Comparativa del desempeño ambiental y social de empresas del sector de la biomedicina

El següent projecte presenta un estudi comparatiu de l'acompliment mediambiental, econòmic i social d'empreses del sector de la biomedicina, les quals tenen presència a Espanya. Es centra, principalment, en l'anàlisi i l'avaluació dels indicadors que recull la memòria de la guia GRI com a principals i / o secundaris dels àmbits socials, econòmics i mediambientals. En aquest treball, ens centrarem principalment en fer una comparativa entre les empreses, gràcies a les dades proporcionades per elles mateixes, per poder observar les mancances i els punts positius de cadascuna d'elles. Posteriorment es realitzarà una avaluació per detectar els errors comesos i finalment es plantejaran propostes de millora per aconseguir un augment de l'eficiència de les empreses del sector

La resiliencia como un principio de vida a través de la Covid-19

Trabajo de síntesis aplicado – Seminario internacionalLa aparición de la COVID-19 ha generado cambios en la vida de las personas, llevando a los gobiernos a tomar medidas sanitarias de aislamiento para preservar la vida. En el presente documento se enumeran los efectos que trae consigo estas medidas y como hacer uso de herramientas que permitan adaptarse frente a cambios inesperados, falta de tolerancia y afectación en la salud mental; resaltamos la importancia del concepto de resiliencia cómo ayuda para afrontar la situación actual, viendo esta como una oportunidad de crecimiento y beneficiando a las personas para salir de este escenario negativo.RESUMEN PALABRAS CLAVE INTRODUCCIÓN DESARROLLO CONCLUSIONES REFERENCIASEspecializaciónEspecialista en Formulación y Evaluación Social y Económica de Proyecto

Urban growth and heat islands: A case study in micro-territories for urban sustainability

[EN] Rapid urbanization contributes to the development of phenomena such as climate variability, especially in tropical countries, which negatively impact ecosystems and humans, factors that influence urban sustainability. Additionally, the increase of building construction prevents the flow of wind streams contributing to the retention of pollutants and hot air masses, causing events such as urban heat islands (UHI). This study aimed to analyze from the micro-territorial level, the influence of urban growth on the UHI phenomenon over the last two decades (2000¿2020) in the locality of Kennedy, in Bogotá, Colombia. For this purpose, environmental and socio-economic factors were evaluated. For the former, Landsat satellite images and spectral indices were used to evaluate the spatial¿temporal variation in the quantity and quality of vegetation, bodies of water, urbanized areas, impervious surfaces, as well as to calculate the land surface temperature and its distribution in the study area. With regard to the socio-economic factors, the variables considered for analysis were population density and energy consumption. Lastly, a principal component analysis was carried out to identify possible associations between the variables and to identify the contribution of each micro-territory to the UHI phenomenon in the study area. The spatio-temporal variations reveal a growing trend over time, especially in impermeable areas where several economic activities, vehicular traffic, and population density converge, which require certain actions to be prioritized in territorial planning and the addition of public green spaces in urban zonesMolina-Gomez, NI.; Varon-Bravo, LM.; Sierra-Parada, R.; López Jiménez, PA. (2022). Urban growth and heat islands: A case study in micro-territories for urban sustainability. Urban Ecosystems. 1-19. https://doi.org/10.1007/s11252-022-01232-9S11

E-Tongues/Noses Based on Conducting Polymers and Composite Materials: Expanding the Possibilities in Complex Analytical Sensing

Conducting polymers (CPs) are extensively studied due to their high versatility and electrical properties, as well as their high environmental stability. Based on the above, their applications as electronic devices are promoted and constitute an interesting matter of research. This review summa- rizes their application in common electronic devices and their implementation in electronic tongues and noses systems (E-tongues and E-noses, respectively). The monitoring of diverse factors with these devices by multivariate calibration methods for different applications is also included. Lastly, a critical discussion about the enclosed analytical potential of several conducting polymer-based devices in electronic systems reported in literature will be offered

In vitro antitumor and hypotensive activity of peptides from olive seeds

Peptides with molecular weights below 3 kDa from the hydrolysis of olive seed proteins with Thermolysin (OS-3 kDa) have demonstrated a high in vitro hypotensive effect. This fraction has been further fractionated by semipreparative RP-HPLC to obtain 8 fractions. ACE inhibitor capacity of fractions was evaluated observing the highest capacity in fraction F5. Peptides in fraction F5 were identified by RP-HPLC- and HILIC-ESI-Q-ToF and cytotoxic effect was assessed in different cell lines. Peptide LLPSY, present in this faction, was synthesized and characterized. Despite antihypertensive capacity was not as high as in fraction F5, a significant anti-proliferative capacity on two different cancer cell lines was observed. Additional studies to assess antitumor activity confirmed that this peptide showed capability to increase the adhesion capacity of tumor cells, to decrease the migration capacity of cancer cells, and to arrest cell cycle on S phase

Incorporation of carbon black into a sonogel matrix: improving antifouling properties of a conducting polymer ceramic nanocomposite

