- Viola Heckel
- Volker Perlitz
- Weiwei Li
- Weiwei Li
- Wendy Wong
- Wiebke Stritter
- William Elder
- Wilma Sanzeni
- Wonmo Jung
- Xaver Frauenknecht
- Xia Wang
- Xiaohong Gu
- Xiaolin Tong
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xiaoyi Yan
- Xin Y. Wu
- Xin Y. Wu
- Xuan Wang
- Xufang Wu
- Xun Li
- Xun Li
- Ying Zhang
- Ying Zhang
- Ying Zhang
- Yongho Lee
- Younghee Yun
- Younghee Yun
- Yuhao Wu
- Yumin Cho
- Yutong Fei
- Yutong Fei
- Yuxiang Wan
- Yvonne M. Scherrer
- Zahra Parvizi
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhaolan Liu
- Zhi X. Lin
- Zian Zheng
- Ziomara Balbarrey
- Zulj Marinko
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2017
- Field of study
Children must be protected from the tobacco industry's marketing tactics.
- Author
- Abdallah Said
- Absalom Gareth
- Adams Nick
- Adeboyeku David
- Agate Rowan
- Agrawal Sanjay
- Ahmed Liju
- Allen Bev
- Anderson Paul
- Anwar Sadia
- Arabnia Gilda
- Ayres Jon
- Badman Ros
- Bafadhel Mona
- Baker Emma
- Banerjee Tushar
- Barker Jack
- Barnes Peter
- Barnett Emma
- Barnham Kate
- Barr Laura
- Barry Simon
- Bartoszewicz Charlotte
- Beasley Victoria
- Berry Matthew
- Bhowmik Angshu
- Bingham Lyn
- Bintcliffe Oliver
- Bloch Susannah
- Boland Alison
- Bolton Charlotte
- Booth Andrew
- Booton Richard
- Bothamley Graham
- Bott Julia
- Bourke Stephen
- Bradley Bethia
- Breen Ronan
- Brennan Amanda
- Bridges Diana
- Britton John
- Brown Joanna
- Brown Louise
- Brown Sarah
- Browne Emma
- Brunet Martin
- Burge Sherwood
- Burgin Karen
- Burke Hannah
- Bush Andrew
- Butcher Jane
- Buttery Robert
- Buxton Maria
- Calverley Peter
- Campbell Colin
- Campbell Ian
- Capstick Toby
- Carlin Chris
- Casswell Georgina
- Chaudhry Nauman
- Chavasse Richard
- Christensen Anne
- Christopher Anne
- Chua Felix
- Clarke Sarah
- Clive Amelia
- Colin Campbell
- Collett Anne
- Collins Andrea
- Collins Nicola
- Connell David
- Connellan Stephen
- Connelly Carol
- Connett Gary
- Connolly Bronwen
- Cookson John
- Cooper Angela
- Cooper David
- Costello Carol Ann
- Coutts Ian
- Cowie Calvin
- Cox Nicola
- Crawfurd Laura
- Creagh-Brown Ben
- Crooks Gillian
- Crooks Gillian
- Crooks Stephen
- Crossingham Iain
- Cullen Kathy
- Cummings Natalie
- Curry Denise
- Curtis Katrina
- Daniels Tracey
- Davey Claire
- Davidson Philip
- Davies Carol-Anne
- Davies Lisa
- Davies Peter
- Davies Sarah
- Davison John
- Davison Tony
- Dayer Mark
- Deegan Paul
- Denniston Sarah
- Deveson Pete
- Dewar Maria
- Diana Bridges
- Dobson Lee
- Docherty Marianne
- Dodd James
- Doe Simon
- Dow Claire
- Downs Janis
- Dowson Lee
- Durham Stephen
- Durrington Hannah
- Dutta P
- Dwarakanath Akshay
- Eaden James
- Edwards Adrian
- Edwards Catherine
- Edwards John
- Edwards Sheila
- Edwina Wooler
- Elizabeth Ringrose
- Elkin Sarah
- Elston Will
- Emerson Peter
- English Peter
- Esterbrook Georgina
- Everett Caroline
- Farmer Ray
- Feary Johanna
- Fern Karen
- Fleming Louise
- Fletcher Tim
- Ford David
- Ford Kate
- Forrest Ian
- Forster Georgia
- Fowler Robert William
- Fowler Stephen
- Fraser Una
- Freeman Debbie
- Fuld Jonathan
- Furness John
- Gaduzo Stephen
- Gardiner Karen
- Georgiadi Adamantia
- Ghosh Dipansu
- Gibson John
- Gill Alison
- Goldman Jon
- Goode Chris
- Graham Alison
- Graham Annika
- Graves Jennifer
- Gray Barry
- Gray Linda
- Greenhalgh Trish
- Greening Neil
- Griffiths Mark
- Griffiths Paul
- Griffiths Valerie
- Grove Alison
- Guadagno Alison
- Guyatt Fran
- Hailes Karen
- Haja Mydin Helmy
- Haney Sarah
- Hankinson Jenny
- Haqqee Raana
- Harle Amelie
- Harrison Brian
- Harrris Ann
- Hart Nicholas
- Harvey John
- Haslam Patricia L
- Heslop Karen
- Hewitt Lee
- Hickman Katherine
- Hicks Alex
- Higgins Bernard
- Hilton Kay
- Hoadley Jacky
- Hodgson Luke
- Hodson Matthew
- Holden Emma
- Holmes Steve
- Hopkinson Nicholas
- Hosker Harold
- Hough Alexandra
- Houghton Catherine
- Howell Tim
- Hughes John
- Hutchinson John
- Hynes Gareth
- Iftikhar Ahsan
- Iles Peter
- Ioakim Shona
- Janes Sam
- Jennings David
- Jha Akhilesh
- John Edwards
- Johnston Carol
- Jolley Caroline
- Jones Helen
- Kaul Sundeep
- Keaney Niall
- Keilty Sarah
- Kemp Samuel
- Ketchell Robert Ian
- Khan Katie
- Kim Randall
- Kowal Julia
- Kumar Sanjay
- Lacy-Colson Amruta
- Lane Amber
- Lane Ian
- Lebus Jenny
- Lenney Warren
- Lenney Warren
- Leonard Andrew
- Leonard Helen
- Lightbody Darren
- Lipman Marc
- Lithgow Anna
- Lloyd Jananee
- Lloyd Julie
- Lock Sara
- Lomas Dean David
- Long Alex
- Lord Victoria
- Lordan James
- Lowe Lesley
- Lyall Rebecca
- Lyons Elizabeth
- Lytton Stephen
- MacBean Vicky
- Macdonald Ian
- Mackenzie Nesta
- Mackinlay Carolyn
- Macmillan Alison Bennett
- Maddocks Matthew
- Majeed Azeem
- Malin Adam
- Mallia-Milanes Brendan
- Malone Sarah
- Man William
- Maqsood Usman
- Marsden Paul
- Marshall Robert
- Martin Katharine
- Martin Sarah
- Matthew Hodson
- Matusiewicz Simon
- Maxwell David
- McAuley Danny
- McCarvill Iona
- McHugh Martin
- McKee Martin
- McNicholl Diarmuid
- Meadows Chris
- Merritt Simon
- Milburn Heather
- Miller Joy
- Miller Lauren
- Mir Misbah
- Mitchell Sally
- Mitchelmore Philip
- Mohd Noh Mohd Shahrin
- Molloy Alanna
- Monaghan Valerie
- Montgomery Hugh
- Montgomery Mary
- Moore Caroline
- Moore-Gillon John
- Morgan David
- Morrison Douglas
- Moxham John
- Munday Maureen
- Mungall Sarah
- Murray Clare
- Mustfa Naveed
- Myerson James
- Narasimhan Divya
- Naveed Shams-un-nisa
- Nelson Christopher
- Newey Alison
- Nicholl David
- Nickol Annabel
- Nicoll Debby
- Nikolic Marko
- Nyman Cyril
- O'Callaghan Una
- O'Connor Sally
- O'Driscoll Ronan
- O'Hara Doreen
- O'Kane Cecilia
- Ohri Chandra
- Olive Sandra
- Olivier Sharon
- Olley Amy
- Ong Yee Ean
- Ormerod Lawrence
- Padmanaban Vijay
- Parker Samuel
- Parkes Marilyn
- Parmar Sonia
- Parry Diane
- Partridge Martyn
- Partridge Samuel
- Patel Anant
- Patel Irem
- Paterson Ian
- Paton James Y
- Pawulska Barbara
- Peedell Clive
- Pengo Martino
- Phitidis Elpida
- Pieri-Davies Sue
- Pillai Anilkumar
- Powell Helen
- Powrie Duncan
