Deformations of Resolutions of Two-Dimensional Singularities

Paper by Henry B. Laufe

On Upper Bounds for Toroidal Mosaic Numbers

In this paper, we work to construct mosaic representations of knots on the torus, rather than in the plane. This consists of a particular choice of the ambient group, as well as different definitions of contiguous and suitably connected. We present conditions under which mosaic numbers might decrease by this projection, and present a tool to measure this reduction. We show that the order of edge identification in construction of the torus sometimes yields different resultant knots from a given mosaic when reversed. Additionally, in the Appendix we give the catalog of all 2 by 2 torus mosaics.Comment: 10 pages, 111 figure

Structural characterization of a first-generation articulated-truss joint for space crane application

A first-generation space crane articulated-truss joint was statically and dynamically characterized in a configuration that approximated an operational environment. The articulated-truss joint was integrated into a test-bed for structural characterization. Static characterization was performed by applying known loads and measuring the corresponding deflections to obtain load-deflection curves. Dynamic characterization was performed using modal testing to experimentally determine the first six mode shapes, frequencies, and modal damping values. Static and dynamic characteristics were also determined for a reference truss that served as a characterization baseline. Load-deflection curves and experimental frequency response functions are presented for the reference truss and the articulated-truss joint mounted in the test-bed. The static and dynamic experimental results are compared with analytical predictions obtained from finite element analyses. Load-deflection response is also presented for one of the linear actuators used in the articulated-truss joint. Finally, an assessment is presented for the predictability of the truss hardware used in the reference truss and articulated-truss joint based upon hardware stiffness properties that were previously obtained during the Precision Segmented Reflector (PSR) Technology Development Program

HIT: a Human-Inspired Trust model

This paper presents a new approach to assign trust levels in ad hoc networks. Our system is inspired by the human concept of trust. The trust level considers the recommendation of trustworthy neighbors and their own experience. For the recommendation computation, we take into account not only the trust level, but also its accuracy and the relationship maturity. We also propose the Recommendation Exchange Protocol (REP), which minimizes the number of exchanged messages. The results show the efficacy of the system and the influence of main parameters.8th IFIP/IEEE International conference on Mobile and Wireless CommunicationRed de Universidades con Carreras en Informática (RedUNCI

Endocrine-disrupting alkylphenols are widespread in the blood of lobsters from southern New England and adjacent offshore areas

Author Posting. © National Shellfisheries Association , 2012. This article is posted here by permission of National Shellfisheries Association for personal use, not for redistribution. The definitive version was published in Journal of Shellfish Research 31 (2012): 563-571, doi:10.2983/035.031.0216.Endocrine-disrupting pollutants in rivers and oceans represent a poorly understood but potentially serious threat to the integrity of aquatic and coastal ecosystems. We surveyed the hemolymph of lobsters from across southern New England and adjacent offshore areas for 3 endocrine-disrupting alkylphenols. We found all 3 compounds in hemolymph from every year and almost every region sampled. Prevalence of contamination varied significantly between regions, ranging from 45% of lobsters from southern Massachusetts to 17% of lobsters from central Long Island Sound. Mean contamination levels varied significantly as a function of region, year sampled, and collection trip, and were highest overall in lobsters from western Long Island Sound and lowest in lobsters from central Long Island Sound. Surprisingly, lobsters from offshore areas were not less contaminated than lobsters from inshore areas. Contamination levels also did not vary as a function of lobster size or shell disease signs. Contaminated lobsters held in the laboratory did not retain alkylphenols, suggesting that hemolymph contamination levels represent recent, rather than long-term, exposure. Our data set is the first, to our knowledge, to survey endocrine-disrupting contaminants in a population across such a broad temporal and spatial scale. We show that alkylphenol contamination is a persistent, widespread, but environmentally heterogeneous problem in lobster populations in southern New England and adjacent offshore areas. Our work raises serious questions about the prevalence and accumulation of these endocrine-disrupting pollutants in an important fishery species.This work was supported by the National Marine Fisheries Service as the New England Lobster Research Initiative: Lobster Shell Disease under NOAA grant NA06NMF4720100 to the University of Rhode Island Fisheries Center

