RTsim: A register transfer simulator

The growing complexity and size of VLSI processors are demanding extremely accurate, yet efficient, simulation facilities for microcode debugging, logic verification, and system integration. However, reliance on mask iterations to remedy problems on a chip not only raises costs, but also extends the design cycle. Simulation justifies itself in both the turn around time and the design cost. Gate level simulation is one method for reducing errors in a chip design. However, gate level simulation of large designs are extremely expensive, and sometimes impossible when the gate level representation is not known. This thesis attempts to solve this problem by providing a functional level approach, consisting of a register transfer description language, an embedded functional modeling language, a reconfigurable assembler, and a functional simulation program. Mixed-level simulation capability is also provided by allowing the replacement of a functional unit by a transistor network which is being simulated by a switch-level logic simulator

The application of information technologies to public transportation

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1994.Includes bibliographical references (leaves 2218-222).by Chi Fun Jimmy Lam.M.S

3D Self-Localization of Drones using a Single Millimeter-Wave Anchor

We present the design, implementation, and evaluation of MiFly, a self-localization system for autonomous drones that works across indoor and outdoor environments, including low-visibility, dark, and GPS-denied settings. MiFly performs 6DoF self-localization by leveraging a single millimeter-wave (mmWave) anchor in its vicinity - even if that anchor is visually occluded. MmWave signals are used in radar and 5G systems and can operate in the dark and through occlusions. MiFly introduces a new mmWave anchor design and mounts light-weight high-resolution mmWave radars on a drone. By jointly designing the localization algorithms and the novel low-power mmWave anchor hardware (including its polarization and modulation), the drone is capable of high-speed 3D localization. Furthermore, by intelligently fusing the location estimates from its mmWave radars and its IMUs, it can accurately and robustly track its 6DoF trajectory. We implemented and evaluated MiFly on a DJI drone. We demonstrate a median localization error of 7cm and a 90th percentile less than 15cm, even when the anchor is fully occluded (visually) from the drone

Special Libraries, January 1930

Volume 21, Issue 1https://scholarworks.sjsu.edu/sla_sl_1930/1000/thumbnail.jp

Calidad en el sector de salud privado de lima metropolitana en el 2014

El presente trabajo de investigación se ha realizado con el propósito de identificar el nivel de cumplimiento de los factores de éxito de la Administración de la Calidad Total en las empresas del sector Salud Privado de Lima Metropolitana en el Perú en el año 2014. Para llevar a cabo el estudio se realizó una encuesta a un total de 247 clínicas del sector salud privado de Lima Metropolitana, delimitando este sector al conjunto de entidades que velan por el bienestar y prevención de la salud de las personas dentro de una población, sean estos centros de salud, policlínicos particulares, clínicas y consultorios privados. El resultado de la encuesta permitió obtener una muestra total de 70 entidades, con las cuales se procedió a tabular y realizar el análisis de los resultados. A nivel general, la calificación obtenida de los nueve factores de éxito de la Administración de la Calidad Total, fue de 3.71 dentro de una escala de Likert de 1 a 5, por el valor promedio obtenido se puede concluir que las empresas del sector de salud privado de Lima Metropolitana en el Perú al 2014, tienden a cumplir los factores de éxito de la Administración de la Calidad Total, sin embargo aún tienen oportunidad de realizar una mejor gestión para incrementar su desempeño en cada uno de los factores de éxito.The aim of the present study was to identify the level of compliance of the success factors of Total Quality Management applied in companies of the Lima Private Health Sector by 2014. In order to carry out the study, a survey was performed in 247 private health sectors, focusing on health centers, private clinics, clinics and private practices. The result of the survey yielded a total sample of 70 institutions that we proceeded to tabulate and analyze the results. Overall, the score obtained for the nine Total Quality Management success factors was 3.71 in Likert scale from 1 to 5. Due to the average value obtained, it can be concluded that the Lima-Peru Private Health Sector companies by 2014 met the success factors of Total Quality Management. However, they still have opportunity to improve their performance management of each of the success factors.Tesi

In vitro selection of small RNA-cleaving deoxyribozymes that cleave pyrimidine–pyrimidine junctions