- Primhak Robert
- Prowse Keith
- Prowse Keith
- Purcell Helen
- Puthucheary Zudin
- Pye Kathy
- Quint Jennifer
- Radnan Paul
- Rafferty Gerrard
- Rajhan Ashwin
- Raju Raghu
- Ramsay Michelle
- Range Simon
- Redington Anthony
- Reilly Jacqui
- Restrick Louise
- Ridyard John
- Rigge Lucy
- Ringrose Elizabeth
- Robinson Grace
- Robinson Louise
- Rodman Anne
- Roots Debbie
- Roots Debbie
- Rosalind Backham
- Ross David
- Round Jonathan
- Ruiz Gary
- Russell Richard
- Ryan Helen
- Safavi Shahideh
- Saini Sarvesh
- Sapey Elizabeth
- Satia Imran
- Satkunam Karnan
- Scaffardi Anthony
- Scheele Kate
- Seaton Douglas
- Serlin Matthew
- Seymour John
- Shaheen Fizah
- Sharkey Emma
- Sharp Charles
- Sherrington Rebecca
- Shields Michael
- Shribman Jonathan
- Shrikrishna Dinesh
- Simon Ward
- Simonds Anita
- Simpson John
- Sloper Katherine
- Smith David
- Smith Peter
- Spencer Charlotte
- Spencer David
- Spiro Stephen
- Stableforth David
- Stanton Andrew
- Starren Elizabeth
- Steel Mark
- Steier Joerg
- Stern Myra
- Stewart Tara
- Stockley Robert
- Stocks Janet
- Stratford- Martin James
- Sturney Sharon
- Suh Eui-Sik
- Summers Geoffrey
- Sumner Helen
- Sutherland Tim
- Sylvester Karl
- Szram Joanna
- Tate Paul
- Taylor Amy
- Templeton-Wright Suzanne
- Thomas Ajit
- Thomas Angela
- Thomas Matt
- Thomson Fiona
- Thomson Neil
- Tilbrook Sean
- Timlett Amber
- Towns Rebecca
- Tracey Mathieson
- Treharne Jo
- Tunnicliffe Georgia
- Turner Sally
- Turner Steve
- Vaughan Sophie
- Voase Nia
- Walker Paul
- Walker Woolf
- Wallis Colin
- Walmsley Sandy
- Walters Nicola
- Ward Ann
- Ward Simon
- Warner John
- Warwick Geoffrey
- Watson John
- Wedzicha Wisia
- Wheatley Iain
- White John
- Whitfield Ruth
- Wicker Jacquelyne
- Wieboldt Jason
- Williams Ruth
- Williamson Kathryn
- Wilson Patrick
- Wilson Robert
- Winter Barbara
- Winter Robert
- Winter-Burke Alice
- Wood Fraser
- Wood Marion
- Woodcock Ashley
- Woodhead Mark
- Wooler Edwina
- Woolhouse Ian
- Wright Joanne
- Yasso Razouqi
- Zoumot Zaid
- Zurek Andrew
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2013
- Field of study
Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.
- Author
- Aanensen David M
- Abudahab Khalil
- Acheson Erwan
- Adams Alexander
- Adams Helen
- Adriaenssens Evelien M
- Afifi Safiah
- Aggarwal Dinesh
- Ahmad Shazaad SY
- Alam Mohammad T
- Alcolea-Medina Adela
- Alderton Alex
- Alikhan Nabil-Fareed
- Allan John
- Allara Elias
- Amato Roberto
- Andersson Monique
- Angyal Adrienn
- Aranday-Cortes Elihu
- Ariani Cristina
- Asad Hibo
- Asamaphan Patawee
- Ashworth Jordan
- Atkinson Laura
- Attwood Stephen
- Auckland Cressida
- Awan Ali R
- Aydin Alp
- Baker David J
- Baker Paul
- Balcazar Carlos E
- Ball Jonathan
- Barton Edward
- Bashton Matthew
- Batra Rahul
- Baxter Laura
- Beale Mathew A
- Beaver Charlotte
- Beckett Angela
- Beer Robert
- Beggs Andrew
- Bell Andrew
- Bellis Katherine L
- Berger Duncan J
- Berriman Matt
- Berry Lisa
- Berry Louise
- Betancor Gilberto
- Betteridge Emma
- Bewshea Claire M
- Bibby David
- Bicknell Kelly
- Birchley Alec
- Bird Paul
- Bishop Chloe
- Blane Beth
- Bolt Frances
- Bonsall David
- Boswell Tim
- Bosworth Andrew
- Bourgeois Yann
- Boyd Olivia
- Boyes John
- Bradley Declan T
- Bradshaw Daniel
- Breen Cassie
- Bresner Catherine
- Breuer Judith
- Bridgewater Hannah E
- Brooks Tony T
- Broos Alice
- Brown Julianne Rose
- Brown Paul E
- Brown Rebecca
- Brunker Kirstyn
- Bucca Giselda
- Buck David
- Buddenborg Sarah K
- Bull Matthew
- Bull Matthew
- Burton-Fanning Shirelle
- Butcher Ethan
- Caddy Sarah L
- Caller Laura G
- Campbell Sharon
- Carlile Matthew
- Carmichael Stephen N
- Casey Anna
- Castellano Sergi
- Chalker Vicki
- Chand Meera
- Chapman Michael R
- Chappell Joseph G
- Charalampous Themoula
- Charles Ian G
- Chaudhry Yasmin
- Chauhan Anoop J
- Cheng Jeffrey KJ
- Churcher Carol M
- Clark Gemma
- Coll Francesc
- Collins Jennifer
- Colquhoun Rachel
- Colquhoun Rachel M
- Connor Thomas R
- Connor Thomas R
- Constantinidou Chrystala
- Coombes Jason
- Corden Sally
- Cormie Claire
- Cortes Nicholas
- Cortes Nick
- Cottrell Simon
- Coupland Lindsay J
- Cowell Angela
- Cox Alison
- Craine Noel
- Cronin Michelle
- Crooke Derrick
- Curran Martin D
- Curran Tanya
- da Silva Filipe Ana
- da Silva Filipe Ana
- Dabrera Gavin
- Danesh John
- Darby Alistair C
- Davidson Rose K
- Davies Alisha
- Davis Thomas
- de Cesare Mariateresa
- De Lacy Elen
- de Oliveira Martins Leonardo
- de Silva Thushan I
- Debebe Johnny
- Dervisevic Samir
- Dewar Rebecca
- Dias Joana
- Diaz Maria
- Dibling Thomas
- Dorman Matthew J
- Downing Fatima
- Drury Eleanor
- du Plessis Louis
- Duckworth Nichola
- Dyal Patricia L
- Eccles Richard
- Edgeworth Jonathan
- Edwards Sue
- Eldirdiri Sahar
- Ellaby Nicholas
- Ellard Sian
- Elliott Scott
- Eltringham Gary
- Elumogo Ngozi
- Essex Sarah
- Evans Cariad
- Evans Johnathan M
- Eyre David
- Fairley Derek J
- Fallon Karlie
- Farbos Audrey
- Farr Ben
- Feltwell Theresa
- Fina Laia
- Findlay Jacqueline
- Fisher Chloe L
- Fleming Vicki M
- Forrest Leysa M
- Forrest Sally
- Foulser Luke
- Francois Sarah
- Fraser Christophe
- Freeman Timothy M
- Frost Lucy R
- Fuller William
- Gallagher Eileen
- Gallagher Michael D
- Garcia-Casado Maria V
- Gaskin Amy
- Gatica-Wilcox Bree
- Gavriil Artemis
- Geidelberg Lily
- Geidelberg Lily
- Gemmell Matthew
- Georgana Iliana
- George Ryan P
- Gifford Laura
- Gilbert Lauren
- Gill Harmeet K
- Gilroy Rachel AJ
- Girgis Sophia T
- Glaysher Sharon
- Golubchik Tanya
- Goncalves Sonia
- Goodfellow Ian
- Goodfellow Ian G
- Goodwin Scott
- Graham Clive
- Graham Lee
- Grammatopoulos Dimitris
- Green Angie
- Green Luke R
- Greenaway Jane
- Gregory Richard
- Griffith Luke
- Groves Danielle C
- Groves Natalie
- Guest Martyn
- Gulliver Huw
- Gutierrez Ana Victoria
- Hadjirin Nazreen F
- Haldenby Sam T
- Hale Antony D
- Hall Grant
- Halstead Fenella
- Hamilton William L
- Haque Tanzina
- Harper Katherine L
- Harris Kathryn Ann
- Harrison Ewan M
- Harrison Ian
- Harrison James W