Conifold geometries, topological strings and multi-matrix models

We study open B-model representing D-branes on 2-cycles of local Calabi--Yau geometries. To this end we work out a reduction technique linking D-branes partition functions and multi-matrix models in the case of conifold geometries so that the matrix potential is related to the complex moduli of the conifold. We study the geometric engineering of the multi-matrix models and focus on two-matrix models with bilinear couplings. We show how to solve this models in an exact way, without resorting to the customary saddle point/large N approximation. The method consists of solving the quantum equations of motion and using the flow equations of the underlying integrable hierarchy to derive explicit expressions for correlators. Finally we show how to incorporate in this formalism the description of several group of D-branes wrapped around different cycles.Comment: 35 pages, 5.3 and 6 revise

Vocabulary depth and its contribution to text quality in the early years of primary school = Profundidad de vocabulario y su contribución a la calidad textual en los primeros años de Educación Primaria

p. 82 - 116El propósito de este estudio es analizar cómo evoluciona la profundidad de vocabulario durante los primeros cursos de Educación Primaria y comprobar qué efecto tiene en la calidad de los textos producidos por el alumnado. Participaron 332 estudiantes españoles, de 1º a 4º de Educación Primaria, que llevaron a cabo una tarea de sinónimos/ antónimos, para evaluar la profundidad del vocabulario, y varias tareas de escritura de textos descriptivos para evaluar la calidad del texto. La profundidad de vocabulario se analizó con un sistema de cuatro dimensiones creado ad hoc: cambio de lexema, ajuste al sentido del significado solicitado, preservación de la categoría sintáctica y grado de convencionalidad. Como indicadores de la calidad textual se eligieron la productividad, el índice de subordinación y la estructura textual. Los resultados revelaron que tanto la profundidad del vocabulario como la calidad de los textos producidos mejoraron significativamente con el nivel escolar. Se encontró también que este tipo de conocimiento léxico contribuye significativamente a la calidad textual de los textos evaluados. Se comentan las posibles implicaciones didácticas de estos hallazgos.S

Inhibition of gastric H,K-ATPase activity and gastric epithelial cell IL-8 secretion by the pyrrolizine derivative ML 3000

BACKGROUND: ML 3000 ([2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl]-acetic acid) is an inhibitor of both cyclooxygenase and 5-lipoxygenase in vitro, and shows promise as a novel non-steroidal anti-inflammatory drug (NSAID). Unlike conventional NSAIDs which are associated with gastric ulcerogenic effects, ML 3000 causes little or no damage to the gastric mucosa, even though it significantly depresses gastric prostaglandin synthesis. METHODS: As part of an effort to clarify mechanisms underlying the gastric sparing properties of ML 3000, we studied the effects of ML 3000 on H,K-ATPase activity in vitro, on acid accumulation in isolated gastric parietal cells, and on IL-8 secretion by gastric epithelial cells in culture. RESULTS: SCH28080-sensitive H,K-ATPase activity in highly-purified pig gastric microsomes was dose-dependently inhibited by ML 3000 (IC(50) = 16.4 μM). Inhibition was reversible, and insensitive to ML 3000 acidification in the pH range 2.0–8.0. In rabbit gastric parietal cells, ML 3000 dose-dependently inhibited histamine-stimulated acid accumulation (IC(50) = 40 μM) and forskolin-stimulated acid accumulation (IC(50) = 45 μM). Lastly, in human gastric adenocarcinoma (AGS) cells, ML 3000 dose-dependently inhibited both baseline and IL-1β-stimulated (20 ng/ml) IL-8 secretion with IC(50)s of 0.46 μM and 1.1 μM respectively. CONCLUSION: The data indicate that ML 3000 affects acid-secretory mechanisms downstream of cAMP mobilization induced by histamine H(2) receptor activation, that it directly inhibits H,K-ATPase specific activity, and that baseline gastric epithelial cell IL-8 secretory inhibition may be mediated by ML 3000 inhibition of 5-lipoxygenase activity. We conclude that these gastric function inhibitory data may underlie the gastric sparing properties of ML 3000

A validation of the Oswestry Spinal Risk Index

Purpose The purpose of this study was to validate the Oswestry Spinal Risk Index (OSRI) in an external population. The OSRI predicts survival in patients with metastatic spinal cord compression (MSCC). Methods We analysed the data of 100 patients undergoing surgical intervention for MSCC at a tertiary spinal unit and recorded the primary tumour pathology and Karnofsky performance status to calculate the OSRI. Logistic regression models and survival plots were applied to the data in accordance with the original paper. Results Lower OSRI scores predicted longer survival. The OSRI score predicted survival accurately in 74% of cases (p = 0.004). Conclusions Our study has found that the OSRI is a significant predictor of survival at levels similar to those of the original authors and is a useful and simple tool in aiding complex decision making in patients presenting with MSC