246 research outputs found
Borderline Q-waves in individuals without overt cardiovascular disease: relations with adiposity, subclinical atherosclerosis and vascular stiffness
Background:
Characteristics and risk factors associated with electrocardiographic borderline Q-waves are not fully elucidated, especially in individuals without overt cardiovascular disease (CVD). Also, the relation of isolated and non-isolated borderline Q-waves with subclinical atherosclerosis and vascular stiffness is unknown.
Methods and results:
We included 5746 Netherlands Epidemiology of Obesity study participants without overt CVD. Participants were divided in three groups: no Q-waves (93.7%), isolated (4.6%) and non-isolated borderline Q-waves (1.7%). Borderline Q-waves were defined as Minnesota Codes 1.2.x and 1.3.x and non-isolated as ≥1 of abnormal QRS axis, left ventricular hypertrophy or ST/T abnormalities. Several characteristics and measures of body fat were assessed. Vascular stiffness was assessed by pulse wave velocity (PWV) and subclinical atherosclerosis by carotid intima-media thickness (cIMT). Percentage of men, alcohol intake, blood pressure and fasting glucose concentrations were, compared with no Q-waves, higher in the isolated and highest in the non-isolated borderline Q-wave group. Isolated borderline Q-waves were associated with higher body mass index (difference compared with no Q-waves: 1.0 kg/m2; 95%CI: 0.3–1.7; p-value: 0.006), waist circumference (3.4 cm; 1.0–5.8; 0.005), and visceral adipose tissue (21.9 cm2; 7.4–36.3; 0.003) and differences were even larger for non-isolated borderline Q-waves. Compared with no Q-waves, non-isolated borderline Q-waves were associated with higher PWV (1.2 m/s; 0.4–2.0; 0.004) and cIMT (23.4 μm; 3.0–43.8; 0.024), whereas isolated borderline Q-waves were not.
Conclusion:
Cardiovascular risk factors and measures of body fat, especially abdominal adiposity, were higher in participants with isolated borderline Q-waves, compared with no Q-waves, and highest in the non-isolated borderline Q-wave group. Non-isolated borderline Q-waves were associated with subclinical atherosclerosis and vascular stiffness. Future studies should investigate potential added value of borderline Q-waves in CVD prediction
Effect of bending test on the performance of CdTe solar cells on flexible ultra-thin glass produced by MOCVD
The development of lightweight and flexible solar modules is highly desirable for high specific power applications, building integrated photovoltaics, unmanned aerial vehicles and space. Flexible metallic and polyimide foils are frequently used, but in this work an alternative substrate with attractive properties, ultra-thin glass (UTG) has been employed. CdTe solar cells with average efficiency reaching 14.7% AM1.5G efficiency have been produced on UTG of 100 μm thickness. Little has been reported on the effects on PV performance when flexed, so we investigated the effects on J-V parameters when the measurements were performed in 40 mm and 32 mm bend radius, and in a planar state before and after the bend curvature was applied. The flat J-V measurements after 32 mm bending test showed some improvement in efficiency, Voc and FF, with values higher than the first measurement in a planar state. In addition, two CdTe solar cells with identical initial performance were subjected to 32 mm static bending test for 168 hours, the results showed excellent uniformity and stability and no significant variation on J-V parameters was observed. External quantum efficiency and capacitance voltage measurements were performed and showed no significant change in spectral response or carrier concentration. Residual stress analysis showed that no additional strain was induced within the film after the bending test and that the overall strain was low. This has demonstrated the feasibility of using CdTe solar cells on UTG in new applications, when a curved module is required without compromising performance
Spatiotemporally localized solitons in resonantly absorbing Bragg reflectors
We predict the existence of spatiotemporal solitons (``light bullets'') in
two-dimensional self-induced transparency media embedded in a Bragg grating.
The "bullets" are found in an approximate analytical form, their stability
being confirmed by direct simulations. These findings suggest new possibilities
for signal transmission control and self-trapping of light.Comment: RevTex, 3 pages, 2 figures, to be published in PR
The effect of two-temperature post-shock accretion flow on the linear polarization pulse in magnetic cataclysmic variables
The temperatures of electrons and ions in the post-shock accretion region of
a magnetic cataclysmic variable (mCV) will be equal at sufficiently high mass
flow rates or for sufficiently weak magnetic fields. At lower mass flow rates
or in stronger magnetic fields, efficient cyclotron cooling will cool the
electrons faster than the electrons can cool the ions and a two-temperature
flow will result. Here we investigate the differences in polarized radiation
expected from mCV post-shock accretion columns modeled with one- and
two-temperature hydrodynamics. In an mCV model with one accretion region, a
magnetic field >~30 MG and a specific mass flow rate of ~0.5 g/cm/cm/s, along
with a relatively generic geometric orientation of the system, we find that in
the ultraviolet either a single linear polarization pulse per binary orbit or
two pulses per binary orbit can be expected, depending on the accretion column
hydrodynamic structure (one- or two-temperature) modeled. Under conditions
where the physical flow is two-temperature, one pulse per orbit is predicted
from a single accretion region where a one-temperature model predicts two
pulses. The intensity light curves show similar pulse behavior but there is
very little difference between the circular polarization predictions of one-
and two-temperature models. Such discrepancies indicate that it is important to
model some aspect of two-temperature flow in indirect imaging procedures, like