- Hartman Hassan
- Hattersley Andrew
- Heaney Judith
- Helmer Thomas
- Hesketh Andrew R
- Heyburn David
- Higginson Ellen E
- Hill Verity
- Hill Verity
- Hilvers Ember
- Hiscox Julian A
- Holden Matthew TG
- Holmes Alison
- Holmes Christopher
- Holmes Nadine
- Hoosdally Sarah
- Hopes Richard
- Hosmillo Myra
- Houldcroft Charlotte J
- Howe Robin
- Howson-Wells Hannah C
- Hubb Jonathan
- Hughes Joseph
- Hughes Margaret
- Hunter Adam D
- Hutchings Stephanie
- Impey Robert
- Irish-Tavares Dianne
- Iturriza-Gomara Miren
- Jackson Ben
- Jackson Ben
- Jackson David A
- Jackson David K
- Jackson Kathryn A
- Jahun Aminu S
- James Keith
- Jamrozy Dorota
- Jarrett Ruth
- Jeffries Aaron R
- Jesudason Natasha
- Jesudason Natasha G
- John Michaela
- Johnson Kate
- Johnson Natasha
- Johnson Rob
- Johnson Robert
- Johnston Ian
- Jones Hannah
- Jones Katie
- Jones Rachel
- Jones Sophie
- Jorgensen David
- Jorgensen David
- Joseph Amelia
- Justice Anita
- Kane Leanne
- Kay Gemma L
- Kay Sally
- Keatley Jon-Paul
- Keeley Alexander J
- Kenyon Anita
- Kermack Leanne M
- Khakh Manjinder
- Khokhar Fahad A
- Kidd Stephen
- Kingsley Robert A
- Kitchen Christine
- Knight Bridget A
- Kolyva Anastasia
- Koshy Cherian
- Kraemer Moritz
- Kristiansen Mark
- Kumziene-Summerhayes Sara
- Kwiatkowski Dominic
- Lackenby Angie
- Langford Cordelia
- Lawniczak Mara
- Le-Viet Thanh
- Lee David
- Lee Jack CD
- Letchford Laura
- Levene Nick
- Levett Lisa J
- Li Kathy
- Li Kathy K
- Liggett Steven
- Lindsey Benjamin B
- Lister Michelle M
- Livett Rich
- Lloyd Allyson
- Lo Stephanie
- Loh Joshua
- Loman Nicholas J
- Loman Nicholas J
- Loose Matthew W
- Loveson Katie F
- Lowe Hannah
- Lucaci Anita O
- Ludden Catherine
- Lynch Jessica
- Lyons Ronan A
- Macfarlane-Smith Louissa R
- Machin Nicholas W
- MacIntyre-Cockett George
- Madona Pinglawathee
- Maes Mailis
- Mahungu Tabitha W
- Mair Daniel
- Maksimovic Joshua
- Manesis Nikos
- Manley Robin
- Manso Carmen
- Marchbank Angela
- Martincorena Inigo
- Martinez-Nunez Rocio T
- Masoli Jane AH
- Mason Jenifer
- Mather Alison E
- Mbisa Tamyo
- McCluggage Kathryn
- McClure Patrick C
- McCrone John T
- McCrone JT
- McGuigan Samantha
- McHugh Martin P
- McKenna James P
- McKerr Caoimhe
- McMinn Liz
- McMurray Claire
- Meader Emma J
- Meadows Lizzie
- Menegazzo Mirko
- Meredith Luke W
- Merrick Ian
- Mestek-Boukhibar Lamia
- Miah Shahjahan
- Michell Stephen L
- Michelsen Michelle L
- Molnar Zoltan
- Monaghan Lynn
- Mookerjee Siddharth
- Moore Catherine
- Moore Catrin
- Moore Christopher
- Moore Nathan
- Morgan Mari
- Morgan Sian
- Mori Matilde
- Moses Samuel
- Muir Peter
- Munn Robert
- Myers Richard
- Nascimento Fabricia F
- Nascimento Fabricia F
- Naydenova Plamena
- Neaverson Alexandra S
- Nebbia Gaia
- Nelson Andrew
- Nelson Charlotte
- Nelson Rachel
- Nicholls Sam
- Nicholls Samuel M
- Nichols Jenna
- Niebel Marc O
- Niola Paola
- Nomikou Kyriaki
- O'Toole Elaine
- O'Toole Áine
- Orton Richard J
- Osman Husam
- Ott Sascha
- O’Grady Justin
- O’Toole Áine
- Pacchiarini Nicole
- Pacchiarini Nicole
- Padgett Debra
- Page Andrew J
- Palmer Sophie
- Palmer Steve
- Panchbhaya Yasmin N
- Pandey Sarojini
- Park Naomi
- Parker Matthew D
- Parmar Surendra
- Parr Yasmin A
- Parsons Paul J
- Partridge David G
- Pascall David J
- Patel Gaurang
- Patel Minal
- Patel Vineet
- Paterson Steve
- Payne Brendan AI
- Peacock Sharon J
- Pearson Clare
- Perry Malorie
- Peto Timothy
- Pinckert Malte L
- Platt Steven
- Plimmer Amy
- Poplawski Radoslaw
- Potter Will
- Prakash Reenesh
- Prestwood Liam
- Price Anna
- Price Anna
- Price James
- Puethe Christoph
- Pybus Oliver
- Pybus Oliver G
- Pymont Hannah M
- Quail Mike
- Quick Joshua
- Raghwani Jayna
- Ragonnet-Cronin Manon
- Rainbow Lucille
- Rajatileka Shavanthi
- Rambaut Andrew
- Rambaut Andrew
- Ramsay Mary
- Randell Paul A
- Raviprakash Veena
- Raza Mohammad
- Resende Silva Paola C
- Rey Sara
- Rey Sara M
- Reynolds Nicola
- Richter Alex
- Robertson David L
- Robertson David L
- Robinson Esther
- Robinson Trevor I
- Robson Samuel C
- Rogers Hazel A
- Rooke Stefan
- Rowan Aileen
- Rowe Will
- Roy Sunando
- Rudder Steven
- Ruis Chris
- Ryan Felicity
- Sambles Christine M
- Sang Fei
- Scarlett Garry P
- Schaefer Ulf
- Scher Emily
- Scott Carol
- Scott Garren
- Sethi Dheeraj K
- Shaaban Sharif
- Shah Divya
- Shah Rajiv
- Shah Rajiv N
- Shankar Giri
- Shaw Robert
- Shepherd James
- Shepherd James G
- Sheriff Nicola
- Shirley Lesley
- Signell Adrian W
- Sillitoe John
- Simpson David A
- Singer Joshua B
- Sivaprakasam Venkat
- Siveroni Igor
- Siveroni Igor
- Sloan Tim J
- Sluga Graciela
- Smith Christen
- Smith Colin P
- Smith Darren L
- Smith Nikki
- Smith Wendy
- Smollett Katherine L
- Snell Luke B
- Souster Emily
- Southgate Joel
- Southgate Joel
- Spellman Karla
- Spencer-Chapman Michael
- Sridhar Sushmita
- Stanley Rachael
- Stanton Thomas D
- Starinskij Igor
- Stark Richard
- Stockton Joanne
- Stuart Claire
- Studholme David J
- Swindells Emma
- Swingler Tracey
- Taha Yusri
- Tang Julian
- Taylor Ben EW
- Taylor Graham P
- Taylor Sarah
- Taylor-Joyce Grace
- Tedim Ana P
- Temperton Ben
- Templeton Kate E
- Thompson Thomas
- Thomson Emma C
- Thomson Emma C
- Thomson Nicholas M
- Thornton Alicia
- Thurston Scott
- Todd John A
- Tong Lily
- Tonkin-Hill Gerry
- Torok M Estee
- Trebes Amy
- Trotter Alexander J
- Tsoleridis Theocharis
- Tucker Rachel M
- Turtle Lance
- Tutill Helena J
- Underwood Anthony P
- Unnikrishnan Meera
- Vamos Edith E
- Vasylyeva Tetyana
- Vattipally Sreenu
- Vipond Ian B
- Volz Erik
- Volz Erik M
- Wain John
- Walsh Sarah
- Wang Dennis
- Wantoch Michelle
- Warne Ben
- Warwick-Dugdale Joanna
- Wastenge Elizabeth
- Watkins Joanne
- Watts Joanne
- Waugh Sheila
- Webber Mark A
- Weeks Sam
- Weldon Danni
- Whitehead Mark
- Williams Charlotte A
- Williams Chris
- Williams David
- Williams Rachel J
- Williams Rebecca
- Williams Thomas
- Williamson Kathleen A
- Willingham Iona
- Wilson Harry D
- Wise Emma
- Workman Trudy
- Wright Victoria
- Wyles Matthew
- Wyllie Sarah
- Yakovleva Anna