A new electrochemical sensor device has been developed through the modification of a polyaniline-silicon oxide network with carbon black (CB). Enhanced electrical conductivity and antifouling properties have been achieved due to the integra- tion of this cheap nanomaterial into the bulk of the sensor. The structure of the developed material was characterized using Fourier transform infrared spectroscopy, energy-dispersive X-ray spectroscopy, and scanning electron microscopy tech- niques. Cyclic voltammetry was used to characterize electrochemically the Sonogel-Carbon/Carbon Black-PANI (SNG-C/ CB-PANI) sensor device. In addition, differential pulse voltammetry was employed to evaluate the analytical response of the sensor towards sundry chlorophenols, common environmental hazards in aqueous ecosystems. The modified sensor material showed excellent antifouling properties, which led to a better electroanalytical performance than the one displayed with the bare sensor. Notably, a sensitivity of 5.48 × 103 μA mM−1 cm−2 and a limit of detection of 0.83 μM were obtained in the determination of 4-chloro-3-methylphenol (PCMC) at a working potential of 0.78 V (vs. 3 M Ag/AgCl/KCl), along with proficient values of reproducibility and repeatability (relative standard deviation < 3%). Finally, the analysis of PCMC was carried out in multiple validated water samples using the synthesized SNG-C/CB-PANI sensor device, obtaining excellent results of recovery values (97–104%). The synergetic effect of polyaniline and carbon black leads to novel antifouling and electrocatalytic effects that improve the applicability of this sensor in sample analysis versus complex conventional devices

Memory stem T cells modified with a redesigned CD30-chimeric antigen receptor show an enhanced antitumor effect in Hodgkin lymphoma

Altres ajuts: This work was supported in part by grants from La Marató TV3 (Exp. 20130710), Deutsche José Carreras Leukämie Stiftung (DJCSL 10R/2016), Fundación Científica Asociación Española Contra el Cáncer (AECC-AIO2017), Fundacion Bancaria 'La Caixa', TerCel (SG/11/2008)Adoptive cell therapy (ACT) with mature T cells modified with a chimeric antigen receptor has demonstrated improved outcome for B-cell malignancies. However, its application for others such as Hodgkin lymphoma remains a clinical challenge. CD30 antigen, expressed in Hodgkin lymphoma cells, is absent in most healthy tissues, representing an ideal target of ACT for this disease. Despite that, efficacy of CD30-chimeric antigen receptor (CAR) T cells for Hodgkin lymphoma remains modest. Here, we have developed and tested a novel CD30-CAR T to improve efficacy of CD30-CAR therapy, using a targeting epitope within the non-cleavable part of CD30 receptor, and memory stem T cells (T) to improve engraftment, persistence and antitumor activity. T cultures were generated and expanded ex vivo and transduced at day 1 or 2 with a lentiviral vector encoding the CD30-CAR. Therapeutic in vivo experiments were performed using NSG mice injected with L540 (sc) or L428 (iv) and treated with CD30-CAR T cells when the tumor was established. CD30-CAR T cells generated and expanded ex vivo, despite CD30 expression and fratricide killing of CD30 + CAR T cells, were not impaired by soluble CD30 and completely eradicated Hodgkin lymphoma in vivo, showing high persistence and long-lasting immunity. In addition, highly enriched CD30-CAR T products confer a survival advantage in vivo, in contrast to more differentiated CAR T cells, with higher tumor infiltration and enhanced antitumor effect. This study supports the use of a refined CD30-CAR T cells with highly enriched T products to improve clinical efficacy of CAR T for Hodgkin lymphoma. We have studied the efficacy of a redesigned CD30-chimeric antigen receptor (CAR) targeting a proximal epitope to enhance the antitumor efficacy. CD30-CAR T cells show potent in vivo antitumor effect in different Hodgkin lymphoma models, and overcome inhibition by soluble CD30. CD30-CAR memory stem T-cell products show long-term persistence, improved tumor homing and long-lasting immunity

Fascioliasis en caballos de valles andinos de Lujan de Cuyo, Mendoza: prevalencia y parámetros hematológicos

La fascioliasis es una enfermedad parasitaria cuyo agente etiológico en el Nuevo Mundo es el tremátodo Fasciola hepatica y afecta a numerosas especies de mamíferos y al ser humano. A pesar de que en Argentina el rol de los rumiantes como reservorios ha sido bastante estudiado, a la fecha es muy poca la información disponible sobre fascioliasis en equinos, tanto a nivel internacional como nacional. Su importancia como reservorio se ve incrementada dado que estos animales son trasladados frecuentemente a eventos deportivos o utilizados como animales de carga y transporte, particularmente en zonas andinas. En lo concerniente al efecto que puede tener este parásito sobre los parámetros hematológicos del caballo, la información a nivel mundial es sumamente escasa. Su objetivo es describir prevalencia de fascioliasis en caballos de valles andinos de Luján de Cuyo. Describir pará- metros hematológicos en caballos naturalmente parasitados con Fasciola hepatica

Premios MetaComunicación: un proyecto para el aprendizaje de la gestión de intangibles en las organizaciones

El proyecto 'Premios MetaComunicación' es una experiencia docente, enmarcada en la asignatura Gabinetes de Comunicación, de tercer curso del Grado en Periodismo, con la que los alumnos de esta asignatura, impartida por el profesor Joaquín Sotelo González en la Facultad de Ciencias de la Información, ponen en práctica los planteamientos teóricos de la asignatura. En esencia, se trata de una iniciativa con la que se premia a algunos de los mejores profesionales de la Comunicación en España, según el criterio de los propios estudiantes de la Facultad de Ciencias de la Información de la Universidad Complutense de Madrid