Stokes imaging, especially at the edges of extended accretion regions, were the
specific mass flow is low, and especially for ultraviolet data.Comment: Accepted for publication in Astrophysics & Space Scienc
The Muonium Atom as a Probe of Physics beyond the Standard Model
The observed interactions between particles are not fully explained in the
successful theoretical description of the standard model to date. Due to the
close confinement of the bound state muonium () can be used as
an ideal probe of quantum electrodynamics and weak interaction and also for a
search for additional interactions between leptons. Of special interest is the
lepton number violating process of sponteanous conversion of muonium to
antimuonium.Comment: 15 pages,6 figure
Parameters of the Magnetic Flux inside Coronal Holes
Parameters of magnetic flux distribution inside low-latitude coronal holes
(CHs) were analyzed. A statistical study of 44 CHs based on Solar and
Heliospheric Observatory (SOHO)/MDI full disk magnetograms and SOHO/EIT 284\AA
images showed that the density of the net magnetic flux, , does
not correlate with the associated solar wind speeds, . Both the area and
net flux of CHs correlate with the solar wind speed and the corresponding
spatial Pearson correlation coefficients are 0.75 and 0.71, respectively. A
possible explanation for the low correlation between and
is proposed. The observed non-correlation might be rooted in the structural
complexity of the magnetic field. As a measure of complexity of the magnetic
field, the filling factor, , was calculated as a function of spatial
scales. In CHs, was found to be nearly constant at scales above 2 Mm,
which indicates a monofractal structural organization and smooth temporal
evolution. The magnitude of the filling factor is 0.04 from the Hinode SOT/SP
data and 0.07 from the MDI/HR data. The Hinode data show that at scales smaller
than 2 Mm, the filling factor decreases rapidly, which means a mutlifractal
structure and highly intermittent, burst-like energy release regime. The
absence of necessary complexity in CH magnetic fields at scales above 2 Mm
seems to be the most plausible reason why the net magnetic flux density does
not seem to be related to the solar wind speed: the energy release dynamics,
needed for solar wind acceleration, appears to occur at small scales below 1
Mm.Comment: 6 figures, approximately 23 pages. Accepted in Solar Physic
Cosmological parameters from SDSS and WMAP
We measure cosmological parameters using the three-dimensional power spectrum
P(k) from over 200,000 galaxies in the Sloan Digital Sky Survey (SDSS) in
combination with WMAP and other data. Our results are consistent with a
``vanilla'' flat adiabatic Lambda-CDM model without tilt (n=1), running tilt,
tensor modes or massive neutrinos. Adding SDSS information more than halves the
WMAP-only error bars on some parameters, tightening 1 sigma constraints on the
Hubble parameter from h~0.74+0.18-0.07 to h~0.70+0.04-0.03, on the matter
density from Omega_m~0.25+/-0.10 to Omega_m~0.30+/-0.04 (1 sigma) and on
neutrino masses from <11 eV to <0.6 eV (95%). SDSS helps even more when
dropping prior assumptions about curvature, neutrinos, tensor modes and the
equation of state. Our results are in substantial agreement with the joint
analysis of WMAP and the 2dF Galaxy Redshift Survey, which is an impressive
consistency check with independent redshift survey data and analysis
techniques. In this paper, we place particular emphasis on clarifying the
physical origin of the constraints, i.e., what we do and do not know when using
different data sets and prior assumptions. For instance, dropping the
assumption that space is perfectly flat, the WMAP-only constraint on the
measured age of the Universe tightens from t0~16.3+2.3-1.8 Gyr to
t0~14.1+1.0-0.9 Gyr by adding SDSS and SN Ia data. Including tensors, running
tilt, neutrino mass and equation of state in the list of free parameters, many
constraints are still quite weak, but future cosmological measurements from
SDSS and other sources should allow these to be substantially tightened.Comment: Minor revisions to match accepted PRD version. SDSS data and ppt
figures available at http://www.hep.upenn.edu/~max/sdsspars.htm
Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes
Background/ObjectivesEndocannabinoids (ECs) are associated with obesity and ectopic fat accumulation, both of which play a role in the development of cardiovascular disease (CVD) in type 2 diabetes (T2D). The effect of prolonged caloric restriction on ECs in relation to fat distribution and cardiac function is still unknown. Therefore, our aim was to investigate this relationship in obese T2D patients with coronary artery disease (CAD).Subjects/MethodsIn a prospective intervention study, obese T2D patients with CAD (n = 27) followed a 16 week very low calorie diet (VLCD; 450–1000 kcal/day). Cardiac function and fat accumulation were assessed with MRI and spectroscopy. Plasma levels of lipid species, including ECs, were measured using liquid chromatography-mass spectrometry.ResultsVLCD decreased plasma levels of virtually all measured lipid species of the class of N-acylethanolamines including the EC anandamide (AEA; −15%, p = 0.016), without decreasing monoacylglycerols including the EC 2-arachidonoylglycerol (2-AG). Baseline plasma AEA levels strongly correlated with the volume of subcutaneous white adipose tissue (SAT; R2 = 0.44, p p p p p p p p = 0.016).ConclusionsCaloric restriction in T2D patients with CAD decreases AEA levels, but not 2-AG levels, which is paralleled by decreased lipid accumulation in adipose tissue, liver and heart, and improved cardiovascular function. Interestingly, baseline AEA levels strongly correlated with SAT volume. We anticipate that dietary interventions are worthwhile strategies in advanced T2D, and that reduction in AEA may contribute to the improved cardiometabolic phenotype induced by weight loss.Molecular Physiolog
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