- Yasir Muhammad
- Yeats Corin A
- Yew Wen C
- Young Gregory R
- Young Jamie
- Yu Xiaoyu
- Zarebski Alex
- Publication venue
- Cell
- Publication date
- 01/09/2020
- Field of study
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant
Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension
- Author
- Acary Souza Bulle Oliveira
- Adam Hart
- Adife Veske
- Aditya Kumar
- Aikaterini Dimitriou
- Akihiro Mukaino
- Akiko Kanzaki
- Akiyuki Uzawa
- Akshay Shah
- Alan Ross Berger
- Albert Hietala
- Alberta Locatelli
- Alejandra Dalila Garcia
- Alejandro Tobon Gonzalez
- Alessandro Filla
- Alex Fondaw
- Alexandre Guerreiro
- Alexandre Guerreiro
- Ali Malekniazi
- Aline de Cassia Santos
- Alzira Alves de Siqueira Carvalho
- Amaiak Chilingaryan
- Amanda Anderson
- Amelia Evoli
- Amna Shah
- Amy Saklad
- Amy Woodall
- Ana Carolina Amaral de Andrade
- Ana Lazaro
- Ana Paula Macagnan
- Ana Paula Melo
- Andrea Corse
- Andrea Kelley
- Andrea Swenson
- Angela Ardoin
- Angela Campanella
- Angela Marsili
- Angela Micheels
- Angiola Fasanaro
- Anh Tran
- Anita Mogensen
- Ann D'Hont
- Anna Gonzalez
- Anne Cooley
- Anne Mette Ostergaard Autzen
- Anneke van der Kooi
- Annelies Depreitere
- Annelies Vanhee
- Anthony Amato
- Antonella Di Pasquale
- Antonella Di Pasquale
- April McVey
- Arshira Seddigh
- Arzu Meherremova
- Ashley Mallon
- Aya Mizugami
- Ayse Kutlu
- Baki Dogan
- Barbara Lokaitis
- Barbora Kurkova
- Bengu Balkan
- Benison Keung
- Benjamin Brooks
- Beth DiSanzo
- Betsy Mosmiller
- Booth H. D. E.
- Brajesh Agrawal
- Brian Droker
- Brian Minton
- Brigitta Szabadosne
- Brittany Harvey
- Bruno Bezerra Rosa
- Bryan Kim
- Byoung Joon Kim
- Byung-Jo Kim
- Can Ebru Bekircan-Kurt
- Cansu Semiz
- Carlo Antozzi
- Carlos Casasnovas
- Carol Herbert
- Carolina Miranda
- Caroline Schotte
- Cecile Phan
- Celal Tuga
- Chae Won Shin
- Chafic Karam
- Chafic Karam
- Chang Nyoung Lee
- Charlene Hafer-Macko
- Charlotte Smetcoren
- Christian Homedes-Pedret
- Christopher Nance
- Claire Brown
- Clara Schommer
- Claudio Gabriel Mazia
- Colleen Pineda
- Craig Donahue
- Cristiani Fernanda Butinhao
- Csilla Rozsa
- Cynthia Bodkin
- Cynthia Carter
- Da Yoon Koh
- Dae Lim Koo
- Dai Matsuse
- Daiane da Cruz Pacheco
- Daisuke Yamamoto
- Dallas Forshew
- Daniel Ambrosio
- Daniel Dicapua
- Danielle Sheldon
- Dave Watling
- David Feder
- Debbie Davies
- Debora Dada Martineli Torres
- Dennis Jeffery
- Derrick Blackmore
- Diana Dimitrova
- Diego Lopergolo
- Donna Carnes
- Doreen Ho
- Délphine Mahieu
- Edina Varga
- Elaine Weiner
- Elena Bravver
- Elena Cortes Vicente
- Elena Giacomelli
- Eliana Reyes
- Elisabet Arribas-Ibar
- Elizabeth Watt
- Emanuela Onesti
- Emiko Tsuda
- Enrico Marano
- Eri Kobayashi
- Erica Nogueira Coelho
- Eriko Higuchi
- Eriko Miyawaki
- Eun Bi Hwang
- Eun Bin Cho
- Eun Haw Choi
- Exuperio Diez Tejedor
- Ezgi Yilmaz
- Fabio Barroso
- Faisal Sohail
- Fatima Maqsood
- Fernanda Carrara
- Fernanda Troili
- Filiz Muharrem
- Fiona Norwood
- Floyd Jones
- Francesco Saccà
- Francisco Javier Rodriguez de Rivera
- Frank Lin
- Fredrik Piehl
- Fujita K. P.
- Fumie Meguro
- Gabor Lovas
- Gabor Lovasamela César
- Gabriel Paiva
- Gabrielle Rico
- Gal Maier
- Gedeonne Jakab
- Gedeonne Jakab
- Giannis Sokratous
- Giorgia Camera
- Giorgia Puorro
- Giovanni Antonini
- Girija Sadalage
- Gisela Gili
- Gonzalo Mazuela
- Gonzalo Vidal
- Graziela Pinto
- Gulmohor Roy
- Gulsah Becerikli
- Gulsah Orsel
- Gustavo Duran
- Guy Van den Abeele
- Gyorgyi Szabo
- H James Jones
- Ha Young Shin
- Ha-Neul Jeong
- Hakan Cavus
- Harpreet Kaur
- Heena Olalde
- Heike Arndt
- Henning Andersen
- Henrique Mohr
- Hidekazu Suzuki
- Hirokazu Shiraishi
- Hiroyuki Murai
- Hisako Kobayashi
- Hong Vu
- Hoo Nam Kang
- Howard J. F.
- Hui Gong
- Huned Patwa
- Hung Youl Seok
- Husnu Efendi
- HyeJin Ra
- HyeLim Lee
- Hyung Seok Lee
- Iandra Souza
- Igor Dias Brockhausen
- Ihsan Sengun
- Ikuko Kamegamori
- Ikuko Yasuda
- Irene Yang
- Isabel Illa
- Ivana Jurajdova
- Iveta Novakova
- Jaana Eriksson
- Jae-Sung Lim
- Jaimin Shah
- Jakit Gollogly
- James Gilchrist
- Jan De Bleecker
- Jan Vynckier
- Jana Junkerova
- Jane Distad
- Jane Pedersen
- Janice Massey
- Jasmine Hewlett
- Jaya Trivedi
- Jayashri Srinivasan
- Jeffery Statland
- Jeffrey Guptill
- Jeffrey Narayan
- Jeffrey Rosenfeld
- Jenna Seelbach
- Jeri Sieren
- Jerry Locheke
- Ji Ye Hwang
- JiEun Lee
- Jinmyoung Seok
- JinWoo Jung
- Jiri Pitha
- Joan Højgaard
- Joan Nye
- Joanne Nemeth
- John Kincaid
- John Kissel
- John Loor
- John Vissing
- Jonathan Katz
- Jonathan McKinnon
- Jordan Jara
- Jordana Gonçalves Geraldo
- Jordi Diaz-Manera
- Josef Bednarik
- Josep Gamez Carbonell
- Joseph Chad Hoyle
- Ju-Hong Min
- Judit Matolcsi
- Juha-Pekka Erälinna
- Julie Agriesti
- Julie Khoury
- Julie Steele
- Juliet Saba
- Jun Kawamata
- Justin Kwan
- JuYoung Kwon
- Kaitlyn McKenna
- Kaori Osakada
- Kaori Uwasa
- Kara Patrick
- Karan Alcon
- Karen Callison
- Karen Zakalik
- Katarina Reguliova
- Kate Beck
- Katherine Amato
- Kathryn Johns
- Kathy de Koning
- Katrien De Mey
- Katsuhisa Masaki
- Kazumi Futono
- Kazumi Takada
- Keiko Kikutake
- Kelley Emmons
- Kendrick Henderson
- Kenichi Tsukita
- Kenkichi Nozaki
- Kerry Naunton
- Kevin Daniels
- Khema Sharma
- Kimberly Robeson
- Kimiaki Utsugisawa
- Koichi Narikawa
- Krishna Polaka
- Kristen Roe
- Kristin Huynh
- Lara Katzin
- Laszlo Vecsei
- Laura Diez Porras
- Laura Echevarria
- Laura Fionda
- Laura Fionda
- Laura Golden
- Laura Haar
- Laura Herbelin
- Lauren Wheeler
- Laurie Gutmann
- Lena Bjarbo
- Lesly Welsh
- Liang Lu
- Liene Duarte Silva
- Linda Wagemaekers
- Lindsay Zilliox
- Lisa Hobson-Webb
- Lisa Smith
- Livia Dezsi
- Lorenzo Maggi
- Lorraine Dishman
- Lotte Vinge
- Louisa Mezache
- Lucas Eduardo Pazetto
- Luciana Ferreira
- Luciana Renata Cubas Volpe
- Luciana Souza Duca
- Ludwig Gutmann
- Luis Antonio Querol Gutiérrez
- Luiz Augusto da Silva
- Luiz Otavio Maia Gonçalves
- Maeda Yasuko
- Magda Chmelikova
- Maki Jingu
- Makoto Samukawa
- Mamatha Pasnoor
- Manisha Chopra
- Mantegazza R.