Herein, we sought new or improved endoribonucleases based on catalytic DNA molecules known as deoxyribozymes. The current repertoire of RNA-cleaving deoxyribozymes can cleave nearly all of the 16 possible dinucleotide junctions with rates of at least 0.1/min, with the exception of pyrimidine–pyrimidine (pyr–pyr) junctions, which are cleaved 1–3 orders of magnitude slower. We conducted four separate in vitro selection experiments to target each pyr–pyr dinucleotide combination (i.e. CC, UC, CT and UT) within a chimeric RNA/DNA substrate. We used a library of DNA molecules containing only 20 random-sequence nucleotides, so that all possible sequence permutations could be sampled in each experiment. From a total of 245 clones, we identified 22 different sequence families, of which 21 represented novel deoxyribozyme motifs. The fastest deoxyribozymes exhibited kobs values (single-turnover, intermolecular format) of 0.12/min, 0.04/min, 0.13/min and 0.15/min against CC, UC, CT and UT junctions, respectively. These values represent a 6- to 8-fold improvement for CC and UC junctions, and a 1000- to 1600-fold improvement for CT and UT junctions, compared to the best rates reported previously under identical reaction conditions. The same deoxyribozymes exhibited ∼1000-fold lower activity against all RNA substrates, but could potentially be improved through further in vitro evolution and engineering

Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Controversy surrounds the use of PSA as a biomarker for prostate cancer detection, leaving an unmet need for a novel biomarker in this setting; urinary EN2 may identify individuals with clinically relevant prostate cancer. Male BRCA1 and BRCA2 mutation carriers are at increased risk of clinically significant prostate cancer and may benefit from screening. Urine samples from 413 BRCA1 and BRCA2 mutation carriers and controls were evaluated. Subjects underwent annual PSA screening with diagnostic biopsy triggered by PSA > 3.0 ng/ml; 21 men were diagnosed with prostate cancer. Urinary EN2 levels were measured by ELISA and had a sensitivity of 66.7% and specificity of 89.3% for cancer detection. There was no statistically significant difference in EN2 levels according to genetic status or Gleason score. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals

Common susceptibility variants are shared between schizophrenia and psoriasis in the Han Chinese population

Previous studies have shown that individuals with schizophrenia have a greater risk for psoriasis than a typical person. This suggests that there might be a shared genetic etiology between the 2 conditions. We aimed to characterize the potential shared genetic susceptibility between schizophrenia and psoriasis using genome-wide marker genotype data

Effect of real-time computer-aided polyp detection system (ENDO-AID) on adenoma detection in endoscopists-in-training: a randomized trial

Background The effect of computer-aided polyp detection (CADe) on adenoma detection rate (ADR) among endoscopists-in-training remains unknown. Methods We performed a single-blind, parallel-group, randomized controlled trial in Hong Kong between April 2021 and July 2022 (NCT04838951). Eligible subjects undergoing screening/surveillance/diagnostic colonoscopies were randomized 1:1 to receive colonoscopies with CADe (ENDO-AID(OIP-1), Olympus Co., Japan) or not (control) during withdrawal. Procedures were performed by endoscopists-in-training with <500 procedures and <3 years’ experience. Randomization was stratified by patient age, sex, and endoscopist experience (beginner vs intermediate-level, <200 vs 200-500 procedures). Image enhancement and distal attachment devices were disallowed. Subjects with incomplete colonoscopies or inadequate bowel preparation were excluded. Treatment allocation was blinded to outcome assessors. The primary outcome was ADR. Secondary outcomes were ADR for different adenoma sizes and locations, mean number of adenomas, and non-neoplastic resection rate. Results 386 and 380 subjects were randomized to CADe and control groups, respectively. The overall ADR was significantly higher in CADe than control group (57.5% vs 44.5%, adjusted relative risk 1.41, 95%CI 1.17-1.72, p<0.001). The ADRs for <5mm (40.4% vs 25.0%) and 5-10mm adenomas (36.8% vs 29.2%) were higher in CADe group. The ADRs were higher in CADe group in both right (42.0% vs 30.8%) and left colon (34.5% vs 27.6%), but there was no significant difference in advanced ADR. The ADRs were higher in CADe group among beginners (60.0% vs 41.9%) and intermediate-level endoscopists (56.5% vs 45.5%). Mean number of adenomas (1.48 vs 0.86) and non-neoplastic resection rate were higher in CADe group (52.1% vs 35.0%). Conclusions Among endoscopists-in-training, the use of CADe during colonoscopies was associated with increased overall ADR. (ClinicalTrials.gov: NCT04838951