- Marcela Silva
- Marcela Wolfova
- Marcelo Annes
- Marcelo Chaves
- Marcelo Rugiero
- Marek Cierny
- Marguerite Engel
- Maria Antonia Alberti Aguilo
- Maria da Penha Ananias Morita
- Maria Gabriele
- Maria Gori
- Maria Pasanisi
- Maria Salvado Figueras
- Maria Sastre
- Marianne de Visser
- Mariela Bettini
- Marina Pozo
- Martin Bilsker
- Mary Varghese
- Maryanne Burdette
- Masahiro Mori
- Masakatsu Motomura
- Masaki Saitoh
- Masako Tsurumaru
- Masanori Takahashi
- Masayuki Nakamori
- Matteo Garibaldi
- Maureen Walsh
- Maurer Pereira Martins
- Maurizio Inghilleri
- Maurício AndréGheller Friedrich
- Mayuko Noshiro
- Mazen Dimachkie
- Megan Kramer
- Megumi Koga
- Meinoshin Okumura
- Melanie Glenn
- Melinda Horvath
- Michael Benatar
- Michael Hehir
- Michael Pulley
- Michael Weiss
- Michaela Tyblova
- Michal Vytopil
- Miguel Wilken
- Mihoko Takada
- Miju Shin
- Mikko Laaksonen
- Mireya Fernandez-Fournier
- Mireya Fernandez-Fournier
- Miri Kim
- Miriam Freimer
- Misa Shimpo
- MiSong Choi
- Miwako Sato
- Miyuki Morikawa
- Mohamed Kazamel
- Mohamed Mahdi-Rogers
- Mohammad Alsharabati
- Mohammed Salajegheh
- Mohammed Sanjak
- Mollie Vanderhook
- Mona Elsayed
- Monika Konyane
- Muppidi S.
- Murat Terzi
- Murilo Santos Engel
- Musa Kazim Onar
- Muzeyyen Ugur
- Nadia Sattar
- Namie Taichi
- Namita Goyal
- Nanna Witting
- Naoki Kawaguchi
- Naoko Ishiyama
- Natalia Julia Palacios
- Natalia Prando
- Natália Assis
- Naya McKinnon
- Nazire Pinar Acar
- Neelam Goyal
- Nicholas Silvestri
- Nicholas Ventura
- Nicolas Vandenbussche
- Nicole Jenci
- Nicole Kressin
- Nivedita Jerath
- Nuria Vidal
- O'Brien F. L.
- Ohito Tano
- Olga Zapletalova
- Olivier Stevens
- Olli Oksaranta
- Ozlem Tun
- Paolo Emilio Alboini
- Patricia Padilla
- Patrícia Fernandes
- Pedro Lopez Ruiz
- Petra Tilkin
- Philip Van Damme
- Pilar Gomez Salcedo
- Pilar Sune
- Pinar Ozcelik
- Pravin Torane
- Pravin Torane
- Raffaele Iorio
- Ratna Bhavaraju-Sanka
- Rebecca Traub
- Rebekah Garcia
- Rekha Pillai
- Renata Martins Ribeiro
- Ricardo Rojas Garcia
- Richard Barohn
- Richard Nowak
- Rikako Kurihara
- Rikki Roderus
- Riley Snook
- Robert Miller
- Robert Pascuzzi
- Rosana Rocha
- Rudy Mercelis
- Rumi Takeyama
- Rup Tandan
- Sabrina Pol
- Sachiko Kamakura
- Said Beydoun
- Saiju Jacob
- Salma Akhter
- Sanaz Karimi
- Sandi Mumfrey-Thomas
- Sandra Guingrich
- SangAe Park
- Sara-Claude Michon
- Sarada Sakamuri
- Sarah Plevka
- Sarah Verjans
- Scott Cunningham
- Seda Aydinlik
- Sedat Sen
- Seiko Yoshida
- Seung Min Kim
- Sevim Erdem-Ozdamar
- Shachie Aranke
- Shannon Lucy
- Sharmeen Alam
- Sharon Chelnick
- Sharon Downing
- Sharon Nations
- Shin Hisahara
- Shirley Paulose
- Shirli Toska
- Shizuka Asada
- Shoko Amamoto
- Shuichiro Suzuki
- Shun Shimohama
- Shun Shimohama
- Shunsuke Yoshimura
- Sien Van Daele
- Silvia Bonanno
- Sivakumar Sathasivam
- So-Hyun Ahn
- Soichiro Funaka
- Sonia Garcia
- Stanislav Vohanka
- Stanislava Toncrova
- Stefania Morino
- Stephanie Kohlrus
- Stephanie Scala
- Steve Hopkins
- Susan Strom
- Susanne Krogh
- Tahseen Mozaffar
- Taira Uehara
- Takashi Hayashi
- Takashi Murahara
- Takuya Matsushita
- Tamar Gibson
- Tamires Cristina Gomes da Silva
- Taylor Darnell
- Teiichiro Miyazaki
- Teresa Costabile
- Terry McClain
- Terry McClain
- Tessa Marburger
- Tetsuya Akiyama
- Tetsuya Kanai
- Thabata Veiga
- Thomas Arnold
- Thomas Cochrane
- Thomas Harbo
- Tierney Scott
- Tina Liu
- Tiyonnoh Cash
- Tomihiro Imai
- Tomihiro Imai
- Tomohiro Kawamura
- Tomoko Tsuda
- Tomomi Kobashikawa
- Tomoya Hasuike
- Tomás Augusto Suriane Fialho
- Tuan Vu
- Tugce Kirbas Cavdar
- Tulio Bertorini
- Tuula Harrison
- Valentina D'Amato
- Valentina Velez Santamaria
- Valeria Cavalcante Lino
- Valerie Young
- Veena Mathew
- Vern Juel
- Victor Doan
- Vinay Chaudhry
- Vittorio Frasca
- Vittorio Frasca
- Waqar Waheed
- Wiendl H.
- Wladimir Pinto
- Wolfe G. I.
- Yagmur Caliskan
- Yasmeen Shabbir
- Yasmeen Shabbir
- Yasushi Suzuki
- Ye Liu
- Yoko Ishiyama
- Yoko Kaneko
- Yong Seo Koo
- Yool-Hee Kim
- Yoon-Ho Hong
- Yoshiko Sano
- Yuen T So
- Yuka Saito
- Yukiko Ozawa
- Yuko Fujii
- Yumi Yamashita
- Yumiko Nakamura
- Yunxia Wang
- Yuriko Nagane
- Yusuke Fukuda
- Zaeem Siddiqi
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo
Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab
- Author
- Agrawal Brajesh
- Agriesti Julie
- Ahn So-Hyun
- Akhter Salma
- Akiyama Tetsuya
- Alam Sharmeen
- Alcon Karan
- Alsharabati Mohammad
- Alves de Siqueira Carvalho Alzira
- Amamoto Shoko
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andoin Angela
- André Gheller Friedrich Maurício
- Annes Marcelo
- Antonia Alberti Aguilo Maria
- Antonini Giovanni
- Antonio Querol Gutiérrez Luis
- Antozzi Carlo
- Aranke Shachie
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Assis Natália
- Augusto da Silva Luiz
- Augusto Suriane Fialho Tomás
- Aydinlik Seda
- Balkan Bengu
- Barohn Richard
- Barroso Fabio
- Becerikli Gulsah
- Beck Kate
- Bednarik Josef
- Benatar Michael
- Bertorini Tulio
- Bettini Mariela
- Beydoun Said
- Bezerra Rosa Bruno
- Bhavaraju-Sanka Ratna
- Bi Hwang Eun
- Bilsker Martin
- Bin Cho Eun
- Bjarbo Lena
- Blackmore Derrick
- Bodkin Cynthia
- Bonanno Silvia
- Bravver Elena
- Brooks Benjamin
- Brown Claire
- Burdette Maryanne
- Caliskan Yagmur
- Callison Karen
- Camera Giorgia
- Campanella Angela
- Carnes Donna
- Carolina Amaral de Andrade Ana
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Carlos
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavus Hakan
- Chad Hoyle Joseph
- Chaudhry Vinay
- Chaves Marcelo
- Chelnick Sharon
- Chilingaryan Amaiak
- Chmelikova Magda
- Choi MiSong
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Cristina Gomes da Silva Tamires
- Cunningham Scott
- César Pamela
- D'Amato Valentina
- D'Hont Ann
- da Cruz Pacheco Daiane
- da Penha Ananias Morita Maria
- Dada Martineli Torres Debora
- Dalila Garcia Alejandra
- Daniels Kevin
- Darnell Taylor
- Davies Debbie
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- de Visser Marianne
- Depreitere Annelies
- Dezsi Livia
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Porras Laura
- Diez Tejedor Exuperio
- Dimachkie Mazen
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Dishman Lorraine
- Distad Jane
- Doan Victor
- Dogan Baki
- Donahue Craig
- Downing Sharon
- Droker Brian
- Duarte Silva Liene
- Duran Gustavo
- Ebru Bekircan-Kurt Can
- Echevarria Laura
- Eduardo Pazetto Lucas
- Efendi Husnu
- Elsayed Mona
- Emilio Alboini Paolo
- Emmons Kelley
- Engel Marguerite
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Erälinna Juha-Pekka
- Evoli Amelia
- Fasanaro Angiola
- Feder David
- Fernanda Butinhao Cristiani
- Fernandes Patrícia
- Fernandez-Fournier Mireya
- Fernandez-Fournier Mireya
- Ferreira Luciana
- Filla Alessandro
- Fionda Laura
- Fionda Laura
- Fondaw Alex
- Forshew Dallas
- Frasca Vittorio
- Frasca Vittorio
- Freimer Miriam
- Fujii Yuko
- Fukuda Yusuke
- Funaka Soichiro
- Futono Kazumi
- Gabriel Mazia Claudio
- Gabriele Maria
- Gamez Carbonell Josep
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gili Gisela
- Glenn Melanie
- Golden Laura
- Gollogly Jakit
- Gomez Salcedo Pilar
- Gong Hui
- Gonzalez Anna
- Gonçalves Geraldo Jordana
- Gori Maria Cristina
- Goyal Namita
- Goyal Neelam
- Guerreiro Alexandre
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Haar Laura
- Hafer-Macko Charlene
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Harvey Brittany
- Hasuike Tomoya
- Haw Choi Eun
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbelin Laura
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Ho Doreen
- Hobson-Webb Lisa
- Homedes-Pedret Christian
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Howard Jr James
- Huynh Kristin
- Højgaard Joan
- Illa Isabel
- Imai Tomihiro
- Imai Tomihiro
- Inghilleri Maurizio
- Iorio Raffaele
- Ishiyama Naoko
- Ishiyama Yoko
- Jacob Saiju
- Jakab Gedeonne
- James Jones H
- Jara Jordan
- Javier Rodriguez de Rivera Francisco
- Jeffery Dennis
- Jenci Nicole
- Jeong Ha-Neul
- Jerath Nivedita
- Jingu Maki
- Johns Kathryn
- Jones Floyd
- Joon Kim Byoung
- Juel Vern
- Julia Palacios Natalia
- Jung JinWoo
- Junkerova Barbora Kurkova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kanai Tetsuya
- Kaneko Yoko
- Kanzaki Akiko
- Karam Chafic
- Karam Chafic
- Karimi Sanaz
- Katz Jonathan
- Katzin Lara
- Kaur Harpreet
- Kawaguchi Naoki
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Kazim Onar Musa
- Kelley Andrea
- Keung Benison
- Khoury Julie
- Kikutake Keiko
- Kim Bryan
- Kim Byung-Jo
- Kim Miri
- Kim Yool-Hee
- Kincaid John
- Kirbas Cavdar Tugce
- Kissel John
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Kohlrus Stephanie
- Konyane Monika
- Kramer Megan
- Kressin Nicole
- Krogh Susanne
- Kumar Aditya
- Kurihara Rikako
- Kutlu Ayse
- Kwan Justin
- Kwon JuYoung
- Laaksonen Mikko
- Lazaro Ana
- Lee HyeLim
- Lee JiEun
- Lim Koo Dae
- Lim Jae-Sung
- Lin Frank
- Liu Tina
- Liu Ye
- Locatelli Alberta
- Locheke Jerry
- Lokaitis Barbara
- Loor John
- Lopergolo Diego
- Lopez Ruiz Pedro
- Lovas Gabor
- Lu Liang
- Lucy Shannon
- Maeda Yasuko
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu Délphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Mallon Ashley
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
- Marsili Angela
- Martins Ribeiro Renata
- Masaki Katsuhisa
- Massey Janice
- Mathew Veena
- Matolcsi Judit
- Matsuse Dai
- Matsushita Takuya
- Mazuela Gonzalo
- McClain Terry
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
- McVey April
- Meguro Fumie
- Meherremova Arzu
- Mercelis Rudy
- Mette Ostergaard Autzen Anne
- Mezache Louisa
- Micheels Angela
- Michon Sara-Claude
- Miller Robert
- Min Kim Seung
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Miyawaki Eriko
- Mizugami Aya
- Mogensen Anita
- Mohr Henrique
- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Mozaffar Tahseen
- Muharrem Filiz
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Nagane Yuriko
- Nakamura Yumiko
- Nam Kang Hoo
- Nance Christopher
- Narayan Jeffrey
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nogueira Coelho Erica
- Norwood Fiona
- Noshiro Mayuko
- Novakova Iveta
- Nowak Richard
- Nozaki Kenkichi
- Nye Joan
- Nyoung Lee Chang
- Oksaranta Olli
- Okumura Meinoshin
- Olalde Heena
- Onesti Emanuela
- Orsel Gulsah
- Osakada Kaori
- Otavio Maia Gonçalves Luiz
- Ozawa Yukiko
- Ozcelik Pinar
- Padilla Patricia
- Paiva Gabriel
- Park SangAe
- Pasanisi Maria
- Pascuzzi Robert
- Pasnoor Mamatha
- Patrick Kara
- Patwa Huned
- Paula Macagnan Ana
- Paula Melo Ana
- Paulose Shirley
- Pedersen Jane
- Pereira Martins Maurer
- Phan Cecile
- Piehl Fredrik
- Pillai Rekha
- Pinar Acar Nazire
- Pineda Colleen
- Pinto Graziela
- Pinto Wladimir
- Pitha Jiri
- Plevka Sarah
- Pol Sabrina
- Polaka Krishna
- Pozo Marina
- Prando Natalia
- Previous
- Previous
- Previous
- Pulley Michael
- Puorro Giorgia
- Ra HyeJin
- Reguliova Katarina
- Renata Cubas Volpe Luciana
- Reyes Eliana
- Rico Gabrielle
- Robeson Kimberly
- Rocha Rosana
- Roderus Rikki
- Roe Kristen
- Rojas Garcia Ricardo
- Rosenfeld Jeffrey
- Ross Berger Alan
- Roy Gulmohor
- Rozsa Csilla
- Rugiero Marcelo
- Saba Juliet
- Saccà Francesco
- Sadalage Girija
- Saito Yuka
- Saitoh Masaki
- Sakamuri Sarada
- Saklad Amy
- Salajegheh Mohammed
- Salvado Figueras Maria
- Samukawa Makoto
- Sanjak Mohammad
- Sanjak Mohammed
- Sano Yoshiko
- Santos Engel Murilo
- Sastre Maria
- Sathasivam Sivakumar
- Sato Miwako
- Sattar Nadia
- Scala Stephanie
- Schommer Clara
- Schotte Caroline
- Seddigh Arshira
- Seelbach Jenna
- Semiz Cansu
- Sen Sedat
- Sengun Ihsan
- Seo Koo Yong
- Seok Lee Hyung
- Seok Jinmyoung
- Shabbir Yasmeen
- Shabbir Yasmeen
- Shah Akshay
- Shah Amna
- Shah Jaimin
- Sharma Khema
- Sheldon Danielle
- Shimohama Shun
- Shimohama Shun
- Shimpo Misa
- Shin Miju
- Shiraishi Hirokazu
- Siddiqi Zaeem
- Sieren Jeri
- Silva Marcela
- Silvestri Nicholas
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- Sohail Faisal
- Sokratous Giannis
- Souza Bulle Oliveira Acary
- Souza Duca Luciana
- Souza Iandra
- Srinivasan Jayashri
- Statland Jeffery
- Steele Julie
- Stevens Olivier
- Strom Susan
- Sub-Investigators
- Sune Pilar
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
- Szabo Gyorgyi
- T So Yuen
- Taichi Namie
- Takada Kazumi
- Takada Mihoko
- Takahashi Masanori
- Takeyama Rumi
- Tandan Rup
- Tano Ohito
- Terzi Murat
- Tilkin Petra
- Tinerney Scott
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Torane Pravin
- Toska Shirli
- Tran Anh
- Traub Rebecca
- Trivedi Jaya
- Troili Fernanda
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tsurumaru Masako
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uwasa Kaori
- Uzawa Akiyuki
- Van Daele Sien
- Van Damme Philip
- Van den Abeele Guy
- van der Kooi Anneke
- Vandenbussche Nicolas
- Vanderhook Mollie
- Vanhee Annelies
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Velez Santamaria Valentina
- Ventura Nicholas
- Verjans Sarah
- Veske Adife
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vohanka Stanislav
- Vu Hong
- Vu Tuan
- Vynckier Jan
- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Walsh Maureen
- Wang Yunxia
- Watling Dave
- Watt Elizabeth
- Weiner Elaine
- Weiss Michael
- Welsh Lesly
- Wheeler Lauren
- Wilken Miguel
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Won Shin Chae
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yang Irene
- Yasuda Ikuko
- Ye Hwang Ji
- Yilmaz Ezgi
- Yoon Koh Da
- Yoshida Seiko
- Yoshida Seiko
- Yoshimura Shunsuke
- Youl Seok Hung
- Young Shin Ha
- Young Valerie
- Zakalik Karen
- Zapletalova Olga
- Zilliox Lindsay
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC .
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE .
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert Jürgen
- DEGESCO .
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene .
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- EADB .
- EADI .
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen .
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- GERAD .
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- GR@ACE .
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- Hernández Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- Author
- Abner Erin
- Adams Hieab H
- Adams Perrie M.
- Aguilar Miquel
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Victoria
- Amin Najaf
- Amouyel Philippe
- Apostolova Liana G.
- Arcaro Marina
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Imelda S.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Behrens Timothy W.
- Beiser Alexa S.
- Bellenguez Céline
- Benito Yoland Aladro
- Bennett David A.
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Blacker Deborah
- Blesa Rafael
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paolo
- Bossù Paola
- Bowen James D.
- Boxer Adam
- Braae Anne
- Braddel Amy
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A
- Brookes Keeley
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido María J.
- Burgess Jeremy D.
- Burke James R.
- Burns Jeffrey M.
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carrasquillo Minerva M.
- Carrell David
- Carroll Steven L.
- Cecchetti Roberta
- Chakrabarty Paramita
- Chapman Jade
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimón Jordi
- Clark David G.
- Collinge John
- Combarros Onofre
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cupidi Chiara
- Cupples L Adrienne
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-François
- De Deyn Peter P.
- De Jager Philip L
- Decarli Charles
- Deleuze Jean-François
- Denning Nicola
- Derbois Céline
- Dermecourt Vincent
- Destefano Anita L.
- Diaz Carolina Ceballos
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W
- Dombroski Beth
- Doody Rachelle S.
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Dulary Cécile
- Dunstan Melanie
- Dupuis Josée
- Eiriksdottir Gudny
- Emilsson Valur
- Engelborghs Sebastien
- Epelbaum Jacques
- Ertekin-Taner Nilufer
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fairén Mònica Díez
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernadez Carmen Muñoz
- Ferris Steven
- Fievet Nathalie
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Forstner Andreas J.
- Fortea Juan
- Fox Nick C.
- Frank-García Ana
- Fratiglioni Laura
- Frosch Matthew P.
- Funk Cory C.
- Galasko Douglas R.
- Galimberti Daniela
- Gallo Maura
- Garcia Florentino Sanchez
- Garcia Melissa E.
- Garzia Fabienne
- Gearing Marla
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Goate Alison M.
- Golamaully Feroze
- Golde Todd E.
- Graff Caroline
- Graff-Radford Neill R.
- Graham Robert R
- Green Robert C.
- Grenier-Boley Benjamin
- Grove Megan L.
- Growdon John H.
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Henández Isabel
- Herms Stefan
- Heun Reinhard
- Hill Matt
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hoffmann Per
- Hofman Albert
- Holmes Clive
- Honig Lawrence S.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Johnston Janet
- Jones Lesley
- Jr W T Longstreth
- Jun Gyungah
- Kamboh M Ilyas
- Karydas Anna
- Katz Mindy J.
- Kauwe John Keoni
- Kaye Jeffrey A.
- Keene C Dirk
- Keller Lina
- Kilander Lena
- Kim Ronald
- Kinhult-Stählbom Anne
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Laferla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Lawlor Brian
- Leber Markus
- Leverenz James B.
- Levey Allan I.
- Levy Daniel
- Li Ge
- Li Hongdong
- Li Shuo
- Lieberman Andrew P.
- Lilius Lena
- Lin Honghuang
- Lipton Richard B.
- Lleó Alberto
- Lopez Oscar L.
- Lord Jenny
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Maier Wolfgang
- Majounie Elisa
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mayeux Richard
- Mayhaus Manuel
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John C.
- Mosley Thomas H.
- Mukherjee Shubhabrata
- Munger Ron
- Murrell Jill R.
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C
- Naranjo Maria Candida Deniz
- Norton Maria
- Nöthen Markus M.
- O'Bryant Sid
- O'Donnell Christopher J.
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orfei Maria Donata
- Ortega-Cubero Sara
- Owen Michael J.
- Pankratz Vernon S.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pichler Sabrina
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John
- Price Nathan D.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C
- Ruiz Agustin
- Rujescu Dan
- Sacchinelli Eleonora
- Sager Mark A.
- Sano Mary
- Satizabal Claudia L.
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Septier Gislain
- Seripa Davide
- Serpente Maria
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Sleegers Kristel
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Sánchez-Juan Pascual
- Tanzi Rudolph E.
- Tarraga Lluis
- Taylor Sarah
- Thomas Charlene
- Thomas Rhodri
- Thonberg Hakan
- Thornton-Wells Tricia A.
- Todd Stephen
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Joann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Tzourio Christophe
- Tzourio Christophe
- Uitterlinden Andre G.
- Uphill James
- Urbano Maria
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- Van Der Lee Sven J
- Van Duijn Cornelia M.
- Van Eldik Linda J.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vellas Bruno
- Vinters Harry V.
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Wang Xue
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wingo Thomas S.
- Winslow Ashley R.
- Wolters Frank J
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2017
- Field of study
We identified rare coding variants associated with Alzheimer’s disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1×10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5×10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38×10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56×10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55×10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development
Canagliflozin and renal outcomes in type 2 diabetes and nephropathy
- Author
- A Kaldun Nossuli
- Aamir Jamal
- Adalbert Schiller
- Adam Cheifetz
- Adarsh Daswani
- Adeera Levin
- Adline Ghazi
- Adrian Guinsburg
- Adriana Cif
- Adriana Gabriela Onaca
- Adriana Ilavska
- Adriana Villarino
- Agarwal R.
- Agnieszka Starzec
- Ahmed Arif
- Ahmed Awad
- Aiping Yin
- Akimichi Asano
- Alan Jackson
- Alan McMahon
- Alan Perlman
- Alberto Di Carlo
- Alberto Esquenazi
- Alejandra Oviedo
- Alejandro Valdes Depeda
- Aleksandra Kendereski
- Alex Valenzuela
- Alexander Dreval
- Alexander Gonzalez
- Alexander Shinkov
- Alexander Turchin
- Alexandre Klein
- Alfonso Soto Gonzalez
- Alfred Penfornis
- Alfredo Chew Wong
- Alfredo Wassermann
- Ali Torshizi
- Alicia Chilito
- Alina Agafyina
- Alison Dawson
- Alva Hansraj
- Amer Al-Karadsheh
- Amorin Remus Popa
- Amrendra Kumar
- Amy Sprague
- Ana Limos
- Ana Maria Cusumano
- Ana Maria Elosegui
- Anabella Amigo
- Anatoliy Kazmirchuk
- Andrea Phillips
- Andrea Stella
- Andreas Maddux
- Andrej Dzupina
- Andres Alvarisqueta
- Andrew Johnson
- Andrew O'Shaughnessy
- Andrew Steele
- Andrian Yakov
- Andrzej Januszewicz
- Andrzej Madej
- Angelina Angelova
- Anibal Gastaldi
- Anil Gupta
- Anita Bhajan Manocha
- Anjanette Tan
- Anna Kaminska
- Anna Maria Veronelli
- Anna Strzelecka
- Anna Zateyshchikova
- Anselmo Bordonava
- Antanas Navickas
- Anthony Gunstone
- Anthony Roberts
- Antonio Ceriello
- Antonio Galan Serrano
- Antonio Scafuto Scotton
- Antonio Terrelonge
- Antônio Roberto Chacra
- Anupama Gowda
- Arjun D Sinha
- Armando Perez
- Ashot Mkrtumyan
- Atanas Koundurdjiev
- Augusto Vallejos
- Aurelian-Emil Ranetti
- Ayim Akyea-Djamson
- Aysha Badat
- Bakris G.
- Baldev Singh
- Barbara Greco
- Barbara Kaczmarek
- Barbara Rewerska
- Barry M Brenner
- Belia Martin Del Camp Blanco
- Bernard Zinman
- Bertrand Cariou
- Bertrand Dussol
- Bhasker Mehta
- Bhimavarapu Sudhakar
- Björn Paschen
- Bompoint S.
- Borys Mankovskyy
- Botond Csiky
- Boyan Nonchev
- Brenner B. M.
- Brett Kissela
- Brian Nichol
- Bruce Neal
- Bruce Trippe
- Bruno Geloneze Neto
- Bull S.
- Byung-Wan Lee
- C B Keshavamurthy
- Cannon C. P.
- Capuano G.
- Carlo Giorda
- Carlos Alberto Cuneo
- Carlos Arauz-Pacheco
- Carlos Barrera
- Carlos Perez
- Carmel Hawley
- Carmen Crisan
- Carol Pollock
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- Caroucel Chuateco
- Caryl David
- Cecilia Garcia Ballesteros
- Cecilia Jimeno
- Celso Amodeo
- Cesar Javier Zaidman
- Cesar Yoiti Hayashida
- Chamberlain Obialo
- Chang-Hsun Hsieh
- Charles Cook
- Charles Kaupke
- Charytan D. M.
- Chek Loong Loh
- Chen Leia
- Cheol-Young Park
- Chih-Ching Lin
- Christopher P Cannon
- Christy Yao
- Chu P. -L.
- Chwen-Tzuei Chang
- Chye Lee Gan
- Clara Barrios
- Claude Galphin
- Claudia Goycoa
- Claudia Moreira de Brito
- Clodoaido Caringal
- Cristian Serafinceanu
- Cristina Toarba
- Cristobal Morales Portillo
- Csaba Kovesdy
- Cynthia Bowman-Stroud
- Cynthia Christiano
- Cynthia Mustieles Rocha
- Cyrus Desouza
- Cássio Slompo Ramos
- Dagmar Bartaskova
- Dale Crawford Allison
- Dalia Kozloviene
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- Dana Cosma
- Daniel Coyne
- Daniel Hiser
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- Daniel Panarotto
- Daniel Pella
- Daniel Weiner
- Daniil Chizhov
- Dariusz Sowinski
- Darren K McGuire
- Davesh Sennik
- David C Wheeler
- David Cherney 3rd
- David Gorson
- David Johnson
- David M Charytan
- David Packham
- David Scott
- David Wheeler
- De Zeeuw D.
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- Domingos d'Avila
- Donald Brandon
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- Dong-Wan Chae
- Dora Inés Molina de Salazar
- Dorota Mlodawska-Choluj
- Doru Negru
- Edgar Arcos
- Edoardo Mannucci
- Eduardo Farias
- Edward Watson
- Edwards R.
- Egle Gaupsiene
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- Ekaterina Velichkova
- Elena Christofides
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- Eleonora Harcsa
- Elizabeth Barranco
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- Hector Rodriguez
- Heerspink H. J. L.
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- Stanislav Zemek
- Stanislaw Mazur
- Stefan Dimitrov
- Stephan Maxeiner
- Stephen Grubb
- Stephen Smith
- Steven Fishbane
- Stuart Handelsman
- Suely Keiko Kohara
- Sun Kim
- Sun-Hee Park
- Sunil Sheth
- Susumu Kashine
- Svetlana Goykhman
- Svitlana D Bilyk
- Swee Win Lam
- Sylvia Rosas
- Sylvia Shaw
- Szilard Vasas
- Sérgio Alberto Cunha Vêncio
- Sérgio Yamada
- Tadashi Iitsuka
- Takamoto Kodera
- Takashi Wada
- Takayuki Watanabe
- Tamara Malek Marin
- Tamas Oroszlan
- Tara Chang
- Tareq Nassar
- Tarissa Beatrice Zanata Petry
- Tatiana Koroleva
- Tatiana Morugova
- Tatiana Raskina
- Tatyana Zykova
- Te-Lin Hsia
- Terue Sakakibara
- Tetiana Zlova
- Tetsuji Niiya
- Tetyana Pertseva
- Tiago Schuch
- Timothy Hall
- Tom Christensen
- Tom Greene
- Tomas Drasnar
- Tomas Smith Casabella
- Tonatiu Diaz Escalante
- Toshihiko Yanase
- Toshio Kawada
- Vadym Vizir
- Vanassa Ratnasingam
- Venessa Tsang
- Venkata Behara
- Vera Klokocnikova
- Vera Krane
- Veronica Anghel
- Veselka Genadieva
- Vesna Popovic-Radinovic
- Viacheslav Marasaev
- Victor Commendatore
- Victor Saavedra Gajardo
- Vijayaraman Arutchelvam
- Viktor Margaritov
- Viktor Zaviriukha
- Viktoria Andreeva
- Vimladhevi Govender
- Vincent Pichette
- Vincent Woo
- Vira Tseluyko
- Virginia Esther Visco
- Vivek Sood
- Vivekan Jha
- Vladimir Dobronravov
- Vladimir Khirmanov
- Vladimir Tesar
- Vlado Perkovic
- Volker Burst
- Volodymyr Botsyurko
- Walter Guillermo Douthat
- Walter Pharr
- Wasim Hanif
- Wataru Yumita
- Wayne H-H Sheu
- Wayne Turner
- Wei Yen Kong
- Weihong Song
- Weiping Lu
- Wendy Lane
- Wenge Li
- Wheeler D. C.
- Wladmir Saporito
- Xuemei Li
- Xueqing Yu
- Yamil Canaan
- Yan Ren
- Yannick Le Meur
- Yaozhong Kong
- Yasuro Kumeda
- Yasushi Wakida
- Yavin Y.
- Yeong Hoon Kim
- Yevgeniya Svyshchenko
- Young Min Cho
- Yulia Samoylova
- Yung-Chuan Lu
- Yuriy Mostovoy
- Yuriy Shwartz
- Yvette Ethel Yap
- Zaynab Abejuela
- Zdravko Kamenov
- Zeid Khitan
- Zhang H.
- Zinman B.
- Zishan Ali
- Zuzana Ochodnicka
- Ângela Regina Nazario Sabbag
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years
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